Category: Blog

Brief History

 

Functional mushrooms have seen various therapeutic applications in ancient civilizations for millenia. Both Lion’s Mane and Reishi (also known as Ling Zhi) mushrooms were regularly used in ancient China for thousands of years to treat various ailments. In Traditional Chinese Medicine, Lion’s Mane was often used to treat gastrointestinal problems, improve cognitive function, and mental health conditions like anxiety, depression, and insomnia. Reishi was used in Traditional Chinese Medicine to treat ailments related to the heart, lungs, liver, kidneys, and mental health. It was especially common as a medicine for cough and asthma. Similar uses of these mushrooms have been documented across ancient civilizations. However, despite this long documented history of therapeutic application, empirical research on functional mushrooms remains more limited than one might expect. Here’s what we know.

 

Therapeutic Applications

 

Lion’s Mane

 

Neuroprotective/neuroregenerative effects: Lion’s Mane has repeatedly demonstrated strong potential in treating neurodegenerative diseases such as Alzheimer’s and Parkinson’s. The mushroom contains components that are neuroprotective and promote neuroregeneration.

 

Cognitive benefits: Lion’s Mane has been found to improve cognitive performance among multiple populations: older adults ages 50-80 with mild cognitive impairment, healthy older adults (55+), and healthy adults. Lion’s Mane has also been found to improve memory. These improvements are likely caused by the substance’s well-documented neuroprotective and neuroregenerative properties.

 

Improvement in hearing: Lion’s Mane improved hearing among geriatric adults with hearing degeneration. It especially improved the ability to hear high frequencies and speech recognition.

 

Neurotrophic effects: Lion’s Mane has therapeutic potential to treat mood and sleep disorders. Studies have shown that Lion’s Mane can reduce depression, relieve anxiety, and improve sleep.

 

Anticancer: Lion’s Mane has been found to have antitumor properties. Constituents of the mushroom inhibit tumor and cancer cell growth.

 

Other effects: Lion’s Mane has therapeutic potential to treat gastrointestinal disorders by regulating gut microbiota and reducing inflammation. It has also been found to improve cholesterol by reducing the amount of lipids in the blood. Additionally, anti-aging properties have been observed. 

 

Reishi

 

Anticancer: Reishi has been found to have strong synergistic effects when used in tandem with chemotherapy or radiotherapy. A review found that patients including Reishi in the treatment were 1.27 times more likely to respond to chemotherapy and radiotherapy.

 

Anticonvulsant effects: There’s some evidence that Reishi has antiepileptic properties. Studies have shown that Reishi spore powder reduces seizure frequency by reducing accumulation of calcium, a primary characteristic of epilepsy.

 

Immunomodulatory effects: A clinical trial found that Reishi increases the number of immune cells present in peripheral blood among healthy children, and this finding was later corroborated in healthy adults. Reishi’s immunomodulatory activity contributes to its effectiveness in assisting with cancer treatment.

 

Cardiovascular effects: Reishi is commonly used to treat cardiovascular disease because it targets common risk factors. Reishi’s antioxidant, hypotensive, anti-inflammatory, metabolic effects work synergistically to treat and prevent cardiovascular diseases.

 

Metabolic effects: Reishi has been found to be effective in treating Chronic Fatigue Syndrome (CFS) by promoting the metabolic process in a way that allows the body and brain to utilize energy more effectively. Reishi has also been reported to have anti-diabetic effects.

 

Other effects: A variety of effects have been attributed to Reishi including: antiviral, antibacterial, prebiotic properties. Reishi has also been shown to improve high-fat diet induced obesity; by altering the gut biome, mouse models have shown reduced obesity and weight gain characteristics.

 

Functional Mushrooms for Epilepsy Study

 

For the past year, Realm of Caring, Unlimited Sciences, and Lily’s Lighthouse have been working in collaboration on an exciting mixed methods case study with multiple cases to highlight the therapeutic potential of Lion’s Mane and Reishi mushrooms for treating epilepsy. Data collection for the study has recently closed, and our research team has been excited to see reported improvements across various epilepsy and seizure types. In fact, 90% of participants reported a mild to strong belief that functional mushrooms have had a positive impact on the way seizures affect their life. Stay tuned for our publication detailing improvements in epilepsy symptoms and quality of life among those with epilepsy using functional mushrooms!

