Category: Education

Our collective knowledge of the benefits of the cannabis plant for epilepsy continues to increase year after year. In addition to seizure reduction, we have learned through the literature that cannabis use may be attributed to an increase in the overall quality of life for one living with an epilepsy diagnosis. These improvements can range from decreased side effects of pharmaceuticals to better sleep and lessened anxiety. 

It has been discovered that approximately one-third of individuals living with epilepsy do not respond well to conventional antiepileptic drugs (AEDs) and are therefore considered to have Treatment Resistant Epilepsy or Drug Resistant Epilepsy (TRE/DRE). This creates a demand for an antiepileptic solution that has reportedly better efficacy and less adverse effects.

In this blog you will find historical uses of cannabis for epilepsy, current research across various epilepsy diagnoses with cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), and cannabidvarin (CBDV), and additional resources for support. 

Historical Uses of Cannabis for Epilepsy

Historical uses of cannabis and hemp for medicinal reasons date back thousands of years. Ancient Sumerian and Akkadian tablets found in the Middle East from as early as 1800 BCE record the use of cannabis for nocturnal convulsions. Arabic literature from around 1100 CE from Ali ibn al-Abbas al-Mayusi has been translated to state “the juice of the leaves of cannabis instilled in the nostril serves to treat epilepsy”, also suggesting that the active ingredient was tetrahydrocannabinolic acid (THCA). 

The first clinical application for cannabis and epilepsy, however, is known to have taken place in the early 19th century with Irish physician William O’Shaughnessy, an army surgeon who served in India. In what can be considered the first detailed modern study of the use of cannabis-based products for anti-seizure benefits, he published his findings in 1843 after testing the behavioral effects in several mammals, fish, and birds. Among these subjects was a 40-day old baby girl with recurrent convulsive episodes. She initially responded well and after a few weeks of trials with various cannabis tinctures, taken under the tongue (sublingually), her convulsions had stopped. Several months later, O’Shaughnessy had noted that “the child is now in the enjoyment of robust health, and has regained her natural plump and happy appearance.” 

From here, notice was taken across physicians in Europe and North America and by 1850 cannabis had made its way as “marijuana” into the United States Pharmacopeia, listing it as a treatment for numerous afflictions, including: neuralgia, tetanus, typhus, cholera, rabies, dysentery, alcoholism, opiate addiction, anthrax, leprosy, incontinence, gout, convulsive disorders, tonsillitis, insanity, excessive menstrual bleeding, and uterine bleeding, among others. In 1881 Neurologist Sir William Gowers wrote of the use of cannabis for seizure control in his monograph Epilepsy and Other Convulsive Disorders. 

By the early 20th century, references to cannabis extractions and tinctures began to fall out in favor of Western medicine (notably phenobarbital in 1912 and phenytoin in 1937). With this, and with the soon prohibition of cannabis, the therapeutic claims and those first clinical trials took a backseat. 

Despite this, chemists and pharmacologists began diving into the chemical characteristics of the active ingredients and effects on biological activity. Specifically the molecular structures of THC and CBD were investigated by Dr. Raphael Mechoulam in Israel, famously known as the “father of cannabis research”. 

Researchers began to look more at CBD as potential for anti-seizure therapeutic benefits, as promising results in animal models were reviewed. Anecdotal and pre-clinical evidence increased over the years, and with the discovery of cannabinoid receptors in the late 1980’s and early 1990’s, renewed interest in the understanding of therapeutic potential of cannabinoids in how they may modulate the endocannabinoid system came about. 

While smaller scale studies took place to consider the efficacy of CBD, larger scale studies began to emerge around 2015 when neurologist Orrin Devinksy and colleagues observed the antiepileptic effect of CBD among over 200 participants, ages 1-30. Their findings suggested that CBD may reduce seizure frequency and may also have an adequate safety profile in children and young adults with highly treatment-resistant epilepsy, warranting future trials. 

Realm of Caring Published Research 

It was around this time that Realm of Caring began enrolling participants for an Observational Research Registry in collaboration with Johns Hopkins University School of Medicine. Between April 2016 and July 2020, 1,783 individuals enrolled in this online, self-reported survey. Of the enrolled individuals, 418 participants were identified to understand benefits for epilepsy where 93% had listed epilepsy as their primary medical condition with the remaining noting epilepsy as a secondary medical condition. In this sample size, there were 71 adults and 209 adult caregivers of children or dependent adults who were utilizing CBD products for medicinal use. In addition, there was a control group of 29 adults and 109 adult caregivers who were considering CBD use but had not yet begun. In-depth information from 110 participants in the study helped to conclude that the calculated median dose of CBD was 50mg/day, which equated to 1.4mg/kg/day. 

The purpose of this analysis was to evaluate how CBD product use is associated with quality of life, mental health, healthcare utilization, and epilepsy-specific outcomes within a large, observational group of people with epilepsy. 

Compared with controls, CBD Users had a greater health satisfaction, higher ratings of quality of life, and better scores on psychological health. Taking a deeper look, CBD Users reported lower anxiety and depression and improved sleep scores. 

Other findings that were of significance relate to pharmaceutical use, healthcare visits, and caregiver burden. CBD Users had lower instances of reported prescription medication use, lower medication-related adverse effects, less ER visits, and less missing school and/or work days. In addition, caregivers of CBD Users that noted consistent use through the follow-up period reported significant decreases in the Caregiver Burden total score. 

The strides that have been made in recognizing cannabis compounds for their clinical benefit to epilepsy are evident in that the U.S. Food and Drug Administration (FDA) and the European Medicines Agency have approved a CBD isolate pharmaceutical, Epidiolex, for TRE in patients with Lennox-Gastaut Syndrome (LGS) and Dravet Syndrome. Since the 2018 debut of Epidiolex, it has been approved for additional uses and further research, including that of other cannabis compounds, has taken place.  

