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What is in your CBD? Minor Cannabinoid and Supplement Benefits

In previous blogs we have discussed known benefits of major cannabinoids like cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) as well as minor cannabinoids such as cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), and cannabidiolic acid (CBDA). We have also looked at how terpenes may alter your cannabis experience. Here we will dive into some of the lesser known minor cannabinoids plus additional ingredients in your CBD that may provide a synergistic benefit boost. 


Major Cannabinoid vs Minor Cannabinoid


The cannabis plant has been grown and cultivated for medicinal, industrial, and recreational uses throughout recorded history. Originally, two main species of cannabis were described as Cannabis indica and Cannabis sativa, however strain lineage and our understanding have evolved vastly over time. Important advancements in understanding the pharmacology of cannabis came with the isolation of the two most abundant phytocannabinoids found in Cannabis sativa L.: CBD and Δ9-THC. In addition to these major cannabinoids, over 120 other phytocannabinoids (as well as an abundance of related compounds) are produced. These phytocannabinoids are referred to as minor cannabinoids as they are present in smaller amounts when compared to CBD and Δ9-THC. 


Cannabichromene (CBC) 


CBC is one of the most abundant minor cannabinoids found in cannabis. Cannabinoid receptor studies using CBD are limited, however it is known to be a potent activator of the transient receptor potential ankyrin 1 (TRPA1) channel, which is largely expressed in sensory nerves.


The anti-inflammatory effects of CBC were first reported in the 1980s, where high doses of CBD were more effective than the observed nonsteroidal anti-inflammatory drug (NSAID). In addition to reducing inflammation, it has also been observed to reduce pain associated with osteoarthritis without the negative side effects of NSAIDs. 


Tetrahydrocannabivarin (THCV) 


Like many other minor cannabinoids, THCV has researched actions at TRP channels and 5HT1A receptors. Also, like other minor cannabinoids, THCV has shown in rodent models to reduce inflammation and inflammatory related pain. 


Research in the last decade shows promise for THCV as an anti-epileptic and in the treatment of neurodegeneration in Parkinson’s disease. Rodent models have shown a reduced incidence of seizures, a reduction of slow motor movements, and prevention of neuronal degradation. 


It has been observed through studies that THCV regulates blood glucose levels, suggesting its potential usefulness for weight reduction and diabetes regulation. 


Cannabicyclol (CBL)


CBL is a rare cannabinoid that naturally occurs as CBC oxidizes. It was first discovered in Raphael Mechoulem’s laboratory in Israel in the 1960s and was more recently found in a 2,700 year old Caucasoid shaman grave in China, where in the tomb was a large cache of preserved cannabis. As cannabis ages, it begins to have less THC and CBD, however findings like these prove that even after sitting for thousands of years, there are still active compounds present as the cannabis ages. 


Given that the cannabis plant must age appropriately before active CBL may be obtained and studied, it makes researching the compound difficult. However the unique arrangement of atoms shows that it lacks psychoactive properties. 


Additional Ingredients in your Products


Just by looking in your spice cabinet you may find an array of products with stimulating or sedative properties which, when combined with cannabis, may enhance your desired state. But before going to make your own concoction, there are several quality companies who are already combining beneficial ingredients into one product for your convenience and safety. While these ingredients are regarded as generally safe on their own, oversight from a medical professional and education from a cannabis expert are always recommended to ensure you are getting the most out of your experience at the right amount. Here are some of those ingredients that may provide additional synergistic effects to your cannabinoid therapy. 


Valerian Root


Valerian root is an herbal supplement with historical uses as a traditional medicine. It is now classified domestically as a dietary supplement by the Food and Drug Administration (FDA), used widely as a sleep aid or to lessen anxiousness. If your intended use of cannabis is to improve the quality of your sleep, finding a product with valerian root may enhance drowsiness helping you to fall asleep faster. When taken in small amounts, it may also be beneficial to easing feelings of anxiousness and promoting a sense of calm. 


Lemon Balm


In addition to using lemon balm as a companion plant to cannabis to repel the “bad bugs” and disguise the cannabis plant smell, it has benefits for your body as well. Lemon balm is known to improve mood, cognition, and aid as a natural anti-inflammatory, anti-oxidant, and decongestant. Combining CBD and lemon balm may calm the nervous system to ease stress, refocus energy, and relax. 


Lion’s Mane 


Research has found the functional mushroom lion’s mane to have a host of benefits for neurodegenerative diseases such as ischemic stroke, Parkinson’s, Alzheimer’s, and depression. It may also promote recovery and enhance nerve regeneration, therefore improving cognitive performance and reducing brain fog. Benefits have also been evaluated for temporal lobe epilepsy (TLE), showing that lions’ mane supplementation could promote neuroprotection after seizure activity and prevent damage to nerve cells. The combination of lion’s mane and CBD may assist in easing feelings of anxiousness while improving clarity and focus. 


