Category: Blog

There are currently 6.7 million Americans living with Alzheimer’s disease, a number that is expected to rise to 13 million by 2050. Alzheimer’s disease is the most common cause of dementia that affects memory, thinking, and behavior, accounting for 60-80% of dementia cases. The greatest known risk factor is increasing age, with the majority of those suffering from Alzheimer’s aged 65 and older. It is a progressive disease, with no known cure, however treatments may slow the progression and improve the quality of life for those living with Alzheimer’s and their caregivers. 

 

Neuroprotection

 

Neuropsychiatric symptoms occur frequently in individuals living with Alzheimer’s disease. These symptoms include: psychosis, agitation, aggression, depression, anxiety, and apathy. Frequent prescriptions to target these symptoms include neuroleptics, antidepressants, sedatives, hypnotics, and anxiolytics; which all may have issues related to tolerability and side effects. It has been well documented that benzodiazepines to target agitation in patients may increase cognitive decline and make them vulnerable to injurious falls. Despite decades of research, reliable treatments for neuropsychiatric symptoms have not been found. 

 

It is likely that regimens that target Alzheimer’s disease require a number of therapeutic strategies to target various stages of development, including neuroprotective intervention. The concept of delaying onset or slowing progression, may eliminate symptomatic Alzheimer’s disease as a significant factor in advanced age. 

 

Neuroprotection is the ability for a therapy to prevent neuronal cell death by intervening in and inhibiting the pathogenic cascade that results in cell dysfunction and eventual death. Neuroprotective methods often target oxidative stress and excitotoxicity

 

Antioxidant benefits of cannabidiol (CBD)

 

Oxidative stress takes place when potentially harmful free radicals, which are atoms that may cause damage to cells, proteins, and DNA, overwhelm the body’s natural antioxidants. Insufficient levels of antioxidants in the body also lead to oxidative stress, resulting in damage to cell structure, function, and chronic excessive inflammation. We consume antioxidants through foods and supplements to assist our body in the prevention of or to decrease oxidative stress. The antioxidants safely interact with the free radicals before molecules become damaged. Endogenous antioxidants you may be familiar with are vitamin e, vitamin c, beta-carotene, and zinc; which many of us find in fruits and vegetables or as supplements.

 

Research has shown the ability of CBD to be successful at blocking or modulating toxic levels of glutamate. Glutamate is an excitatory neurotransmitter that is released by nerve cells in the brain and responsible for sending signals. Glutamate plays an important role in our learning and memory, however, it can also be damaging to nerve cells and the brain as a whole. When there are abnormally high concentrations of glutamate or when the receptors are overly sensitive (meaning less glutamate is needed to excite the cell) then the cells can become over-excited leading to their damage or death, in other words, oxidative stress. 

 

When studied, the effects of CBD on toxic glutamate levels were comparable to the industrial antioxidant known as BHT, suggesting its role as an effective antioxidant. This also shows promise for the CBD as a neuroprotectant.

 

Effect of cannabinoids on CB2 receptors

 

In addition to antioxidant benefits, cannabinoids may also have neuroprotective benefits in how they interact with CB2 receptors, mainly found in microglia cells. Microglia cells are known as the immune cells of the central nervous system and play important roles in brain infections and inflammation. CB2 receptors have become interesting targets for the treatment of neurological diseases as their activation has been related to a delayed progression of neurodegenerative events. Research has shown that in resting, healthy brains, microglia move constantly to survey the brain. Activation of CB2 receptors, and likewise active microglia, may rapidly respond to pathological insults that may lead to disease progression by providing neuronal protection. 

 

Targeting specific behavioral disturbances with Cannabinoid Therapy: sleep, agitation, depression

 

Sleep 

 

Sleep disorders are among the most behavioral disturbances in individuals living with Alzheimer’s disease. CBD has therapeutic properties that have the potential to mitigate symptoms that interfere with sleep. It also has the potential to improve sleep-wake cycles leading to an increase in the percentage of total quality sleep overtime.

 

Assessed data from a 2020 published observational study looking at various quality of life measures showed that adult cannabis users had greater sleep quality, shorter sleep latency, longer sleep duration, fewer sleep disturbances, and a significantly better sleep score compared with the control group.

 

Anxiety and Agitation 

 

Anxiety and agitation symptoms affect 25-70% of the dementia population, though there are no FDA-approved medications that treat these behavioral symptoms associated with Alzheimer’s disease.

 

An observational study published in 2023, evaluated 30 patients diagnosed with mild, moderate, or severe Alzheimer’s disease aged 65-90 years. After dosing a THC:CBD cannabis extract twice a day for 12 weeks, findings showed reduced behavioral misconduct, such as agitation and cognitive impairment.

 

Depression 

 

It has been suggested that the endocannabinoid system may be involved in the pathophysiology of depression. Evidence shows that endocannabinoids and CB1 receptors are widely distributed in the brain areas that are often related to mood disorders and that their expression is regulated by antidepressants. 

 

The 5-HT1A receptor is a serotonin receptor that is located in presynaptic and postsynaptic regions. Activating these receptors have been involved in the mechanism of action of anti-anxiety, antidepressant, and antipsychotic medications. Data indicate that repeated administration of CBD may produce an effect that is consistent with results from studies testing traditional antidepressant medications.

 

Realm of Caring was able to collect and publish data on cannabis use for anxiety and/or depression. Cannabis Users reported lower baseline depression, significantly better past-month sleep quality, a higher overall quality of life, and lower past-month average pain compared to Controls.

 

Future research

 

There are a number of agents with potential to provide neuroprotective effects, however before determining their capability to delay onset or slow disease progression, additional clinical testing will be required. However, key findings across several studies show promising therapeutic actions of cannabinoids as neuroprotective agents and for symptom relief from Alzheimer’s disease. 

 

Realm of Caring and Johns Hopkins University School of Medicine have developed the Observational Research Registry (ORR) to better understand medicinal cannabis use and its impact on key health outcomes. Our registered clients provide critical information that leads to important insights into the therapeutic capabilities of medicinal cannabis. The ORR helps us develop client educational resources and may ultimately serve to legitimize the medicinal use of cannabis.