 

Flavonoids are compounds found in several parts of plants including the root, stem, and leaves. They play a variety of biological activity and are abundantly found in products of plant origin such as fruits, vegetables, tea, flowers, grains, and cannabis. Just as terpenes provide plants their smell, flavonoids provide plant their color while functioning as UV filters, signaling molecules, detoxifying agents, plant heat acclimatization and as a freezing tolerance. Currently around 6,000 flavonoids have been discovered. Through research, flavonoids have been considered an absolutely necessary component in a variety of nutraceuticals, pharmaceutical, medicinal, and cosmetic applications due to their broad range of health-promoting properties. 

 

Flavonoids in Cannabis

 

More than 20 flavonoids have been identified in cannabis Sativa. Cannabis is not a singular compound, rather it encompasses a vast and complicated molecular profile. The interaction of cannabinoids, terpenes, and flavonoids make up the “entourage effect” phenomenon, producing enhanced therapeutic effects. 

 

Full-Spectrum CBD Products

 

Hemp (industrial hemp) is a class of cannabis sativa, which is grown for industrial use and consumable use. Cannabidiol (CBD) products are derived from hemp and are considered full spectrum if all extracts from the plant are utilized including CBD, <0.3% delta-9-tetrahydrocannabinol (THC), other minor cannabinoids, terpenes, essential oils, and flavonoids. Broad spectrum is similar with the exception that there is not a detectable amount of THC found. Isolate products only contain the CBD molecule from the plant. 

 

When utilizing full-spectrum CBD products, the included flavonoids offer potential health benefits, such as antioxidant and anti-inflammatory effects. They work with cannabinoids and terpenes, contributing to CBD’s complex impact on the body.

 

Identified Potential Health Applications

 

Flavonoids have shown promise in various health applications that may contribute to overall well-being.

 

Inflammation and Pain Management

 

Flavonoids show anti-inflammatory properties, potentially managing pain. Cannflavin A may enhance the pain-relieve effects of CBD and THC through synergistic interaction.

 

Neuroprotective Properties

 

Several flavonoids exhibit neuroprotective qualities that may benefit brain health. Cannabis flavonoids luteolin and apigenin show promise for cognitive health. Luteolin may protect the brain, enhance memory, and combat brain fog. Apigenin potentially treats Alzheimer’s and offers sedative and muscle-relaxing benefits for mental well-being.

 

Cardiovascular Health

 

CBD flavonoids may benefit heart health. Anthocyanidins potentially prevent heart disease and manage blood pressure. Quercetin protects against oxidative stress. Kaempferol’s antioxidant properties may reduce cardiovascular risks. These compounds support overall heart function.

 

Key Flavonoids Found in CBD

 

Full and broad spectrum CBD products may contain various flavonoids that contribute to their unique properties and potential health benefits. Here are some of the key flavonoids you may find in your CBD:

 

Quercetin

 

Quercetin is known for its antioxidant and anti-inflammatory properties, which may have positive effects on heart health, cancer prevention, and allergy relief. 

 

Kaempferol

 

This natural substance has potent antioxidant properties, even surpassing vitamins C and E in effectiveness  in combating oxidative stress and inflammation, making it a potential candidate for treating disorders associated with chronic immune activation .

 

Luteolin

 

It has been found to have potential benefits in reducing oxidative stress and inflammation in various conditions may help alleviate allergy symptoms, reduce inflammation in multiple sclerosis, and even have anti-cancer properties.

 

Apigenin

 

Apigenin, an antioxidant bioflavonoid, has anti-anxiety effects and potential cancer-fighting properties.

 

Cannflavins

 

Cannflavins (A, B, C) are flavonoids partially unique to cannabis sativa. We say partially unique because Cannflavin A has also been identified in Mimulus bigelovii, a plant in the Phrymaceae family. Cannflavin A may offer neuroprotection, potentially benefiting Alzheimer’s disease.

 

Flavonoids synergize with other cannabis compounds, enhancing CBD benefits via the entourage effect. Cannflavin A and B show promise as an anti-inflammatory as they were about 30 times more effective than aspirin when studied in human rheumatoid cells.

 

Conclusion

 

Flavonoids offer diverse health benefits, complementing cannabinoids and terpenes. They influence inflammation, neuroprotection, and heart health. Compounds like quercetin, kaempferol, luteolin, apigenin, and cannflavins contribute to CBD’s complex effects. Ongoing research may lead to more targeted CBD formulations, exploring specific mechanisms and optimal compound combinations.