Finding a product


Finding products containing rare, minor cannabinoids may not be a simple task just yet. However, there are quality products available that combine major cannabinoids and other natural supplements. To learn more about what products are available and how to source a company you can trust, contact the Realm of Caring care team for free guidance! 

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CBDV Research

Cannabidivarin (CBDV) is a naturally occurring, minor cannabinoid found in the cannabis plant, almost identical in structure to cannabidiol (CBD). CBDV has been discovered in landrace strains of cannabis, which are types of cannabis that are unadulterated and typically grow in a specific location, known as their native environment. 


Like CBD, CBDV is well tolerated and non-intoxicating as it has weak affinity for CB1 receptors, which are responsible for the euphoric effects associated with cannabis use. Recent studies have shown that CBDV exerts beneficial effects towards neurological and motor impairments, cognitive deficits, helps nerve cells to be less active, and improves nausea, inflammation, and pain. Here we take a closer look at the researched benefits in Epilepsy, Autism, and gut health.




In recent years, CBDV has gained attention when 2014 research noted that it has significant anticonvulsant properties that may rival the therapeutic potential of CBD. 


Studies have shown CBDV to have benefits for individuals living with Epilepsy to include reduction in seizure frequency and epileptiform paroxysmal activity, even when looking at pediatric populations. 


The first study to identify anticonvulsant effects of CBDV was published in the British Journal of Pharmacology in 2012. They found that CBDV significantly reduced several seizure types while completely preventing tonic-clonic convulsions. When co-administered with traditional anti-epileptic drugs (AEDs), CBDV was well-tolerated without interacting antagonistically with them. Lastly, researchers looked closely at adverse effects, as many AEDs exert significant, life limiting motor side effects. CBDV’s anticonvulsant actions were due to a direct action on seizures, without causing motor suppression. In conclusion, researchers noted CBDV as a potential standalone AED or as a clinically useful adjunctive treatment alongside other AEDs. 


Ameliorates Autism-Like Behaviors


Due to studies showing CBDV’s ability to reduce motor impairments and cognitive deficits in models of Rett syndrome, researchers published in 2019 the therapeutic potential of CBDV for individuals living with Autism. At intermediate doses, CBDV normalized locomotor activity and improved short-term memory deficits. 


The study showed preclinical evidence to support CBDV to ameliorate behavioral abnormalities resembling the associated symptoms of Autism. Benefits were attributed to CBDV’s ability to restore hippocampal endocannabinoid signaling and neuroinflammation. 


Gut Health


CBDV activates a member of the transient receptor potential channels, which plays a pivotal role in intestinal inflammation. A published study from 2019 investigated the potential of CBDV for ulcerative colitis. This preclinical study showed that CBDV exerted intestinal anti-inflammatory effects in both rodents and pediatrics with ulcerative colitis. It also altered the dysregulation of gut microbiota and lessened cytokine expression. Early studies have also shown CBDV’s potential as an anti-nausea.


Looking to try CBDV?


Just as with many of the other cannabinoids of the cannabis plant, CBDV has been regarded through research as safe and non-intoxicating. Realm of Caring has carefully vetted companies whose formulations offer higher amounts of CBDV, than what you might find in a full-spectrum CBD product. Learn more by reaching out to our dedicated and knowledgeable care team

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CBD Ban in Wyoming

The Joint Judiciary Interim Committee of Wyoming introduced a House Bill Draft to prohibit hemp production and edible hemp products across the state of Wyoming. The plan is to introduce this bill on Tuesday, September 19th, 2023.


This bill (Draft 24LSO-0129v0.4) would prohibit hemp with any detectable amount of THC and prohibit the production of hemp for human consumption. It explicitly states that “no person shall produce, process, possess, purchase, sell, transport or use edible hemp or any edible hemp product”.


Please fill out the below form to urge Wyoming Legislators to block this bill and share this action item with friends, family, associates and social media contacts in Wyoming.


Patient voices are the most impactful. If eliminating hemp product purchasing and use in Wyoming would affect you or a loved one, please consider taking this advocacy effort to protect the safe and responsible CBD product companies.


Wyoming 24LSO-0129

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Dear Wyoming State Legislators,

Please PROTECT WYOMINGs Hemp Industry and Consumers by blocking efforts to move Working Draft 24LSO-0129v0.4 forward that would eliminate hemp products from being produced, processed, possessed, purchased, sold, transported, or used in the state of Wyoming. Your constituents rely on these products for their livelihood. Limiting the naturally occurring, non-intoxicating THC amounts found in hemp would result in tens of thousands of vulnerable and at-risk children and adults losing access to life saving medicine.
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In addition to using the form, you may contact your local representatives and senators by visiting


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Healthy Aging with Cannabis

September is Healthy Aging month, an annual health observance designed to focus national attention on the positive aspects of growing older. According to Carolyn Worthington, editor-in-chief of Healthy Aging Magazine, “We saw a need to draw attention to the myths of aging, to shout out ‘Hey, it’s not too late to take control of your health, it’s never too late to get started on something new.’ Why not think about the positive aspects of aging instead of the stereotypes and the negative aspects?” Activities for the observed month are designed to encourage individuals to rejuvenate and focus on positive measures that impact areas of physical, social, financial, and mental wellness. 