 

Finding Support

 

Finding free one-on-one support with cannabinoid therapy can be difficult, but that is where Realm of Caring may step in to help. Our care specialists are trained to help with product and practical administration suggestions – whether you be an experienced user or novice. In general, cannabis is safe but responsible use and guidance, as well as oversight by a healthcare professional, are always recommended. We are here to help start and facilitate those conversations along the way through these extremely difficult times. 

 

If you want to reach out to our care team to discuss anything cannabinoid therapy related one on one – we are here for you! You can call our free hotline at 719-347-5400, email info@realmofcaring.org, or schedule an appointment. 

 

The cannabis plant contains over 100 active compounds known as cannabinoids. Two major cannabinoids that are well-known and well-researched for their promising medicinal applications are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). One thing that the cannabis plant continues to be known for is an appetite stimulant, but is that always the case and can that lead to unwanted weight gain? 

 

The ability of THC to promote eating has been documented for centuries. The FDA has approved one synthetic form of THC, Dronabinol (Marinol), prescribed to those suffering from anorexia, nausea and vomiting as a result of chemotherapy, and cachexia (wasting syndrome), which is often linked to diseases such as cancer, AIDS, heart failure, COPD, cystic fibrosis, and kidney disease. In certain states, these same diseases may be considered eligible conditions for a medical cannabis card. 

 

Will the “munchies” cause weight gain? 

 

User anecdotes suggest that cannabis use will promote appetite. Studies have shown that caloric intake increases among cannabis users when compared with non-users. This leads to the popular belief that cannabis use leads to weight gain, however many human epidemiological studies show the opposite. 

 

Cannabinoid Receptor 1 (CB1) activation by THC may stimulate short-term feeding when administered, however this does not necessarily mean weight gain will follow. When one study observed the effects of THC administration on diet-induced obese mice, data showed that chronic administration of THC prevented weight gain over time. 

 

While THC may increase levels of ghrelin (“hunger hormone”) and activate dopamine levels that may enhance enjoyment of sensational eating, it may also affect leptin – the hormone responsible for regulating food intake and metabolic rate. 

 

Cannabinoids and obesity 

 

It was found in the US National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) that there is a lower prevalence of obesity in cannabis users compared with non-users. Anecdotes, preclinical studies, and cross-sectional evidence show inverse associations between cannabis use and obesity as well as inverse associations between cannabis use and increased BMI. 

 

It is well established that the endocannabinoid system (ECS) is involved in the regulation of energy balance and the development of obesity. Cannabinoid receptors regulate thermogenesis, food intake, and inflammation. Cannabinoid receptors are responsible for the browning of white adipose tissue (the process of burning fat in the body). CBD plays a modulatory role in this process as well as promotes lipid metabolism, therefore is considered a promising therapeutic agent for preventing obesity. 

 

How cannabinoids may benefit anorexia and wasting syndrome

 

In 2011 a study looked at THC as an appetite stimulant for treatment of cancer-induced anorexia. The results showed that THC-treated patients reported premeal appetite, that food “tasted better”, and that quality of sleep and relaxation were increased. 

 

Among appetite loss, afflictions of wasting syndrome include nausea, pain, anxiety, and inflammation. All of these symptoms may be mitigated with cannabis use. 

 

The non-intoxicating cannabinoid, cannabidiolic acid (CBDA) shows promise that it may be helpful for nausea and vomiting, including anticipatory nausea for which no specific therapy is currently available. Anticipatory nausea is conditioned or psychological nausea, often provoked by a reminder of an event that leads to vomiting, such as an individual going through chemotherapy. This is researched to be a result of 5-HT receptor activation by CBDA. 

 

Data has demonstrated in animal tests that another non-intoxicating cannabinoid, cannabigerol (CBG) showed as a novel appetite stimulant. The results showed that administration of CBG to rodents significantly increased total food intake in that they began feeding sooner, consumed more meals, and consumed more during those meals. 

 

Changing the narrative: How cannabinoids may promote a healthy weight

 

The ECS plays a role with our appetite control – from the suppression of appetite to counter over-consumption to the treatment of conditions that involve reduced appetite and weight loss. This is why cannabinoid receptor antagonists (such as CBD) may manage obesity while agonists (such as THC) may be a therapy option for anorexia. 

 

Unwanted weight gain may be attributed to poor sleep, lack of physical activity, and nutrition. Therefore the approach to combating this may be a combination of lifestyle changes. 

 

Cannabinoid therapy may be a part of the equation for its potential to support our overall health and wellbeing. Research points towards cannabinoids as strong candidates for antioxidant, preventative, and recovery benefits. In addition, cannabinoids may decrease stress levels, improve sleep, and benefit metabolic syndrome. 

 

Finding Support for Cannabinoid Therapy

 

When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance to answering questions your family has about your decision to choose cannabis – we are here every step of the way. Send as an email to info@realmofcaring.org, call us at 719-347-5400 or chat with us at realmcaring.org.

Since the mid 90’s, the U.S federal government has allowed for states to implement medicinal cannabis programs. Each state has created their own set of regulatory licensing guidelines and requirements surrounding the cultivation, manufacturing, possession, use, sale, and distribution of commercial cannabis products. About a decade ago, Colorado became the first state to permit and open recreational cannabis dispensaries. The “Green Rush” that followed has resulted in a vast influx of different cannabis products and dispensaries available to the public. Establishing and adopting cannabis legislation is slow but the cannabis industry continues to grow exponentially. This incompatibility has led to questionable manufacturing practices and inconsistent quality products – raising public health and safety concerns. 

 

The cannabis industry speaks a whole new language and many beginners find that navigating dispensary menus and understanding product labeling can be intimidating. At this time there is no mandated cannabis education for budtenders who sell cannabis products. Cannabis marketing utilizes two main terms as descriptors for all cannabis chemovars (“strains”): indica and sativa. The problem with these terms is that they (often inaccurately) describe the physical characteristics of the plant, such as leaf shape, which has nothing to do with how efficacious a chemovar might be (Lynch, 2019). Further, the widespread “strain” classification system is based on geographic origin and other meaningless descriptors (McPartland, 2018; Russo, 2019) that perpetuate the inaccurate stigma that cannabis has no medicinal value. Many cannabis scientists argue that in order to forecast the therapeutic properties of a specific cannabis product and its potential to alleviate symptoms, the chemical profile is the most useful tool (Clarke, 2013; Elzinga, 2015; Hazekamp, 2012; Small, 2015). 

