Category: Education

“Go gray in May” represents bringing awareness to the brain tumors that affect nearly 700,000 individuals in the United States today. If you are affected by a brain tumor or know someone who is, we have resources to support and help you to increase your quality of life.

In this blog, for Brain Tumor Awareness Month, we aim to answer your questions about brain tumors and cannabinoid therapy research. For those new to this plant-based therapy, just know that you are not alone. Realm of Caring is here to navigate this difficult journey with you. 

Terms to know:

Endocannabinoid System (ECS): Largest neurotransmitter system in the body, composed of endogenous cannabinoids, cannabinoid receptors, and metabolizing enzymes. It helps the body to maintain biological harmony across all major body systems. 

Endogenous cannabinoids (endocannabinoids): Cannabinoids produced naturally within the body that bind to or modulate receptors present all throughout the body. Examples include anandamide (AEA) and 2-arachidonoylglycerol (2-AG). 

Phytocannabinoids: Cannabinoids found in cannabis plants such as Delta-9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD). 

How they may help:

Tumor angiogenesis is the growth of new blood vessels that are needed to increase tumor size. Therefore, antiangiogenic properties are correlated with suppressing tumors or halting their growth. The antiangiogenic activity of cannabinoids has been well-researched. The anti-tumor effects of THC, CBD, endocannabinoids AEA and 2-AG, and synthetic cannabinoids have been clinically studied for decades now. Recently, more phytocannabinoids are being researched for like-benefits. The ability of these cannabinoids to modulate cell survival and death, as it relates to tumor and cancer growth, has been considered as “significant from a drug development perspective”. 

There is a large body of data with solid scientific evidence that points to the role of the ECS in tumor generation and progression. The introduction of cannabinoids to the ECS has resulted in the inhibition of tumor growth as well as suppression of malignant cell growth and cancer cell death. The combination has shown promising efficacy against glioma among other tumor and cancer types. 

The cannabinoids that have been used to study these effects also show the ability to decrease negative side effects of conventional cancer therapies as well as having an acceptable safety profile. It is believed that cannabinoids are safe to take in conjunction with traditional cancer therapies. Talking with a doctor is always suggested, but research does suggest that cannabinoids may actually increase the effectiveness of chemotherapy and radiation treatments. 

Current strategies to combat cancer utilize combined therapies, to target cancer cells and tumor growth. The idea is that cannabinoids with other anticancer agents work together to slow down or cease the progression. One combined approach includes a 1:1 ratio of CBD:THC. Administering the two together may potentiate each other’s ability. Anecdotally, many cancers respond to this ratio well although the exact milligram needed to be an antiangiogenic or cause apoptosis is unknown and can vary depending on the cancer type and stage. 

Realm of Caring has Cancer Dosing Guidelines to help you get started in this process. There is a lot to consider when starting cannabinoid therapy but, as always, a Realm of Caring care specialist is here to help with your questions. Contact us today by calling (719) 347-5400 or by emailing info@realmofcaring.org. 

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Disclaimer

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Delta-8-Tetrahydrocannabinol (delta-8-THC) is a cannabinoid that is growing in popularity due to its accessibility in the hemp industry. It is less psychotropic and chemically more stable than its isomer Delta-9-Tetrahydrocannabinol (delta-9-THC), while still having its own researched benefits. 

Delta-8-THC and Delta-9-THC are practically identical. They have the same molecular formula of C21H30O2; which also happens to be the same molecular formula as cannabinoids cannabichromene (CBC) and cannabidiol (CBD), and the hormone progesterone. Their metabolisms follow the same pathways and they have been researched for their like-benefits, as they both have an affinity for CB1 receptors in the brain. For example, both delta-8-THC and delta-9-THC have been studied for their benefits as antiglaucoma agents and for their ability to reduce tumor growth in rodent models. While their chemical behavior is very similar in most cases, there are a few chemical differences that set delta-8-THC and delta-9-THC apart.

First, delta-8-THC is less psychoactive than delta-9-THC, resulting in individuals being able to tolerate higher amounts per administration. In one study, children with hematologic cancers were able to take considerably higher doses of delta-8-THC than delta-9-THC to prevent vomiting due to antineoplastic treatment. They were administered 480 treatments of delta-8-THC and all participants reported feeling relief. This shows promise for delta-8-THC as an effective, yet inexpensive, option to relieve pediatric cancer patients of their nausea and vomiting from chemotherapy, with negligible side effects.

