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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Cannabinoid Therapy in Athletics: A Review of Current Cannabis Research to Evaluate Potential Real-World Cannabinoid Applications in Sport


Please use this link to access this publication. Abstract The increasing legalization of Cannabis sativa plant products has sparked growing interest in their therapeutic applications. Prohibition laws established in 1937 hindered formal […]

April 19, 2025


In Vitro and In Vivo Anti-Inflammatory and Antidepressant-like Effects of Cannabis sativa L. Extracts


Please use this link to access this publication. Abstract Cannabis sativa L. has been widely used by humans for centuries for various purposes, such as industrial, ceremonial, medicinal, and food. The […]

April 18, 2025


Cannabis legalization and increasing cannabis use in the United States: Data from urine toxicology testing in emergency room patients


  Please use this link to access this publication. Abstract Study objectives Rates of cannabis use disorder (CUD) appear to be increasing nationally, with increases greater in states that legalized […]


Patients’ Health‑Related Quality of Life and Use of Medicinal Cannabis: A Cross‑Sectional Survey Study


Abstract Background: Studies on medicinal cannabis (MC) have primarily investigated effects on diseases and symptoms, while there is only sparse knowledge on patients’ health-related quality of life. Our aim was, firstly, […]


Cannabis consumption and risk of asthma: a systematic review and meta-analysis


Abstract Background Cannabis is the third most widely used psychoactive substance globally, and its consumption has been increasing, particularly with the growing trend of legalization for medicinal and recreational use. […]


The comparative effectiveness of medicinal cannabis for chronic pain versus prescription medication treatment


Please use this link to access this publication. Abstract Reviews of the effectiveness of medicinal cannabis for chronic pain vary in their conclusions. IASP has identified that a key missing […]


Cancer risk and legalisation of access to cannabis in the USA: overview of the evidence


Summary Cannabis in the USA is transitioning from a nationwide illegal status to liberalisation for medicinal or recreational use across different jurisdictions. As the acceptability and accessibility of cannabis continue […]

April 17, 2025


Drug dependence epidemiology in palliative care medicinal cannabis trials


Please use this link to access this publication. Abstract Objectives Drug dependence is becoming increasingly common and meeting palliative care patients with substance use disorders is inevitable. However, data on substance […]


The acute effects of vaporized cannabis on drivers’ hazard perception and risk-taking behaviors in medicinal patients: A within-subjects experiment


Abstract Introduction: As the medically prescribed use of cannabis flower continues to increase, there is a need to understand how vaporized cannabis can acutely affect driving-related skills and risk-taking behaviors […]


In the weeds: A comprehensive review of cannabis; its chemical complexity, biosynthesis, and healing abilities


Abstract For millennia, various cultures have utilized cannabis for food, textile fiber, ethno-medicines, and pharmacotherapy, owing to its medicinal potential and psychotropic effects. An in-depth exploration of its historical, chemical, and therapeutic dimensions […]


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