Category: Blog

The menopausal transition most often begins between ages 45 and 55, and usually lasts around 7 years, but can be as long as 14 years. Perimenopause and menopause can cause a number of symptoms that greatly affect quality of life. During this time, hormones go haywire, temperature regulation becomes more difficult, and mental clarity vanishes. Some symptoms may cause discomfort and others may leave women feeling emotionally unstable. As a result, an increasing number of women are turning to cannabis to alleviate menopause-related symptoms, according to new survey data. 

 

86% of participants reported presently using cannabis, and 78% endorsed the use of medical cannabis for symptoms associated with menopause, e.g. hot flashes, sleep disturbance, mood changes and vaginal dryness or pain. The top related symptoms women reported treating with cannabis in the survey were sleep disturbance and mood or anxiety issues. A majority of the participants smoked cannabis for their symptom relief (84%), while 78% reported they used edibles to treat ailments. 

 

Previous surveys, such as those here and here, have estimated that one-third of women consume cannabis for purposes of managing menopause-related symptoms. 

 

Some effects of perimenopause (e.g. depression, anxiety, mood swings, lower libido, and difficulty sleeping) may happen in response to lower levels of estrogen. Estrogen is an important part of the endocannabinoid system because it regulates fatty acid amide hydrolase (FAAH) and is responsible for breaking down certain endocannabinoids. This is why extra doses of cannabinoids, such as those received when using medical cannabis, may help with common menopause symptoms.

 

A primary cause for sleep disturbance during the menopausal transition is hot flashes, and one of the biggest triggers of hot flashes is anxiety. “When a woman finds herself in a high-stress moment, she may start to sweat and flash,” says Dr. Melanie Bone, Ob-Gyn. “This is often ameliorated with cannabis. I find that higher-CBD products are best to reduce anxiety, but years of practicing have taught me that every patient is unique and there are women who respond best to higher doses of THC to help mitigate anxiety.”  

 

While cannabis is often used to treat anxiety across a number of ages, there is a specific science behind the benefits among menopausal women. Our amygdala is the region of the brain considered the integrative center for emotions, behavior, and motivation. During menopause, these are especially heightened, and cannabis helps to suppress the negative responses, causing less anxiety and depression.

 

Products like cannabis-powered vaginal suppositories and topicals have also been mentioned by women to provide soothing relief for issues of vulvar dryness. Why choose a suppository? Unlike edibles, which go through the digestive system and become metabolized before entering the bloodstream, suppositories surpass the digestive tract and liver, and solely depend on body temperature in order to be absorbed by the surrounding skin. In addition, the female reproductive system has its own cannabinoid receptors that can interact with the suppositories.  This eliminates the variables of body weight, metabolism speeds, and stomach contents that come into consideration with edibles.

 

There are also other factors to consider, such as whether to treat symptoms with THC or CBD. THC can act as a sedative for some, while others report stimulating effects, particularly for those who are new cannabis users or take greater amounts. In these instances, the THC could cause further sleep disruption, whereas CBD, especially taken in larger doses, may induce sleepiness. 

 

Presently, there have been no peer-reviewed clinical studies of women in menopause using cannabis and so there is currently no one-size-fits-all approach, or can it be considered a proven therapy for menopause. This goes the same for replacing Hormone Therapy completely with cannabis to treat menopause symptoms. Some doctors report a dose reduction in hormones in a lot of women who use cannabinoids, and others urge cannabis be used in conjunction with hormones for best results. 

 

As with any cannabis treatment, effective dosing varies widely by individual and condition. Our specialists at Realm of Caring are here to help you find a product and dose that works for each of us! If you would like to reach out to our Care Team (719-347-5400 option 1), they would be so happy to help you individualize your therapy and find a product that is right for you.

Palliative Care can be defined as an approach that improves the quality of life of patients (adults and children) and their families who are facing problems associated with life-threatening illness. It prevents and relieves suffering through the early identification, correct assessment and treatment of pain and other problems, whether physical, psychosocial or spiritual.

 

The majority of adults in need of palliative care have chronic diseases such as cardiovascular diseases (38.5%), cancer (34%), chronic respiratory diseases (10.3%), AIDS (5.7%) and diabetes (4.6%).

 

Pain and difficulty in breathing are two of the most frequent and serious symptoms experienced by patients in need of palliative care. The search for therapeutic strategies is ongoing as poor symptom control and/or intolerable adverse effects are attributed to opioids and other medications currently utilized among palliative care patients.

 

Current guidelines

 

It has been stated by Dr. Claude Cyr that “if we are going to integrate cannabis products into medicine, palliative care is the best port of entry”.

 

Integrating cannabinoid based therapies into palliative care has been delayed by limited clinical research data, little knowledge in dosing guidelines, conflicting regulation, and stigma. Surveys in recent years have shown that a decent majority of US oncologists view cannabinoid therapies as a helpful adjunct to standard pain management strategies. In 2019, the Dutch government agreed to fully reimburse medical cannabis for terminally ill patients. 

