Category: Blog

Dearest Charlotte, 

 

We thank you, we thank you, we thank you! You changed the world in your short 13 years. Today is your day, April 7th, Charlotte Figi day. We would much rather you be here with us with your laughter, your ability to devour an entire plate of french fries, us – trying to pry the fork out of your chunky little fist and finally giving in because if you did shank someone they likely deserved it and we usually did give in to your perseverance.  Or maybe an opportunity to read you one more story… perhaps The Bear Snores On. But instead we will light a candle for you dear one, we will continue to tell your story and the story of tens of thousands and try our damndest to carry on your legacy. Thank you. 

 

You showed us what it was to discover a new path, one filled with empowerment over our health care decisions and the ability to use a plant to change our lives. You showed us we could reclaim our health and our quality of life. That we had sovereignty of choice over our healthcare. That we did not need to keep doing the things that were not working. If not for you dear Charlie, hemp could very well still be illegal. If not for you the progress that has been made in the name of cannabis would not be where it is today. Thank you. 

 

We are sorry your journey was so full of challenges. The early seizures that lasted hours at only three months old. Having to try so many medications that failed you many of which making you worse. This made the eventual success so much sweeter for your family. Thank you. 

 

From the moment your mom administered your first dose of CBD at 5 years old, the movement began. You started a movement, precious one. Quietly, you didn’t say a word. You just got better. It started with families moving here to Colorado for access to achieve the same life-saving results you had and growing to federal legislation legalizing hemp. We could not have said it better than your friend Dr. Sanjay Gupta, “Charlotte Figi was more than an individual, she was an entire movement wrapped up into a sweet girl with a big smile and an even bigger heart.” Thank you for the movement you inspired. Thank you for the candle that you lit that continues to light our path forward to this day. 

 

You showed us Charlotte that cannabis could serve as a legitimate medicine. You helped all of us to move from a place of stigma to a place of compassion. After decades of prohibition, cannabis was more widely making its way into daily conversation, the medical community, and scientific research. The power of the plant that our ancestors, centuries before us, knew to be sacred was making a name for itself once again as a natural solution. And this was all because the world witnessed you Charlotte as you reclaimed your quality of life. We are so thankful your parents shared you with us. For their courage, which they surely learned from you, we thank you.

 

Lovingly and in your service, 

Your Realm of Caring family

 

On April 7th, 2020, Charlotte very suddenly and tragically passed away. The globe shook as it mourned the loss of this mighty individual and it was felt across continents. Tributes were made, a day was named in her honor, hearts outpoured with emotion for Charlotte, celebrating the path she paved. 

 

Today, and every day, Realm of Caring is guided by our North Star, Charlotte, reminding us why we fight for access for all – through education, research, and advocacy. We continue because everyone deserves the dignity of choice. We continue because Charlotte’s impact remains the footprint of our path forward; toward care for all through the healing power of the Earth.

 

Charlotte Figi, we love you. 

 

If Charlotte and/or Realm of Caring have personally touched your life, please feel free to send a message to info@realmofcaring.org. We will share messages to Charlotte with her family.

 

 

In recent years we have seen a lot of hemp products become available on the market. One item of more recent interest is hemp or CBD coffee. Hemp coffee involves blending hemp, as powder or seeds, in with coffee grounds and CBD coffee will be CBD oil infused coffee grounds or CBD oil added to a brewed cup of coffee. At Realm of Caring we look to research to best understand how cannabinoids and parts of the cannabis plant will interact with our bodies as well as the administration or delivery method for optimal absorption and benefit. So let’s take a look at what potential benefits there may be to adding Cannabis sativa to your daily routine. 

 

Hemp as a functional food  

 

Cannabis sativa is considered one of the most ancient cultivated plants and is incredibly versatile. The hemp seed has been claimed as one of the most nutritionally complete food sources, with the ability to offer total nutrition to the body. They contain high levels of omega-3 and omega-6 fatty acids and are a great source of protein in that they provide all nine essential amino acids. Hemp seeds also have an assortment of minerals and vitamins such as magnesium, potassium, iron, zinc, vitamin B, and the well-researched antioxidant, vitamin E.  It also has something else that sets it apart from most superfoods we know of today. One of those omega-6 fatty acids hemp seeds contain is known as gamma linolenic acid (GLA), which is also found in breast milk.

 

Coffee is well-known to have its own health benefits and even reduce the risk of certain diseases. Therefore when coffee and hemp combine, some consider the duo to create a “superfood drink”. 