While working to improve your daily health, natural changes may happen in the body with age that one may want to focus on so you can get to feeling your best. These changes include skin damage from sun exposure, loss of physical strength and muscle mass, and changes in sleep patterns, energy levels, and appetite. In addition, chronic diseases become more prevalent as we age. These include heart disease, diabetes, arthritis, and Alzheimer’s, among others. Here we will discuss further potential benefits that adding cannabis to your routine may bring to potentially help combat some of the more common changes and diagnoses that occur with aging. 


Skin Health


There is a continuous need to seek more efficient, safer, and widely available methods to treat medical conditions, skin pathology included. 


Of the cannabinoids researched to date for skin health, cannabidiol (CBD) is a widespread ingredient in skin care products formulated as body oils, moisturizers, salves, lotions, and balms. Delta-9-Tetrahydrocannabinol (THC), and potentially cannabinol (CBN), may also be responsible for skin benefits such as reducing cytokine production and oxidative stress. Additionally, cannabigerol (CBG) has powerful anti-inflammatory and antibacterial properties that may add benefit to our skin health. 


Hyperpigmentation can take place as a result of melasma, sun exposure, imbalanced hormone levels, or skin conditions such as acne, dermatitis, or psoriasis. CBD has been quoted through research as a powerful antioxidant. Studies have also shown that CBD may help to hydrate dry and irritated skin. The combination of the ability to defend against free radicals and oxidative stress as well as increase moisture, may help to improve discoloration of the skin.


Muscle Mass


A study published in the Frontiers in Public Health examined the exercise habits of over 600 cannabis users. Surprisingly, the study found that cannabis users reported higher levels of weekly exercise compared to non-users. This unexpected correlation suggests that cannabis might play a role in motivating individuals to stay active.


There is indication that cannabis users experienced greater feelings of positive affect, tranquility, and enjoyment during exercise compared to non-users. This suggests that cannabis may enhance the overall exercise experience, making workouts more enjoyable and potentially leading to increased adherence.


Sleep and Energy


In normal aging, the serotonin system shows reduced receptor binding and losses in related functions, such as sleep and its quality. Cannabis Sativa is often used for improved sleep and relaxation, attributed to Indian hemp in the nineteenth century. 


For starters, hemp seeds contain a vitamin B6 content that can trigger the conversion of our body’s tryptophan into serotonin, which can then be converted to melatonin. 


CBD has been researched for its therapeutic potential for sleep disorders through limiting symptoms that may keep us awake at night but also may contribute to an increase in sleep duration and depth, as well as decrease in the anxiety responses induced by sleep disturbance. 


In comparison to CBD, THC has shown in studies as having an effect on mental and physical sedation, even in low amounts. THC also has positive therapeutic benefits that may lead to better sleep.


Cannabinoids CBD, THC, and CBN have been lightly studied for their effects in balancing melatonin production. Cannabinoids are also being studied to better understand the complementary relationship they have with melatonin. Data published in 2022 suggest that a CBD-melatonin formula could be competitive with synthetic-hypnotic drugs (i.e. Ambien, Unisom). The antioxidant activity of melatonin that benefits the brain network coupled with the pain reduction and anti-anxiety effects of CBD promoted a balanced sensation of wellbeing during sleep. 


A qualitative analysis published in 2022 paid close attention to the notable quality of life improvements attributed to medicinal cannabis use. The two overarching categories were “enhanced well-being” and “improved daily functioning”. Enhanced well-being includes feelings such as regaining a sense of hope, enjoying family life, and laughing more often. An adult from the study with Lyme Disease was quoted saying, “People such as myself are able to become productive and valued members of society again when we can have the quality of life improved so simply.” 




The Endocannabinoid System (ECS) plays a role with our appetite control – from the suppression of appetite to counter over-consumption to the treatment of conditions that involve reduced appetite and weight loss. This is why cannabinoid receptor antagonists (such as CBD) may manage obesity while agonists (such as THC) may be a therapy option for anorexia. 


Unwanted weight gain may be attributed to poor sleep, lack of physical activity, and nutrition. Therefore the approach to combating this may be a combination of lifestyle changes. 


