Blog Education Featured

Curbing Tobacco Addiction with Cannabinoid Therapy

Tobacco use is responsible for more than 480,000 deaths each year in the U.S., according to the CDC, which estimates that it accounts for nearly one of every five deaths annually.


Tobacco use is responsible for more than 480,000 deaths each year in the U.S., according to the CDC, which estimates that it accounts for nearly one of every five deaths annually. It is the leading cause of preventable death in this country; there are approximately 1,300 deaths from smoking each day. Tobacco use is a major risk factor for heart disease, cancer and lung disease—and these diseases kill more people than any other health problem. The good news is that by quitting smoking and tobacco use, you can reduce your risk of developing many serious health problems. Even better news? Cannabinoids may help curb tobacco addiction and even assist you in this process.


New research shows that compounds found naturally in cannabis plants reverse attentional bias to cigarette cues in a human experimental model of tobacco withdrawal.


New research shows that compounds found naturally in cannabis plants reverse attentional bias to cigarette cues in a human experimental model of tobacco withdrawal. The study, published in the National Library of Medicine, shows that treatment with cannabidiol (CBD), a non-psychoactive cannabinoid found naturally in cannabis, may be a promising novel smoking cessation treatment due to its anxiolytic properties, minimal side effects and research showing that it may modify drug cue salience.


Researchers used an experimental medicine approach with thirty non-treatment seeking dependent cigarette smokers, by administering 800 mg oral CBD or matched placebo (PBO) in a counterbalanced order. Withdrawal, craving, side effects, heart rate and blood pressure were repeatedly reviewed. The results showed that a single 800‐mg oral dose of cannabidiol reduced the salience and pleasantness of cigarette cues, compared with placebo, after overnight cigarette abstinence in dependent smokers. Cannabidiol did not influence tobacco craving or withdrawal or any subjectively rated side effects. These findings suggest that cannabidiol may hold promise for aiding in nicotine withdrawal, and may also be effective in improving other addictive behaviors.


Further promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction.


Further promising results from preclinical studies suggest that manipulation of the endocannabinoid system could be a potential therapeutic strategy for treating nicotine addiction. The possible involvement of the endocannabinoid system in the rewarding effects of nicotine was evaluated by using the conditioned place preference (CPP) in mice.


Researchers set out to examine the role of cannabinoid receptors in the brain’s reward circuitry by evaluating the CPP in mice, and were surprised to learn how critical they are for mediating nicotine reinforcements in the rodents. The scientists found that the brain’s response to nicotine triggers the activity of cannabinoid receptors and increased levels of an important enzyme called cPLA2, which is involved in activating these receptors. They then demonstrated that inhibiting cPLA2 activity dramatically reduced nicotine reinforcement by preventing the activation of cannabinoid receptors. Such findings suggest that promoting cannabinoid receptor signaling in the brain could be useful in treating nicotine addiction and other substance abuse disorders, although it is too soon to recommend cannabis as a solution to curbing tobacco addiction.


When quitting smoking, CBD may be a promising therapeutic tool to help ease withdrawal symptoms.


CBD seems to be a promising therapeutic tool due to its anti-inflammatory, anxiolytic, neuroprotective, and non-psychoactive effects. In humans, treatment with CBD has been reported to reduce cigarette consumption and pleasantness of cigarette cues after overnight abstinence.


Kicking a nicotine addiction is hard, and often the hardest part for addicts is getting through the uncomfortable withdrawal symptoms that many fall victim to, thus keeping them in a cycle of dependency on cigarettes and nicotine-containing products. Some symptoms of nicotine withdrawals that CBD can aid in relief of may include anxiety, irregular sleep patterns, headaches, nausea, and irritability.


For those looking for a natural ally in curbing tobacco addiction, CBD could be an effective aid. Choosing quality products from reliable retailers is an important part of this process. We recommend checking out our list of supported brands.


At Realm of Caring, we believe in taking an individual approach to cannabinoid therapy to find a product and dose that works for each of us! If you would like to reach out to our Care Team (719-347-5400 option 1), they would be happy to help you individualize your therapy and find a product that is right for you.

Blog Education Featured

Delta-8 THC Legal Update

Delta-8 tetrahydrocannabinol (delta-8 THC) has become a growing topic of discussion due to its legal controversy and recently issued warning letters by the FDA. The FDA’s growing concerns stem from companies reported to have illegal marketing and drug misbranding. Delta-8 is currently legal in 32 states, however this could change rapidly as states are beginning to regulate or create legislation to prohibit products containing the compound completely. Before we dive into the legal gray area, let’s review what exactly delta-8 THC is.


What is delta-8 THC?