 

There is a disconnect between substantial research and interest by patients and families, making it difficult for healthcare professionals when it comes to recommendations and support. Because of this, there is a sense of urgency to understand the pharmacology, mechanisms of action, and available research to support cannabis use in these circumstances. 

 

Pain

 

Definition of clear, clinical objectives with patients and their families is incredibly important among palliative care. The focus is often pain. 

 

Cannabis use for pain can be traced back thousands of years. Observationally in research, the response to pain in individuals has been favorable when compared to baselines or controls. 

 

A review of literature published through June 2017 examined trials regarding cannabinoid use for pain in patients with neuropathy and malignant diseases. Out of 18 trials, 15 demonstrated a significant analgesic effect of cannabinoids as compared to placebo, the reduction in pain intensity was considered clinically significant. The most commonly reported adverse effects were well tolerated. 

 

To date, however, the widespread use of medical cannabis is still controversial even in palliative care settings mostly because the plant may produce both therapeutic and psychoactive effects. There is strong evidence suggesting that the non-intoxicating cannabinoids, such as cannabidiol (CBD), can also alleviate chronic inflammation and pain in animals. CBD has been characterized as an ideal therapeutic agent for inflammation and neuropathic pain as it may suppress both without causing significant intoxicating side effects or analgesic tolerance. 

 

Difficulty breathing

 

This is another topic of major concern among the palliative care population. Based on the neurophysiology of labored breathing and the distribution of cannabinoid receptors within the central nervous system, it has been hypothesized that the unpleasantness of breathlessness will be relieved in humans by cannabinoids. Observational studies have shown some promise among individuals with Chronic obstructive pulmonary disease (COPD). However, there is still a need in clinical trials to observe significantly positive or negative effects on airway function and exertional breathlessness in adults. 

 

Other Symptoms

 

Many patients in palliative care may want to address other common symptoms at end of life, such as anxiety, depression, nausea, anorexia, or insomnia, which may all be relieved by cannabinoid therapy. Others may be looking to reduce or stop altogether certain medications, specifically opioids with serious adverse effects. 

 

An Israeli study published in 2018 on cannabis use in nearly 3,000 cancer patients showed significant improvement in the control of common symptoms other than pain, including sleep disorders (70.8%), fatigue (55.9%), anxiety and depression (74.1%) and nausea and vomiting (54.7%). 18.7% reported a good quality of life prior to treatment initiation while 69.5% reported good quality of life after 6 months. 

 

These findings align with published results from Realm of Caring’s observational research registry, where cannabis users self-reported significantly better quality of life, greater health satisfaction, improved sleep, lower average pain severity, lower anxiety, and lower depression compared with controls. Therefore, cannabinoid therapies may be beneficial across a broad range of symptoms realized in palliative care settings, beyond pain management. The argument may then be made that the role of cannabinoid therapy should not only be under consideration for a palliative care setting, but earlier in the course of palliative care strategy. 

 

Preclinical evidence and case studies have shown the potential for cannabinoids to have disease-modifying effects. Several studies have demonstrated their anti-tumoral, anti-inflammatory, and neuroprotective properties, for example. However, more clinical research is necessary to provide evidence necessary to fully support disease-modifying effects.

 

Opioid-sparing effects

 

When it comes to pain management, opioids in particular have considerable side effects, including constipation, impaired sleep, and respiratory depression. In recent decades, we have witnessed an increase in the prescription of opioids – therefore an increase in opioid use disorders and opioid-related mortality. Therefore, the need has increased to discover combinations of medications that complement each other’s actions for maximizing pain-alleviating responses to allow lower doses of each. The endocannabinoid system represents an ideal target because it is a key endogenous system in modulating pain-processing pathways. 

 

It has been observed that CB2 receptors indirectly stimulate opioid receptors located in the central nervous system. Therefore, in addition to having direct pain-relieving effects on their own, cannabinoids may work synergistically to enhance opioid effects. 

 

A published review looked at 28 studies providing data relating to the potential opioid-sparing effects of cannabinoids in the context of pain management. Most of the pre-clinical studies examined reported reduced opioid requirements when co-administered with cannabinoids. Two controlled clinical studies found no effect of cannabinoids on opioid dose requirements. One case provided low quality evidence and few controlled clinical studies measured opioid sparing as a goal, so findings relating to pain management were mixed. Controlled clinical studies demonstrated some beneficial effects of co-administration on outcomes of pain, sleep, and functioning in chronic pain patients. 

 

Despite the potential for cannabinoids to reduce opioid dose requirements and extend pain relieving effects, it is recommended that increased studies be carried out and observed as there is inconsistent data thus far. Future study considerations should carefully document adverse effects from co-administration to better understand potential harms and examine dose range and tolerability.