Additional, Recent Research From the Last Year

Pediatric neurologist Ellen N. Hurley published findings in early 2022 looking at five female children with Rett Syndrome and, consequently, TRE. As animal studies have demonstrated an anti-seizure effect and favorable safety profile for CBDV, the compound was used in this study to determine the safety and tolerability of it for pediatric Rett Syndrome patients. An oral CBDV solution was provided and all five witnessed a reduction in mean monthly seizure frequency. 

A systematic review published in October 2022 sought to assess the effects of CBD in epilepsy patients. In conclusion, the study showed that CBD is highly efficacious both as a standalone and adjunct therapy with clobazam for controlling seizures while limiting side effects. 

A study published in November 2022 analyzed thirty-five patients who were respectively prescribed CBD isolate oils, CBD broad spectrum oils, and CBD:THC combination oils. Results showed that 65.7% of patients achieved a seizure frequency of greater than or equal to 50%, demonstrating a positive signal of improved seizure frequency in children treated with cannabis-based medicinal products for treatment-resistant epilepsies. 

Observational findings published in Pediatric Neurology in October 2023 support the effectiveness of purified CBD as an add-on therapy in everyday clinical practice, as researched among a mixed population of patients with DRE.

Recap: 5 Things to Consider When Starting Cannabinoid Therapy for Epilepsy

1. There is published research to support benefits, which you do not have to navigate on your own. Realm of Caring features a library of these findings and a care team on standby to offer free one-on-one guidance as you read through. 
2. AED interactions are possible. An assessment of data suggests that changes in serum levels of AEDs taken with cannabinoid administration have been generally minor for the majority tested and may be well-tolerated. However it should be taken into consideration that several cannabinoids are processed by the body’s cytochrome P-450 (CYP450) system. Therefore it is best to consult with your doctor when co-administering cannabinoids with drugs that are also metabolized by enzymes CYP3A4 or CYP2C19. 
3. Patience and the biphasic response are helpful when setting expectations. Administration may be made complicated by the non-linear response of cannabinoids and we should be cautioned to assume that higher amounts of cannabinoids will yield enhanced therapeutic effects. Realm of Caring care specialists abide by the “start low and go slow” method; a strategy with a goal to find a therapeutic dose at the lowest possible amount. 
4. There are a variety of administration and extraction methods available. The first and most commonly used administration method would be sublingual or buccal administration with an oil or tincture. Individuals also administer by capsule or tablet, through g or j tube, and rectally as a suppository. For extractions of CBD, we have isolate, broad spectrum, full spectrum as well as formulations that include additional, natural supplements. There are also a variety of processes to extract the plant compounds. When looking for what may be most effective for you, a Realm of Caring care specialist is here to help, starting you with a quality product. 
5. You are not alone. In addition to the Realm of Caring care team, there is a community to support you. Many resources are available for connecting to services or more information. Reach out to our team by calling 719-347-5400 or emailing info@realmofcaring.org. 

Recently, an increasing number of advertisements have appeared online highlighting various CBD products, typically gummies, endorsing benefits such as pain relief, improved sleep, and lessened anxiety. Unfortunately, to the consumer and the legitimate companies, many of those heavily marketed “miracle cure” CBD products may be a part of a larger scam. 

How do these scams work?

Many, reputable, companies will use subscription models as a way to save you money. It has shown to be a great service to offset the cost of your cannabinoid therapy. However, subscription traps do often take place by scammers; unwittingly locking you into costly, repeated payments. These offers often seem too good to be true, for example, receiving a free CBD product where all you have to pay for is shipping.

When (or if) these products arrive, there may be no CBD in them at all or they may have harmful other defects. Numerous times CBD products readily available on the market have been tested by multiple laboratories. In one study only 15% of the products tested were accurately labeled. 

What are the health implications of buying an illegitimate product?

The hemp plant has numerous benefits, including to our environment. One of its specialities is the ability to absorb a vast range of compounds from the soil to include heavy metals, radioactive elements, pesticides, fungicides, and more. So, if hemp is coming from polluted land, it is likely that high concentrations of these compounds can show up in the final product that individuals are consuming. Contaminated products may cause pain, muscle weakness, vomiting, diarrhea, allergic and respiratory issues. Buying from illegitimate companies might not just rob you of your money but of your health. Therefore we cannot stress enough that the quality of your product absolutely matters. 

How to spot the scams.

Often, widely elaborate scams aim to trick consumers with false testimonials and manipulated imagery. Recently, claims were attributed to a fraudulent company as a “miracle gummy”. Scammers even included false endorsements from Shark Tank celebrities in their ads, which is not the first time a CBD scam has used the TV show in their attempt to dupe consumers. It should be known that no CBD products have been aired in an episode of Shark Tank to date. 

Clicking the scam ad will often lead to a sales page with more deceitful claims and countdown timers to create a false sense of urgency to purchase. An initial charge is requested and what may be more downplayed, or missing entirely, is language about this being a recurring monthly charge. After the first transaction, cancellation often becomes incredibly difficult as these “companies” do not respond to phone calls and emails or refuse refunds. 

How do you know if your product is legitimate?

There are several CBD companies that offer safe, affordable, quality products. Because the FDA does not regulate CBD, checking if a company is legitimate falls heavily back on the consumer. You do not want your trust and confidence in CBD to be impacted by scammers, so here are some action steps you can take before you buy:

• Contact a Realm of Caring Care Specialist. Our team is here to help with free one-on-one support to ensure you find a safe and quality product to help you achieve your goals. We have our own rigorous vetting process, and the products that have passed you may find on our supported brands page. As an organization founded by mom’s who were looking for safe solutions for their children, we take product quality very seriously.

• Use our Quality of Product Matters Checklist to help you vet a company. 

• Research the brand you are looking to shop from. The most reputable are often the ones who show results from third-party lab testing, are transparent about their sourcing and/or how they manufacture their products. If you have questions, they should have a support team you can contact for more information. 

• Be skeptical of those products who claim to be a “miracle cure” or offer a free trial while requiring your credit card information. 

What to do if you feel that you have been scammed. 