Delta-8 THC is one of the cannabinoids produced naturally by the cannabis plant, but is not found in significant amounts of the cannabis plant. Concentrated amounts of delta-8 THC are typically manufactured from hemp-derived cannabidiol (CBD). However less psychoactive than delta-9 THC, delta-8 THC still has similar psychoactive and intoxicating effects to delta-9 THC, the cannabinoid most popular in the cannabis plant for getting people “high”.


The two compounds are almost identical in structure except for the location of a double bond. The double bond is found on the 8th carbon in delta-8’s structure and the 9th carbon in delta-9. This difference of the double bond location makes delta-8 less potent, meaning that individuals may be able to tolerate more per administration. The effects of delta-8 have been reported by users as mild euphoria, happiness, uplifting feelings, and relief of pain.


Is Delta-8 THC a synthetic cannabinoid?


Because delta-8 THC is not found in significant amounts in cannabis some assume that it is a synthetic cannabinoid, or man made, but it is a natural compound. Delta-8 products do, however, require manual intervention for there to be a consumable amount available. While it is not a synthetic cannabinoid, it is synthetically derived. 


Delta-8 THC Federal Legal Standing


Delta-8’s current legal standing is controversial on the federal level. Interpreting it as legal is due to a loophole through The Farm Bill. In 2018, the Farm Bill removed hemp with very small concentrations of THC from the definition of marijuana in the Controlled Substances Act. Hemp is defined as products derived from the cannabis plant containing less than 0.3% of delta-9 THC. Tetrahydrocannabinol’s are listed by the DEA as a Schedule I drug, “except for tetrahydrocannabinols in hemp“. Because of the federally legal status of hemp, manufacturers have derived delta-8 using a conversion process from CBD. 


Delta-8 THC State Legal Standing 


Many states have begun to regulate delta-8 THC due to the lack of research on its effects and considering it is synthetically derived. 


Delta-8 THC is currently prohibited or illegal in these 13 states: Alaska, Colorado, Delaware, Idaho, Iowa, Montana, Nevada, New York, North Dakota, Rhode Island, Vermont, Utah and Washington. The reasoning for the ban of Delta-8 THC products can be summed up by the Colorado Department of Public Health and Environment as “chemically modifying or converting any naturally occurring cannabinoids from industrial hemp is non-compliant with the statutory definition of ‘industrial hemp product’.”


Connecticut and Michigan regulate Delta-8 THC the same way they do recreational cannabis. State authorities in Arizona, California and Mississippi have not released a clear statement on whether delta-8 is legal, partially illegal, or completely illegal. 


Finally, Delta-8 THC is currently legal in these 32 states:  Alabama, Arkansas, Florida, Georgia, Hawaii, Illinois, Indiana, Kansas, Kentucky, Maine, Maryland, Massachusetts, Minnesota, Missouri, Nebraska, New Hampshire, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Oregon, Pennsylvania, South Carolina, South Dakota, Tennessee, Texas, Virginia, West Virginia, Wisconsin, Wyoming, and in Washington D.C.


What does this all mean for the future of Delta-8 THC?


It should come as no surprise that the legality surrounding this newly popularized cannabinoid is confusing and even contradicting in some states. The legal gray area is something the cannabis industry knows intimately and it is suggested to keep an eye on your state’s legislation because that is likely to change before the federal level. Overall, at the Realm of Caring we always advocate for more research so that we can have a better understanding of all aspects of the cannabis plant. If you support the research & education of cannabis, please consider making a donation here or joining our Observational Research Registry (ORR).




The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.


Blog Education Featured

Thank You For Helping Hemp Products

Update 5/11/22


We’re pleased to announce that this new version of the bill, with slight technical amendments, was overwhelmingly passed by the Colorado House and Senate during the final day of the session. Here’s the final bill. In summary, this legislation will:


  • Create a task force of hemp and marijuana industry representatives and government officials to intentionally study the topic of intoxicating compounds and propose legislative and rule recommendations. The task force will have broad representation from regulators, manufacturers, refiners, retailers, labs, consumer nonprofit organizations, and adult-use patients, and is intended to ensure that all viewpoints are captured and incorporated in whatever recommendations develop.
  • Provide immediate authority to the Colorado Department of Public Health & Environment to develop regulations to prohibit the sale of chemically-converted and synthetically-derived intoxicating THC isomers.
  • Provide immediate authority—and nearly $600,000 in funding—to the Colorado Attorney General to crack down on deceptive trade practices and other consumer protection issues regarding hemp products.


The legislation has been sent to Governor Jared Polis, who is expected to sign it shortly. We are grateful to the Governor, his staff, legislative leaders, and especially YOU, for your swift take action.  They listened to the hemp industry’s concerns and helped transform a flawed bill into one that will address our mutual concerns.



UPDATE 5/3/22:


In policy, if everyone is only a little unhappy, you probably are in a good place. We worked hard with the hemp industry, stakeholders, lobbyists as well as President Fenberg to come to consensus language on SB205 on 5/2/22.