 

Spiritual and Existential Suffering

 

Cannabinoid therapy approaches may offer unique potential benefits known more through traditional medicinal and cultural uses and shown through anecdotal reports from patients and caregivers. Mild euphoria, sensory enhancement, and overall sense of well-being could play an important therapeutic role for patients faced with the despair of terminal conditions and the loss of function that tends to accompany it. 

 

Patient’s right to access

 

In cases where individuals expect medical cannabis to be presented as a strategy for their advanced health condition, this leads into a topic of palliative care that deserves to be mentioned: personal autonomy in medical decisions for alleviation of pain and suffering. The facilitation of a patient’s right to access experimental treatments and therapies in line with their wishes and beliefs, is something to be considered as research continues to evolve in this specific area of care.

 

Questions that remain

 

Finding support with cannabinoid therapy and palliative care can be difficult, but that is where Realm of Caring may step in to help. Our care specialists are trained to help with product and practical administration suggestions – whether you be an experienced user or novice. In general, cannabis is safe but responsible use and guidance, as well as oversight by a healthcare professional, are always recommended. We are here to help start and facilitate those conversations along the way through these extremely difficult times. 

 

If you want to reach out to our care team to discuss anything cannabinoid therapy related one on one – we are here for you! You can call our free hotline at 719-347-5400, email info@realmofcaring.org, or schedule an appointment. 

 

What is Polycystic Ovarian Syndrome? 

 

The U.S Department of Health and Human Services (HHS) defines Polycystic Ovarian Syndrome (PCOS) as a lifelong hormonal and metabolic imbalance. This condition affects approximately 5-15% of people with ovaries, after the onset of puberty and persisting beyond menopause (Walker et al., 2019). Most people diagnosed with PCOS experience menstrual cycle irregularities, abnormally high levels of androgen hormones and ovarian cysts. The risk of developing PCOS is higher for people that are obese, and for those with a family history of the PCOS (HHS, 2017). 

 

People often go undiagnosed until they experience infertility. Most symptoms are complex issues that need a variety of different treatments. People with the ability to become pregnant that desire to do so, should disclose that information to their health care provider in order to develop the most suitable treatment plan, and avoid anything that may contribute to infertility or cause harm. PCOS presents with a multitude of signs and symptoms, some of these may include (Walker et al., 2019): 

 

• Ovarian cysts 
• Infertility 

○ PCOS is the leading cause of infertility 

○ It is still possible to become pregnant with PCOS 

• Metabolism syndromes 
• Abnormally heavy periods 
• Amenorrhea (no menstrual periods) 
• Oligomenorrhea (infrequent periods) 
• Anovulation (absence of ovulation, bleeding may still occur) 
• Obesity, weight gain, and/or difficulty losing weight 
• Hirsutism (excess hair typically on the face, chest, belly, and upper thighs)
• Pelvic pain, ranging from tolerable to debilitating 
• Severe and persistent acne 
• Excessively oily skin 
• Inflammation 

 

Furthermore, the Centers for Disease Control (CDC) and HHS claim that people who have PCOS are at an increased risk for: 

 

• Stroke 
• Miscarriage 
• Insomnia 
• Gestational and Type 2 Diabetes 
• Cardiovascular Disease 
• Obstructive Sleep Apnea 
• Endometrial hyperplasia 
• Endometrial cancer 
• Thinned scalp hair and baldness 
• Mood disorders including depression and anxiety 

 

The Endocannabinoid System (ECS) and Hormones in PCOS

Research suggests that the endocannabinoid system of someone with PCOS may be dysfunctional (DiBlasio, 2013). The endocannabinoid system regulates homeostasis and is involved in regulating appetite, food intake, and glucose metabolism. The ECS can affect ovarian function by modulation of pathways involved in homeostasis and metabolic regulation (Juan et al., 2015). 

 

Obesity is associated with menstrual irregularities, including oligomenorrhea and anovulation, and infertility (Juan et al., 2015). Many people with PCOS also suffer from insulin resistance, causing increased androgen production, increased appetite, and acanthosis nigricans, a condition that presents thickened and darkened patches of skin in certain areas especially in any folds or creases (HHS, 2017). The ECS may influence insulin resistance and obesity (Walker et al., 2019). Limited data from research using animal models suggests a relationship exists between obesity and the dysregulation of the main endocannabinoids produced by the body, N-arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) (Maccarrone, 2005). 

 

Many of the most common PCOS symptoms are due to increased androgen and low estrogen hormone levels. An excess of androgens may lead to cyst formation in ovarian follicles, increased hair growth and acne on the face and body, and may even interfere with brain signals that initiate ovulation. It should be noted that not every person with PCOS develops ovarian cysts (Walker et al., 2019). 