If you feel that you are a victim of a subscription scam and the customer service team for the company is non-existent or not responding, you may want to contact your credit card provider or bank to inform them to stop charges. If you purchased a product that is causing an adverse reaction and, again, the company customer service is non-existent or not responding, you may want to contact Safety Call to report the event. 

The Bottom Line? Get help in advance of product buying.

Realm of Caring takes part in research and education for safe and responsible use of CBD and cannabis products. We are here to help with quality product selection, administration guidance, and free one on one support. Understand what to look for and how much to take of any CBD product before you head to the store or order online. You can reach our care team by calling 719-347-5400, emailing info@realmofcaring.org or scheduling an appointment.  

According to the American Thyroid Association (ATA), an estimated 20 million Americans have some form of thyroid disease and an estimated 60% are unaware of their condition. Women are more likely to develop a thyroid disorder, which, if left untreated, can lead to a host of other conditions such as osteoporosis and infertility. 

What is the thyroid? 

The thyroid is a butterfly-shaped endocrine gland located in the front of the neck. Its role is to make thyroid hormones that are secreted into the blood and carried throughout the body. The thyroid controls the body’s metabolism, can increase heart rate, and regulate blood pressure and body temperature. The gland also produces calcitonin, which aids bone cells in processing calcium and adding it to the bones. Thyroid disorders types include:

• Hyperthyroidism
• Hypothyroidism
• Hashimoto’s Thyroiditis
• Thyroid Tumors
• Thyroid Cancer

Early warning signs of thyroid problems include: 

• Overactive thyroid – Racing heart rate, palpitations, anxiety, insomnia, nervousness, weight loss with increased appetite, excessive sweating/heat intolerance, muscle fatigue
• Underactive thyroid – fatigue (mental and physical), cold intolerance, constipation, hair loss, weight gain, depression

A doctor and/or endocrine specialist is best to speak to if you are witnessing these symptoms and are concerned about whether or not you have a thyroid-related condition. 

Finding relief

There are a variety of care options that a medical professional may guide you through to address thyroid conditions. Scientists have been observing how the endocannabinoid system (ECS) is involved in the regulation of several body processes. Cannabinoids exert their effects in the ECS by interaction with the cannabinoid receptors CB1 and CB2. To date, cannabinoids have been confirmed to participate in the regulation of food intake, energy homeostasis of the body, and have a significant impact on endocrine system, including the activity of the pituitary gland, adrenal cortex, thyroid gland, pancreas, and gonads. Here we will discuss recent research that points to the potential of cannabidiol (CBD) in benefitting thyroid health.

The ECS and Endocrine System

The ability of the ECS to control appetite, food intake, and energy balance has received great attention. Some of the earliest reports of effects of cannabis consumption on humans were related to endocrine system changes. It has been proposed through research that the ECS may control hormonal balance also through a direct effect at the level of target organs. The endocrine system is a complex network of glands and organs, using hormones to control and coordinate the body’s metabolism, energy levels, reproduction, growth and development, and response to injury, stress, and mood. 

Cannabis and Thyroid Function

Early studies show that delta-9-tetrahydrocannabinol (THC) is able to decrease thyroid hormones and iodine accumulation in rat models. Additional studies indicated that the thyroid gland itself may be the direct target of cannabinoid action. 

Given the established safety profile of CBD and protective effects on kidney inflammation and damage, it is being researched for several treatment-resistant diseases as well as an alternative to medications that may come with adverse side effects. CBD research for thyroid disorders is still in early stages, however the existence of the ECS receptors on the thyroid gland and in the brain region that controls thyroid function is promising. 

Numerous studies point to CBD as helpful in managing symptoms commonly associated with thyroid disorders such as energy levels, anxiety and depression, insomnia, cardiovascular health, gut health, hair loss and weight changes. A study published in 2022 sought to better understand the role of CBD as a potential therapy for thyroid disorders and discovered that CBD treatment of rat models in the study significantly improved the levels of thyroid hormones. In addition, it was reported that cannabinoid receptors are involved in the healing of malignant and benign thyroid lesions and relief from inflammation, hormonal imbalance, and depression. 

Finding Support

There is a lot to consider when starting cannabinoid therapy but, as always, a Realm of Caring care specialist is here to help with free one-on-one support to answer your questions. Contact us today by calling (719) 347-5400 or by emailing info@realmofcaring.org.

Fall is here, and with it comes the cozy comforts of warm sweaters, colorful foliage, and the delicious flavors of the season. If you’re looking to elevate your autumn experience, why not consider infusing your favorite fall recipes with a bit of cannabis? Cooking with cannabis can be a fun and therapeutic way to enjoy the season!

When talking about cooking with cannabis in this blog, we are referring to both THC and CBD. Whichever you choose to cook with is up to you and the legality in your state, but keep in mind they are interchangeable in our tips and recipes throughout. 

The Benefits

Cooking with cannabis offers a host of benefits that are gaining widespread recognition in the culinary world. One of the key advantages is precise dosage control, making it a preferred choice for both medical and recreational users. Unlike traditional methods like smoking, cooking allows users to accurately measure the amount of THC and CBD they consume, ensuring a more predictable and controlled experience. This precise dosing is particularly valuable for those seeking to manage specific health issues or seeking symptom relief, as they can fine-tune their intake to match their needs.

What makes cooking with cannabis truly remarkable is the potential therapeutic advantages it offers. First, we’ll dive into the raw form of cannabis. This includes the leaves, stalks, stems, and seeds, all of which are rich sources of essential nutrients such as carbohydrates, protein, fiber, fat, amino acids, water, magnesium, calcium, beta-carotene, zinc, and an array of vitamins (E, C, B1, B3, B6), among others. Moreover, raw cannabis boasts acidic cannabinoids, terpenes, and flavonoids, each holding unique health benefits in their own right.

As cannabis is heated, studies suggest that additional health benefits emerge as these acidic cannabinoids undergo decarboxylation. This process unlocks their therapeutic potential, offering the possibility of:

• Inflammation and pain reduction
• Spasm relief
• Nausea relief
• Improved sleep
• Improved mood
• & so much more!