You are the HERO: Your rapid take action allowed this committee to see that what they were being told by the Big Marijuana Lobby, (we agree with their 15-page bill that would secretly kill hemp in CO)  was… in fact –  a lie.  The committee, and particularly President Fenberg took control of the circus along with Mark Ferrandino, Executive Director at the Colorado Department of Revenue to get to a place most people could live with and do the three things that we felt were most important:


  1. Protect access to the products that our families have grown to rely on for the last decade. 
  2. Allow the regulatory body to have the clarity to regulate the bad actors masquerading their intoxicating, and chemically synthesized (Delta 8 and Delta 10 THC) products as hemp. 
  3. Create a Task Force so that Colorado can develop more regulatory structures around hemp with all the stakeholders at the table. 



Do you or a loved one rely on hemp products everyday? This week’s blog is all about the Colorado Bill: SB 22-205 and what you can do to help us take action now! The products you rely on are in jeopardy. With your voice, effort and support, we can let our Colorado representatives know that we will not stand for this.



What is the name of the bill and where can I read about it online? 




Intoxicating Hemp And Tetrahydrocannabinol Products: Concerning the regulation of cannabis-related products that may potentially cause a person to become intoxicated when used. SESSION: 2022 Regular Session


Read it here:



Who does this affect? 


  • Hemp companies that operate in Colorado and ship nationwide. 


  • Consumers who buy these hemp products. 



What does the bill do? Why is it a problem? 



  • Non-intoxicating hemp extract tinctures would be limited to 20 mg of THC per bottle, with criminal penalties and/or civil rights of action for violations.  This would virtually wipe out full spectrum hemp tincture commerce.


  • The bill would require Colorado CBD manufacturers to immediately destroy much of their stock of non-intoxicating full-spectrum products that exceed the 20 mg THC package cap (including tinctures, caplets, gummies, etc.), prohibiting them from selling these products to states where they are legal, and potentially imposing criminal and civil penalties on their storage and distribution.


  • In determining whether future cannabinoid products are intoxicating, the law would not require a scientific analysis and could lead to improperly classifying some novel non-intoxicating compounds as adult-use cannabis. For example, CBN that naturally occurs in hemp products. 


  • The legislation does not provide a certain path to protect the retail sale of CBN products that are demonstrably non-intoxicating. Protections for non-intoxicating products are limited to CBD, CBG, and CBC (and acids), stifling all innovation.


  • There would be no grace period whereby retailers could sell non-intoxicating products that are packaged legally as of today but would fall outside the new limits.  There are also no safe harbors for manufacturers handling in-process or bulk ingredients. This would require small businesses to immediately destroy intoxicating products that complied with the rules when they were manufactured or face possible criminal penalties.



What is happening right now? 


Fortunately, we were able to work with the Hemp Industry to get new language in and we need to shout loud and clear to support the Hemp Industry amendment.  

The new amended language would:


  1. Allow the Colorado Department of Public Health and Environment (CDPHE) in conjunction with the Attorney General’s Office be empowered with the authority to immediately enforce against both retail and online sales of hemp products that contain substantially more than 2.0 mg of delta-9 THC per serving, as well as other products that are likely to cause intoxication or marketed as intoxicating, such as delta-8 and delta- 10 THC.
  2. Will also require CDPHE and the Marijuana Enforcement Division (MED) within the Department of Revenue (DOR) to work together on a collaborative, stakeholder-driven rulemaking process that utilizes science-based standards to determine which hemp products should be designated as intoxicating.


What is the bottom line?


Intoxicating hemp products for retail sale in Colorado are increasingly becoming an issue and the Colorado Hemp Industry as a whole is united behind addressing this problem. However, Senate Bill 205 was hastily drafted with input only from the Marijuana industry and out of state interests who seek to disadvantage hemp manufacturing in the state of Colorado and would cause irreparable economic damage to thousands in our state whether it is from consumers who rely on affordable access to full spectrum hemp products or manufacturers who provide over a thousand jobs in rural communities. This bill is overreaching and will prevent you and I from getting the hemp products you have trusted for the last 10 years.





If you would like to talk to a care specialist about this please call 719-347-5400 ext 1 or email


Blog Education Featured

End the Stigma, Participate in Research

There is no question that we, as a country, have a moral obligation to build restorative measures for those who have been negatively impacted by the War on Drugs. Black and brown individuals and communities have been unfairly targeted and are still paying the price for an exploding industry that the majority of Americans believe should be legal for recreational use. If we want to re-invest in these communities fully, we need to accept responsibility for the decades-long stigma as well.