Medicinal use of cannabis for chronic pain has been reported across a number of conditions. Although not researched as often, cannabis is widely used for abdominal pain and mounting evidence suggests that compounds of the plant may play a therapeutic role. 

 

Abdominal pain

 

Stomach pain may refer to pain experienced in any one of the organs or muscles within the digestive system, abdominal wall, or abdominal shell. There is a broad range of diagnoses for abdominal cramping and pain and most everyone has experienced one form of it at some point in their lives. As some over the counter pain medications are not recommended for abdominal pain, due to the potential to worsen symptoms, alternative therapy options with lessened side effects are needed. 

 

The ECS and the digestive system

 

Increasing our understanding of the endocannabinoid system (ECS) helps to define new treatment options for various conditions. Evidence suggests that dysregulation of the ECS may have a role in intestinal disorders including inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). One of the many physiological roles the ECS fulfills is regulation of gastrointestinal function, therefore it is a logical target for the treatment of these conditions. Additionally, endocannabinoids are known to modulate pain through regulation of pain sensation and anti-inflammatory actions, which may further provide symptomatic relief. 

 

Cannabis use and pain

 

Cannabis use is commonly seen in patients looking for symptomatic relief from conditions associated with abdominal pain; such as IBD, endometriosis, IBS, ulcerative colitis, and gastroparesis. Patients have noted reduced pain coming from bloating, cramping, and inflammation. The most often used cannabinoids from the cannabis plant are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). 

 

Researched findings are revealing that these cannabinoids have a protective effect on the gut, which decreases inflammation and bloating, and further inherently suppress pain receptors serving as a “natural painkiller.” 

 

A 2021 published review looking at completed research on cannabis compounds for IBD found that there is a “great therapeutic potential” in this setting, particularly as potential treatments for abdominal pain and pain-modifying issues like diarrhea and nausea.  

 

Neuropathic pain is often difficult to treat and a symptom of gastroparesis. Due to limited treatment options and the neuromodulating ability of cannabinoids, researchers looked at the effect of prescribed cannabinoids on gastroparesis symptoms in a 2018 published study. Patients were prescribed either cannabis, the cannabis synthetic, Dronabinol, or a combination of both. When analyzed, all methods showed statistically significant improvement in abdominal pain scores.

 

When observing gut inflammation in biopsies from patients with ulcerative colitis and in rodent models with intestinal inflammation, researchers in 2011 concluded that CBD is a potent compound, able to modulate gut inflammation via the neuro-immune axis. 

 

Terpenes for gut health

 

In addition to cannabinoids, specific terpenes have shown to have intestinal anti-inflammatory activity as well as block oxidative stress, combat dysbiosis, and restore intestinal permeability. 

 

Among those researched terpenes that are also found in cannabis varieties are:

 

Alpha-Phellandrene/Phellandrene

 

This common monoterpene is found in several essential oils for a good reason. It shows extensive biological activity to include anti-inflammatory, anti-cancer, antidepressant, and analgesic properties. Historically used in Chinese medicine for digestive issues, this monoterpene is also found in turmeric and eucalyptus.

 

Strains of cannabis with phellandrene: Jack Herer and Trainwreck 

 

Borneol 

 

Used in traditional Chinese medicine, Borneol has shown pharmacological activity as an anti-inflammatory, vasorelaxant, and neuroprotectant. 

 

Borneol is considered a secondary terpene in cannabis due to minor amounts, however is found in Sour Diesel, OG Kush, and Amnesia Haze.

 

Carvacrol

 

This monoterpene has several pharmacological activities such as antioxidant, antibacterial, anti-inflammatory, cardioprotective, antinociceptive, and gastroprotective. Findings from one study indicated that administration of carvacrol reduced inflammation and oxidative damage in the model studied. 

 

Strains of cannabis with Carvacrol: Gorilla Glue and Chemdawg/Chemdog.

 

Geraniol

 

Found in essential oils of aromatic plants, including Cinnamomum tenuipilum and Valeriana officinalis, Geraniol holds antioxidant and anti-inflammatory properties, gastroprotective activity, and gastric healing. Results from a study showed that when administered daily, Geraniol was a powerful antimicrobial agent, able to prevent dysbiosis associated with colitis and reduce the inflammatory profile of colictic animals. 