Moreover, cooking with cannabis opens up a world of culinary creativity. Infusing oils, butters, or even entire recipes with cannabis enables enthusiasts to craft a wide range of dishes, from savory to sweet. This versatility means you can enjoy the therapeutic benefits of cannabis while indulging in delicious meals tailored to your palate. Whether you’re exploring new flavors or simply seeking a unique culinary adventure, cooking with cannabis offers an exciting and enjoyable way to embrace the plant’s potential benefits. As cannabis continues to gain acceptance, its integration into the kitchen promises to be an innovative and exciting culinary frontier.

Our Go-To Tips and Tricks:

• • Use high quality ingredients, this includes your cannabis! However, there’s no need to drain your wallet on premium cannabis flower. Many edible-makers will even use shake or trim in their recipes and achieve desired results. We suggest a middle ground: don’t spend too much on cannabis that you’re just going to cook away, but avoid selecting old or poor-quality weed–as you are still ingesting it.
  • Start low and go slow. CBD specifically works through the accumulation of the Endocannabinoid System. In order for it to provide day to day relief from your symptoms, you may want to explore consistent dosing. When cooking with it, you will want to have enough to where it may provide some added benefit but not too much so that it will overwhelm the taste of your recipe or be too high of a starting dose. This is especially the case when cooking with THC, as it is psychoactive.
  • Calculate your dosages and potency. You’ll need no more than one (1) cup of cannabis flower to each cup of oil or butter, so there’s no need to dump a whole pack of cannabis into your recipe. Utilizing lab-tested flower with well-defined cannabinoid percentages will help you to accurately dose your recipe and plan your serving sizes. 
  • Decarboxylate your cannabis. Making edibles isn’t as straightforward as merely adding cannabis to your recipe; you need to activate it through decarboxylation, or heating it. This process transforms the THCA in the plant into THC, the CBDA into CBD, and so forth. To decarboxylate:
    • Evenly spread out your flower on a baking sheet
    • Heat the oven to 245 degrees Fahrenheit/120 degrees Celsius
    • Bake for 30-40 minutes, flipping the buds every ten minutes
  • Avoid overchopping your cannabis. Chopping or grinding your weed into excessively small pieces will make it more challenging to remove plant matter from your cannabutter. Instead, break it into small, uniform pieces large enough to be caught in a cheesecloth or strainer.
  • Select your infused ingredient. You have the option of either cannabutter or infused oil, depending on your recipe. The process for making both types of infused ingredients is roughly the same, so your choice primarily relies on taste preferences and the type of recipes you intend to create.
  • Strain any plant matter. After infusing your butter or oil, you’ll want to get rid of any plant matter, as this can help improve the flavor and shelf life of your butter or oil. Cheesecloth is an excellent choice for straining, as it allows oil to pass through while leaving behind the leftover bud.
  • Mix well. A common mistake in making edibles is not properly distributing the infused ingredient throughout the recipe. Neglecting proper mixing can be risky since certain portions of the food might contain significantly higher THC doses than others, leading to an unexpectedly potent experience.
  • Don’t heat over 340 degrees fahrenheit. THC, CBD and other chemicals in cannabis start to degrade at temperatures that exceed 350 degrees Fahrenheit, diminishing the potency.

• Store and label properly. Labeling your creation, however, is of the utmost importance. Keep your edibles out of the reach of children, animals or unsuspecting adults who might not be aware of the cannabis content in your homemade treats.

If you can follow instructions, you’re going to love this blog! We’ve put together four cannabis-infused recipes perfect for embracing the fall spirit.

Cannabis-Infused Pumpkin Spice Latte

Ingredients: 

2 cups of preferred milk

2 tablespoons of canned pumpkin puree

2 tablespoons of sugar

1-2 tablespoons of cannabis-infused coconut oil or butter (adjust to your preferred potency)

1/2 teaspoon of pumpkin spice blend

1/2 cup of strong brewed coffee or espresso

Whipped cream (optional)

Cinnamon sticks (optional)

Instructions:

1. In a saucepan over medium heat, combine the milk, pumpkin puree, sugar, and cannabis-infused coconut oil or butter. Whisk until well blended and heated through, but do not boil.
2. Remove from heat and stir in the pumpkin spice blend.
3. Pour the brewed coffee or espresso into your favorite mug.
4. Carefully pour the pumpkin spice mixture over the coffee. Option to use a handheld blender to mix together.
5. Top with whipped cream and garnish with a cinnamon stick for extra flair.
6. Sip and savor your cannabis-infused fall delight!

Cannabis-Infused Butternut Squash Herb Soup:

Ingredients:

1 large butternut squash, peeled, seeded, and cubed

1 onion, chopped

2 cloves of garlic, minced

4 cups of vegetable broth

2 tablespoons of cannabis-infused olive oil

1/2 teaspoon of dried thyme

Salt and pepper to taste

1/2 cup of heavy cream (optional)

Fresh sage leaves for garnish (optional)

Instructions:

1. In a large pot, heat the cannabis-infused olive oil over medium heat.
2. Add the chopped onion and garlic, sauté until fragrant and translucent.
3. Add the butternut squash, vegetable broth, and dried thyme. Bring to a boil, then reduce heat and simmer until the squash is tender.
4. Use an immersion blender to puree the soup until smooth.
5. Season with salt and pepper to taste.
6. Stir in the heavy cream if desired for a creamy texture.
7. Serve hot, garnished with fresh sage leaves.

Crispy Cannabis-Infused Apple Crisp:

Ingredients:

6 cups of sliced apples (peeled and cored)

1 tablespoon of lemon juice

1/2 cup of granulated sugar

1/2 teaspoon of ground cinnamon

1/4 teaspoon of ground nutmeg

1/4 cup of cannabis-infused butter or coconut oil

1 cup of old-fashioned rolled oats

1/2 cup of all-purpose flour

1/2 cup of brown sugar

Vanilla ice cream (optional)

Instructions:

1. Preheat your oven to 350°F (175°C).
2. In a large mixing bowl, combine the sliced apples, lemon juice, granulated sugar, cinnamon, and nutmeg. Toss until the apples are well coated, then transfer to a greased baking dish.
3. In another bowl, mix the cannabis-infused butter or coconut oil, rolled oats, flour, and brown sugar until it forms a crumbly mixture.
4. Sprinkle the oat mixture evenly over the apples.
5. Bake for 40-45 minutes or until the topping is golden brown and the apples are tender.
6. Allow the apple crisp to cool slightly before serving.
7. Serve warm with a scoop of vanilla ice cream for an extra indulgent treat.