Another difference between the two are their chemical stability and how they are extracted. Delta-9-THC will readily oxidize to cannabinol (CBN) with oxygen, light, or natural aging. Delta-8-THC, on the other hand, is a stable molecule with a long shelf life. Although stable, extracting delta-8-THC is not quite as simple. Delta-8-THC grows in very small amounts in cannabis, however it may be able to be derived from hemp or from CBD; which also makes it technically legal in several states. Many delta-8-THC products are created synthetically by converting CBD into delta-8-THC through a process Dr. Raphael Mechoulam patented, called isomerization. 

A few other differences to mention are some advantages that delta-8-THC may have. A study published in 2004 tested small amounts of delta-8-THC in mouse models for its effect on cognitive function and food consumption. Over the course of the study, delta-8-THC showed a tendency to improve cognitive function without the psychoactive effects that are typically associated with cannabis. Food intake increased with a similar performance to delta-9-THC but at a significantly higher rate, showing delta-8-THC as having therapeutic potential for weight disorders. 

A question you may be curious about is: will delta-8-THC show up on a drug test that is looking for delta-9-THC? And the answer is, most likely. After cannabinoids are metabolized they are excreted for days. As THC molecules break down in the body, they become smaller molecules known as THC metabolites. The major, excreted glucuronic metabolite through the urine is THC-COOH glucuronide. The urine tests are not looking for the specific THC isomer that goes in the body, they are instead looking for the THC-COOH metabolites that come out. 

As with many cannabinoids, much research still needs to be completed and considered on delta-8-THC before we can fully understand its full potential. What we do know is that there is a lot of promise as a less psychotropic alternative to delta-9-THC. 

Disclaimer

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Observational studies and trials in both humans and rodents in recent years have reported the beneficial use of cannabinoids in the form of cannabidiol (CBD) cannabis and hemp extracts as a therapeutic potential for ASD. In addition to being beneficial, these studies have also reported that, even in adolescents, the side effects of the cannabis extracts were either nonexistent or less frequent than those who reported drugs that are traditionally used for ASD, ADHD, sleep disorders, or epilepsy. 

When considering ASD, there are currently no defined drugs or psychotherapeutic approaches capable of extensively improving the quality of life, social skills, and cognitive functioning of the most severe cases. While the currently available drugs may mitigate certain symptoms, the effectiveness is, reportedly, limited and may have undesirable side effects. So, how is it then, that cannabinoid therapy may work differently with the body to possibly provide therapeutic benefit? To understand the difference of cannabinoid therapy in comparison to the available, conventional treatments it is helpful to first gain an understanding of the Endocannabinoid System (ECS) these plant cannabinoids are interacting with.

The ECS is the largest neurotransmitter system in the body, involved in regulating nearly every physiological process. It is composed of two receptors called CB1 and CB2 receptors, endocannabinoids, and metabolizing enzymes. Two key endocannabinoids have been identified as Anandamide (AEA) and 2-arachidonoylglycerol (2-AG). These endocannabinoids are responsible for activating the CB1 and CB2 receptors that are found throughout our bodies and brains. Once endocannabinoids activate these receptors, physiological actions take place. 

Research has shown that one thing individuals with ASD have in common, is that AEA levels are more reduced than in non-ASD individuals. This is a concept known as clinical endocannabinoid deficiency (CED), a theory presented in 2001 and more thoroughly explored in 2004, where decreased AEA levels were found to be associated with a lower pain threshold, post traumatic stress disorder (PTSD), gastrointestinal disorders, and inflammation. 

When experiencing a deficiency of endocannabinoids, such as decreased AEA levels, research suggests the benefit of naturally increasing levels with the modulating cannabis compound, CBD. By supplementing with phytocannabinoids, like CBD, we may be able to mimic the action of those endocannabinoids to fill in gaps of deficiency, which means those decreased levels may become normalized. 

Since discovering this connection between decreased AEA levels and ASD, it has been shown that AEA modulation may potentially improve some aspects of behaviors, such as anxiety, without affecting social behaviors. There have even been suggestions that increasing AEA activity at CB1 receptor sites may actually lead to prosocial behavior. AEA modulation has also been linked as an important role in those with epileptic conditions. 

In addition to modulating AEA levels, CBD has been researched for its modulating benefits in other physiological processes. This includes how effectively our body may facilitate the serotonin it creates, allowing for more regulation of our moods. It also includes the shifting of glutamate and inhibitory y-aminobutyric acid (GABA), which may regulate excitatory and inhibitory neurotransmission in the brain. Due to the many processes CBD may modulate, participants in studies have seen a reduction in anxiety, cognitive impairment, and discomfort factors as well as an increase in the processing of emotional information.