Cannabinoid therapy may be a part of the equation for its potential to support our overall health and wellbeing. Research points towards cannabinoids as strong candidates for antioxidant, preventative, and recovery benefits. In addition, cannabinoids may decrease stress levels, improve sleep, and benefit metabolic syndrome


Cardiovascular Diseases


CBD has been researched for the many ways it may benefit our heart health, some of the most notable therapeutic actions of the molecule are the anti-inflammatory and antioxidant properties. Some cardiovascular conditions and diseases that are associated with inflammation and oxidative stress are diabetes, cardiomyopathy, stroke, arrhythmia, atherosclerosis, and hypertension. The therapeutic potentials of CBD are why it is being considered in research for the prevention and treatment of these conditions and diseases. In addition, CBD has particularly gained momentum because it does not appear to have effects on resting blood pressure or heart rate, rather it has shown in vivo to reduce the cardiovascular response to various stress types. 




Researchers examined the effects of cannabis on glucose regulation and insulin secretion, publishing findings in August of 2023. From this publication, a meta-analysis of 7 studies containing 11 surveys and 4 cohorts revealed that the odds of developing type 2 diabetes in individuals exposed to cannabis was 0.48 times lower than those without cannabis exposure. 


The ECS plays an important role in modulating metabolism and appetite. CBD may help the browning of white adipose tissue (the process of burning fat in the body) and promote lipid metabolism. This may help with the weight gain often associated with irregular menstrual cycles and menopause. Sometimes, this weight gain may lead to Type 2 Diabetes. Being that Type 2 Diabetes is an inflammatory condition, the anti-inflammatory properties of cannabinoids, as well as their ability to prohibit oxidative stress, could help to be a preventative measure. There is also research to show promise of CBD and THCV in reducing insulin resistance and moderating blood sugars. 




Cannabinoids are commonly investigated as pain-relieving agents, but in recent years more evidence has accumulated on their potential immunomodulatory effect, supported by results in animal models of certain rheumatic diseases. While results that demonstrate the same effect in humans are lacking, cannabinoids and cannabis remain potential options to alleviate the pain associated with rheumatic diseases, as they were shown as safe and causing little to no adverse effects. 


We know through research that CBD has a wide spectrum of biological activity, including anti-inflammatory activity. This is why its activity in the prevention and treatment of diseases whose development is associated with inflammation has been tested. In addition, CBD creates a physiological response with several inflammatory mediator receptors within us. These are known as the PPARy, GPR, and Adenosine A2A Receptors. 


The anti-inflammatory contributions of THC are also extensively studied, showing PGE-2 synthesis, decreased platelet aggregation, and stimulation of lipoxygenase, all actions related to reducing inflammation. THC has 20 times the anti-inflammatory potency of aspirin and twice that of hydrocortisone. 


Neurodegenerative Diseases 


A recently published study showed the first attempt in which significant focus has been imparted on all three aspects of cognition: memory consolidation, learning, and retrieval. 

Modern studies have shown that cannabis has numerous beneficial effects in neurodegenerative disorders of Alzheimer’s, Parkinson’s, epilepsy, Huntington’s Disease, multiple sclerosis, and amyotrophic lateral sclerosis. Reports have also shown that cannabis possesses anti-inflammatory, anti-depressant, anti-anxiety, antipsychotic, and anti-schizophrenic effects. 


Oral administration of CBD, in one study, improved the cerebral blood flow to the hippocampus and regions associated with memory advancement, indicating improved overall memory function, and building the case to perform further studies with CBD for neurological impairments.


Finding Support


There is a lot to consider when starting cannabinoid therapy but, as always, a Realm of Caring care specialist is here to help with free one-on-one support to answer your questions. Contact us today by calling (719) 347-5400 or by emailing

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The CannaMom & Dad’s Back-to-School Guide

Leaves are changing colors, and parents all around the country are gearing up for the much-anticipated back to school season. This can be an exciting but often hectic time of year for parents and guardians! For those who are cannabis advocates, and either use it themselves or administer it to their children, this can be its own unique experience to navigate, specifically with the surrounding stigma. 


One of the most misunderstood aspects of being a CannaMom or Dad is when either parent or child consume cannabis. With laws and regulations constantly changing, plus outdated stereotypes due to lack of understanding, this can feel all the more overwhelming when you mix in places of education and other parents and their children.


Whether you’re here to simply learn more about this topic or are a parent seeking further reassurance, we’re here to help break down the ins and outs of going back to school as a CannaMom or Dad so you can do so with confidence.


Navigating Back-to-School Stress with Cannabis


As a parent, this time of year can feel exceptionally hard to manage. Parents who choose to use cannabis may do so for a variety of reasons unique to their needs, including:


  • Stress Relief: The juggling act of school schedules, extracurricular activities, and daily household duties can be overwhelming. Cannabis can help to unwind and reduce stress, making it easier to tackle responsibilities.


  • Pain Management: Many moms deal with chronic pain, whether from past injuries, childbirth, or the physical demands of parenting. Cannabis’ pain-relieving properties can provide much-needed relief.