 

Data from a PCOS and ECS centered study using non obese participants suggests the menstrual cycle’s proliferative and secretory phases show a significant reduction of fatty acid amide hydrolase (FAAH) levels in the endometrium of infertile participants with PCOS, compared to infertile participants without PCOS (Cui et al., 2016). FAAH is an integral enzyme involved in metabolism of endocannabinoids AEA and 2-AG. The absence of these catabolic reactions involved in degradation, suggest that high levels of AEA may be indicative of PCOS (Cui et al., 2016). Lack of endocannabinoid degradation causes high endocannabinoid levels and insulin resistance, often causing hepatic stress and injury (Luschnig, 2019). A study using non obese participants with PCOS found that a combined treatment of antiandrogens, antiestrogens and an oral hypoglycemic, significantly reduces high AEA levels (Cui et al., 2016). 

 

The cause of PCOS is unknown but science suggests that both genetic and environmental factors contribute to the development of the disease. Dysregulation of the ECS is also involved (Luschnig, 2019). PCOS is incurable but some options for treatment may include cannabinoid therapy by balancing the ECS to provide relief from pain and inflammation. Additionally, lifestyle changes including weight loss, oral contraceptives, insulin sensitizing agents, antiandrogens, hair removal and acne treatment may be incorporated. 

 

As always, we recommend speaking with a licensed medical professional before starting a new cannabis regime. To learn more about the potential benefits of cannabinoid therapy, please reach out to a member of the Realm of Caring team! 

 

By: Jazmin Oliver / Cannabis Science Consultants

 

References 

1. U.S Department of Health and Human Services (HHS). Polycystic Ovary Syndrome (PCOS). Jan 2017. https://www.nichd.nih.gov/health/topics/pcos.
2. Centers for Disease Control. PCOS (Polycystic Ovary Syndrome) and Diabetes. March 2020. PCOS CDC.
3. Cui, N. et al. Decreased Expression of Fatty Acid Amide Hydrolase in Women with Polycystic Ovary Syndrome. Gynecological Endocrinology. Sept 2016. Doi: 10.1080/09513590.2016.1269742.
4. Cui, N. et al. Restored Plasma Anandamide and Endometrial Expression of Fatty Acid Amide Hydrolase in Women With Polycystic Ovary Syndrome by the Combination Use of Diane-35 and Metformin. Clinical Therapeutics. April 2017. Doi: 10.1016/j.clinthera.2017.02.007. 
5. DiBlasio, A. et al. The Endocannabinoid Pathway and the Female Reproductive Organs. Journal of Molecular Endocrinology. Feb 2013. doi: 10.1530/JME-12-0182.
6. Duma, M. Is Cannabis a Natural PCOS Treatment? We Asked an Expert. Sept 2018. Leafly.
7. Juan, C. et al. Endocannabinoid System Activation may be Associated with Insulin Resistance in Women with Polycystic Ovary Syndrome. Fertility and Sterility. July 2015. doi: 10.1016/j.fertnstert.2015.03.027.
8. Luschnig, P. et al. Cannabinoids in Gynecological Diseases. Journal of Medical Cannabis and Cannabinoids. May 2019. doi: 10.1159/000499164.
9. Maccarrone, M. et al. Up-regulation of the Endocannabinoid System in the Uterus of Leptin Knockout (ob/ob) Mice and Implications for Fertility. Molecular Human Reproduction. January 2005. doi: 10.1093/molehr/gah130
10. Walker, O. et al. The Role of the Endocannabinoid System in Female Reproductive Tissues. Journal of Ovarian Research. Jan 2019. doi: 10.1186/s13048-018-0478-9.

 

 

The link between cannabis use and the development of a psychotic disorder is a controversial topic and often misrepresented in research. While there is consideration among the medical community of a causal relationship between exposure to chronic cannabis and the development of psychosis, there is also a frequent co-occurrence between serious mental illnesses and cannabis use. Therefore, it is difficult to determine if there is a definitive cause and effect. 

 

What we are aware of is that there is a resemblance between euphoria as both a byproduct of psychosis and from consuming cannabis that has high concentrations of specific intoxicating cannabinoids.

 

Euphoria and Psychosis

 

Euphoria can be described as a heightened, exaggerated, or extremely positive sense of happiness or well-being. This experience has been witnessed among those who suffer from psychiatric disorders such as schizophrenia and bipolar depression. In this context, euphoria may coexist with additional symptoms such as restlessness, hallucinations, confusion, paranoia, disorientation, and/or mood swings. 

 

THC and Euphoria

 

Cannabis has several mechanisms of action within the body. When the cannabis consumed contains high amounts of delta9-tetrahydrocannabinol (THC), it has been shown to produce euphoric effects in some cannabis users (it is important to note that every individual may have a different experience). Additional psychotropic and somatic short-term side effects that have been experienced by cannabis users may include anxiety, perceptual changes, disorientation, nausea, and/or headache. These intense experiences when consuming large amounts of THC could be defined as acute psychosis. 