Legitimate research to understand the medicinal benefits of cannabis allows for an opportunity to truly de-stigmatize the plant. It is not enough to decriminalize or legalize and then free the incarcerated of cannabis crimes. Changing the mindset of society so that these individuals are accepted and feel welcome on the other side is critical. And that is a job that should not fall on the shoulders of the already disadvantaged. This is a job for those who know the power of the plant and are ready to prove it. Cannabis is utilized as a medicine, and it needs to be recognized as such. The cannabis industry is accountable and there needs to be the realization that research should be a priority, not an afterthought. 


There are frustrations among industry advocates and stakeholders because we still find ourselves caught in an era of prohibition. However, it has been written about by universities that advocacy research is necessary to influence the formal and informal policies established by policymakers. Not only does the research need to be conducted but there needs to be collaboration in the scientific and political communities where research is translated into law and policy, a gap that widely hinders advances in public health. 


Realm of Caring serves to fill this gap with our Observational Research Registry (ORR). Alongside Johns Hopkins University School of Medicine, we are gathering and publishing compelling data on how individuals are using cannabis for their ailments in everyday life. 


Read below our Diversity, Equity and Inclusion (DEI) statement on industry accountability so you may learn more about Realm of Caring’s initiatives, and how you can get involved. 


Industry Accountability


The Realm of Caring is committed to extending DEI efforts to engage the industry in its responsibility to appropriately represent the history, research, and future of cannabis. 


Our Commitment


We will play an active role in righting the wrongs of our industry’s past by speaking loudly about the injustices of our legal system and the impact on families and communities, particularly those of color. Our goal is to transform society by understanding our fears and challenging oppressive ideologies, policies, and systems.


  • Through research and education, we will actively pursue the legalization and acceptance of cannabis use.
  • Through research and education, promote a culture that destigmatizes and normalizes cannabis use for medical or recreational purposes.
  • Through partnering with stakeholders and sponsors to embody the collective message that speaks to cannabis legalization and acceptance.
  • Through advocacy for the rights and dignity of all people by rejecting criminalization and stigma of drug use.
  • By openly influencing social and legislative reforms that represent the industry’s supporters and customers.


You, too, can take part in these efforts. Here is how:


Join research.

Whether you are a cannabis user or non-user you can join. Cannabis and hemp users may report on what product they are using and how they are using it in their everyday lives. Caregivers may report on behalf of cannabis and hemp users. For non-users, this is an excellent way for you to advocate on behalf of someone who is using cannabis or hemp – your participation is equally as important. 


Donate so that we may continue to publish research.

As of now, we have published 3 compelling articles. It is our goal to continue to recruit and publish more so we may further legitimize cannabinoid therapy. Our research also fuels our free call center where we help individuals worldwide with their questions about cannabis. Our work is far from done, help us keep it going. 


Are you a product company? Get your product in research! 

ORR data represents an alternative solution to profile medicinal use of cannabinoid products on individuals’ health conditions in their natural environment. Repeated assessments provide a rich opportunity to examine the impact of cannabinoid therapy over time among individuals with a diverse list of health conditions. ORR data also provides the opportunity to examine product dosing over time and between products.


View the results from our published research papers:


A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health, 2020


Cross-Sectional and Longitudinal Evaluation of Cannabidiol (CBD) Product Use and Health Among People with Epilepsy, 2021


Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial, 2021




The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Blog Featured

Charlotte’s Impact

Dearest Charlotte, 


We thank you, we thank you, we thank you! You changed the world in your short 13 years. Today is your day, April 7th, Charlotte Figi day. We would much rather you be here with us with your laughter, your ability to devour an entire plate of french fries, us – trying to pry the fork out of your chunky little fist and finally giving in because if you did shank someone they likely deserved it and we usually did give in to your perseverance.  Or maybe an opportunity to read you one more story… perhaps The Bear Snores On. But instead we will light a candle for you dear one, we will continue to tell your story and the story of tens of thousands and try our damndest to carry on your legacy. Thank you. 


You showed us what it was to discover a new path, one filled with empowerment over our health care decisions and the ability to use a plant to change our lives. You showed us we could reclaim our health and our quality of life. That we had sovereignty of choice over our healthcare. That we did not need to keep doing the things that were not working. If not for you dear Charlie, hemp could very well still be illegal. If not for you the progress that has been made in the name of cannabis would not be where it is today. Thank you. 


We are sorry your journey was so full of challenges. The early seizures that lasted hours at only three months old. Having to try so many medications that failed you many of which making you worse. This made the eventual success so much sweater for your family. Thank you. 


From the moment your mom administered your first dose of CBD at 5 years old, the movement began. You started a movement, precious one. Quietly, you didn’t say a word. You just got better. It started with families moving here to Colorado for access to achieve the same life-saving results you had and growing to federal legislation legalizing hemp. We could not have said it better than your friend Dr. Sanjay Gupta, “Charlotte Figi was more than an individual, she was an entire movement wrapped up into a sweet girl with a big smile and an even bigger heart.” Thank you for the movement you inspired. Thank you for the candle that you lit that continues to light our path forward to this day. 