 

Strains of cannabis with Geraniol: Harlequin, Lemon G, Strawberry Diesel, Tahoe OG, Dutch Hawaiian, Kimbo Kush

 

Limonene

 

Limonene is one of nature’s most common terpenes, found in orange, lemon, mandarin, lime, and grapefruit, it can decrease oxidative stress and inflammation, has potential benefits for colon cancer, antibacterial activity, and anti-nausea properties. 

 

Strains of cannabis with Limonene: Dosidos, Gush Mintz, Jet Fuel, Kush Mints, LA Kush Cake, Pink Runtz, Sour Diesel, Strawberry Banana, Wedding Cake

 

Cannabinoid Hyperemesis Syndrome

 

Cannabinoid Hyperemesis Syndrome (CHS) is a condition that leads to repeated and severe bouts of vomiting. It seems “paradoxical” that a medicine used as an antiemetic for several conditions could be responsible for vomiting episodes, however the hypothesis stands that an overstimulation of endocannabinoid receptors may be responsible for development of CHS. Over time, the market has seen an increase in the content of THC compared to other cannabinoids and terpenes. This is believed to be a factor in the genesis of CHS because the body builds a tolerance to THC. So, as tolerance increases, the amount of THC consumed increases, and therefore overstimulation of receptors may take place. 

 

If you feel you have taken too much THC, there are options available to you to help remedy the situation. At times a tolerance break may also be beneficial if you feel your current dosage is more than you would like to be consuming. 

 

Finding Support 

 

There is a lot to consider when starting cannabinoid therapy, but, as always, a Realm of Caring care specialist is here to help with free one-on-one support to answer your questions. Contact us today by calling (719) 347-5400 or emailing info@realmofcaring.org.

As of April 2024, recreational marijuana is legal in 24 states, or nearly half the country, according to the Pew Research Center and medical marijuana is legal in 13 states. This can indicate that many mothers may be questioning the safety of using medical or recreational cannabis while breastfeeding. The official guideline is that breastfeeding women are advised against using cannabis, due to insufficient research to determine “safe amounts” of cannabis use during breastfeeding. The emphasis is on caution due to the unknowns surrounding the transfer and effects of THC through breast milk. This article aims to dissect the most recent research on THC transfer to breast milk. 

 

The Biology of Breastfeeding

 

Breastfeeding is a complex biological process that provides essential nutrients and antibodies to infants. According to the American Academy of Pediatrics (AAP), breastfeeding is recommended exclusively for the first six months of life, followed by continued breastfeeding along with appropriate complementary foods for up to one year or longer, as mutually desired by mother and infant. The AAP emphasizes that breastfeeding offers numerous health benefits for both the mother and the baby, including reduced risks of infections, chronic conditions, and certain types of cancers.

 

Breast milk composition is influenced by the mother’s diet and health, making it crucial to understand how substances like cannabis can affect breast milk and, subsequently, the infant. A recent study indicates that only minimal amounts of THC, the psychoactive component in cannabis, transfer into breast milk. Research from Colorado involving eight breastfeeding mothers shows that, on average, just 2.5% of the THC consumed by the mother reaches the baby.

 

Key Findings:

 

1. Low THC Concentration: Only 2.5% of the mother’s THC dose is passed through breast milk, with an even lower bioavailability rate in the baby’s system.
2. Rapid Decline Post Consumption: Peak THC concentration in breast milk occurs one hour after consumption, dropping significantly after four hours.

 

Practical Recommendations for Breastfeeding Mothers:

 

1. Timing of Consumption: Consuming cannabis immediately after breastfeeding can minimize the baby’s exposure to peak THC levels.
2. Use of Pumped Milk: Utilizing previously pumped breast milk or formula for the first feeding after cannabis consumption can further reduce exposure.
3. Strain Selection: Choosing cannabis strains with higher CBD and lower THC content can reduce overall THC exposure.
4. Consider Edibles: Edibles may produce a longer-lasting but lower-intensity THC exposure compared to inhaling.

 

Considerations for Mother’s Using Cannabis

The discussion around cannabis use while breastfeeding should focus on compassion and understanding. Raising children is demanding, and many mothers might seek relief through cannabis, which can calm anxiety and reduce stress.