Getting started with cannabinoid therapy can be overwhelming, especially when considering a neurodevelopmental disorder as complex as ASD. Most of the evidence of the efficacy of CBD with ASD comes from anecdotal and observational data; so although findings conclude that the cannabinoid is safe and may provide relief for associated symptoms, there is plenty of room for further clinical research to explore the full therapeutic potential of CBD, as well as the ability of other cannabinoids to potentiate its ability. 

If you are seeking data-driven answers to your questions about this cannabinoid therapy and ASD, Realm of Caring (RoC) can help. RoC has 8 years of collected data and research based on individuals utilizing plant-based therapies. They can guide you through product selection, dosing and administration, how to talk with your doctor, and the results individuals are realizing.

The RoC Care Team is here to assist. They care a lot about helping you to find success. Reach them by calling (719) 347-5400, emailing info@realmofcaring.org, or by scheduling appointment.

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Disclaimer
The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.

Here at Realm of Caring, we strive to educate our clients on the science behind cannabis. One of the most popular questions we get is, “What is a terpene?”. Terpenes play an important part in cannabinoid therapy as they may enhance therapeutic effects. In an effort to get you to know more about them, we have here the three things to know about terpenes. 

#1. What is a Terpene?

To put it in simple terms, terpenes are compounds produced by plants such as fruits, trees, herbs, and a variety of other plant species that are responsible for determining their distinct scents. Terpenes are so abundant in nature that they form the largest group of plant chemicals. They are commonly used for food flavoring, cosmetic products, and as a natural folk medicine. Of all of the plants known to man, cannabis has more terpenes than any other, having over 100 identified. 

#2. What do Terpenes do?

Found in the flowers, roots, and leaves, plants use terpenes as a defense mechanism to protect themselves from the environment and predators. They release a strong odor and flavor that is intended to ward off certain insects or herbivores. Not only do they play a role in protecting plants, but research shows terpenes to have multiple health-promoting properties in humans. Many individuals will look for cannabis strains with specific terpenes for specific conditions. The therapeutic properties of terpenes combined with the therapeutic properties of cannabinoids may enhance the overall therapeutic effect that the cannabis plant can offer. This combination, known as the entourage effect, can improve effectiveness due to increased bioavailability and affinity to certain receptors. The cannabinoids and terpenes are essentially working as a team to provide optimal relief. 

#3. What are the most popular terpenes?

Of the more than 100 terpenes found in the cannabis plant, there are specific ones found in higher concentrations in certain cannabis and/or hemp strains. Below are six of the most popular terpenes found in cannabis and cannabis products, as well as some of their reported benefits.

Myrcene

Reported to have active sedating, potent anti-inflammatory, and analgesic and anxiolytic properties. 

Also found in lemongrass, basil, mangos, and thyme.

β-caryophyllene 

Reported to have anti-inflammatory, anti-bacterial, and antioxidant properties.

Also Found in black pepper, cloves, hops, rosemary, and copaiba.

α-humulene 

Reported to have anti-inflammatory and analgesic properties. 

Also Found in hops, sage, and ginseng.

Α-pinene

Reported to have anti-inflammatory and anxiolytic properties as well as aid in cognitive function and as a bronchodilator. 

Also Found in pine needles, hops, mint, holy basil, and camphor.

Limonene 

Reported to have anxiolytic, antioxidant, anti-inflammatory, and anticancer properties. 

Also found in most citrus fruit peels such as oranges, lemon, and lime. 

Linalool 

Reported to have sedative, analgesic, anxiolytic, anti-microbial, anti-inflammatory, and anticonvulsant properties. 

Also Found in lavender, birch trees, sweet basil, and cinnamon. 

There is much research to be done on the many terpenes found in nature and how they react with other compounds and the human body to promote internal balance. Once you know what a terpene is and what it does, you will have a better understanding of how it can enhance your cannabinoid therapy. Give us your thoughts below or direct your questions to a care specialist at info@realmofcaring.org.

Disclaimer

The Realm of Caring Foundation specifically invokes the first amendment rights of freedom of speech and of the press without prejudice. These statements have not been evaluated by the food and drug administration. the products discussed are not intended to diagnose, cure, prevent or treat any disease. Realm of Caring always recommends when and wherever possible that licensed local healthcare professionals be consulted.

The Realm of Caring Foundation is an independent nonprofit with its own governing board. We do not produce or sell cannabinoid products, nor do we receive funds from the sale of other company’s products.