 

Therapeutic potential of CBD

 

What you may also find on the market is CBD infused coffee. Before the oil can be added to coffee, the hemp flower must be decarboxylated to activate the compounds. These compounds will then offer a different set of potential therapeutic benefits to the body. 

 

CBD has been researched for its benefits as a powerful antioxidant and therapeutic actions that include reducing oxidative stress, anxiety, inflammation and improving kidney function and the immune system. Therefore adding CBD to a daily regimen, such as your morning cup of coffee may seem like a good way to add a wellness boost. 

 

There have been claims that CBD may improve the negative effects one might experience from caffeine or caffeine withdrawal such as headaches, anxiety, fatigue, lack of focus, and depression, among others. However, research is still lacking on the combined effects of CBD and caffeine. Any potential CBD effects are going to be dose-dependent and any one individuals’ response to a combination of CBD and caffeine is difficult to predict.

 

Finding a product

 

If trying one of these new coffee varieties is of interest to you, at Realm of Caring we will always emphasize the importance of the quality of the product. It is beneficial to do some research into the hemp extract that is sourced for the product. You want to know the finished product is free from pesticides, fungicides, heavy metals, and additional harmful contaminants. Use our guide to help you vet your products! Realm of Caring’s free one-on-one support care team can also help with these questions when looking into a company. 

 

 

In recent years, Cannabidiol, or CBD, has grown in popularity due to increased research and interest in its potential health benefits. Studies show that CBD can help alleviate a variety of conditions, such as anxiety and depression, arthritis, chronic pain, epilepsy, migraines, inflammation, sleep conditions, and so much more. The market itself is quickly growing as well, saturated with a variety of products that range in quality and type. Before purchasing CBD, there are several factors to consider, including the type of CBD product, its potency, and the provider or manufacturer. 

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Currently, the FDA does not regulate CBD products, so it’s the buyer’s responsibility to choose quality products. ⁠⁠It’s up to you as the consumer to ensure that when you purchase CBD you get what you pay for and can feel confident on your journey exploring the benefits of CBD. We put together the following recommendations that can act as your Buyer’s Guide to CBD.

 

Look for a COA

 

A certificate of analysis, or COA, is one of the most important factors to consider when purchasing a CBD product. Essentially, it is a form of quality control that confirms whether the product contains the quantities of CBD that the manufacturer claims or advertises. When a plant contains 0.3 percent or less THC, the federal government considers it hemp-derived CBD, but if a plant has THC levels above 0.3 percent, the federal government considers it cannabis. 

 

Additionally, it’s important that consumers check the COA for contaminants, as their presence could have long-term health effects. Cannabis plants easily absorb heavy metals, pesticides, and other potentially harmful chemicals that can be present in the soil or water, so it’s important that cannabis products be tested while growing as well as when they become finished products. Microbial contaminants (e.g. E. coli, salmonella), heavy metals like lead, mercury, and arsenic, and residual solvents such as heptane and hexane can cause serious illness. Each contaminant should receive its own individual status of passing to be considered clean and safe to consume.

 

Think of the COA as the product’s quality control, and always be sure it comes from an accredited, trustworthy lab.

 

Consider the Potency

 

The potency of the CBD product is another important factor to consider, as it varies greatly depending on the individual’s needs. CBD products usually display dosages in milligrams (mg). However, it is important to remember that there is little human research to guide suitable dosing for various conditions. If you want to avoid the head high that is associated with THC content, we recommend  you look for CBD products that are made from hemp. 

 

When buying CBD, you should also consider the specific amount of cannabidiol present not only in the whole offering, but also in each dose. Dosages are typically described in milligrams, and can vary considerably depending on the different products. Metabolism, tolerance levels, and the method of intake can all influence the dosage required. A great rule of thumb is to start low and slowly increase. Every individual will have varying needs, and once you have found the right dosage for your cannabinoid therapy, it’s a good idea to continue to stick to it. 

 

Understand Types of CBD

 

Although the effects tend to be the same, some people may prefer one type of CBD product over another, depending on how or when they plan to use it. Oils and tinctures, edibles, vaporizers, creams, and lotions, are all different methods of CBD consumption. Various methods of consumption have differing onset times, which can be a deciding factor when buying CBD. In some cases, inhaling CBD or using it topically may have a quicker effect than if taken orally or as a food product, which typically takes longer to be absorbed into your system. Different ailments may also require different methods of usage, while some may be based on personal preference. For example, to potentially manage localized areas inflammation one could use a topical cream, or also choose to use a tincture.