  • Creativity and Relaxation: Cannabis can enhance creativity and help to find moments of relaxation amid the busy school year. It can also foster deeper connections with our children and partners.


De-stigmatizing Canna Parents


The stigma surrounding CannaMom and Dads is a persistent challenge. Many still associate cannabis use with irresponsible parenting or illicit behavior, when this is absolutely not the case. It’s time to challenge these stereotypes and recognize that CannaMom and Dads are just like any other parents, but with a unique approach to self-care and wellness. Whether you are doing so for yourself, or a loved one, here are ways you can challenge the stigma:


  • Education: We must start with education—understanding the science behind cannabis, differentiating between CBD and THC and other cannabinoids, and recognizing their respective benefits and responsible use.


  • Open Conversations: Parents who consume cannabis should feel comfortable discussing their choices with friends, family, and healthcare professionals. By sharing our experiences and insights, we can help normalize these conversations.


  • Advocate for Regulation: Advocating for sensible cannabis legalization and regulation is essential. A regulated market ensures product quality and safety, making it easier for CannaMom and Dads to access reliable cannabis products.


CBD for Children


CBD, short for cannabidiol, is a non-psychoactive compound found in cannabis that may offer numerous therapeutic benefits for kids, including:


  • Anxiety Relief: Starting a new school year can be overwhelming for children. CBD can help reduce anxiety, allowing them to face the challenges of school with more confidence.


  • Focus and Concentration: Some children struggle with attention and focus in the classroom. CBD may aid in improving these aspects, enabling them to engage more effectively with their studies.


  • Pain Relief: For kids dealing with chronic pain, CBD can provide relief, allowing them to participate fully in school activities.


  • Seizure Control: For children with epilepsy or who suffer from seizures, CBD can be a vital piece of their medical treatment. 


Whether a child is a medical cannabis patient is up to the parent to decide. For those parents who do require it, we understand what a big responsibility it is to advocate for your children. If you are currently navigating how to administer your child’s medicine throughout the school day, we are here to help.


On-Campus Administration 


Back to school for students who are medical cannabis patients can be a challenging time if their medicine is taken throughout the day. Under most state laws, a medical cannabis card or recommendation for pediatrics does not permit the use of medical cannabis on school grounds, on a school bus, or at a school activity unless the county or district has adopted a policy permitting the use.


There are few exceptions in states such as Colorado. In 2021, legislation passed that required school boards to implement policies which would allow possession and self-administration of non smokable medicinal cannabis if prescribed by a licensed health practitioner. However, there are stipulations to these rulings. For example, in Colorado, districts are not required to adopt this policy if the school district loses, or will lose, federal funding as a result of implementing the requirement.


As it stands, along with Colorado, California, Delaware, Florida, Illinois, Maine, New Jersey, New Mexico, and Washington have passed similar measures to allow medicinal cannabis use on school grounds. If your child is a medical cannabis patient, it is always best to check in with your school district on their cannabis policy. If you find that their dose needs to be adjusted, a Realm of Caring care specialist is just a phone call away to assist. 


Embracing Differences


As the back-to-school season unfolds, we encourage you to remember that CannaMom and Dads are ordinary parents with unique self-care choices. They are just as wonderful parents as any other, who simply believe in the benefits of cannabinoids for their children and for themselves, while still being committed to responsible use. It is possible for a healthy balance between parenthood and cannabis consumption to be maintained! 

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CBD Ban in California

State Assemblywoman Cecilia Aguiar-Curry introduced California Assembly Bill 420 (AB420) with a goal to redefine terms, ensure raw hemp extract follows Federal hemp guidelines, and eliminate the sale of hemp products with synthetic or synthetically derived cannabinoids (cannabinoids not found in nature in meaningful quantities).


Unfortunately, amendments have been added to use this bill as a vehicle to impose THC limits on hemp-derived CBD products that would effectively remove access to full spectrum and broad spectrum products. Amendments would set a package limit of 5 servings per package and a total THC limit of 0.001 mg/g for hemp products.


Please fill out the below form to urge Assemblywoman Cecilia Aguiar-Curry to block these amendments and to share this action item with friends, family, associates and social media contacts in California. Time is of the essence, as the legislature resumed taking action on this bill after the Labor Day holiday.


Patient voices are the most impactful. If eliminating full spectrum and broad spectrum purchasing in California would affect you or a loved one, please consider taking this advocacy effort to protect the safe and responsible CBD product companies.


