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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Cannabis Glandular Trichomes: A Cellular Metabolite Factory


Abstract Cannabis has been legalized for recreational use in several countries and medical use is authorized in an expanding list of countries; markets are growing internationally, causing an increase in […]

June 11, 2025


The Effects of Cannabis on Female Reproductive Health Across the Life Course


Abstract Introduction: Cannabis is commonly used for its medicinal and therapeutic benefits and is also widely used as a recreational drug. Cannabis use has been increasing in Canada, including among […]


Safety and Efficacy of Medicinal Cannabis in the Treatment of Fibromyalgia: A Systematic Review


Please use this link to access this publication. Abstract Background: Fibromyalgia (FMS) is a complex condition that is characterized by various pain syndromes and fatigue, among other symptoms experienced. Current medical […]

June 7, 2025


Older Cannabis Users Are Not All Alike: Lifespan Cannabis Use Patterns


Please use this link to access this publication. Abstract Although several studies have examined individual-level correlates of cannabis use in later life, there is scant evidence identifying heterogeneity among older […]


Cannabis Abuse and Perioperative Complications Following Inpatient Spine Surgery in the United States


Please use this link to access this publication. Abstract Mini Due to its complicated legal status, the effects of cannabis on elective spine surgery patients have not been well studied. […]


Neuropsychological performance in young adults with cannabis use disorder


Abstract Background and Aims: Cannabis is a commonly used recreational drug in young adults. The worldwide prevalence in 18- to 25-year-olds is approximately 35%. Significant differences in cognitive performance have […]


Effect of preoperative cannabis use on perioperative outcomes: a retrospective cohort study


Please use this link to access this publication. Abstract Introduction The reported use of cannabis within surgical population is increasing. Cannabis use is potentially associated with increased harms and varied effects […]


Cannabis use and psychosocial functioning: evidence from prospective longitudinal studies


Please use this link to access this publication. Abstract Cannabis legalization is expected to result in more frequent and compulsive use, potentially contributing to worsening psychosocial functioning among some cannabis […]


Cannabis Affects Cerebellar Volume and Sleep Differently in Men and Women


Abstract Background: There are known sex differences in behavioral and clinical outcomes associated with drugs of abuse, including cannabis. However, little is known about how chronic cannabis use and sex interact […]


Cannabis and Migraine: It’s Complicated


Please use this link to access this publication. Abstract Purpose of Review The use of cannabis for the treatment of migraine has become an area of interest with the legalization […]


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