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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2


Osteosarcoma is the most frequent primary malignant bone tumor that occurs in children and adolescents. The present study aimed to identify novel therapeutic strategies for osteosarcoma, by assessing the antitumor […]

September 19, 2019


Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism


Ceramide levels are elevated in mantle cell lymphoma (MCL) cells following treatment with cannabinoids. Here, we investigated the pathways of ceramide accumulation in the MCL cell line Rec-1 using the […]


Potential, Limitations and Risks of Cannabis-Derived Products in Cancer Treatment


Simple Summary It is easy to find success stories on the internet of patients with cancer who seem to benefit from using cannabis products. However, scientific substantiation is usually lacking. […]

October 3, 2024


Potential therapeutic benefits of cannabinoid products in adult psychiatric disorders: A systematic review and meta-analysis of randomised controlled trials


Please use this link to access this publication. Abstract The utility of cannabinoids and cannabinoid-based products (CBPs) as a pharmacological aid to treat psychiatric disorders in adulthood is still poorly […]

March 25, 2024


Potential Role of Cannabidiol on Sports Recovery: A Narrative Review


Abstract The use of cannabidiol (CBD) among athletes is becoming extensive and frequent. This could be due to the elimination of CBD from the list of prohibited substances by federations […]

April 23, 2024


Potential role of cannabidiol in Parkinson’s disease by targeting the WNT/β-catenin pathway, oxidative stress and inflammation


Abstract Parkinson’s disease (PD) is a major neurodegenerative disease (ND), presenting a progressive degeneration of the nervous system characterized by a loss of dopamine in the substantia nigra pars compacta. […]

April 25, 2024


Potential Risks from Cannabis-Infused Beverages: A Critical Review


Abstract Although Canada legalized cannabis beverages in 2019, most available research on acute cannabis intoxication derives from dried flower and edible products. The distinct bioavailability and pharmacokinetic properties of phytocannabinoids […]

April 19, 2025


Potential Probiotic or Trigger of Gut Inflammation – The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract


Please use this link to access this publication. Abstract Cannabidiol (CBD) is the major non-psychotropic phytocannabinoid present in Cannabis sativa. In 2018, Congress designated certain C. sativa plant material as “hemp,” thus removing […]

July 1, 2024


Potential Pro-Inflammatory Effect of Vitamin E Analogs through Mitigation of Tetrahydrocannabinol (THC) Binding to the Cannabinoid 2 Receptor


Abstract Vitamin E acetate, which is used as a diluent of tetrahydrocannabinol (THC), has been reported as the primary causative agent of e-cigarette, or vaping, product use-associated lung injury (EVALI). […]

February 12, 2024


Potential of cannabinoids as treatments for autism spectrum disorders


Please use this link to access this publication. Abstract Current treatments for autism spectrum disorders (ASD) are limited in efficacy and are often associated with substantial side effects. These medications typically ameliorate problem […]

October 30, 2024


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