You showed us Charlotte that cannabis could serve as a legitimate medicine. You helped all of us to move from a place of stigma to a place of compassion. After decades of prohibition, cannabis was more widely making its way into daily conversation, the medical community, and scientific research. The power of the plant that our ancestors, centuries before us, knew to be sacred was making a name for itself once again as a natural solution. And this was all because the world witnessed you Charlotte as you reclaimed your quality of life. We are so thankful your parents shared you with us. For their courage, which they surely learned from you, we thank you.


Lovingly and in your service, 

Your Realm of Caring family


On April 7th, 2020, Charlotte very suddenly and tragically passed away. The globe shook as it mourned the loss of this mighty individual and it was felt across continents. Tributes were made, a day was named in her honor, hearts outpoured with emotion for Charlotte, celebrating the path she paved. 


Today, and every day, Realm of Caring is guided by our North Star, Charlotte, reminding us why we fight for access for all – through education, research, and advocacy. We continue because everyone deserves the dignity of choice. We continue because Charlotte’s impact remains the footprint of our path forward; toward care for all through the healing power of the Earth.


Charlotte Figi, we love you. 

Please leave a comment on Charlie’s memorial page for her family to read.



Blog Education Featured

Hemp and CBD Coffee: What Does Research Tell Us?

In recent years we have seen a lot of hemp products become available on the market. One item of more recent interest is hemp or CBD coffee. Hemp coffee involves blending hemp, as powder or seeds, in with coffee grounds and CBD coffee will be CBD oil infused coffee grounds or CBD oil added to a brewed cup of coffee. At Realm of Caring we look to research to best understand how cannabinoids and parts of the cannabis plant will interact with our bodies as well as the administration or delivery method for optimal absorption and benefit. So let’s take a look at what potential benefits there may be to adding Cannabis sativa to your daily routine. 


Hemp as a functional food  


Cannabis sativa is considered one of the most ancient cultivated plants and is incredibly versatile. The hemp seed has been claimed as one of the most nutritionally complete food sources, with the ability to offer total nutrition to the body. They contain high levels of omega-3 and omega-6 fatty acids and are a great source of protein in that they provide all nine essential amino acids. Hemp seeds also have an assortment of minerals and vitamins such as magnesium, potassium, iron, zinc, vitamin B, and the well-researched antioxidant, vitamin E.  It also has something else that sets it apart from most superfoods we know of today. One of those omega-6 fatty acids hemp seeds contain is known as gamma linolenic acid (GLA), which is also found in breast milk.


Coffee is well-known to have its own health benefits and even reduce the risk of certain diseases. Therefore when coffee and hemp combine, some consider the duo to create a “superfood drink”. 


Therapeutic potential of CBD


What you may also find on the market is CBD infused coffee. Before the oil can be added to coffee, the hemp flower must be decarboxylated to activate the compounds. These compounds will then offer a different set of potential therapeutic benefits to the body. 


CBD has been researched for its benefits as a powerful antioxidant and therapeutic actions that include reducing oxidative stress, anxiety, inflammation and improving kidney function and the immune system. Therefore adding CBD to a daily regimen, such as your morning cup of coffee may seem like a good way to add a wellness boost. 


There have been claims that CBD may improve the negative effects one might experience from caffeine or caffeine withdrawal such as headaches, anxiety, fatigue, lack of focus, and depression, among others. However, research is still lacking on the combined effects of CBD and caffeine. Any potential CBD effects are going to be dose-dependent and any one individuals’ response to a combination of CBD and caffeine is difficult to predict.


Finding a product


If trying one of these new coffee varieties is of interest to you, at Realm of Caring we will always emphasize the importance of the quality of the product. It is beneficial to do some research into the hemp extract that is sourced for the product. You want to know the finished product is free from pesticides, fungicides, heavy metals, and additional harmful contaminants. Use our guide to help you vet your products! Realm of Caring’s free one-on-one support care team can also help with these questions when looking into a company. 



Blog Education Featured

A Buyer’s Guide to CBD

In recent years, Cannabidiol, or CBD, has grown in popularity due to increased research and interest in its potential health benefits. Studies show that CBD can help alleviate a variety of conditions, such as anxiety and depression, arthritis, chronic pain, epilepsy, migraines, inflammation, sleep conditions, and so much more. The market itself is quickly growing as well, saturated with a variety of products that range in quality and type. Before purchasing CBD, there are several factors to consider, including the type of CBD product, its potency, and the provider or manufacturer. 