 

Key Indicators of Quality

 

Most reputable CBD oils include the following information on their labels: amount of CBD as an active ingredient per serving, supplement fact panel – including other ingredients, net weight, manufacturer or distributor name, suggested use, CBD compounds, batch or date code. CBD compounds to choose from are as follows:

 

• Full-spectrum CBD: contains all of the naturally available compounds of the cannabis plant, including THC. However, in hemp-derived full-spectrum CBD, the THC will be no more than 0.3 percent at the dry weight. THC levels rise when the flowers are extracted into oil.
• Broad-spectrum CBD: contains all of the naturally occurring compounds, except all of the THC—or all but a very tiny amount–is typically removed.
• CBD isolate: the purest form of CBD, isolated from the other compounds of the hemp plant. CBD isolate should have no THC. [Source: Healthline]

 

Where to Buy CBD Products

 

There are many options available when it comes to buying CBD products. You can find topicals, oils, edibles, and more online directly from a number of retailers. If you live in a state where dispensaries are legal, knowledgeable staff may be able to help with recommendations and answer any questions you may have in your process.

The most important thing is that you are able to confidently understand what to look for when buying CBD, so that you can shop for high quality products with confidence and find one that’s right for you. At Realm of Caring, we believe in taking an individual approach to cannabinoid therapy to find a product and dose that works for each of us! If you would like to reach out to our Care Team (719-347-5400 option 1), they would be so happy to help you individualize your therapy and find a product that is right for you.

If you are familiar with the benefits of cannabinoid therapy, then you may have also heard of the biphasic properties of cannabinoids. In short this means that low and high amounts of cannabis compounds can produce bidirectional, or opposite, effects. Here we will discuss more about this phenomenon and what it means for you and your cannabinoid therapy journey. 

 

When considering cannabinoid therapy in particular, much of the research available does not focus on low dose responses; rather the focus is on high concentration effects. There are long-standing beliefs that, when considering medications, titrating up quickly in dose is best. However, methods such as the biphasic dose-response challenge that dogmatic acceptance. Now we are seeing with specific conditions the magnitude of low doses and inhibitory responses at higher doses. 

 

Contradictory effects at low and high doses of cannabinoids have led researchers to investigate further. For example, when it comes to delta-9-tetrahydrocannabinol (THC), many choose to avoid this intoxicating component of the cannabis plant due to the undesirable side effects. Exposure to cannabis has been associated with cognitive impairments like short-term memory disruption. However, recent studies have shown that in older populations THC may promote hippocampal neurogenesis, prevent the neurodegenerative process of Alzheimer’s Disease, protect against inflammation-induced cognitive damage, and restore memory and cognitive function. 

 

Results over time have demonstrated that the involvement of THC in memory impairment is due to use associated with high-THC concentrations. Compelling evidence has shown that THC taken at extremely low concentrations in aging animal models may have the capacity to slow or halt neurodegenerative diseases such as Alzheimer’s Disease. 

 

The biphasic responses of cannabinoids have also been shown in cerebral metabolism, seizure disorders, pain, and anxiety responses. A known observation of the influence of cannabinoids is on emotional processing, such as anxiety and fear. Researchers have begun to intimately understand the biphasic effects of cannabinoids at the molecular level.

 

Cannabidiol (CBD) has been looked into for its potential, similar biphasic response to THC with anxiety. Both cannabinoids have shown that lower doses tend to produce anti-anxiety effects while higher doses may produce anxiety-like effects. Although future clinical trials are suggested as one study showed that higher amounts of CBD did not equate to increased feelings of anxiety. 

 

Researchers have recommended that if improvements seen during cannabinoid therapy begin to diminish over time, especially after an increase, then reducing the amount taken may be a potential strategy. For CBD, this is due to the idea that the compound has a reverse tolerance because of the role it plays in the endocannabinoid system as a modulator, rather than directly binding to receptors. Although many cannabinoids are shown to have favorable safety profiles, higher amounts of cannabinoids will not always yield enhanced therapeutic effects. 

 

While biphasic dose responses have shown to be significant with both cannabinoid therapy and clinical pharmacology, it is not the only method to consider. The best approach to cannabinoid therapy is an individual approach, as we all are unique and will respond differently to each cannabinoid and the concentrations of those cannabinoids in products. Working with a care specialist at Realm of Caring can help you to start low and slowly increase to find your optimal dose. We are here to talk with you one-on-one. Reach out by calling 719-347-5400 or emailing info@realmofcaring.org. 