Cannabis-Infused Hot Apple Cider:

Ingredients:

4 cups of apple cider

1/4 cup of cannabis-infused honey (adjust to your preferred potency)

2 cinnamon sticks

4 cloves

4 slices of orange peel

Whipped cream (optional)

Ground cinnamon for garnish (optional)

Instructions:

1. In a saucepan, combine the apple cider, cannabis-infused honey, cinnamon sticks, cloves, and orange peel.
2. Simmer over low heat for 15-20 minutes, allowing the flavors to meld.
3. Remove the cinnamon sticks, cloves, and orange peel.
4. Ladle the infused apple cider into mugs.
5. Top with whipped cream and a sprinkle of ground cinnamon if desired.
6. Sip and savor this warm and soothing cannabis-infused fall beverage.

Fall is the perfect season to experiment with THC or CBD cannabis-infused recipes, adding an extra layer of comfort and relaxation to your culinary adventures. Whether you’re craving the warmth of a Pumpkin Spice Latte, the heartiness of Butternut Squash Soup, the sweetness of Apple Crisp, or the soothing embrace of Hot Apple Cider, these recipes are sure to elevate your fall experience. Remember to consume responsibly and be mindful of your desired potency. 

If you have any questions about this topic, a Realm of Caring Care Specialist is here to help. Call us at 719-347-5400 option 1, email us at info@realmofcaring.org, or visit our website and sign up for a free client account at www.realmofcaring.org.

In previous blogs we have discussed known benefits of major cannabinoids like cannabidiol (CBD) and delta-9-tetrahydrocannabinol (Δ9-THC) as well as minor cannabinoids such as cannabigerol (CBG), cannabinol (CBN), cannabidivarin (CBDV), and cannabidiolic acid (CBDA). We have also looked at how terpenes may alter your cannabis experience. Here we will dive into some of the lesser known minor cannabinoids plus additional ingredients in your CBD that may provide a synergistic benefit boost. 

Major Cannabinoid vs Minor Cannabinoid

The cannabis plant has been grown and cultivated for medicinal, industrial, and recreational uses throughout recorded history. Originally, two main species of cannabis were described as Cannabis indica and Cannabis sativa, however strain lineage and our understanding have evolved vastly over time. Important advancements in understanding the pharmacology of cannabis came with the isolation of the two most abundant phytocannabinoids found in Cannabis sativa L.: CBD and Δ9-THC. In addition to these major cannabinoids, over 120 other phytocannabinoids (as well as an abundance of related compounds) are produced. These phytocannabinoids are referred to as minor cannabinoids as they are present in smaller amounts when compared to CBD and Δ9-THC. 

Cannabichromene (CBC) 

CBC is one of the most abundant minor cannabinoids found in cannabis. Cannabinoid receptor studies using CBD are limited, however it is known to be a potent activator of the transient receptor potential ankyrin 1 (TRPA1) channel, which is largely expressed in sensory nerves.

The anti-inflammatory effects of CBC were first reported in the 1980s, where high doses of CBD were more effective than the observed nonsteroidal anti-inflammatory drug (NSAID). In addition to reducing inflammation, it has also been observed to reduce pain associated with osteoarthritis without the negative side effects of NSAIDs. 

Tetrahydrocannabivarin (THCV) 

Like many other minor cannabinoids, THCV has researched actions at TRP channels and 5HT1A receptors. Also, like other minor cannabinoids, THCV has shown in rodent models to reduce inflammation and inflammatory related pain. 

Research in the last decade shows promise for THCV as an anti-epileptic and in the treatment of neurodegeneration in Parkinson’s disease. Rodent models have shown a reduced incidence of seizures, a reduction of slow motor movements, and prevention of neuronal degradation. 

It has been observed through studies that THCV regulates blood glucose levels, suggesting its potential usefulness for weight reduction and diabetes regulation. 

Cannabicyclol (CBL)

CBL is a rare cannabinoid that naturally occurs as CBC oxidizes. It was first discovered in Raphael Mechoulem’s laboratory in Israel in the 1960s and was more recently found in a 2,700 year old Caucasoid shaman grave in China, where in the tomb was a large cache of preserved cannabis. As cannabis ages, it begins to have less THC and CBD, however findings like these prove that even after sitting for thousands of years, there are still active compounds present as the cannabis ages. 

Given that the cannabis plant must age appropriately before active CBL may be obtained and studied, it makes researching the compound difficult. However the unique arrangement of atoms shows that it lacks psychoactive properties. 

Additional Ingredients in your Products

Just by looking in your spice cabinet you may find an array of products with stimulating or sedative properties which, when combined with cannabis, may enhance your desired state. But before going to make your own concoction, there are several quality companies who are already combining beneficial ingredients into one product for your convenience and safety. While these ingredients are regarded as generally safe on their own, oversight from a medical professional and education from a cannabis expert are always recommended to ensure you are getting the most out of your experience at the right amount. Here are some of those ingredients that may provide additional synergistic effects to your cannabinoid therapy. 

Valerian Root

Valerian root is an herbal supplement with historical uses as a traditional medicine. It is now classified domestically as a dietary supplement by the Food and Drug Administration (FDA), used widely as a sleep aid or to lessen anxiousness. If your intended use of cannabis is to improve the quality of your sleep, finding a product with valerian root may enhance drowsiness helping you to fall asleep faster. When taken in small amounts, it may also be beneficial to easing feelings of anxiousness and promoting a sense of calm. 