 

Similar to introducing a new medication or supplement to your routine, selecting an appropriate cannabis product to meet your goals requires education and some self experimentation. Determining which products might be best for you can be challenging. A great way to organize your cannabis experiences over time is by keeping a detailed journal of your experiences trying different cannabis products and dosages. We suggest “The Cannabis Companion: An Educational Guide & Workbook for Tracking Cannabis Chemovar Efficacy” by Jazmin Oliver. 

 

In the next installment of this series we will dive into the different types of commercial cannabis products, discuss how they are used, and what they might be most appropriate to treat. As always, we recommend speaking with a licensed medical professional before starting a new cannabis regime. To learn more about the potential benefits of cannabinoid therapy, please reach out to a member of the Realm of Caring team! 

 

Authored by Jazmin Oliver for Realm of Caring

 

References

1. Clarke, R. C. (2013). The myth of the indica–sativa classification of cannabis. Cannabis and Cannabinoid Research, 1(1), 3-4. https://www.liebertpub.com/doi/full/10.1089/can.2015.29003.ra
2. Elzinga, S., Fischedick, J., Podkolinski, R., Raber, J. C., & Beletsky, A. (2015). Cannabinoids and terpenes as chemotaxonomic markers in cannabis. Natural products chemistry & research, 3(5), 1-6. https://doi.org/10.4172/2329-6836.1000181
3. Hazekamp, A., & Fischedick, J. T. (2012). Cannabis-from cultivar to chemovar II: a metabolomics approach to cannabis classification. Cannabis and Cannabinoid Research, 1(1), 202-215.https://doi.org/10.1002/dta.407
4. Lynch, R. C. (2019). Cannabis chemovars: Terpenes and cannabinoids from different strains. ACS Omega, 4(9), 16138-16146.  https://pubs.acs.org/doi/full/10.1021/acsomega.9b02256
5. McPartland, J. M. (2018). Cannabis systematics at the levels of family, genus, and species. In Handbook of Cannabis (pp. 19-36). Oxford University Press. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140263/
6. Small, E. (2015). Evolution and classification of Cannabis sativa (marijuana, hemp) in relation to human utilization. Botanical Review, 81(3), 189-294. https://link.springer.com/article/10.1007/s12229-015-9157-3
7. Russo, E. (2019). The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No “Strain,” No Gain. Front. Plant Sci., 9:1969. https://doi.org/10.3389/fpls.2018.01969

Struggling to reverse hair loss? Among the many amazing and powerful health benefits of CBD, is its newfound ability to potentially promote hair growth. 

 

As CBD helps to promote balance and overall wellness in the body, this is extended to hair and scalp health. By regulating hormone levels, reducing stress, and improving sebum production, CBD may lead to healthier and shinier hair. To learn more about how CBD works and how to use it for optimal hair growth and wellness, continue reading.

 

What is CBD?

 

Derived from the hemp plant Cannabis sativa, CBD is a natural compound with various potential health benefits. It is a non-addictive and safe substance that has been approved as an anti-seizure medication and can be used to treat an array of health conditions, including chronic pain, inflammation, anxiety, neurological disorders, and sleep disorders. CBD is popular among those looking to support their overall wellness, improve mental health, and aid in post-workout recovery.

 

CBD supports the endocannabinoid system (ECS) in the body, which is responsible for maintaining balance and homeostasis. This system regulates many of our essential functions. The body produces endocannabinoids that bind to cannabinoid receptors in the ECS to maintain physical and emotional equilibrium. CBD then interacts with these receptors to increase the production of natural endocannabinoids, which activate and prolong the body’s natural healing mechanisms. These therapeutic benefits are produced naturally by the body, with minimal side effects, making CBD a promising option for promoting healing and wellness.

 

How Can CBD Help Support Hair Growth?

 

Targeting Stress 

 

As with most things, getting to the root cause is a great way to find solutions and next steps. The same goes for promoting hair growth! For many people, stress is often a leading factor of hair loss. Because the endocannabinoid system is one of the main regulators of the stress response, and CBD supports the endocannabinoid system, by targeting stress with CBD you may slow down the process of hair loss. 

 

The endocannabinoid system constrains the magnitude of the stress response, promotes return of the HPA axis to non-stressed levels, and facilitates habituation of the stress response to repeated or ongoing stress. Research shows that, “Between 35% and 65% of people using CBD for medicinal purposes in the UK, USA, Denmark, and New Zealand were found to be administering it for stress, and over 90% reported feeling less stressed with CBD, with no respondents reporting feeling more stressed.” With such promising results for CBD in terms of managing stress, it could be a great option for reducing hair loss and giving the body a better chance of encouraging new hair growth.

 

Blood Flow Stimulation

 

Another amazing benefit of CBD is its potential to stimulate blood flow. Thus, applying CBD products to the scalp for hair loss can be effective due to the potential of CBD to increase blood circulation, soothe and calm the skin, and encourage hair growth around the follicle. Additionally, CBD’s ability to reduce inflammation may create a nurturing environment for hair to grow, combating thinning hair. Overall, improved blood flow around hair follicles can bring more nutrients to the area, remove harmful toxins, and promote healthier and stronger hair, and CBD can help.

 

CBD for Alopecia

 

A study was done of 35 subjects with Androgenetic alopecia (AGA) using a once daily topical hemp oil formulation, averaging about 3-4 mg per day of CBD and minimal amounts of other cannabinoids for six months. A hair count of the greatest area of alopecia was carried out before treatment and again after six months. The results revealed that men did slightly better than women, and the vertex area did better than the temporal areas. On average there was a statistically significant 93.5% increase in hair after 6 months. All subjects had some regrowth. This is extremely promising research for the possibility of CBD as a solution for hair loss and as an effective supplement to stimulate hair growth.

 

Postpartum or Menopausal Hair Loss

 

Many women experience hair loss as a result of Postpartum or Menopause. Specifically, dermatologists refer to this condition as excessive hair shedding. The excessive shedding is caused by falling estrogen levels. Research has shown CBD to display diverse pharmacological activities relevant to postmenopause and Postpartum changing estrogen levels, indicating that CBD may be an effective option for estrogen-deficient individuals looking to encourage new hair growth after shedding.

