Bronchodilator Effect of Delta-Tetrahydrocannabinol

The principal psycho-active constituent of cannabis, ∆-trans-tetrahydrocannabinol (∆-THC) has bronchodilator activity in man, both in normal subjects (Vachon, Fitzgerald, Solliday, Gould & Gaensler, 1973; Tashkin, Shapiro & Frank, 1973) and […]

November 18, 2020

Endocannabinoids and Gonadal Hormones: Bidirectional Interactions in Physiology and Behavior

Endocannabinoids act as a major neuromodulatory system in a variety of physiological and behavioral functions. Three major lines of evidence suggest that the endocannabinoid system interacts with gonadal hormones. First, […]

September 16, 2020

The Relationship between Marijuana Use Prior to Sex and Sexual Function in Women

Introduction Scientific research on the effects of marijuana on sexual functioning in women, including libido, arousal, orgasm, and satisfaction, is limited. Aim To evaluate women’s perceptions of the effect of […]

Cannabis, Cannabinoids, and Sleep: a Review of the Literature

Purpose of Review The current review aims to summarize the state of research on cannabis and sleep up to 2014 and to review in detail the literature on cannabis and […]

Review of the neurological benefits of phytocannabinoids

Background: Numerous physical, psychological, and emotional benefits have been attributed to marijuana since its first reported use in 2,600 BC in a Chinese pharmacopoeia. The phytocannabinoids, cannabidiol (CBD), and delta-9-tetrahydrocannabinol […]

Therapeutic Effects of Prolonged Cannabidiol Treatment on Psychological Symptoms and Cognitive Function in Regular Cannabis Users

Introduction: Chronic cannabis use has been associated with impaired cognition and elevated psychological symptoms, particularly psychotic-like experiences. While Δ9-tetrahydrocannabinol (THC) is thought to be primarily responsible for these deleterious effects, […]

Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes

OBJECTIVE Cannabidiol (CBD) and Δ9-tetrahydrocannabivarin (THCV) are nonpsychoactive phytocannabinoids affecting lipid and glucose metabolism in animal models. This study set out to examine the effects of these compounds in patients […]

Role of Cannabinoids in Gastrointestinal Mucosal Defense and Inflammation

Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid receptors as well as regulatory enzymes responsible for the synthesis or degradation of endocannabinoids […]

Therapeutic Use of Cannabis in Inflammatory Bowel Disease

The marijuana plant Cannabis sativa and its derivatives,cannabinoids, have grown increasingly popular as a potential therapy for inflammatory bowel disease (IBD). Studies have shown that modulation of the endocannabinoid system, […]

Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing

Cannabinoid ligands regulate bone mass, but skeletal effects of cannabis (marijuana and hashish) have not been reported. Bone fractures are highly prevalent, involving prolonged immobilization and discomfort. Here we report […]