Currently, the FDA does not regulate CBD products, so it’s the buyer’s responsibility to choose quality products. ⁠⁠It’s up to you as the consumer to ensure that when you purchase CBD you get what you pay for and can feel confident on your journey exploring the benefits of CBD. We put together the following recommendations that can act as your Buyer’s Guide to CBD.


Look for a COA


A certificate of analysis, or COA, is one of the most important factors to consider when purchasing a CBD product. Essentially, it is a form of quality control that confirms whether the product contains the quantities of CBD that the manufacturer claims or advertises. When a plant contains 0.3 percent or less THC, the federal government considers it hemp-derived CBD, but if a plant has THC levels above 0.3 percent, the federal government considers it cannabis. 


Additionally, it’s important that consumers check the COA for contaminants, as their presence could have long-term health effects. Cannabis plants easily absorb heavy metals, pesticides, and other potentially harmful chemicals that can be present in the soil or water, so it’s important that cannabis products be tested while growing as well as when they become finished products. Microbial contaminants (e.g. E. coli, salmonella), heavy metals like lead, mercury, and arsenic, and residual solvents such as heptane and hexane can cause serious illness. Each contaminant should receive its own individual status of passing to be considered clean and safe to consume.


Think of the COA as the product’s quality control, and always be sure it comes from an accredited, trustworthy lab.


Consider the Potency


The potency of the CBD product is another important factor to consider, as it varies greatly depending on the individual’s needs. CBD products usually display dosages in milligrams (mg). However, it is important to remember that there is little human research to guide suitable dosing for various conditions. If you want to avoid the head high that is associated with THC content, we recommend  you look for CBD products that are made from hemp. 


When buying CBD, you should also consider the specific amount of cannabidiol present not only in the whole offering, but also in each dose. Dosages are typically described in milligrams, and can vary considerably depending on the different products. Metabolism, tolerance levels, and the method of intake can all influence the dosage required. A great rule of thumb is to start low and slowly increase. Every individual will have varying needs, and once you have found the right dosage for your cannabinoid therapy, it’s a good idea to continue to stick to it. 


Understand Types of CBD


Although the effects tend to be the same, some people may prefer one type of CBD product over another, depending on how or when they plan to use it. Oils and tinctures, edibles, vaporizers, creams, and lotions, are all different methods of CBD consumption. Various methods of consumption have differing onset times, which can be a deciding factor when buying CBD. In some cases, inhaling CBD or using it topically may have a quicker effect than if taken orally or as a food product, which typically takes longer to be absorbed into your system. Different ailments may also require different methods of usage, while some may be based on personal preference. For example, to potentially manage localized areas inflammation one could use a topical cream, or also choose to use a tincture.


Key Indicators of Quality


Most reputable CBD oils include the following information on their labels: amount of CBD as an active ingredient per serving, supplement fact panel – including other ingredients, net weight, manufacturer or distributor name, suggested use, CBD compounds, batch or date code. CBD compounds to choose from are as follows:


  • Full-spectrum CBD: contains all of the naturally available compounds of the cannabis plant, including THC. However, in hemp-derived full-spectrum CBD, the THC will be no more than 0.3 percent at the dry weight. THC levels rise when the flowers are extracted into oil.
  • Broad-spectrum CBD: contains all of the naturally occurring compounds, except all of the THC—or all but a very tiny amount–is typically removed.
  • CBD isolate: the purest form of CBD, isolated from the other compounds of the hemp plant. CBD isolate should have no THC. [Source: Healthline]


Where to Buy CBD Products


There are many options available when it comes to buying CBD products. You can find topicals, oils, edibles, and more online directly from a number of retailers. If you live in a state where dispensaries are legal, knowledgeable staff may be able to help with recommendations and answer any questions you may have in your process.

The most important thing is that you are able to confidently understand what to look for when buying CBD, so that you can shop for high quality products with confidence and find one that’s right for you. At Realm of Caring, we believe in taking an individual approach to cannabinoid therapy to find a product and dose that works for each of us! If you would like to reach out to our Care Team (719-347-5400 option 1), they would be so happy to help you individualize your therapy and find a product that is right for you.

Blog Featured Stories

How CBD Brought Instant Relief to My Son’s Hives

An estimated 1 in 5 people will experience hives, also known as urticaria, at some point in their lives. A multitude of situations and substances can trigger the skin rash, which often looks like raised itchy bumps, either red or skin-colored. The affected area can range from a few millimeters to the size of a hand. There are presently two different types of hives doctors will diagnose:


  • Acute urticaria: the rash clears completely within six weeks
  • Chronic urticaria: occur almost daily for more than six weeks


When urticaria appears, itching, burning, and stinging can affect any part of the body, including the face, tongue, ears, and large areas of skin. In extreme cases, it can also cause joint pain, fever, and digestive problems. 