 

Starting Your Cannabinoid Therapy Journey

 

While the reasons for hair loss may vary from individual to individual, early studies and anecdotal evidence suggest that CBD may be a promising natural remedy for hair loss and other hair-related issues. As researchers continue studies in order to fully understand the benefits of CBD for hair growth, and to determine the optimal dosage and application method, we expect even greater arguments supporting CBD as a solution for hair loss. 

 

In the meantime, if you are wondering if cannabinoid is right for you on your wellness journey, or in need of dosage specific guidance, our care specialists are here to talk with you one-on-one. Reach out by calling 719-347-5400 or emailing info@realmofcaring.org.

Do you wake up in the morning having feelings of worry and stress? At times, anxiety can be present in our bodies and sink in before we are alert and able to provide ourselves with typical coping mechanisms we might use, especially if already diagnosed with a generalized anxiety disorder (GAD). This is often referred to as the non-medical term of “Morning Anxiety” and relates to the cortisol awakening response (CAR). 

 

Cortisol is known as our “stress hormone” and increases in the second half of the night and then steadily into morning. The night awakening is suggested to not coincide with actual experiences, where CAR is speculated to serve a specific function of preparing individuals for the upcoming demands of the day. Research has stated that “it is likely that individuals with an excessive number of duties and tasks already engage in the process of coping with these duties as soon as they wake up in the morning”. For healthy individuals, this may be useful for thinking about how to manage their day. However, one with an underlying anxiety disorder may find it to be paralyzing. 

 

Studies have found many psychosocial factors and physical and mental disorders may be at increased risk for an increased morning stress-response. For example, CAR has been observed in relapsing-remitting multiple sclerosis, upper respiratory symptoms, obesity, women with metabolic syndrome, peritraumatic dissociation and acute stress disorder, and major depression. 

 

Managing morning anxiety can look like:

• Eating a magnesium-rich breakfast while limiting caffeine and sugar
• Physical activity 
• Breathing and/or meditation practices
• Establishing routines for better quality sleep
• Seeking alternative therapies/treatments for an underlying disorder

 

Cannabinoid therapy may provide benefits to our mental health in a number of ways. Let us take a closer look at how they may supplement our journey to waking up with less debilitating anxiety. 

 

Depression and Anxiety

 

It has been suggested that the endocannabinoid system may be involved in the pathophysiology of depression. Evidence shows that endocannabinoids and CB1 receptors are widely distributed in the brain areas that are often related to mood disorders and that their expression is regulated by antidepressants. 

 

The 5-HT1A receptor is a serotonin receptor that is located in presynaptic and postsynaptic regions. Activating these receptors have been involved in the mechanism of action of anti-anxiety, antidepressant, and antipsychotic medications. Growing research to understand how cannabinoids regulate these receptors supports potential cannabidiol (CBD) and cannabigerol (CBG) use for anti-anxiety, antidepressant, antipsychotic, and stress-reducing effects. 

 

Data indicate that repeated administration of CBD may produce an effect that is consistent with results from studies testing traditional anti-anxiety and antidepressant medications and that CBG may have strong therapeutic potential as an antidepressant. These are known to be clinically relevant findings as several cannabinoids are known to benefit while exhibiting few side effects, supporting the initiation of clinical trials testing the efficacy of cannabinoid-based compounds for the treatment of mood disorders. 

 

Realm of Caring was able to collect and publish data on CBD use for anxiety and/or depression. Between April 2016 and July 2020, 538 participants were enrolled in an observational research study between Realm of Caring Foundation and Johns Hopkins University School of Medicine. Upon completion of a baseline survey, participants were invited to complete additional follow-up surveys every 3 months.

 

Cannabis Users reported lower baseline depression, significantly better past-month sleep quality, a higher overall quality of life, and lower past-month average pain compared to Controls.

 

Cannabis Users did not report lower baseline anxiety, however baseline Controls who had initiated cannabis use reported a significant reduction in both mean anxiety and depression scores from baseline to follow-up surveys [evaluated using the Hospital Anxiety and Depression Scale (HADS)]. This observation was not realized among non-initiators throughout the study. A similar effect was observed among participants who sustained medicinal cannabis use throughout the study, suggesting an improvement in symptoms of anxiety and depression with both the onset of cannabis use and with extended use. The CBD doses that were used in trials that found anti-anxiety effects were greater than the average reported by participants. 

 

Sleep

 

Studies have also shown favorable effects of CBD in sleep disorders, a disorder that is closely related to mental illnesses such as depression. Psychiatric disorders are one of the many causes of insomnia. Not getting enough sleep can have serious implications for our stress-response and high stress levels can contribute to poor sleep quality. 

 

CBD has been researched for its therapeutic potential for sleep disorders through limiting symptoms that may keep us awake at night but also may contribute to an increase in sleep duration and depth, as well as decrease in the anxiety responses induced by sleep disturbance. 

 

Studies confirm that a misalignment of the sleep-wake cycle has a negative impact on the stress system. Our circadian rhythm aligns our sleep and wakefulness with day and night to provide stability in restorative rest that enables increased daytime activity. Low doses of CBD may be associated with wakefulness to help our focus and cognition during the day. CBD may modulate waking through activation of neurons in the hypothalamus and dorsal raphe nucleus (DRD). Studies show that therapeutic levels of CBD administration may increase total sleep time and decrease frequency of arousals at night – leading to an increase in total percentage of sleep over time. 

 

Cannabinoids and Cortisol Levels

 

While research on CBD and cortisol is its infancy, there have been several clinical trials and one partially controlled trial looking at CBD for stress. All showed that CBD was effective in significantly reducing the stress response and comparable to pharmaceuticals where included. 

 

To date, findings from two notable studies show that CBD may be used to modulate cortisol responses. 

 

One study with patients at clinical high risk for psychosis looked at the effect of CBD on cortisol. The purpose was to investigate the effects of short-term CBD treatment for experimentally induced stress in the context of psychosis risk. It was found that CBD may potentially reduce abnormalities in response to acute stress in daily life. 

