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Found 770 Results

Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. In this study, we have investigated the effects of a nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant […]

The Endocannabinoid System of Animals

Our understanding of the Endocannabinoid System of animals, and its ubiquitous presence in nearly all members of Animalia, has opened the door to novel approaches targeting pain management, cancer therapeutics, modulation of neurologic disorders, stress reduction, anxiety management, and inflammatory diseases. Both endogenous and exogenous endocannabinoid-related molecules are able to function as direct ligands or, […]

Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats

The use of cannabidiol (CBD)-rich hemp-based nutraceuticals is increasing in dogs and cats for disorders related to anxiety, seizures, cancer and pain. To date, there is little information related to appropriate dosing or long-term effects on serum chemistry or complete blood counts (CBC), and little data on the pharmacokinetics of single- or long-term dosing in […]

Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

Osteoarthritis (OA) is the most common chronic condition that dogs face. If diagnosed, it is important to focus on managing the symptoms versus find a cure. This study shows that cannabidiol (CBD) can help increase comfort and activity levels in dogs with OA. Objectives: The objectives of this study were to determine basic oral pharmacokinetics, […]

US Veterinarians’ Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions

Due to the myriad of laws concerning cannabis, there is little empirical research regarding the veterinary use of cannabidiol (CBD). This study used the Veterinary Information Network (VIN) to gauge US veterinarians’ knowledge level, views and experiences related to the use of cannabinoids in the medical treatment of dogs. Participants (n = 2130) completed an […]

A selective review of medical cannabis in cancer pain management

Cancer is one of the most common reported conditions for using medical cannabis. This review can be useful to practitioners and policy makers when making decisions on use for cancer patients and cannabis in the future. Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond […]

Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control

The United States is currently undergoing a tragic opioid epidemic. We have a duty to try to curb this disaster. This study shows that by taking cannabis as an adjunct treatment, patients may be able to lower the amount of opioids needed to find pain relief. Abstract Background: There is currently little evidence regarding the […]

Medical cannabis and insomnia in older adults with chronic pain: a cross-sectional study

Having chronic pain can make it difficult to sleep through the night. And having a lack of sleep can compound the effects of any health issue, leading to a vicious cycle. This study shows that moderate cannabis use can help to maintain sleep throughout the entire night for those with chronic pain.   Objectives Medical […]

Maternal Marijuana Use and Adverse Neonatal Outcomes

OBJECTIVE: To estimate whether marijuana use in pregnancy increases risks for adverse neonatal outcomes and clarify if any increased risk is attributable to marijuana use itself or to confounding factors such as tobacco use. DATA SOURCES: Two authors performed a search of the data through August 2015 utilizing PubMed, Embase, Scopus, Cochrane reviews,, and […]

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