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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Nabilone for the treatment of pain in fibromyalgia


Abstract A randomized, double-blind, placebo-controlled trial was conducted to determine the benefit of nabilone in pain management and quality of life improvement in 40 patients with fibromyalgia. After a baseline […]

November 15, 2023


Myrcene—What Are the Potential Health Benefits of This Flavouring and Aroma Agent?


Myrcene (β-myrcene) is an abundant monoterpene which occurs as a major constituent in many plant species, including hops and cannabis. It is a popular flavouring and aroma agent (food additive) […]

September 1, 2022


Multivariate classification of cannabis chemovars based on their terpene and cannabinoid profiles


Please use this link to access this publication. Abstract Cannabis is used to treat various medical conditions, and lines are commonly classified according to their total concentrations of Δ9-tetrahydrocannabinol (THC) […]

October 3, 2024


Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development


The endocannabinoid system, including its receptors (CB1 and CB2), endogenous ligands (‘endocannabinoids’), synthesising and degrading enzymes, as well as transporter molecules, has been detected from the earliest stages of embryonic […]

September 19, 2019


Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders


Cannabidiol (CBD) is a major phytocannabinoid present in the Cannabis sativa plant. It lacks the psychotomimetic and other psychotropic effects that the main plant compound D9 -tetrahydrocannabinol (THC) being able, […]


Multimodal MRI data fusion reveals distinct structural, functional and neurochemical correlates of heavy cannabis use


Abstract Heavy cannabis use (HCU) is frequently associated with a plethora of cognitive, psychopathological and sensorimotor phenomena. Although HCU is frequent, specific patterns of abnormal brain structure and function underlying […]

March 14, 2024


Multigenerational consequences of early-life cannabinoid exposure in zebrafish


Please use this link to access this publication. Abstract While Δ9-tetrahydrocannabinol (THC) has been widely studied in the realm of developmental and reproductive toxicology, few studies have investigated potential toxicities from […]

August 1, 2024


Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients with Intractable Cancer-Related Pain


Abstract This study compared the efficacy of a tetrahydrocannabinol:cannabidiol (THC:CBD) extract, a nonopioid analgesic endocannabinoid system modulator, and a THC extract, with placebo, in relieving pain in patients with advanced […]

September 4, 2024


Multi-Modal Cannabis Use Among U.S. Young Adults: Findings from the 2022 and 2023 BRFSS in 23 States


Abstract Cannabis use among young adults in the U.S. has nearly doubled in recent years, driven by diverse methods of consumption and evolving cannabis legalization. Multi-modal cannabis use among young […]

May 1, 2025


Motor effects of delta 9 THC in cerebellar Lurcher mutant mice


The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, […]

September 19, 2019


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