 

Another study looked at 11 healthy volunteers who received placebo or CBD at doses of 300 mg or 600 mg. A decrease in cortisol levels was significant when measured two hours after CBD administration. 

 

These studies provide a pathway for future studies to investigate the potential of CBD to mitigate harmful effects of stress through modulation of cortisol levels. 

 

Finding Support for Cannabinoid Therapy

 

When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance to answering questions your family has about your decision to choose cannabis – we are here every step of the way. Send as an email to info@realmofcaring.org, call us at 719-347-5400 or chat with us at realmcaring.org.

I think weed be great together…

 

Valentine’s Day is right around the corner and we’ve got you covered with the best gift guide for the cannabis lover in your life. What better way to say I love you than with the plant that keeps on giving?

 

My Bud Vase: Jewel Bong

 

Responsible consumption made beautiful. These precious women-owned gems are here to illuminate your sacred rituals and invite only the highest of vibrations into your space. Light a candle next to Jewel and gaze in delight as the facets of colored glass dance in its glow. Whether at a consumption lounge–or lounging at home consuming–any one (or all three, wink) of these precious Jewels are set to bedazzle the scene and create a whole new vibe.

 

Charlotte’s Web: Couple’s Gift Set

 

Enjoy a bundle of relaxation and comfort together with the best Mother Nature offers. The Charlotte’s Web™ Hemp Extract topical, gummies, and oil, will leave you both feeling rested and renewed. Explore the variety of products offered to see what connects with your needs, fully customizable. From one power couple to another – this Couples Gift Set with CBD gummies and hemp extract topicals was made for sharing with your partner.

 

Cornbread Hemp: CBD Lotion and Menthol

 

Soothe your sweetie and show your love with some CBD. Made with quality ingredients for your quality of life. The CBD Lotion + Menthol is formulated to absorb quickly and provide soothing, cooling relief directly to the source of your discomfort.

 

NuuMe Organics: CBD Blood Orange Drops

 

The Blood Orange Drops are carefully crafted in house by NuuMe Organics. The key active ingredient is their exceptional hemp extract. Manufactured using exclusively their very own organic hemp, which is grown lovingly in sunny Colorado, in a highly regenerative system. It is then extracted, using a proprietary organic cold processing method. The result is an incredibly efficacious extract, with an unparalleled spectrum of actives. To maximize the effect of the extract, it is blended with organic MCT coconut oil, which increases absorption. The final touch comes in the form of a few drops of organic blood orange essential oil, used primarily for flavoring. 

 

Session Goods: Them & Theirs One Hitters

 

A sleek, portable glass one-hitter is your best friend when you’re out and about or just want a quick hit. The Session Goods one hitter comes with a silicone tab to protect your fingers and can be packed with your favorite flower, hold a pre-rolled joint, or used with the Session Bong. Take 15% off when you buy two or more and get it in time, perfect for you and yours.

 

Edie Parker: Love Bud Mini Bag

 

Presenting: a special treat to the one(s) you love most, even if that’s Y-O-U ! Each Valentine’s Day bundle includes special edition packaging and a Vday Card ready to gift. Bundle Includes: Strawberry on Top Crush Cones (Pack of 3), Grinder Case in Pinks, Standard size Lighter, Valentine card, Best Buds mini tote bag.

 

Yew Yew: Stash Bag

 

Smoking, simplified. The Yew Yew Stash Bag is smell-proof! Thanks to a waterproof zipper, carbon lining, and a velcro seal. Plus, interior pockets for organization. This stash bag is vegan leather that easily wipes clean, easily fits a pipe, grinder, lighter, papers, and more! Detachable wrist strap included. The cannabis lover in your life will love this stylish accessory.

 

Equilibria: Better Together Gummies Duo

 

The Better Together Duo is a full day of balance + a full night of sleep = a match made in wellness heaven. Includes a 30-day CBD supply of Daily Gummies and Sleep Gummies. Daily Gummies are infused with 10mg of hand harvested, full-spectrum CBD. These gummies will leave you feeling centered, focused, and ready to take on any day as the best version of you. Sleep Gummies are infused with 25mg full-spectrum CBD + 5mg sleepy hemp-derived compounds. The Bordeaux Cherry flavored Sleep Gummies are here to help you fall asleep luxuriously.

 

Kush Queen: Relax CBD Bath Bomb

 

The Kush Queen Relax CBD Bath Bomb was created to not only relax the body, but to help stabilize the mood as well. A beautiful blend of Lavender, Chamomile and Frankincense come together to assist in the overall body and mind relief while giving your immune system the healthy boost it needs. How it Works: The Relax bath bombs were created with the Entourage Effect in mind. The Entourage Effect occurs when you combine cannabinoids with terpenes/essential oils. Each blend is more than a scent, it is an experience. Our nourishing Relax bath bombs combine the power of organic essential oils and cannabinoids to create effect-specific full-body experiences.

 

oHHo: Dream Cream

 

Typing, cooking, cleaning, working—our hands could use the muscle-relaxing benefits of a CBD topical more than any other body part. There are many options out there, but for a classic handbag hand cream that moisturizes, soothes, and removes any scent of that joint you just smoked, oHHo’s new Dream Cream is a luxurious contender. Scented with neroli, orange and bergamot, it’s a gender neutral, botanical fragrance that anyone would slather on.

 

—–

 

When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance to answering questions your family has about your decision to choose cannabis – we are here every step of the way. Send as an email to info@realmofcaring.org, call us at 719-347-5400 or chat with us at realmofcaring.org.

Cannabidiol (CBD) products have been commercially available in the U.S., at a federal level, since the passage of the 2018 Farm Bill. What we know from a limited amount of studies is that even low amounts of THC may result in a positive urine drug screen. To gain a deeper understanding of how commercially available CBD products may affect a drug test, Realm of Caring submitted a study for Institutional Review Board (IRB) approval and recruited Colorado-based participants. 

 

The purpose of the study was to help consumers make informed decisions about their cannabinoid therapy. An additional goal was to influence nanogram allowance within professional sports, particularly the NFL, as former Ravens offensive tackle Eugene Monroe served as inspiration and contributed funds to the study. At the time this study began, the NFL THC testing limit was at 35 ng/mL. 

