Pregnancy

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Maternal Marijuana Use and Adverse Neonatal Outcomes

OBJECTIVE: To estimate whether marijuana use in pregnancy increases risks for adverse neonatal outcomes and clarify if any increased risk is attributable to marijuana use itself or to confounding factors such as tobacco use. DATA SOURCES: Two authors performed a search of the data through August 2015 utilizing PubMed, Embase, Scopus, Cochrane reviews, ClinicalTrials.gov, and […]

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Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes

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Marijuana Use During Pregnancy and Lactation

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Cannabis Use in Pregnancy A Tale of 2 Concerns

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Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4

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Association of Depression, Anxiety, and Trauma With Cannabis Use During Pregnancy

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The Endocannabinoid-CB Receptor System:Importance for development and in pediatric disease

Endogenous cannabinoids (endocannabinoids) and their cannabinoid CB1 and CB2 receptors, are present from the early stages of gestation and play a number of vital roles for the developing organism. Although most of these data are collected from animal studies, a role for cannabinoid receptors in the developing human brain has been suggested, based on the […]

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Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica: An Ethnographic Stud

OBJECTIVE: To identify neurobehavioral effects of prenatal marijuana exposure on neonates in rural Jamaica. DESIGN: Ethnographic field studies and standardized neuro-behavior assessments during the neonatal period. SETTING: Rural Jamaica in heavy-marijuana-using population. PARTICIPANTS: Twenty-four Jamaican neonates exposed to marijuana prenatally and 20 nonexposed neonates. MEASUREMENTS AND MAIN RESULTS: Exposed and nonexposed neonates were compared at […]

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Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development

The endocannabinoid system, including its receptors (CB1 and CB2), endogenous ligands (‘endocannabinoids’), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic development and throughout pre- and postnatal development. In addition, the endocannabinoids, notably 2-arachidonyl glycerol, are also present in maternal milk. During three distinct developmental stages […]

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Maternal Marijuana Use During Lactation and Infant Development at One Year

Prenatal marijuana exposure is associated with adverse perinatal effects. Very little is known about the effect of postnatal marijuana exposure on infant development. Postnatal exposure can result from maternal use of marijuana during lactation. Delta-9-tetrahydrocannabinol (THC) transfers and concentrates in the mother’s milk and is absorbed and metabolized by the nursing infant. The present study […]

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