Psychoneuroendocrinological links between chronic stress and depression

Abstract   Objective: The goal of this report is to develop a comprehensive model, which integrates psychosocial and neurobiological aspects, for better understanding the link between

August 23, 2023

Psychoactive Drugs Like Cannabis -Induce Hypodopaminergic Anhedonia and Neuropsychological Dysfunction in Humans: Putative Induction of Dopamine Homeostasis via Coupling of Genetic Addiction Risk Severity (GARS) testing and Precision Pro-dopamine Regulation (KB220)

Abstract Many US states now embrace the medical and recreational use of Cannabis. Changes in the laws have heightened interest and encouraged research into both

May 20, 2024

Protein Interactors and Trafficking Pathways That Regulate the Cannabinoid Type 1 Receptor (CB1R)

Abstract The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress synaptic transmission and plays a major role in a diverse range of

August 30, 2025

Protective role of neuronal and lymphoid cannabinoid CB2 receptors in neuropathic pain

Abstract Cannabinoid CB2 receptor (CB2) agonists are potential analgesics void of psychotropic effects. Peripheral immune cells, neurons and glia express CB2; however, the involvement of CB2 from

September 19, 2025

Protective effects of Δ9-tetrahydrocannabinol against N-methyl-Daspartate-induced AF5 cell death

The neuroprotective effects of Δ 9 -tetrahydrocannabinol (THC) were examined using an in vitro model in which the AF5 CNS cell line was exposed to

September 19, 2019

Protective Effects of Cannabidiol on the Membrane Proteome of UVB-Irradiated Keratinocytes

Abstract Ultraviolet (UV) radiation contained in sunlight disturbs the redox state of skin cells, leading to changes in the structures and functions of macromolecules including

April 23, 2024

Protective effects of cannabidiol on the membrane proteins of skin keratinocytes exposed to hydrogen peroxide via participation in the proteostasis network

Abstract Hydrogen peroxide (H2O2) is widely used in clinical practice due to its antiseptic properties and its ability to heal wounds. However, due to its

April 25, 2024

Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration

Disc degeneration is a multifactorial process that involves hypoxia, inflammation, neoinnervation, accelerated catabolism, and reduction in water and glycosaminoglycan content. Cannabidiol is the main non-psychotropic

September 19, 2019

Protective Effects of Cannabidiol on Chemotherapy-Induced Oral Mucositis via the Nrf2/Keap1/ARE Signaling Pathways

Abstract Oral mucositis (OM) is a common complication during chemotherapy characterized by ulceration, mucosa atrophy, and necrosis, which seriously interferes with nutritional intake and oncotherapy

January 17, 2024

Protective effect and mechanism of cannabidiol on myocardial injury in exhaustive exercise training mice

Please use this link to access this publication. Abstract Cannabinoid diphenol (CBD) is a non-toxic main component extracted from cannabis, which has the effects of anti-inflammatory,