 

Key Points:

 

• Risk and Benefit Analysis: Rather than simply advising against cannabis use, it’s essential to help mothers weigh the risks and benefits, based on their unique situation.
• Stress and Cortisol: Maternal mental health significantly impacts the well-being and development of the infant. Elevated stress levels can harm both mother and baby, as cortisol is transferred through breast milk.
• Breastfeeding Benefits: Extended breastfeeding has significant health benefits that may outweigh the minimal transfer of THC when usage is carefully timed and managed.
• Informed Decisions: Providing mothers with accurate data and risk mitigation strategies supports them in making responsible choices.

 

Understanding that many mothers already use cannabis, offering guidance on minimizing risks is a more practical approach than outright prohibition. This empowers mothers to make informed decisions that best suit their individual situations.

 

Pharmaceuticals and Breastfeeding

 

It is essential to note that many pharmaceuticals also pass through breast milk and can have side effects on infants. Common medications prescribed for postpartum depression, anxiety, and other health issues are known to be present in breast milk to varying degrees. Healthcare providers often weigh the benefits of these medications for the mother’s health against potential risks for the infant. This same consideration should be applied to cannabis, particularly when it is used for therapeutic purposes.

 

Conclusion

Cannabis use during breastfeeding should be approached with caution. Informed choices, careful timing, and consulting with healthcare providers can help mitigate potential risks. Mothers must weigh the benefits and risks, with more support and compassion needed to help them make the best decisions for their unique situations.

Before undergoing anesthesia for surgery, it is important to have discussions with your healthcare team about what medications and supplements you are taking that may interact with or disrupt any point of perioperative or postoperative care; cannabis is no exception. While limited in scope, there is an understanding that interactions between cannabinoids and anesthetics take place. 

 

Anesthetics and Endocannabinoids

 

Before we get into plant cannabinoids, it may be valuable to understand how anesthetics interact with the endocannabinoids found in our body and brain. Two of those well-known endocannabinoids are anandamide and 2-arachidonoylglycerol (2-AG). A study published in 2003 discovered that a sedating dose of the anesthetic propofol produced a significant increase in the whole-brain content of both anandamide and 2-AG. Researchers have hypothesized that propofol leads to sedation indirectly; as the anesthetic increases anandamide content and then anandamide activates Cannabinoid receptor 1 (CB1) sites. For decades anandamide has been researched for its ability to induce sleep by binding to CB1 receptors. 

 

An additional study published in 2006 suggested that sustained anandamide signaling by propofol contributed to unique associations with the anesthetic such as reduction in postoperative nausea and vomiting. Alternatively, the anesthetic sevoflurane leads to a decrease in anandamide; postoperative nausea and vomiting were witnessed in groups observed with this anesthetic.

 

Cannabis Compounds and Their Interaction with Anesthesia 

 

The interactions between cannabinoids and general anesthetic agents, as well as the impact on patient care have been mostly reported in preclinical studies and are not yet fully understood.

 

Cannabis: THC Considerations

 

One of the major cannabinoids of the cannabis plant, delta-9-tetrahydrocannabinol (THC), is mainly metabolized in the liver through the Cytochrome-P450 (CYP450) complex, as are many anesthesia drugs. Therefore, there is potential for pharmacokinetic drug interactions. 

 

Some research suggests that patients who regularly use cannabis may require larger initial and/or maintenance doses of anesthesia, depending on the type used. 

 

A retrospective study published in 2020 assessed the impact of preoperative cannabis use in patients undergoing open reduction and internal fixation of tibia fractures. Among the cohort of 118 patients, more than 25% reported cannabis use prior to surgery, meaning they self-reported that cannabis products were used in the month prior to surgery. There was no significant difference in total propofol, dexmedetomidine, etomidate, ketamine, desflurane, midazolam, and fentanyl doses administered between those who used cannabis prior to surgery and those who did not. The only anesthetic where a significant difference was observed was sevoflurane, where a significant amount more was administered during surgery to the group of cannabis users. 

 

There is a lack of current literature in providing clinical guidance as well as support for the association between cannabis use and increased anesthetic doses to reach adequate sedation. Postoperatively, there have been reports that cannabis users are more likely to report higher pain scores, poorer sleep, and need more pain relieving medications in the immediate postoperative period than non-users. While more well-designed studies are needed to help providers mitigate potential perioperative risk and manage postoperative pain, anesthesia professionals would benefit from understanding the current perioperative considerations that exist for patients who use cannabis, whether medically or recreationally. 

 

Cannabis: CBD Considerations

 

Just as THC, the other major cannabinoid found in the cannabis plant, Cannabidiol (CBD), is a lipophilic compound metabolized by CYP450 enzymes and has the potential to interact with pharmaceuticals metabolized in this way. 