AB 420

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Dear Assemblywoman Aguiar-Curry,

Please PROTECT CALIFORNIA's Hemp Industry and Consumers by blocking efforts to impose excessive packaging and THC limits on hemp products as stated in section 111922 of AB 420. Amendments include a package limit of 5 servings per package and a total THC limit of 0.001 mg/g for hemp products. This would eliminate access to broad and full spectrum hemp products in California, which your constituents rely on for their livelihood.
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In addition to using the form, you may contact Assemblywoman Cecilia Aguiar-Curry the following ways:




Capitol Office:
State Capitol
P.O. Box 942849
Sacramento, CA 94249-0004
Tel: (916) 319-2004
Fax: (916) 319-2104


District Offices:
600 A Street, Ste. D
Davis, CA 95616
Tel: (530) 757-1034
Fax: (530) 757-1174


2721 Napa Valley Corporate Drive
Napa, CA 94558
Tel: (707) 224-0440
Fax: (707) 224-0430

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Most Effective CBD

When starting out with cannabinoid therapy, you might find yourself Googling “fastest”, “strongest”, or “most effective” cannabidiol (CBD). While you may get many results for the multitude of products available, it will soon become difficult to sort through the promotional material and find the one that might work best for you


Unfortunately, CBD therapy is not a one-size-fits-all approach. There are several factors to consider when starting out such as ailment, desired outcome, age, taste or administration preferences, current medications, and more. Even with all of the variables involved, finding success with CBD can be possible and Realm of Caring is here to help you get there. 


How to find what is right for you:


Consider the ailment you are looking to address


We may have several ailments happening at once that we would like to see alleviated with CBD. When beginning a cannabinoid therapy routine, it can be beneficial to ask the question “what will success look like to me?” For example, if the cause of your restless sleep is joint pain then you might consider improved sleep to be one success and consistent pain relief another. These benchmarks can provide indication that you are on the right path but also give insight to if an increase or decrease might be necessary. 


Journaling can add a great benefit to your therapy, so you can jot down dose changes, product changes, and improvements along the way. Remember, your cannabinoid therapy journey is about finding what works best for you, journaling is one more tool to ensure your experience is as unique as you are. 


Read your labels


With a lack of FDA oversight, it is up to the consumer to check on the accuracy of CBD labels. This involves an extra step, but is worth it to ensure that you are using a safe and quality product. CBD labels should include how much CBD the product contains (typically in milligrams), as well as the carrier oil, other cannabinoids, supplements, terpenes, and/or flavoring. One way to verify the concentration of listed ingredients is to check it with a certificate of analysis (COA). Each quality company should be able to provide you a COA for the product you purchase, that is verified by a third party lab. 


Look at the concentration of cannabinoids other than CBD


While additional cannabinoids can be listed directly on the label of the product you are purchasing, the cannabis plant has hundreds of minor cannabinoids that may be in your product. Each cannabinoid has potential benefits and works synergistically with the star of the show, CBD. To figure out the list of other cannabinoids that are detected, look back to that COA. If you were finding success with one product and then switched to another and were not achieving the same results, you might find that one had a higher/lower concentration of a specific cannabinoid other than CBD. For example your product could yield a higher percentage of CBG or CBN


Understand what non-cannabis ingredients are added


Many CBD products will have 2-3 ingredients such as: hemp oil, a carrier oil, and (occasionally) a natural flavoring. However, you may recall advertisements for CBD products that promote “best for sleep” or “best for pain”. Typically, these claims can be made if: a. Research supports the claim for the specific product or b. The product includes an ingredient, other than CBD, a carrier oil and a natural flavoring, that has been researched to affect the normal functioning of the body in that way. 


For example, if a CBD product is labeled for sleep, then it may include Melatonin, L-theanine, or Valerian Root. CBD has researched sleep benefits of its own, but may work synergistically with these added ingredients for an additional boost. Before purchasing, understand what ingredients have been added and if those are right for you. 


Figure out your dose


As with any therapy, effective dosing varies widely by individual and condition. Figuring out your dose can help set you up for success and help you determine how much you will be spending. Given the varied prices of CBD, a certain cost may make you feel as if you are getting a “good deal”, however understanding how much you may be starting out with provides a better indication of what you will be spending. Comparing CBD product costs is just like comparing cereal boxes at the grocery store. But instead of looking at cost per ounce, you’ll be looking at cost per milligram (mg). 


Your dose may vary depending on your age, condition, and medications you are taking.  When looking to CBD for medical conditions, we always recommend speaking with a healthcare professional. However, to help you understand what to consider before purchasing or how to talk to your doctor about CBD, contact a Realm of Caring Care Specialist for free one-on-one support by emailing or calling (719) 347-5400. 


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Could Implementing Medicinal Cannabis programs mean lower health insurance costs?

Studies on the long-term impacts of medicinal cannabis policies on healthcare costs and potential, individual healthcare savings have recently emerged. Where initially there were concerns about cannabis legalization leading to an increase in medical expenses, we are actually witnessing a decrease in medical expenses – ranging from decreased prescription use to lessened need for treatment facilities. 


Here we explore some of the researched ways medical savings are taking place when cannabis is legalized for medicinal use. 