Lemon Balm

In addition to using lemon balm as a companion plant to cannabis to repel the “bad bugs” and disguise the cannabis plant smell, it has benefits for your body as well. Lemon balm is known to improve mood, cognition, and aid as a natural anti-inflammatory, anti-oxidant, and decongestant. Combining CBD and lemon balm may calm the nervous system to ease stress, refocus energy, and relax. 

Lion’s Mane 

Research has found the functional mushroom lion’s mane to have a host of benefits for neurodegenerative diseases such as ischemic stroke, Parkinson’s, Alzheimer’s, and depression. It may also promote recovery and enhance nerve regeneration, therefore improving cognitive performance and reducing brain fog. Benefits have also been evaluated for temporal lobe epilepsy (TLE), showing that lions’ mane supplementation could promote neuroprotection after seizure activity and prevent damage to nerve cells. The combination of lion’s mane and CBD may assist in easing feelings of anxiousness while improving clarity and focus. 

Finding a product

Finding products containing rare, minor cannabinoids may not be a simple task just yet. However, there are quality products available that combine major cannabinoids and other natural supplements. To learn more about what products are available and how to source a company you can trust, contact the Realm of Caring care team for free guidance! 

Cannabidivarin (CBDV) is a naturally occurring, minor cannabinoid found in the cannabis plant, almost identical in structure to cannabidiol (CBD). CBDV has been discovered in landrace strains of cannabis, which are types of cannabis that are unadulterated and typically grow in a specific location, known as their native environment. 

Like CBD, CBDV is well tolerated and non-intoxicating as it has weak affinity for CB1 receptors, which are responsible for the euphoric effects associated with cannabis use. Recent studies have shown that CBDV exerts beneficial effects towards neurological and motor impairments, cognitive deficits, helps nerve cells to be less active, and improves nausea, inflammation, and pain. Here we take a closer look at the researched benefits in Epilepsy, Autism, and gut health.

Epilepsy

In recent years, CBDV has gained attention when 2014 research noted that it has significant anticonvulsant properties that may rival the therapeutic potential of CBD. 

Studies have shown CBDV to have benefits for individuals living with Epilepsy to include reduction in seizure frequency and epileptiform paroxysmal activity, even when looking at pediatric populations. 

The first study to identify anticonvulsant effects of CBDV was published in the British Journal of Pharmacology in 2012. They found that CBDV significantly reduced several seizure types while completely preventing tonic-clonic convulsions. When co-administered with traditional anti-epileptic drugs (AEDs), CBDV was well-tolerated without interacting antagonistically with them. Lastly, researchers looked closely at adverse effects, as many AEDs exert significant, life limiting motor side effects. CBDV’s anticonvulsant actions were due to a direct action on seizures, without causing motor suppression. In conclusion, researchers noted CBDV as a potential standalone AED or as a clinically useful adjunctive treatment alongside other AEDs. 

Ameliorates Autism-Like Behaviors

Due to studies showing CBDV’s ability to reduce motor impairments and cognitive deficits in models of Rett syndrome, researchers published in 2019 the therapeutic potential of CBDV for individuals living with Autism. At intermediate doses, CBDV normalized locomotor activity and improved short-term memory deficits. 

The study showed preclinical evidence to support CBDV to ameliorate behavioral abnormalities resembling the associated symptoms of Autism. Benefits were attributed to CBDV’s ability to restore hippocampal endocannabinoid signaling and neuroinflammation. 

Gut Health

CBDV activates a member of the transient receptor potential channels, which plays a pivotal role in intestinal inflammation. A published study from 2019 investigated the potential of CBDV for ulcerative colitis. This preclinical study showed that CBDV exerted intestinal anti-inflammatory effects in both rodents and pediatrics with ulcerative colitis. It also altered the dysregulation of gut microbiota and lessened cytokine expression. Early studies have also shown CBDV’s potential as an anti-nausea.

Looking to try CBDV?

Just as with many of the other cannabinoids of the cannabis plant, CBDV has been regarded through research as safe and non-intoxicating. Realm of Caring has carefully vetted companies whose formulations offer higher amounts of CBDV, than what you might find in a full-spectrum CBD product. Learn more by reaching out to our dedicated and knowledgeable care team! 

The Joint Judiciary Interim Committee of Wyoming introduced a House Bill Draft to prohibit hemp production and edible hemp products across the state of Wyoming. The plan is to introduce this bill on Tuesday, September 19th, 2023.

This bill (Draft 24LSO-0129v0.4) would prohibit hemp with any detectable amount of THC and prohibit the production of hemp for human consumption. It explicitly states that “no person shall produce, process, possess, purchase, sell, transport or use edible hemp or any edible hemp product”.

Please fill out the below form to urge Wyoming Legislators to block this bill and share this action item with friends, family, associates and social media contacts in Wyoming.

Patient voices are the most impactful. If eliminating hemp product purchasing and use in Wyoming would affect you or a loved one, please consider taking this advocacy effort to protect the safe and responsible CBD product companies.

In addition to using the form, you may contact your local representatives and senators by visiting https://wyoleg.gov/Legislators

September is Healthy Aging month, an annual health observance designed to focus national attention on the positive aspects of growing older. According to Carolyn Worthington, editor-in-chief of Healthy Aging Magazine, “We saw a need to draw attention to the myths of aging, to shout out ‘Hey, it’s not too late to take control of your health, it’s never too late to get started on something new.’ Why not think about the positive aspects of aging instead of the stereotypes and the negative aspects?” Activities for the observed month are designed to encourage individuals to rejuvenate and focus on positive measures that impact areas of physical, social, financial, and mental wellness. 

While working to improve your daily health, natural changes may happen in the body with age that one may want to focus on so you can get to feeling your best. These changes include skin damage from sun exposure, loss of physical strength and muscle mass, and changes in sleep patterns, energy levels, and appetite. In addition, chronic diseases become more prevalent as we age. These include heart disease, diabetes, arthritis, and Alzheimer’s, among others. Here we will discuss further potential benefits that adding cannabis to your routine may bring to potentially help combat some of the more common changes and diagnoses that occur with aging. 