 

Few studies have taken place with CBD and perioperative care, however one anesthetic, isoflurane, was observed in rodent models in a study published in 2022. Animals were pretreated with various amounts of CBD to understand anesthetic induction time and recovery time. A shorter induction time was realized if they were pretreated with 20 mg kg−1, however it took longer for the anesthetic to kick in at 2 and 10 mg kg−1, leading to the hypothesis that the dose was too low to affect the course of isoflurane anesthesia. At 100 mg kg−1 the induction period was not much different than that of the control group. 

 

When it came to the recovery period, the CBD doses of 100 mg kg−1 and 2 mg kg−1 showed a longer recovery time which researchers believe is a result of the longer induction time compared to the 20 mg kg−1 dose. A longer isoflurane exposure during the induction time is expected to lead to a longer recovery time as isoflurane is a highly lipophilic compound. 

 

While CBD products are less studied in perioperative care, more research is taking place to understand its potential role in postoperative care as patients are often swapping pain medications for CBD.

 

In a study published in February 2024, CBD has been shown to positively affect the pain and satisfaction of patients immediately following arthroscopic rotator cuff repair. Anesthesiologists are currently working on the largest clinical trial of its kind to “determine whether administering CBD before and after surgery can reduce the need for opioids following total knee replacement.”  

 

In 2022, an online survey was distributed to members of the American Orthopaedic Society for Sports Medicine and the Arthroscopy Association of North America to assess baseline knowledge and opinions regarding CBD. Afterwards they received an educational component and then follow-up questions assessing whether the respondents’ opinions had changed after learning more about CBD. After collecting 101 responses, the results showed that “most respondents believed that there is a role for CBD in postoperative pain management (76%), acute pain and inflammation after an injury (62%), and chronic pain (94%). Most respondents admitted that they were not knowledgeable about the mechanism of action (89%) or their state’s laws (66%) concerning CBD. A minority (25%) believed that CBD has psychoactive properties. While most respondents (76%) did not believe that they would be stigmatized if they were to suggest CBD to a patient, only 48% had ever suggested CBD.”

 

Cannabis: Terpene Considerations

 

Select terpenes from the Cannabis sativa plant are found to be efficacious in relieving neuropathic and inflammatory pain in rodent models. They have been shown to consistently lack reward liability, enhance opioid pain relief, and produce an equivalent antinociceptive tolerance to morphine. 

 

Specific terpenes are known for sedative effects and some (like pinene) have vasodilatory effects, and for that reason may need caution when combined with anesthesia to avoid over-sedation and/or heart complications. Those terpenes that are known to have sedative and/or anesthetic effects based in research are:

 

• Linalool 
• Myrcene
• Citral
• Pinene
• Nerolidol
• Caryophyllene 

 

Concluding Thoughts

 

Cannabinoids are fat-soluble and accumulate in the fatty tissue, meaning that elimination may take place several days after consumption. Therefore, it is a currently recommended practice to cease the use of cannabinoids several days if not several weeks before surgery is scheduled. Your best bet is to consult with your healthcare provider well in advance of any planned surgical procedures.

Cannabis has garnered attention for its numerous health benefits, with people using it for pain relief, anxiety management, and various other medical conditions. However, as its popularity continues to rise, a pertinent question remains: what impact does cannabis have on fertility? In this article, we will explore both the positive and undesirable effects of cannabis on fertility, drawing from current research and medical insights.

 

Cannabis and Female Fertility

 

Cannabis consumption can potentially have both positive and adverse effects on female fertility. This section explores the research findings on how cannabis impacts the menstrual cycle, ovulation, and overall reproductive health.

 

Menstrual Cycle and Ovulation

 

On the positive side, some studies suggest that cannabinoids can help balance hormones and reduce menstrual irregularities. According to a study published in the Journal of Ovarian Research, the endocannabinoid system plays a crucial role in maintaining ovarian function, and cannabinoids may support this system, potentially enhancing fertility.

 

However, other studies have shown that chronic use of THC, the active compound in cannabis, may interfere with the release of gonadotropin-releasing hormone (GnRH), affecting the menstrual cycle. It was also found that THC use in conjunction with tobacco use suppressed the luteinizing hormone (LH), shortening the luteal phase of menstruation. Irregular cycles and anovulation (lack of ovulation) have been observed in women who consume cannabis regularly, which may lead to difficulties in conceiving.