Less ER visits and hospital admissions


The key finding of a 2020 published study, including 1,276 participants, was that medicinal cannabis use was associated with more positive ratings of health and quality of life, assessed across multiple domains. The group of individuals from this study who initiated cannabis use after their first study showed improvement in their health. The group of individuals using cannabis who stopped using cannabis showed diminished health. 


From this study, in addition to 14% of cannabis users reporting less use of current prescription medication, 39% reported less past-month Emergency Room (ER) visits, and 46% reported less hospital admissions. 


Reducing occurrences of substance use disorders


There is a longstanding debate that cannabis use complements use of hard drugs. However, one 2015 study showed no evidence that cocaine and heroin use increases with cannabis use. Instead, in states with medicinal cannabis laws, there was a 20% decrease in treatment for heroin use disorders and no change in treatment for cocaine use disorders following implementation.


A 2022 published study used a longitudinal, co-twin control design in 4043 twins. The tested the effect of cannabis legalization on outcomes of interest and whether legalization interacts with established vulnerability factors (age, sex, or externalizing psychopathology). They found that while legalization was associated with increased cannabis use that it was not associated with cannabis use disorder. Additionally and most notably, the authors found a decrease in alcohol use disorder symptoms and no changes in alcohol or illicit substance consumption.  


Decreased need for mental health treatments


Literature on the effects of expanding cannabis legislation on mental health treatment is scarce. There is evidence to point to decreased prescriptions for antidepressants and sedatives among the elderly and, more recently, research to show a decrease in the number of mental health treatment admissions. Data collected from the Substance Abuse and Mental Health Services Administration (SAMHSA) illustrate the correlation between states who have passed recreational cannabis laws and a clear, immediate, statistically significant decrease in total admissions. Due to limitations, it is difficult to identify the exact mechanisms leading to a decline in seeking mental health treatment; therefore it is recommended that future studies examine outcomes of improved mental health, self-medication, or other factors. 


Type 2 Diabetes Intervention


Diabetes is among the most expensive chronic conditions in the United States, where $1 out of every $4 of healthcare costs is spent on caring for individuals with diabetes. That total annual cost comes to about $327 billion per year, with an estimated cost among medicare beneficiaries who are 65 and older at $5,876 per person, per year. 


Researchers examined the effects of cannabis on glucose regulation and insulin secretion, publishing findings in August of 2023. From this publication, a meta-analysis of 7 studies containing 11 surveys and 4 cohorts revealed that the odds of developing type 2 diabetes in individuals exposed to cannabis was 0.48 times lower than those without cannabis exposure. 


While interventions for chronic conditions are important to reduce the number of individuals affected, and cannabis is being realized as a beneficial intervention, it is recommended that more studies be conducted to increase levels of evidence.


Lower health insurer premiums in the individual market


Implementing medicinal cannabis laws may have a direct effect on individual market health insurance premiums – for both cannabis users and non-users given the nature of insurance pooling. A 2023 published study looked at state-level private health insurer data from the National Association of Insurance Commissioners from 2010-2021. Specifically, researchers were looking at the changes to health insurance premiums after a state adopted a medicinal cannabis policy. 


The authors “provide evidence that although the effect does not begin until seven years post-medical cannabis law implementation, there is a significant and sizable reduction in health insurance premiums” (Cook et al., 2023). A conservative statistical analysis predicts a reduction in annual premiums of $1,663 per individual. When considering the number of individuals enrolled in an individual health insurance market across legalized states – the resulting estimate in annual savings is approximately $9.6 billion. 


Finding Support


Evidence is spreading across the healthcare sector that cannabis has many health benefits. However, one thing that may be challenging is finding a product or dose that is right for you and your specific circumstance. This is where Realm of Caring steps in to support with free one-on-one guidance. Reach our dedicated and knowledgeable care team by calling (719)347-5400 or emailing Quality of life matters, we are here to help. 

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Cannabis & Exercise: What the Research Says

In recent years, the intersection of cannabis and exercise has sparked significant interest among researchers and health enthusiasts alike. With the growing legalization and decriminalization of cannabis, more people are exploring its potential benefits, especially in conjunction with physical activity. Contrary to outdated stereotypes, emerging research suggests that cannabis consumption may be associated with increased physical activity, reduced pain levels, and enhanced positive emotions during exercise. 


Cannabis and Physical Activity: A Surprising Connection


Traditionally, stigma has created a stereotypical image of a cannabis user, i.e. couch-lock and sedentary behavior. However, recent studies have challenged this perception, revealing that cannabis consumers are more inclined to engage in physical activity than previously thought.


A study published in the Frontiers in Public Health journal (2019) examined the exercise habits of over 600 cannabis users. Surprisingly, the study found that cannabis users reported higher levels of weekly exercise compared to non-users. This unexpected correlation suggests that cannabis might play a role in motivating individuals to stay active.


