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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Use of Prescription Pain Medications Among Medical Cannabis Patients: Comparisons of Pain Levels, Functioning, and Patterns of Alcohol and Other Drug Use


Objective: Management of chronic pain is one of the most common reasons given by individuals seeking medical cannabis. However, very little information exists about the concurrent use of cannabis and […]

September 19, 2019


Use of Medicinal Cannabis and Synthetic Cannabinoids in Post-Traumatic Stress Disorder (PTSD): A Systematic Review


Abstract Background and Objectives: Post-traumatic stress disorder (PTSD) is a common psychiatric disorder resulting from a traumatic event, is manifested through hyperarousal, anxiety, depressive symptoms, and sleep disturbances. Despite several […]

August 1, 2024


Use of Medical Cannabis to Treat Traumatic Brain Injury


Please use this link to access this publication. Abstract There is not a single pharmacological agent with demonstrated therapeutic efficacy for traumatic brain injury (TBI). With recent legalization efforts and […]

June 14, 2025


Use of medical cannabis by patients with fibromyalgia in Canada after cannabis legalisation: a cross-sectional studyUse of medical cannabis by patients with fibromyalgia in Canada after cannabis legalisation: a cross-sectional study


Abstract OBJECTIVES: Medications have only small to moderate effects on symptoms in fibromyalgia (FM). Cannabinoids, including medical cannabis (MC) may have potential to fill this gap. Since recreational legalisation of […]

August 18, 2025


Use of Medical Cannabis by Patients With Cancer: Attitudes, Knowledge, and Practice


Please use this link to access this publication. Abstract Context Demand for medical cannabis (MC) is growing among Israeli patients with cancer. Objectives The study sought to assess factors contributing to the […]

October 3, 2024


Use of Marijuana for Medical Purposes among Adults in the United States


November 22, 2023


Use of highly-potent cannabis concentrate products: More common in U.S. states with recreational or medical cannabis laws


Abstract Background Highly-potent cannabis products, e.g., concentrates, entail greater risks of cannabis-related harms than lower-potency products such as plant or flower material. However, little information is available on whether individuals […]

May 22, 2025


Use of Genetically Informed Methods to Clarify the Nature of the Association Between Cannabis Use and Risk for Schizophrenia


Please use this link to access this publication. Abstract Cohort studies and meta-analyses have documented a robust association between cannabis use, heavy use, and misuse with future risk of schizophrenia. […]

June 7, 2025


Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child


Objective: To evaluate the effectiveness of dronabinol (delta-9-THC) as supplementary therapy in a child with autistic disorder. Methods: A child who met the DSM-IV (Diagnostic and Statistical Manual of Mental […]

September 19, 2019


Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats


The use of cannabidiol (CBD)-rich hemp-based nutraceuticals is increasing in dogs and cats for disorders related to anxiety, seizures, cancer and pain. To date, there is little information related to […]

April 7, 2020


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