 

Reproductive Health

 

Cannabis might improve reproductive health by reducing inflammation and oxidative stress, creating a healthier reproductive environment essential for successful conception. However, the same properties of THC may disrupt the endocannabinoid system’s balance, negatively impacting ovarian function.

 

For more detailed insights, the article from Contemporary OB/GYN provides an in-depth look at the effects of marijuana on female reproductive health and pregnancy.

 

Cannabis and Male Fertility

 

The impact of cannabis on male fertility is equally complex, with studies showing both potential benefits and drawbacks. This section explores how cannabis affects sperm production, motility, and overall reproductive hormones.

 

Sperm Production and Motility

 

Some research suggests that cannabis may increase sperm count and motility, potentially enhancing fertility. The National Institutes of Health report highlights that moderate cannabis use is associated with improved semen quality in some cases.

 

Conversely, other studies have shown that chronic THC use may negatively influence sperm count, motility and lead to testicular shrinkage. Lower sperm count and reduced motility may decrease the chances of successful fertilization, as highlighted by various research findings.

 

Hormonal Balance

 

Cannabis may support the hypothalamic-pituitary-gonadal axis, helping to maintain a healthy hormonal balance that is critical for reproductive function. This can improve libido and erectile function. However, THC can also disrupt this balance, leading to decreased testosterone levels and reproductive health issues.

 

The article from Denver Urology elaborates on how marijuana use impacts male fertility and reproductive health.

 

Weighing the Pros and Cons

 

While cannabis offers numerous health benefits, its impact on fertility is a nuanced topic with both positive and potentially undesired aspects. More research is needed to fully understand the extent of these effects, but current findings suggest that cannabis can influence both female and male reproductive health in various ways. As with any medication or substance, understand that cannabis is not a one-size-fits-all approach and dosing in moderation is essential. Consult with a healthcare professional to make informed decisions based on your unique situation and, as always, a Realm of Caring care specialist is here to help prepare you for that discussion. 

 

Understanding Resin & Rosin: Origins and Extraction Methods

 

Live resin and live rosin differ primarily in their extraction methods. The strengths of the finished products vary depending on the strain and the quality of the starting material.

 

Live Resin

 

Live resin is produced using solvents like butane in a closed-loop system, making it a solvent-based extract. The process leads to a full-spectrum product that retains terpenes and cannabinoids as well as the original scent of the plant. Live resin is known for its potent aroma and flavor due to the high concentration of terpenes, which are well-preserved through the cryogenic freezing process.

 

Live Rosin

 

Live rosin is a solventless product, created by applying heat and pressure to either fresh or dried cannabis material, preserving the natural terpenes and flavors. Rosin products come in different textures and consistencies referred to as sap, sauce, budder, or shatter.

 

Popularization of Cannabis Edibles

 

The cannabis edibles market is experiencing rapid growth, driven by increasing awareness of the health benefits associated with cannabis and a shift in consumer preference towards discreet consumption methods. Edibles, including gummies, are becoming a favored choice due to their convenience and the variety of products available, catering to different dietary needs and preferences.

 

Why Choose Rosin or Resin Gummies

 

Rosin and resin gummies offer unique benefits not found in other cannabis edibles. These gummies are known for their potent effects and high terpene content, which may enhance the overall sensory experience. Consumers choose these gummies for a more intense and flavorful experience, often preferring them for both recreational enjoyment and medicinal benefits.

 

How to Choose the Right Gummy for You: Evaluate Quality, Potency, and Effects

 

When selecting THC gummies, start with quality product companies and then consider the potency and your dosage. Beginners should opt for lower doses, to safely gauge their tolerance. Most gummies should have evenly distributed ingredients, therefore may be halved or quartered to lessen the first dose. Understanding the onset time and duration of effects is also important, as edibles can take 30 minutes to 2 hours to manifest and may last several hours.

 

How to Choose the Right Gummy for You: Considerations for Flavor and Experience

 

The flavor of the gummies plays a significant role in the overall experience. Look for products that balance taste and effectiveness, using natural flavors while avoiding harmful additives. Exploring different flavors and formulations, such as those combining THC with other cannabinoids like CBD, can enhance the sensory experience and provide additional benefits.