Pain Management and Exercise: A Dual Approach


One of the most promising aspects of cannabis use in conjunction with exercise is its potential to alleviate pain. Both cannabis and exercise have been independently shown to reduce pain levels, making them a potentially powerful combination for those dealing with chronic pain conditions.


Research published in the National Library of Medicine (2019) and the Cannabis and Cannabinoid Research Journal (2023) explored the impact of cannabis use on pain perception before and after exercise. The studies observed that cannabis users reported lower pain levels after engaging in physical activity compared to non-users. This suggests that cannabis could act synergistically with exercise, offering enhanced pain relief and potentially allowing individuals to push through discomfort during workouts.


Elevated Positive Affect and Enjoyment


The role of positive affect, tranquility, and enjoyment during exercise cannot be underestimated. These emotional states can significantly impact our motivation to work out and our overall satisfaction with the activity.


Diving further into the 2019 study results mentioned above, there is indication that cannabis users experienced greater feelings of positive affect, tranquility, and enjoyment during exercise compared to non-users. This suggests that cannabis may enhance the overall exercise experience, making workouts more enjoyable and potentially leading to increased adherence.


Next Steps


While the emerging studies are promising, it’s important to approach the combination of cannabis and exercise by keeping in mind that further research is still needed. Individual responses to cannabis vary widely, and factors such as dosage, strain, and method of consumption can influence outcomes. 


Before incorporating cannabis into your exercise routine, we always recommend speaking with a healthcare professional, especially if you have any underlying health conditions or are taking medications that may interact with cannabis. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance – we are here every step of the way. Send as an email to, call us at 719-347-5400 or chat with us at


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CBD Benefits for Liver Function

Cannabidiol (CBD), extracted from Cannabis Sativa, has been well-researched for its many benefits and is quickly becoming a favorable therapeutic option as adverse effects are limited, it does not cause psychoactive effects, and it lacks abuse potential. Included in the growing list of well-studied benefits, are the pharmacological properties of CBD that may protect the liver. This is due, in part, to the antioxidant and anti-inflammatory capabilities. 


Here we will discuss CBD’s potential role in restoring liver function, in alleviating liver injuries in alcoholics, and as an anti-cancer therapy. 


Restoring liver function


CBD is being more closely looked at for benefits in individuals suffering from hepatic encephalopathy (HE), a syndrome observed in those with end-stage liver disease and exacerbated by inflammatory responses. Given the novel anti-inflammatory and non-intoxicating properties of CBD, it makes it a promising treatment for HE. 


For one study in particular, researchers injected mice with acute liver injury, which raised their levels of ammonia, bilirubin, and liver enzymes after administration. CBD partially restored all of the indices induced by the injection to normal levels, therefore restoring liver function. For the control animals who did not receive injections, CBD had no effect on any of the liver-associated levels. 


Alleviating liver injuries in alcoholics


Alcohol abuse and high-fat diet-induced liver diseases are among the most prevalent chronic liver diseases as well as the leading reason for liver transplantation around the world. Inflammation has an important role in the formation and progression of liver damage that may be induced by either alcohol or a high-fat diet. 


Published research in 2021 looked to CBD to further study its ability to alleviate liver injuries induced by ethanol plus high-fat cholesterol diets, a model simulating heavy alcohol drinkers in a Western diet. This study took place over a span of 8 weeks with mice liver injury models. 


Results found that CBD ameliorated steatohepatitis (liver inflammation and damage caused by a buildup of fat in the liver), alleviated oxidative stress, decreased hepatic inflammation, prevented key activations responsible for the development of liver diseases, and attenuated liver inflammatory responses. 


Anti-hepatocellular carcinoma potentials


Hepatocellular carcinoma (HCC) represents over 85% of primary liver cancers. Liver cancer is the 5th most common cancer in men and 9th most common for women worldwide. It is estimated that 70% of liver cancers may be prevented. 


Researchers sought to understand the efficacy of Cannabis sativa, specifically an extract with major components delta-9-tetrahydrocannabinol (THC), CBD, and cannabinol (CBN) with percentages at 16.26%, 14.98%, and 13.486% respectively. Clinical trials and observational studies have, for many years, shown the safety of cannabis administration in the treatment of therapies. Therefore researchers in this study wanted to build upon that anti-cancer knowledge. 


The cannabis sativa extract increased the activity of antioxidant enzymes, ameliorated lipid peroxidation, displayed anti-angiogenic potential, lead to apoptosis, and demonstrated anti-inflammatory benefits. 




While benefits are being realized in regards to understanding CBD as a protectant of liver function, more research is needed, especially in the arena of CBD use in combination with pharmaceuticals. As with any therapy, effective dosing varies widely by individual and condition. When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey, the care team at Realm of Caring is here to help! Send an email to, call at 719-347-5400 or schedule an appointment.