 

Research is still uncovering exactly what is happening while the euphoric effects take place. What we do know is that there is a high binding affinity of THC with the CB1 receptors that are densely present in the brain and appear to mediate changes in mood, consciousness, memory processing, and more.

 

It is worth noting that the effect THC may have on any one individual is both dose-dependent and the administration method should be considered. Inhaled cannabis versus oral consumption may produce very different effects. Once processed by the liver, there is potential for a more powerful experience. Our care team is available to you with free one on one support in determining a product, administration, and dose. 

 

THC and CBD use

 

Cannabidiol (CBD) has been shown to have anxiolytic and antipsychotic effects, therefore may offset some adverse effects of THC.

 

In addition to CBD’s researched benefits, there is a molecular mechanism by which CBD may block THC-related side effects. CBD has shown in animal models to block the role of a molecule in the brain’s hippocampus called extracellular-signal regulated kinase (EKR), which triggers the neuropsychiatric effects of THC. If THC cannot overstimulate the ERK pathway, then negative side-effects may be prevented. 

 

Vulnerable populations 

 

Severe or persistent psychotic reactions to THC are rare, dose-related, and are more likely to occur in individuals with a preexisting psychiatric condition. Self-reported studies have suggested that those with schizophrenia use cannabis to mitigate negative symptoms ranging from social anxiety to side-effects of antipsychotics. Those who are psychosis-prone may be more likely to experience positive, negative, and cognitive symptoms to a greater degree relative to healthy individuals. While it is hypothesized that this is due to cannabis’ effects on dopamine, Gamma-aminobutyric acid (GABA), and glutamatergic neurotransmission; the precise mechanism is yet to be discovered. 

 

How do I know if I am psychosis-prone?

 

Medical research points to genetics for determining if we may be prone to a psychotic disorder. Certain mental illnesses tend to run in families, however even if a close family member has a diagnosis, it does not necessarily mean you will develop one. There are resources in the cannabis community that may also help. For example, a DNA report may predict which individuals are most likely to develop schizophrenia; however, knowing if you have a specific gene variant does not mean you are destined to develop any one disease. What this testing does do, is allow you to make informed decisions for your health based on conditions you may have a predisposition to. 

 

Is there a confirmed link? 

 

The short answer is no. Despite some support through research for a causal hypothesis between cannabis use and psychosis, most individuals who use cannabis do not develop a psychiatric disorder and most individuals with a psychiatric disorder have never used cannabis. As it stands in research, the link between cannabis use and developing a psychiatric disorder is not confirmed. It is becoming more clear that cannabinoids may produce symptoms associated with psychosis in healthy individuals and possibly exacerbate symptoms in those diagnosed or with a predisposition to a psychiatric disorder. 

 

While struggling with any condition, it is important to talk with a medical professional about your options. Complementary therapies and a strong focus on wellness may improve cannabinoid therapy results as well as decrease symptoms further. If you would like to discuss more about the potential benefits of cannabinoid therapy, please reach out to our care team!

 

 

 

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Disclaimer

 

 The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. The products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

 

 The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

 

Legislation that would finally get the FDA to regulate hemp extracts like CBD has been a topic of much debate within the cannabis industry. Failure to legally recognize and regulate the sale of CBD products has caused immense struggles for hemp farmers, small businesses, and consumers alike. This has caused a number of issues, from economic hardships for farmers, to quality control and a decline in hemp prices. The bill in question is H.R. 841, presently sitting with the U.S. House of Representatives.

 

What is House Bill H.R.841?

 

Introduced by Representative Kurt Schrader [D-OR] and Morgan Griffith (R-VA), house bill H.R. 841, The Hemp and Hemp-Derived CBD Consumer Protection and Market Stabilization Act, would allow “the use of hemp, cannabidiol (i.e., CBD) derived from hemp, or any other ingredient derived from hemp in a dietary supplement, provided that the supplement meets other applicable requirements.” Presently, the FDA does not allow CBD products to be sold as dietary supplements, and this bill would permit CBD to be marketed as such.

 

The Argument for CBD as a Dietary Supplement

 

Lawfully marketing hemp-derived CBD and other non-intoxicating hemp ingredients as a dietary supplement would bring a number of important benefits to the industry and consumers alike. With a wide range of powerful medical benefits, many people rely on CBD for its treatment options for a variety of ailments. Studies suggest CBD can benefit in the offset of anxiety and depression, treatment of epileptic seizures, reduce PTSD symptoms, aid irregular sleep patterns, and so much more. 

 

To pass, H.R. 841 would protect consumers by ensuring access to top quality CBD products. For years, hemp farmers have been faced with regulatory uncertainty, causing many issues for the manufacturing of CBD products. Economic hardship has caused some small businesses in the industry to cut corners, producing hemp products that are not suitable for market, and yet all the same are available for sale. 