 

 

Disclaimer

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Cannabinoid therapy has gained a lot of attention recently in the world of sports. First, there is approval of Cannabidiol (CBD) by the World Doping Agency, therefore permitted for use in the Olympics, then we have a long list of athletes advocating for the benefits of recovery, performance, and possibly even treatment. 

 

So what are the benefits that are worth advocating for? As it turns out, there may be many. Here we discuss the more well-studied actions of certain cannabinoids that have the potential to benefit athletes.

 

Anti-inflammatory

 

When exercise is particularly strenuous, athletes may encounter what is known as exercise-induced muscle damage, which impairs muscle function and leads to inflammation that may delay recovery and prolong soreness or pain. Cannabinoids have been researched to be anti-inflammatory, in fact researchers use terms such as “novel” and “potent” to describe their anti-inflammatory actions.

 

The potential of alleviating the muscle inflammation may be able to enhance recovery time by decreasing muscle tension, soreness, and pain. While CBD is among the most studied for anti-inflammatory actions, Cannabis sativa contains several other cannabinoids, terpenes and flavonoids that share the same potential benefits. This includes, but is not limited to, cannabinoids THC, THCA, CBDA, CBN, CBC, and CBG; terpenes caryophyllene, borneol, nerolidol, linalool, limonene, and pinene; and flavonoids Cannflavin A, and B. 

 

Neuropathic Pain

 

Neuropathic pain is observed among wheelchair athletes with spinal cord injuries. It can also develop as a result of surgery for a sports injury or repetitive irritation of peripheral nerves from endurance sports. Preclinical studies have observed significant pain-relieving effects of combined THC and CBD on chronic neuropathic pain, suggesting the cannabinoids as possible therapeutic agents for a clinical problem that has proved difficult to treat. 

 

Bone Health

 

Exercise is known to improve bone strength and reduce the risk of fractures. However, for athletes, traumatic injuries that may occur could cause or contribute to the development of bone fractures. One animal study reported that CBD and THC improved femoral fracture healing, proposing the treatment process of bone fracturing may be enhanced with cannabinoid therapy. 

 

Neuroprotectant

 

Concussions in athletes are very common. Recent reports show that in the U.S. there are about 3.8 million concussions that occur each year from sports related-injuries. Concussions may lead to long-term consequences. Increasing evidence shows that a traumatic brain injury (TBI) is a risk factor for neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and chronic traumatic encephalopathy. Studies have shown the impact CBD has on animal models with neuronal injuries and that it may lessen the impact of behaviors that may follow concussions and TBI’s such as anxious and aggressive behavior, depression, pain, and impaired social interactions. 

 

The neuroprotective effects of CBD, in particular, may involve the molecule’s ability to decrease inflammation, oxidative stress, and excitotoxicity. Additionally, CBD has shown to regulate cerebral blood flow and enhance neurogenesis. 

 

Sleep

 

When it comes to recovery, having quality sleep is very important. The first way cannabinoids may assist in improving our sleep is by mitigating the conditions that may be keeping us awake, such as sports performance anxiety (SPA). These conditions may have an effect on our body clock function, therefore leading to sleep disorders. 

 

CBD may directly assist in aligning our circadian rhythms, one of which being the sleep-wake cycle. The actions of our endocannabinoid system appear aligned with our circadian rhythms, therefore may modulate them. CBD, being a modulating molecule, has the potential to improve our sleep wake cycles, leading to an increase in the percentage of total sleep overtime. 

 

THC has shown in studies as having an effect on mental and physical sedation as well as lessening nightmare presence and intensity in PTSD study participants. In addition, THC shares properties of our endocannabinoid known as Oleamide, which is known to benefit apneic events. 

 

Topical Therapy

 

Preclinical and clinical studies show that targeting peripheral inflammation by topical therapy is effective. For wound healing, two of our endocannabinoid receptors, CB1 and CB2 are involved in the process of limiting inflammation, proliferations, and tissue remodeling. Although data on the clinical application of cannabinoids for inflammatory-related pain or aiding the process of wound healing is scarce, the research and anecdotal evidence is promising. 

 

Topical therapy has become a growing option for athletes who are looking to avoid ingesting full spectrum products, but still reap the potential benefits for problem areas or injury. 