 

Findings were published in the February 2023 issue of Therapeutic Drug Monitoring. 

 

To be eligible to participate, individuals had to have been taking an oral, hemp-derived CBD extract for at least 30 days with no other use of cannabis or illicit drugs in the previous two months. They provided two urine samples, one for immunoassay (IA) testing and the other frozen and shipped overnight to a third party lab for confirmatory testing. 

 

Participants, on average, administered 1 ½ doses of hemp-derived, CBD extracts per day at an average of 31.18 mg per dose for at least one month. 

 

For urine drug tests, cutoff levels are expressed using nanograms (ng) per millimeter (mL). The IA tests were at 20 ng/mL and 50 ng/mL. 

 

Results showed that daily use of hemp-derived, CBD products consistently resulted in positive urine IA screens for THC at the detection level of 20 ng/mL (100%). When tested at the 50 ng/mL level, positive results were rare (16%). 

 

To put these findings into perspective, federally-regulated workplace drug testing programs have an initial test cutoff level of 50 ng/mL and a confirmatory test cutoff level of 15 ng/mL. Olympic athletes follow The U.S. Anti-Doping Agency (USADA) guidelines, which has a urinary threshold set at 150 ng/mL. The NFL increased the THC cutoff level in 2021 from 35 ng/mL to 150 ng/mL, and only test for THC during the period between the start of training camp and each team’s first preseason game.  

 

Authors concluded that future research should be completed to understand how to approach testing for hemp-derived THC. In addition, it is recommended that regulators reconsider the detection level of 20 ng/mL as it may result in many false-positive results for users of commercially available, hemp-derived CBD products. 

 

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Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts is authored by: Morgan L. Ferretti, MA; Ryan Vandrey, PhD; Jessica G. Irons, PhD; Heather Jackson, AA; Mallory J. Loflin, PhD; Travis Hyke, PhD; and Marcel O. Bonn-Miller, PhD

 

For general inquiries, please contact info@realmofcaring.org or call (719) 347-5400

 

For media inquiries, please contact rocteam@mygrasslands.com

 

Join our research!

 

Realm of Caring and Johns Hopkins University School of Medicine have developed the Observational Research Registry (ORR) to better understand medicinal cannabis use and its impact on key health outcomes including healthcare utilization, chronic pain, anxiety and depression, caregiver burden, epilepsy, and posttraumatic stress disorder (PTSD). Our registered clients provide critical information that leads to important insights into the therapeutic capabilities of medicinal cannabis. The ORR helps us develop client educational resources and may ultimately serve to legitimize the medicinal use of cannabis.

 

Winter Seasonal Affective Disorder (SAD) is a subtype of Major Depressive Disorder, mostly characterized by an onset of symptoms that begin annually each fall to winter with a full remission in the spring. SAD is especially common in climates where winters are more likely to be harsh.

 

While SAD can affect individuals of any age, older adults (65+) are more vulnerable to the changes of the seasons and may be more likely to experience seasonal depression. This is likely tied to their experiences of isolation and loneliness due to limited mobility, health issues, and lack of social support. 

 

SAD symptoms may appear similar to other mood and depressive disorders, but will show up in the winter. The most common signs to look for are: 

 

• Feeling sad and/or hopeless or restless and agitated
• Loss of interest in enjoyable activities
• Fatigue, brain fog, lack of energy, and difficulty concentrating
• Sleeping much more or less than usual 
• Changes in weight and appetite 

 

While many therapies exist to help combat symptoms of SAD, some are looking towards cannabis for added benefit. Recent research shows how cannabis use for alleviating anxiety and depression may have promising results. Here we will look at the specific symptoms of SAD and what research supports potentially adding cannabinoid therapy to your regimen if you or a loved one are experiencing seasonal depression. 

 

Feeling sad and/or hopeless or restless and agitated

 

The serotonergic mechanism of CBD is distinct from commonly used antidepressant medications in that it does not appear to produce symptoms of withdrawal. CBD has also been shown to synergize with other serotonergic medications. Data suggests that CBD could facilitate the antidepressant effect induced by these antidepressant drugs, therefore allowing the SSRIs to be administered at lower doses, resulting in fewer side effects. 

 

In a recently published observational study, it was found that medicinal cannabis use was associated with lower self-reported depression. Initiation of medicinal cannabis during the follow-up period was associated with significantly decreased anxiety and depressive symptoms, an effect that was not observed in Controls who had not initiated cannabis use. 

 

Loss of interest in enjoyable activities

 

A qualitative analysis published in 2022 paid close attention to the notable quality of life improvements attributed to medicinal cannabis use. The two overarching categories were “enhanced well-being” and “improved daily functioning”. Enhanced well-being includes feelings such as regaining a sense of hope, enjoying family life, and laughing more often. A woman from the study with Lyme Disease was quoted saying, “People such as myself are able to become productive and valued members of society again when we can have the quality of life improved so simply.” 

 

Fatigue, brain fog, lack of energy, and difficulty concentrating

 

The same 2022 qualitative analysis looked at measures of mood disorders. A 63-year-old male with anxiety and depression stated that because of his CBD use, “I can focus, remember tasks, organize better.” 

 

Prolonged CBD therapy has shown positive improvements in psychological symptoms and cognition. Currently, using cannabinoids to benefit neurological issues and serve as a neuroprotectant is being studied. The antioxidant properties of cannabinoids, such as CBD, may have the ability to provide neuroprotection. As well, research is showing that elevation of cannabinoid receptor activity could potentially slow down the progression of brain ageing and alleviate symptoms associated with neurodegenerative disorders, therefore cannabinoids with the ability to activate receptors may provide these additional benefits. 

 

Sleeping much more or less than usual 

 

CBD has therapeutic properties that have the potential to mitigate symptoms that interfere with sleep. It also has the potential to improve sleep-wake cycles leading to an increase in the percentage of total quality sleep overtime.

 

Our circadian rhythm aligns our sleep and wakefulness with day and night to provide stability in restorative rest that enables increased daytime activity. Ongoing studies show that cannabinoids may interact with our Endocannabinoid System (ECS) in such a way that modulates our biological rhythms to promote sleep. Low doses of CBD may be associated with wakefulness to help our focus and cognition during the day. Studies show that therapeutic levels of CBD administration may increase total sleep time and decrease frequency of arousals at night – leading to an increase in total percentage of sleep overtime. 