 

Those who oppose H.R. 841 argue that it would cut short the FDA’s current efforts and create an unsafe CBD market. However, this couldn’t be further from the truth. Jonathan Miller, general counsel to the U.S. Hemp Roundtable, explains: 

 

“They’re arguing that if this bill passes that there would be unsafe CBD products in the marketplace. And it’s just the opposite. There are currently unsafe products in the marketplace because there is no regulation. And that’s why we so desperately need 841, which would provide for an existing regulatory regime for dietary supplements to govern the manufacture of CBD products.”

 

Strict quality control is extremely important in the cannabis industry. A variety of methods of consumption and rise in popularity leaves many opportunities for unsafe products to exist on the market, and so “a multitude of CBD products continue to be sold, some of which raise significant quality, safety and other consumer protection concerns” (U.S. Hemp Roundtable). While consumers can make choices to protect themselves at the time of purchase, there is a lack of widespread knowledge to these options. It is up to the manufacturers to to produce quality products. The Hemp and Hemp-Derived CBD Consumer Protection and Market Stabilization Act would ensure exactly that is happening, giving the FDA more tools to oversee the market bringing greater confidence to CBD products available to consumers.

 

Not only that, but H.R. 841 would help to stabilize the hemp markets, bringing profitability to a hurting industry. Most leading companies are struggling with growth and profitability, as a skyrocketing hemp supply depressed prices. Many hemp advocates believe these hardships to be a direct result of the FDA not allowing the sale of CBD as a food product or dietary supplement. This prevents many brands from selling CBD products, creating both a production and profit decline. Without a demand, prices crash, and thus the industry needs H.R. 841 to pass.

 

We’re All in This Together

 

Unfortunately, while the CBD industry is in favor of H.R. 841, many in the cannabis industry oppose it. It is crucial that this not become a CBD vs. THC issue, and rather is understood as patients vs. ongoing government restrictions. 

 

The 2018 Farm Bill was passed with the intent to allow access to hemp in all 50 states. Hemp is defined as any cannabis plant, or derivative thereof, that contains not more than 0.3 percent delta-9 tetrahydrocannabinol (“THC”) on a dry-weight basis. Prior to the enactment of this bill, the Controlled Substances Act did not differentiate between cannabis and hemp. However, in these past 4 years the two became their own respective industries. 

 

Despite being defined, CBD remains vulnerable to state regulations that may inhibit consumer access. Certain states are attempting to regulate hemp and cannabis together, rather than acknowledging they are two separate industries. Placing them in the same category may have damaging effects on those who have been using a quality hemp product as their medicine for years now. A hemp product that is in the supply chain could be easily removed if, for example, a THC potency cap was placed as a milligram per container in addition to the original 0.3% limit. The FDA regulating the products derived from hemp may provide and ensure access to all consumers – following through with the intentions of the 2018 Farm Bill. 

 

When it comes down to it, this is not a CBD vs THC industry issue. This is about the individuals who are using these therapies as their medicine and standing behind legislation that supports their access.

 

The time to take action is now! If you are a CBD consumer, know someone who benefits from its use, or are passionate about advocating for the consumption we urge you to support the H.R. 841 efforts. Our friends at the U.S. Hemp Roundtable have created an easy to use form so that you can write your Congressperson and either ask that they co-sponsor H.R. 841 or thank them for signing on. You can help further by encouraging your friends and family to fill out the form, and spread the word by sharing this educational blog across your social media channels.

As cannabis legislation continues to evolve, new consumers are entering the market daily. With cannabis consumption comes the question: what product do I use and what is the best way to consume it? While our care team is here to help you with product suggestions specific to your ailment, this blog is here to help you with cannabis devices for smoking. Quality is what we value – from the support you receive, to the product you use, to the device you administer your product with – we only want to recommend the best for you. 

 

This is why we have created this short resource guide for cannabis consumption and devices – because the quality of your product matters, so do the accessories for your cannabis. 

 

First let’s talk about consuming your cannabis. What is the best way? 

 

Cannabinoid therapy truly requires an individualized approach. How you choose to consume may be best determined by the ailment you are seeking relief from as there may be pros and cons to every method. 

 

If you choose to consume flower – where do you start on a device? At Realm of Caring, we value companies who also value education, transparency, excellent customer service, and overall quality. 

 

Not sure what a bubble cap is? No need to worry, CannaDevices has you covered. From handpipes to nectar straws, CannaDevices creates beautiful, safe, handmade glass devices and educates you. For example, they explain why it is important to understand where your product was manufactured. Imported glass may contain toxic chemicals and/or paint that mimics colored glass. As well, glass products may have “glass dust” left behind from where holes were drilled, this is potential residue you do not want to inhale. 