 

Further Research and Finding a Product

 

While research to support the potential of cannabinoid therapy to benefit athletes is still considered to be in early phases, there are many recommendations by the scientific community to continue to study these plant-based options. Observational studies that anyone can join, such as Realm of Caring’s Observational Research Registry, are simple and effective ways to help legitimize this form of therapy. 

 

When looking for a product to aid you in your sports performance and/or recovery, it is always recommended you choose a well tested and high quality product you can trust. Visit Realm of Caring’s supported brands page for our list of trusted products and reach out to our free one-on-one support for guidance on administration by email info@realmofcaring.org. 

 

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Disclaimer

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

 

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

 

Right now, a lot is happening state by state in the name of cannabis. While there are many who aim to legalize this year, we are still witnessing actions towards regulation or a stall in rights to access for states who have already passed legalization legislation. Here we have a list of what is going on in your state and how you can take action today to support legalization efforts and oppose those efforts that may chip away at our rights.  

 

 

Legalization Efforts

 

Delaware

Florida

Hawaii

Indiana

Iowa

Kansas

Kentucky

Maryland

Minnesota

Mississippi

Missouri

North Carolina

Ohio

Pennsylvania

South Carolina

South Dakota

Tennessee

Virginia

Washington, DC

West Virginia

Wisconsin

 

 

Announced Bills to Oppose

 

Florida: Oppose barriers to expungement

Illinois: Oppose THC caps & Oppose criminalizing minors

Michigan: Oppose caregiver restrictions

Nebraska: Oppose the false medical cannabis bill

Rhode Island: Oppose cannabis industry criminal background checks

South Dakota: Oppose THC caps & Oppose limiting patient protections

Virginia: Oppose referendum for retail dispensaries, Allow licensed business to retail seeds and plants, & Oppose traffic stops based on odor

Washington: Oppose THC caps

West Virginia: Oppose removal of employment rights based on medical cannabis use

 

 

Announced Bills to Support for Further Access

 

California: Support employee rights

Hawaii: Support hemp sustainability

Kansas: Ensure broader access to hemp products

Michigan: Strengthen hemp laws 

 

 

We want to get you the most up to date information so you can get involved at the state and federal level. Be sure to follow us on Instagram so you can be informed on any efforts that require immediate action!

Two groundbreaking new preliminary studies have found that not one, not two, but three cannabinoids may block the original, live SARS-CoV-2 virus. The evidence suggests that the cannabis compounds can lessen the severity of COVID-19 infection in both human cells and mice. We break down the findings here.

 

Research published in the Journal of Natural Products found that two cannabinoids, cannabidiolic acid (CBDA) and cannabigerolic acid (CBGA), prevented the entry of the coronavirus into isolated human cells. They were both confirmed to block the original, live virus and two variants of concern: alpha and beta. An approach known as MagMass was used to screen which hemp extracts may bind to the SARS-CoV-2 spike protein. 

 

CBDA administered orally to human volunteers at 0.063 mg/kg showed greater bioavailability than CBD. In beagle dogs, oral administration of CBDA at 1 mg/kg was well tolerated and was 2-fold more bioavailable than CBD. Although no data on the bioavailability of CBGA are yet available, the data for CBDA suggest that concentrations for CBGA should also be possible.

 

Researchers conclude by stating, “With widespread use of cannabinoids, resistant variants could still arise, but the combination of vaccination and CBDA/CBGA treatment should create a more challenging environment with which SARS-CoV-2 must contend, reducing the likelihood of escape.”  

 

Newer findings published in Science Advances treated human cells and mice with cannabidiol (CBD), and found that the cannabinoid can prevent the virus from replicating in human cells after entering those cells. Specifically, CBD activates our system to respond to the pathogens, working on human cells after the virus enters, a telling sign for the potential of CBD as an early response agent.

 

To test the effect of CBD on SARS-CoV-2 replication, human lung carcinoma cells were pretreated for 2 hours with 0–10 μM  CBD prior to infection with SARS-CoV-2. After 48 hours, cells were monitored for expression of the viral spike protein and viral titer. CBD potently inhibited viral replication under non-toxic conditions, as well as inhibited SARS-CoV-2 replication in human lung and monkey kidney epithelial cells. No toxicity was observed at the effective doses. In addition to the original SARS-CoV-2 strain three variants were tested as well, alpha (α), beta (β), and gamma (γ), and their ability to infect cells was comparably inhibited by CBD.

 

Additionally, the study composed an analysis of more than 1,000 individuals using CBD for the treatment of epilepsy and found the patients tested positive for COVID-19 at lower rates than patients who were not administering CBD treatment. 