 

Assessed data from a 2020 published observational study looking at various quality of life measures showed that adult cannabis users had greater sleep quality, shorter sleep latency, longer sleep duration, fewer sleep disturbances, and a significantly better sleep score compared with the control group.

 

Changes in weight and appetite 

 

Stress caused by sleeplessness, anxiety, and depression may be linked to poor eating habits – whether overeating or undereating. Atypical eating habits of depression to include increased appetite and food consumption accompanied with carbohydrate cravings are more common in SAD than non-seasonal depression. 

 

CBD has been shown to regulate stress response within the body and support the reduction of compulsive behaviors, such as overeating. 

 

In addition, the ECS plays an important role in modulating metabolism and appetite. CBD may help the browning of white adipose tissue (the process of burning fat in the body) and promote lipid metabolism. This may also help with weight gain.

 

When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance to answering questions your family has about your decision to choose cannabis – we are here every step of the way. Send as an email to info@realmofcaring.org, call us at 719-347-5400 or chat with us at realmcaring.org.

Cannabis continues to increase in popularity for both recreational and medicinal purposes. In recent years, there has been a growing interest in the potential benefits of cannabis, (particularly of its non-intoxicating compound, CBD) for men’s health. 

 

CBD, or cannabidiol, is a compound found in the cannabis plant that is known for its potential health benefits, including pain relief, anxiety reduction, and sleep improvement. But the benefits of CBD go beyond that, and it’s recently being researched for its potential in treating various men’s health issues such as erectile dysfunction, prostate cancer, and even testosterone levels.

 

In this blog, we will dive into the current research and explore the potential benefits and risks of using these compounds for men’s health issues.

 

CBD and Erectile Dysfunction

 

Recent research suggests that cannabinoids may have benefits for men’s sexual health, particularly in the area of erectile dysfunction (ED), an issue that affects as many as 30 million men. Symptoms of ED can include difficulty achieving or maintaining an erection, as well as a lack of sexual desire. ED can be caused by a variety of factors, including psychological stress, physical health conditions, and the use of certain medications. Determining the root cause of ED can help one to target the issue and decide if cannabinoid therapy could potentially help. 

 

If emotional conditions are at the root cause of ED, then addressing the issue with anti-anxiety or antidepressant pharmaceuticals may be counter-intuitive. Some of these medications have had known side effects to include difficulty in getting an erection. Therefore, exploring options such as CBD with little to no known side effects, may serve as an alternative therapy where emotional conditions are concerned. Furthermore, research shows how the effects of CBD may help to improve libido in people who struggle with ED due to such psychological reasons. By reducing anxiety, CBD may be able to help improve sexual function.

 

Other conditions that list ED as a side effect of possible medications used to treat, include multiple sclerosis. New research is looking at the effectiveness of treating MS with cannabinoid therapy, thus helping to eliminate the risk of ED with traditional medication use. 

 

Poor blood flow and cardiovascular conditions may also be contributing factors to erectile dysfunction or ED, and it can also be a cause of more serious underlying conditions such as blocked arteries, heart disease, or diabetes. Studies have shown CBD may help increase blood flow to the genital area, which could potentially help improve erections from such contributing factors.

 

When considering the benefits of THC vs CBD, it’s important to note that results of a review of five studies showed ED incidence may be twice as high in those who smoke cannabis with THC when compared with those who don’t. Put simply, chronic use of products high in THC may provide temporary relief for emotional conditions that affect performance, but in contrast cannabinoids such as CBD, and the more recently researched CBG, may have a greater potential to treat both underlying causes and common symptoms of ED without the negative side effects.

 

Prostate Cancer and Cannabinoid Therapy

 

Prostate cancer is a global public health problem and is the most common cancer in American men aside from non-melanoma skin cancer. Experimental evidence shows us that prostate tissue has cannabinoid receptors and stimulating these receptors can have an anti-androgenic effect, meaning that androgens are blocked from binding to androgen receptors, causing cancer cells to then starve. 

 

Cannabinoid therapy has been used in association with several cancer types for decades now. One of the first studies completed to describe the antineoplastic (or acting to prevent, inhibit, or halt the development of a tumor) activity of cannabinoids was published in 1975. Here it was demonstrated that the administration of Delta-9-THC, Delta-8-THC, and cannabinol (or CBN) inhibited the growth of Lewis lung adenocarcinoma cell growth in vitro (outside a living organism) and in vivo (within a living organism) after oral administration to mice. 

 

Since then, we have seen through research cannabinoids having an anti-proliferative (inhibiting tumor cell growth), anti-metastatic (inhibiting forming a secondary tumor), anti-angiogenic (reduction of blood vessels) and pro-apoptosis (cancer cell suicide) effects across various cancer types to include: lung, glioma, thyroid, lymphoma, skin, pancreas, uterus, breast, and prostate carcinoma using both in vivo and in vitro models. 

 

Cannabis and the Debated Effects on Testosterone Levels

 

Current evidence is inconclusive to confirm the exact effect of cannabis and cannabinoids on male hormonal levels (some studies show positive while others suggest negative effects), however it is still worth mentioning. Here’s a look at some of the conflicting research:

 

• Men who report having consumed cannabis in the past year possess elevated levels of testosterone as compared to non-users, according to data published in the World Journal of Urology.

 

“[This] analysis of a nationally representative cohort suggests that there is a dose-dependent effect of THC on T levels.”

• A review of eight clinical trials reported that cannabis consumption does not have a significant effect on testosterone (T) levels. Five of those trials also investigated the effects of cannabis on luteinizing hormone (LH) & follicle stimulating hormone (FSH) and the researchers reported that cannabis leads to small but significant decreases in FSH levels, while LH is decreased insignificantly.

• Another trial found a positive effect and 7% higher T levels in cannabis smokers than non-smokers. The increase was comparable to tobacco smokers but both tobacco and cannabis smokers had decreased semen quality.

• Research shows CBD lowers levels of pituitary gonadotropins as well as testosterone and may even lead to reduced testicular size.