Skin Health

There is a continuous need to seek more efficient, safer, and widely available methods to treat medical conditions, skin pathology included. 

Of the cannabinoids researched to date for skin health, cannabidiol (CBD) is a widespread ingredient in skin care products formulated as body oils, moisturizers, salves, lotions, and balms. Delta-9-Tetrahydrocannabinol (THC), and potentially cannabinol (CBN), may also be responsible for skin benefits such as reducing cytokine production and oxidative stress. Additionally, cannabigerol (CBG) has powerful anti-inflammatory and antibacterial properties that may add benefit to our skin health. 

Hyperpigmentation can take place as a result of melasma, sun exposure, imbalanced hormone levels, or skin conditions such as acne, dermatitis, or psoriasis. CBD has been quoted through research as a powerful antioxidant. Studies have also shown that CBD may help to hydrate dry and irritated skin. The combination of the ability to defend against free radicals and oxidative stress as well as increase moisture, may help to improve discoloration of the skin.

Muscle Mass

A study published in the Frontiers in Public Health examined the exercise habits of over 600 cannabis users. Surprisingly, the study found that cannabis users reported higher levels of weekly exercise compared to non-users. This unexpected correlation suggests that cannabis might play a role in motivating individuals to stay active.

There is indication that cannabis users experienced greater feelings of positive affect, tranquility, and enjoyment during exercise compared to non-users. This suggests that cannabis may enhance the overall exercise experience, making workouts more enjoyable and potentially leading to increased adherence.

Sleep and Energy

In normal aging, the serotonin system shows reduced receptor binding and losses in related functions, such as sleep and its quality. Cannabis Sativa is often used for improved sleep and relaxation, attributed to Indian hemp in the nineteenth century. 

For starters, hemp seeds contain a vitamin B6 content that can trigger the conversion of our body’s tryptophan into serotonin, which can then be converted to melatonin. 

CBD has been researched for its therapeutic potential for sleep disorders through limiting symptoms that may keep us awake at night but also may contribute to an increase in sleep duration and depth, as well as decrease in the anxiety responses induced by sleep disturbance. 

In comparison to CBD, THC has shown in studies as having an effect on mental and physical sedation, even in low amounts. THC also has positive therapeutic benefits that may lead to better sleep.

Cannabinoids CBD, THC, and CBN have been lightly studied for their effects in balancing melatonin production. Cannabinoids are also being studied to better understand the complementary relationship they have with melatonin. Data published in 2022 suggest that a CBD-melatonin formula could be competitive with synthetic-hypnotic drugs (i.e. Ambien, Unisom). The antioxidant activity of melatonin that benefits the brain network coupled with the pain reduction and anti-anxiety effects of CBD promoted a balanced sensation of wellbeing during sleep. 

A qualitative analysis published in 2022 paid close attention to the notable quality of life improvements attributed to medicinal cannabis use. The two overarching categories were “enhanced well-being” and “improved daily functioning”. Enhanced well-being includes feelings such as regaining a sense of hope, enjoying family life, and laughing more often. An adult from the study with Lyme Disease was quoted saying, “People such as myself are able to become productive and valued members of society again when we can have the quality of life improved so simply.” 

Appetite

The Endocannabinoid System (ECS) plays a role with our appetite control – from the suppression of appetite to counter over-consumption to the treatment of conditions that involve reduced appetite and weight loss. This is why cannabinoid receptor antagonists (such as CBD) may manage obesity while agonists (such as THC) may be a therapy option for anorexia. 

Unwanted weight gain may be attributed to poor sleep, lack of physical activity, and nutrition. Therefore the approach to combating this may be a combination of lifestyle changes. 

Cannabinoid therapy may be a part of the equation for its potential to support our overall health and wellbeing. Research points towards cannabinoids as strong candidates for antioxidant, preventative, and recovery benefits. In addition, cannabinoids may decrease stress levels, improve sleep, and benefit metabolic syndrome. 

Cardiovascular Diseases

CBD has been researched for the many ways it may benefit our heart health, some of the most notable therapeutic actions of the molecule are the anti-inflammatory and antioxidant properties. Some cardiovascular conditions and diseases that are associated with inflammation and oxidative stress are diabetes, cardiomyopathy, stroke, arrhythmia, atherosclerosis, and hypertension. The therapeutic potentials of CBD are why it is being considered in research for the prevention and treatment of these conditions and diseases. In addition, CBD has particularly gained momentum because it does not appear to have effects on resting blood pressure or heart rate, rather it has shown in vivo to reduce the cardiovascular response to various stress types. 

Diabetes

Researchers examined the effects of cannabis on glucose regulation and insulin secretion, publishing findings in August of 2023. From this publication, a meta-analysis of 7 studies containing 11 surveys and 4 cohorts revealed that the odds of developing type 2 diabetes in individuals exposed to cannabis was 0.48 times lower than those without cannabis exposure. 

The ECS plays an important role in modulating metabolism and appetite. CBD may help the browning of white adipose tissue (the process of burning fat in the body) and promote lipid metabolism. This may help with the weight gain often associated with irregular menstrual cycles and menopause. Sometimes, this weight gain may lead to Type 2 Diabetes. Being that Type 2 Diabetes is an inflammatory condition, the anti-inflammatory properties of cannabinoids, as well as their ability to prohibit oxidative stress, could help to be a preventative measure. There is also research to show promise of CBD and THCV in reducing insulin resistance and moderating blood sugars. 

Arthritis

Cannabinoids are commonly investigated as pain-relieving agents, but in recent years more evidence has accumulated on their potential immunomodulatory effect, supported by results in animal models of certain rheumatic diseases. While results that demonstrate the same effect in humans are lacking, cannabinoids and cannabis remain potential options to alleviate the pain associated with rheumatic diseases, as they were shown as safe and causing little to no adverse effects. 

We know through research that CBD has a wide spectrum of biological activity, including anti-inflammatory activity. This is why its activity in the prevention and treatment of diseases whose development is associated with inflammation has been tested. In addition, CBD creates a physiological response with several inflammatory mediator receptors within us. These are known as the PPARy, GPR, and Adenosine A2A Receptors. 