Annelyn is a busy mom with two teenagers. Her oldest son came home with a small itchy rash on his neck after skiing. She tried OTC topical creams to no avail, and after a few days the rash began to spread around her son’s neck. She came to learn that the rash was in fact hives, and it continued to worsen and spread. Annelyn’s son was miserable, until she discovered Stratos SOOTHE 1:1 Topical CBD:THC Salve. We chatted with her about the relief her family was able to experience with the help of cannabinoid treatment.


ROC: What occurred in your life to make you want to try CBD as an option? 


A: After over a week of my son being miserable from his spreading hives, I tried CBD as a treatment.


ROC: What products have you used that you found relief from? 


A: I tried Stratos SOOTHE 1:1 and instantly my son’s neck felt cooler and not itchy. Within a day his hives started to recede and a couple of days later they were almost gone. 


ROC: What regimen are you currently following? Did you see the results right away?


A: We applied when needed and felt the results immediately. 


ROC: Did you experience any side effects?


A: No.


ROC: What is one piece of advice you’d give to someone who is just starting to use cannabis medicinally for the first time? 

A: Give it a try because it works.


ROC: How would you describe cannabinoid therapy using one word?


A: Amazing!


ROC: What is one stigma about cannabis that you wish you could change? 


A: The bad reputation throughout history. 


Annelyn’s story is one of many where people are finding relief using CBD treatment for a variety of ailments, and we thank her for sharing her story. Cannabidiol has been proven to help reduce inflammation, regulate our immune system, relieve symptoms of anxiety & depression, improve quality of life, and so much more! At Realm of Caring we are proud to support brands like Stratos, who commit to providing quality CBD and THC products that deliver a rapid onset of positive effects, every time.


Have a cannabis experience you’d like to share? We’d love to hear from you! Send us a message on Instagram or write to us by email:

Blog Education Featured

Biphasic Response: What Does it Mean for Cannabinoid Therapy?

If you are familiar with the benefits of cannabinoid therapy, then you may have also heard of the biphasic properties of cannabinoids. In short this means that low and high amounts of cannabis compounds can produce bidirectional, or opposite, effects. Here we will discuss more about this phenomenon and what it means for you and your cannabinoid therapy journey. 


When considering cannabinoid therapy in particular, much of the research available does not focus on low dose responses; rather the focus is on high concentration effects. There are long-standing beliefs that, when considering medications, titrating up quickly in dose is best. However, methods such as the biphasic dose-response challenge that dogmatic acceptance. Now we are seeing with specific conditions the magnitude of low doses and inhibitory responses at higher doses. 


Contradictory effects at low and high doses of cannabinoids have led researchers to investigate further. For example, when it comes to delta-9-tetrahydrocannabinol (THC), many choose to avoid this intoxicating component of the cannabis plant due to the undesirable side effects. Exposure to cannabis has been associated with cognitive impairments like short-term memory disruption. However, recent studies have shown that in older populations THC may promote hippocampal neurogenesis, prevent the neurodegenerative process of Alzheimer’s Disease, protect against inflammation-induced cognitive damage, and restore memory and cognitive function. 


Results over time have demonstrated that the involvement of THC in memory impairment is due to use associated with high-THC concentrations. Compelling evidence has shown that THC taken at extremely low concentrations in aging animal models may have the capacity to slow or halt neurodegenerative diseases such as Alzheimer’s Disease. 


The biphasic responses of cannabinoids have also been shown in cerebral metabolism, seizure disorders, pain, and anxiety responses. A known observation of the influence of cannabinoids is on emotional processing, such as anxiety and fear. Researchers have begun to intimately understand the biphasic effects of cannabinoids at the molecular level.


Cannabidiol (CBD) has been looked into for its potential, similar biphasic response to THC with anxiety. Both cannabinoids have shown that lower doses tend to produce anti-anxiety effects while higher doses may produce anxiety-like effects. Although future clinical trials are suggested as one study showed that higher amounts of CBD did not equate to increased feelings of anxiety. 


Researchers have recommended that if improvements seen during cannabinoid therapy begin to diminish over time, especially after an increase, then reducing the amount taken may be a potential strategy. For CBD, this is due to the idea that the compound has a reverse tolerance because of the role it plays in the endocannabinoid system as a modulator, rather than directly binding to receptors. Although many cannabinoids are shown to have favorable safety profiles, higher amounts of cannabinoids will not always yield enhanced therapeutic effects. 