• One large retrospective study which included more than 5000 participants reported that men who use THC regularly had higher T levels than those who don’t.

 

As our knowledge of the endocannabinoid system continues to evolve, we cannot make a definitive statement about how cannabis affects testosterone without further conclusive research.

 

For a Deeper Understanding

 

Few large-scale, high-quality studies have explored the connection between cannabis and men’s health and the outcomes depend on many factors. These may include your current medications, your overall physical and emotional health, and your wellness goals.

When looking to cannabis for medical conditions, we always recommend speaking with a healthcare professional. However, if you are in need of support while on your journey we are here to help. From product selection to dosing guidance to answering questions your family has about your decision to choose cannabis – we are here every step of the way. Send as an email to info@realmofcaring.org, call us at 719-347-5400 or chat with us at realmcaring.org.

To date, Realm of Caring (RoC) has published four papers highlighting the benefits of cannabinoid therapy. This data has been gathered by participants who have volunteered their time to report on their cannabis use in our Observational Research Registry (ORR).

 

Relatable motivations for choosing medicinal cannabis included a majority belief that traditional treatments were ineffective and/or had intolerable side effects. Thus far, data from the ORR has shown significantly better self-reported quality of life, health satisfaction, and sleep, and significantly lower pain severity, anxiety, and depression. Here we highlight some of the most notable observations. 

 

Enhanced quality of life

 

Remarkable quality of life improvements were attributed to medicinal cannabis use in RoC’s first published paper in 2020. The two overarching categories of quality of life included enhanced well-being and improved daily functioning. The significant health improvements shown in this data indicate that clinical trials evaluating the efficacy of defined cannabinoid products for specific health conditions are warranted. 

 

Health improvements among people with Epilepsy 

 

Of the 1,783 individuals enrolled in this online, self-reported survey researchers identified a sample size of 418 participants. Of the 418 participants, 93% had listed epilepsy as their primary medical condition with the remaining noting epilepsy as a secondary medical condition. In this sample size, there were 71 adults and 209 adult caregivers of children or dependent adults who were utilizing CBD products for medicinal use. In addition, there was a control group of 29 adults and 109 adult caregivers who were considering CBD use but had not yet begun. 

 

Published in 2021, this paper showed that when compared with controls, CBD Users had a greater health satisfaction, higher ratings of quality of life, and better scores on psychological health. Taking a deeper look, CBD Users reported lower anxiety and depression and improved sleep scores. 

 

Other findings that were of significance relate to pharmaceutical use and healthcare visits. CBD Users had lower instances of reported prescription medication use, lower medication-related adverse effects, less ER visits, and less missing school and/or work days. 

 

Decreased caregiver burden

 

Among significant findings for individuals living with epilepsy, caregiver burden was assessed, evaluating Role Strain (stress due to role conflict or overload) and Personal Strain (personal stress from the experience of caretaking). 

 

Caregivers of patients who were using CBD products reported significantly lower scores on the Role Strain subscale compared to caregivers of Controls in the study. 

 

Antidepressant and anti-anxiety benefits

 

The goal of RoC’s third published paper was to provide insight into the effects of medicinal cannabis use for symptoms of anxiety and depression.

 

​​The participants involved were those who were at least 18 years old and reported having anxiety and/or depression without a specific endorsement, as well as specific endorsements, including: major depressive disorder, postpartum depression, dysthymia, premenstrual dysphoric disorder, seasonal affective disorder, generalized anxiety disorder, panic disorder, social anxiety disorder, and agoraphobia. 

 

Of the 538 participants, 368 reported current use of medicinal cannabis products at the baseline. The other 170 participants, who were considering use but had not yet initiated, served as controls. Of the participants who completed the baseline survey, 211 completed at least one follow-up assessment (145 Cannabis Users and 66 Controls). 

 

Cannabis Users reported lower baseline depression, significantly better past-month sleep quality, a higher overall quality of life, and lower past-month average pain compared to Controls.

 

Cannabis Users did not report lower baseline anxiety, however baseline Controls who had initiated cannabis use reported a significant reduction in both mean anxiety and depression scores from baseline to follow-up surveys [evaluated using the Hospital Anxiety and Depression Scale (HADS)]. This observation was not realized among non-initiators throughout the study. A similar effect was observed among participants who sustained medicinal cannabis use throughout the study, suggesting an improvement in symptoms of anxiety and depression with both the onset of cannabis use and with extended use.

 

A qualitative analysis of findings

 

The most recent published paper from RoC in 2022 presents a qualitative analysis of open-ended survey responses that detail the experiences of 808 medicinal cannabis users compared to a control group of 468 patients with similar health issues and demographics but not using medicinal cannabis. 

 

“The data indicate that patients with a wide array of health conditions report notable physical and mental health benefits associated with medicinal cannabis use that are not evident in patients who do not use medicinal cannabis, and that upon initiation of medicinal cannabis use significant improvements are reported across diverse areas such as sleep, mood, and healthcare utilization” (Garcia-Romeu et al., 2022). The qualitative paper provides an account of those participants’ lived experiences as medicinal cannabis users based on open-ended question data. 

 

Most participants reported cannabis benefits for a variety of conditions where traditional treatments were ineffective. 

 

Looking forward

 

The most recent published paper indicated that among cannabis users and nonusers there were concerns regarding cannabis side effects, legality, lack of information, and cost. These findings speak volumes to the fact that continued research and quality education on the safety and efficacy of cannabinoid therapy is needed. While all four manuscripts present findings that are promising, the work is far from complete. 

 

Research is limited on non-pharmaceutical cannabis products and there is a need for patient-level data on the impacts of increased access to and therapeutic use of cannabis. 

 

Join our research! 

 

Realm of Caring and Johns Hopkins University School of Medicine have developed the Observational Research Registry (ORR) to better understand medicinal cannabis use and its impact on key health outcomes including healthcare utilization, chronic pain, anxiety and depression, caregiver burden, epilepsy, and posttraumatic stress disorder (PTSD). Our registered clients provide critical information that leads to important insights into the therapeutic capabilities of medicinal cannabis. The ORR helps us develop client educational resources and may ultimately serve to legitimize the medicinal use of cannabis.