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Research Library

Realm of Caring's Latest Published Research

Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Effects of short-term cannabidiol treatment on response to social stress in subjects at clinical high risk of developing psychosis


Abstract   Rationale Stress is a risk factor for psychosis and treatments which mitigate its harmful effects are needed. Cannabidiol (CBD) has antipsychotic and anxiolytic effects.   Objectives We investigated […]

February 20, 2023


A possible role for the endocannabinoid system in the neurobiology of depression


Abstract   The present review synthetically describes the currently advanced hypotheses for a neurobiological basis of depression, ranging from the classical monoaminergic to the more recent neurotrophic hypothesis. Moreover, the […]


Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity


SUMMARY   Cannabidiol (CBD), a non-euphoric component of cannabis, reduces seizures in multiple forms of pediatric epilepsies, but the mechanism(s) of anti-seizure action remain unclear. In one leading model, CBD […]

February 16, 2023


State Cannabis Legalization and Psychosis-Related Health Care Utilization


Question  Is state cannabis legalization or commercialization associated with increased rates of psychosis-related health care claims?   Findings  In this cohort study of claims data from 63 680 589 beneficiaries from 2003 to 2017, […]


Inhaled D9 -tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression


Abstract   Background: In humans, the effect of cannabis on ventilatory control is poorly studied, and consequently, the effect of D9 -tetrahydrocannabinol (THC) remains unknown, particularly when THC is combined […]


Association of cannabis use during pregnancy with severe acute respiratory syndrome coronavirus 2 infection


Abstract   Background and Aims: Cannabis use is increasingly common among pregnant individuals and might be a risk factor for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed […]


Medical cannabis for treatment-resistant combat PTSD


Targeting the endocannabinoid system may have a role in the treatment of post-traumatic stress disorder (PTSD). However, few studies have examined the effectiveness of cannabis on symptoms of PTSD, and […]


Clinical Outcome Data of Children Treated with Cannabis-Based Medicinal Products for Treatment Resistant Epilepsy


Abstract   Background There is a paucity of high-quality evidence of the efficacy and safety of cannabis-based medicinal products in treatment of treatment-resistant epilepsy (TRE) in children. Methods A case […]

February 14, 2023


Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts


Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens. […]

January 23, 2023


Online survey of medicinal cannabis users: Qualitative analysis of patient-level data


Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations, […]

September 6, 2022


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