The anti-inflammatory contributions of THC are also extensively studied, showing PGE-2 synthesis, decreased platelet aggregation, and stimulation of lipoxygenase, all actions related to reducing inflammation. THC has 20 times the anti-inflammatory potency of aspirin and twice that of hydrocortisone. 

Neurodegenerative Diseases 

A recently published study showed the first attempt in which significant focus has been imparted on all three aspects of cognition: memory consolidation, learning, and retrieval. 

Modern studies have shown that cannabis has numerous beneficial effects in neurodegenerative disorders of Alzheimer’s, Parkinson’s, epilepsy, Huntington’s Disease, multiple sclerosis, and amyotrophic lateral sclerosis. Reports have also shown that cannabis possesses anti-inflammatory, anti-depressant, anti-anxiety, antipsychotic, and anti-schizophrenic effects. 

Oral administration of CBD, in one study, improved the cerebral blood flow to the hippocampus and regions associated with memory advancement, indicating improved overall memory function, and building the case to perform further studies with CBD for neurological impairments.

Finding Support

There is a lot to consider when starting cannabinoid therapy but, as always, a Realm of Caring care specialist is here to help with free one-on-one support to answer your questions. Contact us today by calling (719) 347-5400 or by emailing info@realmofcaring.org.

Leaves are changing colors, and parents all around the country are gearing up for the much-anticipated back to school season. This can be an exciting but often hectic time of year for parents and guardians! For those who are cannabis advocates, and either use it themselves or administer it to their children, this can be its own unique experience to navigate, specifically with the surrounding stigma. 

One of the most misunderstood aspects of being a CannaMom or Dad is when either parent or child consume cannabis. With laws and regulations constantly changing, plus outdated stereotypes due to lack of understanding, this can feel all the more overwhelming when you mix in places of education and other parents and their children.

Whether you’re here to simply learn more about this topic or are a parent seeking further reassurance, we’re here to help break down the ins and outs of going back to school as a CannaMom or Dad so you can do so with confidence.

Navigating Back-to-School Stress with Cannabis

As a parent, this time of year can feel exceptionally hard to manage. Parents who choose to use cannabis may do so for a variety of reasons unique to their needs, including:

• Stress Relief: The juggling act of school schedules, extracurricular activities, and daily household duties can be overwhelming. Cannabis can help to unwind and reduce stress, making it easier to tackle responsibilities.

• Pain Management: Many moms deal with chronic pain, whether from past injuries, childbirth, or the physical demands of parenting. Cannabis’ pain-relieving properties can provide much-needed relief.

• Creativity and Relaxation: Cannabis can enhance creativity and help to find moments of relaxation amid the busy school year. It can also foster deeper connections with our children and partners.

De-stigmatizing Canna Parents

The stigma surrounding CannaMom and Dads is a persistent challenge. Many still associate cannabis use with irresponsible parenting or illicit behavior, when this is absolutely not the case. It’s time to challenge these stereotypes and recognize that CannaMom and Dads are just like any other parents, but with a unique approach to self-care and wellness. Whether you are doing so for yourself, or a loved one, here are ways you can challenge the stigma:

• Education: We must start with education—understanding the science behind cannabis, differentiating between CBD and THC and other cannabinoids, and recognizing their respective benefits and responsible use.

• Open Conversations: Parents who consume cannabis should feel comfortable discussing their choices with friends, family, and healthcare professionals. By sharing our experiences and insights, we can help normalize these conversations.

• Advocate for Regulation: Advocating for sensible cannabis legalization and regulation is essential. A regulated market ensures product quality and safety, making it easier for CannaMom and Dads to access reliable cannabis products.

CBD for Children

CBD, short for cannabidiol, is a non-psychoactive compound found in cannabis that may offer numerous therapeutic benefits for kids, including:

• Anxiety Relief: Starting a new school year can be overwhelming for children. CBD can help reduce anxiety, allowing them to face the challenges of school with more confidence.

• Focus and Concentration: Some children struggle with attention and focus in the classroom. CBD may aid in improving these aspects, enabling them to engage more effectively with their studies.

• Pain Relief: For kids dealing with chronic pain, CBD can provide relief, allowing them to participate fully in school activities.

• Seizure Control: For children with epilepsy or who suffer from seizures, CBD can be a vital piece of their medical treatment. 

Whether a child is a medical cannabis patient is up to the parent to decide. For those parents who do require it, we understand what a big responsibility it is to advocate for your children. If you are currently navigating how to administer your child’s medicine throughout the school day, we are here to help.

On-Campus Administration 

Back to school for students who are medical cannabis patients can be a challenging time if their medicine is taken throughout the day. Under most state laws, a medical cannabis card or recommendation for pediatrics does not permit the use of medical cannabis on school grounds, on a school bus, or at a school activity unless the county or district has adopted a policy permitting the use.

There are few exceptions in states such as Colorado. In 2021, legislation passed that required school boards to implement policies which would allow possession and self-administration of non smokable medicinal cannabis if prescribed by a licensed health practitioner. However, there are stipulations to these rulings. For example, in Colorado, districts are not required to adopt this policy if the school district loses, or will lose, federal funding as a result of implementing the requirement.

As it stands, along with Colorado, California, Delaware, Florida, Illinois, Maine, New Jersey, New Mexico, and Washington have passed similar measures to allow medicinal cannabis use on school grounds. If your child is a medical cannabis patient, it is always best to check in with your school district on their cannabis policy. If you find that their dose needs to be adjusted, a Realm of Caring care specialist is just a phone call away to assist. 

Embracing Differences

As the back-to-school season unfolds, we encourage you to remember that CannaMom and Dads are ordinary parents with unique self-care choices. They are just as wonderful parents as any other, who simply believe in the benefits of cannabinoids for their children and for themselves, while still being committed to responsible use. It is possible for a healthy balance between parenthood and cannabis consumption to be maintained!