 

Martha Rosner, senior author of the Science Advances study explains, “We should think of this as another tool in our arsenal. We imagine if we find it works in clinical trial, it might be useful for breakthrough infections.”

 

So, what does all of this mean for cannabis users? The findings are certainly positive, but shouldn’t be viewed as a substitute for vaccines or other guidelines suggested by the CDC. Unfortunately, there has been no research that shows inhaling cannabis or THC has any positive effect against COVID-19 either. And while it may be tempting to run out and buy the nearest over-the-counter CBD, researchers are stressing the importance of using high-quality, high-purity CBD options, like those available from our supported brands.

 

 

Disclaimer

 

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. The products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

 

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Cannabidiol (CBD) is a major cannabinoid of the Cannabis sativa plant and we have witnessed interest in the compound skyrocket in the past few years due to its potential ability to alleviate the symptoms of several conditions. CBD has been sought after and researched for epilepsy, anxiety and depression, inflammatory conditions, sleep, overall wellness, and so much more. The considerable therapeutic possibilities of CBD have much to do with the modulating effects on the endocannabinoids within our endocannabinoid system as well as the realization that these benefits come without the harsh side effects of many current pharmaceuticals. One thing that individuals are left to wonder, though, is what about any long term effects? 

 

The acceptance from the medical community of CBD as a treatment for chronic conditions may relate to the missing long-term safety data. The U.S. Food and Drug Administration (FDA) has several years of patient data that has come from Epidiolex clinical trial programs; however they have stated that despite safety findings in studies with their trials, it is not clear if this data would be generalizable to the users of non-drug CBD products for healthy adults and children as well as adults and children with other comorbidities other than epilepsy. 

 

Researchers are filling in these gaps of missing data by looking to other ways for measuring long-term outcomes and safety. 

 

A study published in 2020 in the journal Cannabis and Cannabinoid Research, gave us our first look at CBD lifelong exposure data using a living organism. Researchers looked at both acute and long-term exposure studies on the nematode, Caenorhabditis elegans (C. elegans), a species that is accepted as models for studies related to lifelong toxicity of drugs due to their transparent bodies, their short lifespan of 2-3 weeks, and approximately 60-80% of its genes evolving from the same ancestral genes as humans. Because their mortality and motility is easily measured, C. elegans have been used frequently in research for decades to understand the toxicity and efficacy of drugs and have led to many breakthrough discoveries in research on aging. 

 

In this particular study, the C. elegans were exposed to a wide range of CBD amounts, where acute toxicity results showed that no animal from the study died, rather there was a mean maximum life extension of 18.3%. As well, compared to controls, CBD treatment increased the percentage of highly active animals throughout all life stages. At day 15 (old age for a C. elegans), there was a 206.4% increase in activity compared to controls, meaning that CBD reduced typical age-related motility declining. 

 

These findings indicate that there may not be long-term toxic effects of CBD. As it was shown with the C. elegans, CBD extended lifespan and significantly improved activity levels in the late stages of life. This research is important for our understanding of isolated CBD in one living model. For more insight to the questions of lifelong exposure, more research is needed in additional living models and with full spectrum and/or broad spectrum CBD products. 

 

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Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans is authored by M. Hunter Land, Marton L. Toth, Laura MacNair, Siva A. Vanapalli, Timothy W. Lefever, Erica, N. Peters, and Marcel O. Bonn-Miller (RoC Scientific Advisory Board Member).

 

 

Join our research!

 

Realm of Caring and Johns Hopkins University School of Medicine have developed the Observational Research Registry (ORR) to better understand medicinal cannabis use and its impact on key health outcomes including healthcare utilization, chronic pain, anxiety and depression, caregiver burden, epilepsy, and posttraumatic stress disorder (PTSD). Our registered clients provide critical information that leads to important insights into the therapeutic capabilities of medicinal cannabis. The ORR helps us develop client educational resources and may ultimately serve to legitimize the medicinal use of cannabis.

 

 

About Realm of Caring

 

Realm of Caring Foundation (RoC), is a 501(c)3 nonprofit organization that was established by parents in 2013 to support families who were out of medical options. By creating educational resources, conducting research, and assisting families with data-rich answers to their questions, RoC continues to be a leader in the cannabinoid (cannabis/hemp) field. RoC’s no-cost Care Team has served more than 67,000 clients worldwide and supports a network of over 2,000 medical professionals.