 

If you’re seeking a more simple, cost effective option look for ethically sourced and environmentally-friendly rolling papers. The Consumer put together a list of the healthiest paper alternatives that are clean and sustainable, meaning no bleaches or harmful additives. 

 

How do you store your cannabis? 

 

A dad concerned that his kiddos might find or get into his medicine asked the same question. This is why he created Stashlogix, cases and bags with smell proof technology. They serve responsible consumers looking for high quality thoughtful, secure, and discreet products. In addition to trapping and absorbing the odor of your cannabis, most products have an integrated 3-digit combination zipper lock and are shipped to you straight from Colorado.

 

How do you keep your cannabis devices clean? 

 

Leaff carries quality, elegant pieces to fit your lifestyle to speak to the uniqueness of each cannabis consumer. They also educate on best practices like how to keep your devices clean to increase the lifespan of your accessories. If you are going to invest in a tourmaline quartz pipe, you’ll want to make sure you can treasure it for years to come. 

 

Sanitary devices like the Moose Labs MouthPeace have also been devised to dramatically decrease the spread and amount of bacteria on your devices. Made from biodegradable and recycled materials, they also help to enhance your experience by removing resins, contaminants, and tar without reducing the airflow. 

 

If you are new to the cannabis space, it doesn’t have to be intimidating. Our care team is here to support you on your journey. Reach out by emailing info@realmofcaring.org or calling (719) 347-5400, option 1. 

 

Image courtesy of CannaDevices

Endometriosis is a severe and often debilitating chronic inflammatory condition. It affects approximately 10% of reproductive aged people (190 million) with a female
reproductive system on a global scale (World Health Organization, 2021). This condition is defined by endometrial glands, stroma, or other cells found growing outside of the uterus, in locations such as on the ovaries or on the pelvic peritoneum.

 

Endometriosis is characterized by pain (often severe), infertility, psychological distress and fatigue, dysmenorrhea (menstrual cramps), dyschezia (constipation), dyspareunia (painful intercourse), dysuria (painful urination), and chronic non-menstrual pelvic pain. In addition, comorbidities often include bladder pain or irritable bowel syndrome.

 

Over 95% of cases with deep infiltrated endometriosis report suffering from extreme levels of pain. Furthermore, symptoms can begin as early as adolescence and have a negative impact on the developing brain.

 

Since a definitive diagnosis requires surgery, many go undiagnosed for some time after symptoms begin. With many variables and pathways involved, the exact cause of endometriosis is mostly unknown. The general belief is that a combination of hormonal, immunological, and neurological factors contribute to the disease’s development. There is no cure available today, only symptom management.

 

The endocannabinoid system (ECS) plays an important role in the mechanisms involved in endometriosis development, disease maintenance and pain. The ECS is also involved in the immune response, and demonstrates antiproliferative and antifibrotic effects.

 

CB1 receptors are highly expressed in the uterus, whereas both CB1 and CB2 receptors are highly expressed in human oocytes. One of the main enzymes of the endocannabinoid system, Anandamide (AEA), is found in the fluids of the female reproductive tract and ovaries. AEA plays an important role in several key functions including folliculogenesis, preovulatory follicle maturation, oocyte maturation, and ovulation.

 

In terms of current scientific research regarding cannabis and endometriosis, there is a fair number of studies available with promising results. Currently, there are only two trials exploring the use of cannabinoids as a treatment for endometriosis pain, NCT03875261 and NCT04527003 (National Institute of Health, 2022).

 

The current therapeutic options available for endometriosis patients include diet changes, surgery, and pain relieving or anti-inflammatory medications. Unfortunately, these options are associated with severe unwanted side effects, high rates of recurrence and only seem to provide limited efficacy.

 

Cannabinoids are commonly used by chronic pain patients and many people with endometriosis are turning to cannabis for relief. Varied expression of cannabinoid receptors, enzymes, and endocannabinoids will affect how a person responds to treatment.

 

Cannabis has the potential to serve as a therapeutic option for those seeking a more natural treatment, with significantly less side effects than current pharmaceutical therapies. While the ECS has great potential to act as a promising target for treatment of endometriosis, it is important to note that the biphasic effects of the cannabinoid D9-THC may result in undesired outcomes. Lower concentrations of this cannabinoid may increase cancer cell proliferation, but at higher concentrations D9-THC has shown to decrease cancer cell proliferation. This presents as one of the biggest issues for people attempting to determine proper dosage from home.

 

As always, we recommend speaking with a licensed medical professional before starting a new cannabis regime. To learn more about the potential benefits of cannabinoid therapy, please reach out to our care team!