 

How to Choose the Right Gummy for You: Recommendations Based on Preferences

 

For those seeking specific effects or flavor profiles, it’s advisable to choose gummies based on their terpene and cannabinoid content. Products that offer a detailed terpene profile allow for a more tailored experience, catering to preferences for relaxation, creativity, or energy. Always ensure the gummies are lab-tested for potency and purity to guarantee safety and quality. 

 

Conclusion

 

The decision between opting for resin or rosin gummies hinges on individual tastes, experiences sought, and an appreciation for the artisanal versus the intensely flavorful. With a focus on informing and educating clients, the guidance provided here is meant to facilitate a well-informed choice, enhancing the sensory experience of cannabis edibles. As the industry continues to innovate and expand, the importance of staying informed and discerning cannot be overstated. Consumers are encouraged to consider lab reports, THC concentration, and their own tolerance levels as they explore the rich array of cannabis products available, ensuring a selection that truly resonates with their personal cannabis journey.

 

You’re not in this alone

 

Realm of Caring is here to help you find success with your cannabinoid therapy. Cannabis can be overwhelming, but it doesn’t have to be. Contact us today so we can help you on your journey. As always, our one-on-one support is free. 

The saying goes, “it is possible to have too much of a good thing.” Despite how beneficial any one thing is, a large amount of it may often have the opposite or harmful effects. We can apply this to several aspects of our lives from sugar intake to exercise and, yes, even cannabis. Here we will discuss, what happens when you feel you have taken too much, how to handle the situation if it happens, and how to prevent it the next time. Set and setting are important components of cannabis use and, as always, our care team is here on standby to help set you up for success before starting your journey. 

 

What happens when you take too much? 

 

If you feel you have taken too much, first of all – do not panic. Just as with consuming too much caffeine, it may be unpleasant and uncomfortable, but with time it will pass. 

 

It is good to know that cannabis itself will not cause you harm. There is a low density of cannabinoid receptors in the brainstem region and, unlike opioid receptors, there are no cannabinoid receptors in the brainstem areas controlling respiratory function. Therefore, lethal overdoses from cannabis do not occur. However because there are cannabinoid receptors throughout several other parts of the brain and body, if we consume too much we may have unwanted and unpleasant feelings to include:

 

• Increased heart rate
• Decreased blood pressure (which may lead to nausea)
• Muscle relaxation
• Lethargy
• Paranoia
• Anxiety

 

What do I do if I’ve taken too much? 

 

Take a deep breath, get fresh air, and focus on something you enjoy or talking to a close friend to deter any feelings of anxiety. Specific terpenes may also combat the unwanted effects. It is often recommended to drink water with lemon or eat black peppercorns. Limonene, found in lemons, has been studied for its anti-nausea, anti-vomiting, and uplifting properties reported to boost mood and metabolism while decreasing stress and anxiety. Beta-caryophyllene, found in black pepper, is known to be a stress-relieving terpene to help reduce anxiety and promote relaxation. This is why strains high in caryophyllene may have more calming effects versus those that are stimulating. 

 

Another tool for your tool kit is a THC recovery shot, developed by industry veterans at High Not. Their unique terpene blend works to alleviate the intensity of a head high and combat unwanted hangover effects. 

 

Preventing unwanted outcomes or a “cannabis hangover”

 

Starting low and increasing slowly enables one to find their therapeutic dose at the lowest amount possible. Finding your individual threshold can also help to prevent effects that carry over into the following day (a “cannabis hangover”). While you may have a good indication as to where to stop with smoking cannabis, it may become more difficult with edibles given the slow rate at which they will metabolize in the body. This is why Realm of Caring is here to help you find the most success from your cannabis experience – from quality product selection to dosing guidance based on your condition. 

 

We previously spoke with Michael Backes, Cofounder and Chief Product Officer at Perfect and author of Cannabis Pharmacy: The Practical Guide to Medical Marijuana, to better understand prevention of “cannabis hangovers”. 

 

To avoid residual feelings of grogginess the next day, it may be best to pay attention to the terpene content, quality of the product, and how much you are consuming. Backes explains, “Most consumers inhale too rapidly. Reducing the intensity of inhalation also reduces the combustion temperature, which results in a smoother, less harsh experience. I advise taking a gentle inhalation (sipping) rather than hitting hard (ripping).”

 

You’re not in this alone

 

Realm of Caring is here to help you find success with your cannabinoid therapy. Cannabis can be overwhelming, but it doesn’t have to be. Contact us today so we can help you on your journey. As always, our one-on-one support is free.