While biphasic dose responses have shown to be significant with both cannabinoid therapy and clinical pharmacology, it is not the only method to consider. The best approach to cannabinoid therapy is an individual approach, as we all are unique and will respond differently to each cannabinoid and the concentrations of those cannabinoids in products. Working with a care specialist at Realm of Caring can help you to start low and slowly increase to find your optimal dose. We are here to talk with you one-on-one. Reach out by calling 719-347-5400 or emailing





The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Blog Education Featured

CBD for Sports Performance & Recovery

Cannabinoid therapy has gained a lot of attention recently in the world of sports. First, there is approval of Cannabidiol (CBD) by the World Doping Agency, therefore permitted for use in the Olympics, then we have a long list of athletes advocating for the benefits of recovery, performance, and possibly even treatment


So what are the benefits that are worth advocating for? As it turns out, there may be many. Here we discuss the more well-studied actions of certain cannabinoids that have the potential to benefit athletes.




When exercise is particularly strenuous, athletes may encounter what is known as exercise-induced muscle damage, which impairs muscle function and leads to inflammation that may delay recovery and prolong soreness or pain. Cannabinoids have been researched to be anti-inflammatory, in fact researchers use terms such as “novel” and “potent” to describe their anti-inflammatory actions.


The potential of alleviating the muscle inflammation may be able to enhance recovery time by decreasing muscle tension, soreness, and pain. While CBD is among the most studied for anti-inflammatory actions, Cannabis sativa contains several other cannabinoids, terpenes and flavonoids that share the same potential benefits. This includes, but is not limited to, cannabinoids THC, THCA, CBDA, CBN, CBC, and CBG; terpenes caryophyllene, borneol, nerolidol, linalool, limonene, and pinene; and flavonoids Cannflavin A, and B. 


Neuropathic Pain


Neuropathic pain is observed among wheelchair athletes with spinal cord injuries. It can also develop as a result of surgery for a sports injury or repetitive irritation of peripheral nerves from endurance sports. Preclinical studies have observed significant pain-relieving effects of combined THC and CBD on chronic neuropathic pain, suggesting the cannabinoids as possible therapeutic agents for a clinical problem that has proved difficult to treat. 


Bone Health


Exercise is known to improve bone strength and reduce the risk of fractures. However, for athletes, traumatic injuries that may occur could cause or contribute to the development of bone fractures. One animal study reported that CBD and THC improved femoral fracture healing, proposing the treatment process of bone fracturing may be enhanced with cannabinoid therapy. 




Concussions in athletes are very common. Recent reports show that in the U.S. there are about 3.8 million concussions that occur each year from sports related-injuries. Concussions may lead to long-term consequences. Increasing evidence shows that a traumatic brain injury (TBI) is a risk factor for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and chronic traumatic encephalopathy. Studies have shown the impact CBD has on animal models with neuronal injuries and that it may lessen the impact of behaviors that may follow concussions and TBI’s such as anxious and aggressive behavior, depression, pain, and impaired social interactions. 


The neuroprotective effects of CBD, in particular, may involve the molecule’s ability to decrease inflammation, oxidative stress, and excitotoxicity. Additionally, CBD has shown to regulate cerebral blood flow and enhance neurogenesis. 




When it comes to recovery, having quality sleep is very important. The first way cannabinoids may assist in improving our sleep is by mitigating the conditions that may be keeping us awake, such as sports performance anxiety (SPA). These conditions may have an effect on our body clock function, therefore leading to sleep disorders. 


CBD may directly assist in aligning our circadian rhythms, one of which being the sleep-wake cycle. The actions of our endocannabinoid system appear aligned with our circadian rhythms, therefore may modulate them. CBD, being a modulating molecule, has the potential to improve our sleep wake cycles, leading to an increase in the percentage of total sleep overtime. 


THC has shown in studies as having an effect on mental and physical sedation as well as lessening nightmare presence and intensity in PTSD study participants. In addition, THC shares properties of our endocannabinoid known as Oleamide, which is known to benefit apneic events. 


Topical Therapy


Preclinical and clinical studies show that targeting peripheral inflammation by topical therapy is effective. For wound healing, two of our endocannabinoid receptors, CB1 and CB2 are involved in the process of limiting inflammation, proliferations, and tissue remodeling. Although data on the clinical application of cannabinoids for inflammatory-related pain or aiding the process of wound healing is scarce, the research and anecdotal evidence is promising. 


Topical therapy has become a growing option for athletes who are looking to avoid ingesting full spectrum products, but still reap the potential benefits for problem areas or injury. 


Further Research and Finding a Product


While research to support the potential of cannabinoid therapy to benefit athletes is still considered to be in early phases, there are many recommendations by the scientific community to continue to study these plant-based options. Observational studies that anyone can join, such as Realm of Caring’s Observational Research Registry, are simple and effective ways to help legitimize this form of therapy. 


When looking for a product to aid you in your sports performance and/or recovery, it is always recommended you choose a well tested and high quality product you can trust. Visit Realm of Caring’s supported brands page for our list of trusted products and reach out to our free one-on-one support for guidance on administration by email




The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.


The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.