Cannabidivarin (CBDV) is a naturally occurring, minor cannabinoid found in the cannabis plant, almost identical in structure to cannabidiol (CBD). CBDV has been discovered in landrace strains of cannabis, which are types of cannabis that are unadulterated and typically grow in a specific location, known as their native environment.
Like CBD, CBDV is well tolerated and non-intoxicating as it has weak affinity for CB1 receptors, which are responsible for the euphoric effects associated with cannabis use. Recent studies have shown that CBDV exerts beneficial effects towards neurological and motor impairments, cognitive deficits, helps nerve cells to be less active, and improves nausea, inflammation, and pain. Here we take a closer look at the researched benefits in Epilepsy, Autism, and gut health.
In recent years, CBDV has gained attention when 2014 research noted that it has significant anticonvulsant properties that may rival the therapeutic potential of CBD.
Studies have shown CBDV to have benefits for individuals living with Epilepsy to include reduction in seizure frequency and epileptiform paroxysmal activity, even when looking at pediatric populations.
The first study to identify anticonvulsant effects of CBDV was published in the British Journal of Pharmacology in 2012. They found that CBDV significantly reduced several seizure types while completely preventing tonic-clonic convulsions. When co-administered with traditional anti-epileptic drugs (AEDs), CBDV was well-tolerated without interacting antagonistically with them. Lastly, researchers looked closely at adverse effects, as many AEDs exert significant, life limiting motor side effects. CBDV’s anticonvulsant actions were due to a direct action on seizures, without causing motor suppression. In conclusion, researchers noted CBDV as a potential standalone AED or as a clinically useful adjunctive treatment alongside other AEDs.
Ameliorates Autism-Like Behaviors
Due to studies showing CBDV’s ability to reduce motor impairments and cognitive deficits in models of Rett syndrome, researchers published in 2019 the therapeutic potential of CBDV for individuals living with Autism. At intermediate doses, CBDV normalized locomotor activity and improved short-term memory deficits.
The study showed preclinical evidence to support CBDV to ameliorate behavioral abnormalities resembling the associated symptoms of Autism. Benefits were attributed to CBDV’s ability to restore hippocampal endocannabinoid signaling and neuroinflammation.
CBDV activates a member of the transient receptor potential channels, which plays a pivotal role in intestinal inflammation. A published study from 2019 investigated the potential of CBDV for ulcerative colitis. This preclinical study showed that CBDV exerted intestinal anti-inflammatory effects in both rodents and pediatrics with ulcerative colitis. It also altered the dysregulation of gut microbiota and lessened cytokine expression. Early studies have also shown CBDV’s potential as an anti-nausea.
Looking to try CBDV?
Just as with many of the other cannabinoids of the cannabis plant, CBDV has been regarded through research as safe and non-intoxicating. Realm of Caring has carefully vetted companies whose formulations offer higher amounts of CBDV, than what you might find in a full-spectrum CBD product. Learn more by reaching out to our dedicated and knowledgeable care team!