 

 

By: Jazmin Oliver / Cannabis Science Consultants

 

 

Citations 

 

1. Andrieu, T, Chicca, A. Pellegata, D., Bersinger, N., Imboden, S., Nirgianakis, K., Gertsch, J., Mueller, M. Association of endocannabinoids with pain in endometriosis, PAIN: January 2022 – Volume 163 – Issue 1 – p 193-203. doi: 10.1097/j.pain.0000000000002333
2. Bouaziz J, Seidman DS, Soriano D. The Clinical Significance of Endocannabinoids in Endometriosis Pain Management. Cannabis Cannabinoid Res. 2017 Apr 1;2(1):72-80. doi: 10.1089/can.2016.0035. 
3. Sanchez, P. Vigano, A. Mugione, P. Panina-Bordignon, M. Candiani. The molecular connections between the cannabinoid system and endometriosis, Molecular Human Reproduction, Volume 18, Issue 12, December 2012, Pages 563–571. https://doi.org/10.1093/molehr/gas037

4. Saunders P., Horne A., Endometriosis: Etiology, pathobiology, and therapeutic prospects, Cell, Volume 184, Issue 11, 2021, Pages 2807-2824, ISSN 0092-8674, https://doi.org/10.1016/j.cell.2021.04.041. 
5. https://clinicaltrials.gov
6. https://www.who.int/news-room/fact-sheets/detail/endometriosis

 

 

Disclaimer

 

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. The products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

 

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of company’s products we support.

“Picture a room with 1,000 TVs with each TV showing something different. Now try and concentrate on just one TV without getting distracted.”  –Damian DaViking Aird

 

 

Attention deficit hyperactivity disorder (ADHD) is the most frequent neuro-developmental disorder among children and often continues into adolescence and adulthood. It’s most often characterized by an inability to sit still, properly manage behavior, and difficulty focusing. Presently, there are a number of medications prescribed to help better manage symptoms of the disorder, with those searching for alternative options looking to cannabis for relief. 

 

Many adults with ADHD choose to self-treat with cannabis, claiming that it helps some of their more severe symptoms (e.g., agitation, irritability, lack of control) while also carrying fewer side effects to prescription medications. 

 

Can Cannabis Help With ADHD?

 

The current research available gives somewhat of a mixed answer to whether or not cannabinoid therapy can be used as an alternative therapy for ADHD, although there are reports in favor of the plant medicine. 

 

• One study of 59 patients revealed that high doses of cannabinol (CBN) was associated with lower self-reported ADHD symptoms as well as an ADHD medication reduction.
• Another larger study of 1,700 students found that cannabis had beneficial effects on ADHD symptoms (e.g., hyperactivity, impulsivity), and improved medication side effects (e.g., irritability, anxiety)
• A 2019 study comparing THC:CBD to a placebo found that there were no significant effects on ADHD symptoms
• A 2020 study of 112 adult ADHD patients reported those who took higher doses of cannabinoid therapies, like CBD, took fewer traditional medications for ADHD
• Three adult patients reported substantial benefits to treating ADHD with cannabis. Quality of life improved, attentiveness scores rose up to 30%, depression improved by up to 81%, and they were able to obtain or excel at a new job with more responsibility. 

 

Why Do People Seek Alternative Therapies for ADHD?

 

Traditional treatments for ADHD can include stimulants such as Adderall and Ritalin, which can produce unwanted side effects. Common side effects include trouble sleeping, loss of appetite, and increased heart rates. In fact, 21% of parents surveyed reported discontinuing the use of ADHD medication for their children due to psychological side effects. Using these prescription stimulants can also lead to substance abuse or dependence. 

 

In addition to prescription medication, doctors often recommend behavioral therapy, either as its own treatment or in conjunction with medication. Behavioral therapy may be limited in desired results, as it offers no solution to symptoms, but rather a set of skills to manage ADHD more easily. 

 

Cannabis Compounds and Terpenes

 

The levels of THC and CBD in varying strains of cannabis plants have differing effects on the brain and body. Ongoing research suggests that CBD may alleviate anxiety, promote better sleep, and improve overall quality of life. Most research in favor of treating ADHD symptoms with cannabis emphasizes the benefits of CBD rich products. This means high CBD low THC ratio options and whole-plant cannabis (containing a range of cannabinoids and terpenes) may provide relief.

 

Currently, a clinical trial on how CBD-rich oil given to adults orally will affect the symptoms of ADHD disorder is underway. The objectives of the study are listed as follows: 

• to characterize the effects of treatment with cannabis oil on symptoms of ADHD
• to compare safety and efficacy of cannabis oil products with different CBD, Cannabidivarin (CBDV), cannabigerol (CBG) and THC ratio;
• to measure endocannabinoids, THC and CBD and metabolites levels in the blood of the participants

 

Research trials like these provide the necessary opportunity to pair hard data with what appears to be promising possibilities for treating ADHD symptoms. In the meantime, we recommend speaking with a medical professional before starting new treatment options such as described above. If you would like to discuss more about the potential benefits of cannabinoid therapy, please reach out to our care team!