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Research Library

A-Z Conditions  Participate in ORR

The Nonpsychoactive Cannabis Constituent Cannabidiol Is a Wake-Inducing Agent

  • Journal : Behavioral Neuroscience
  • Publication Year : 2008
  • Authors : Eric Murillo-Rodríguez, Marcela Palomero-Rivero, Diana Millán-Aldaco, Raphael Mechoulam, & René Drucker-Colín

Cannabidiol (CBD) is a constituent of Cannabis sativa that induces nonpsychotropic effects, and some of its biological actions in sleep have been described by the authors’ group. Here, the authors report that when administered 10 or 20 g/1 l during the lights-on period directly into either lateral hypothalamus (LH) or dorsal raphe nuclei (DRN), which are wake-inducing brain areas, CBD enhanced wakefulness and decreased slow wave sleep and REM sleep. Furthermore, CBD increased alpha and theta power spectra but diminished delta power spectra. Additionally, CBD increased c-Fos expression in LH or DRN. These findings suggest that this cannabinoid is a wake-inducing compound that presumably activates neurons in LH and DRN.

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Conditions:

  • Sleep

Research Information:

Research Keywords:

  • Cannabidiol (CBD), Cannabinoid receptor/s, delta power spectra, insomnia, slow wave sleep, wakefulness

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