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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Young adult cannabis use disorder treatment admissions declined as past month cannabis use increased in the U.S.: An analysis of states by year, 2008–2017


Please use this link to access this publication. Abstract Objective This short communication reports on the association of annual measures of young adult (age 18–24) past month cannabis use with […]

August 18, 2025


Year-Long Cannabis Use for Medical Symptoms and Brain Activation During Cognitive Processes


Key Points Question  Is there an association between year-long cannabis use for medical symptoms and brain activation during cognitive processes implicated in cannabis use? Findings  In a cohort study of adults who […]

February 27, 2025


Wound healing efficacy of Cannabis sativa L. essential oil in a mouse incisional wound model: A possible link with stress and anxiety


Please use this link to access this publication: https://www.sciencedirect.com/science/article/abs/pii/S0254629923006804 Abstract Cannabis Sativa L. (Cannabaceae) exerts biological effects through its bioactive compounds. Cannabis Sativa L. essential oil (CSEO) is known to have antibacterial properties that can accelerate wound […]

December 6, 2023


Willingness to Use Cannabis for Gynecological Conditions: A National Survey


Abstract Objective: Expanded legal access to cannabis in the United States has led to its increased use for treating medical conditions. We assessed the use of and attitudes toward cannabis for […]

July 18, 2025


Why Use Cannabis? Examining Motives for Cannabis Use in Individuals with Anxiety Disorders


Abstract This study examined cannabis use motives in individuals with anxiety disorders and compared motives between infrequent and frequent cannabis users. It was hypothesised that coping motives would be endorsed […]

October 30, 2024


Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review


Background: Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Δ9-tetrahydrocannabinol […]

September 19, 2019


Who Are Medical Marijuana Patients? Population Characteristics from Nine California Assessment Clinics


Please use this link to access this publication. Abstract Marijuana is a currently illegal psychoactive drug that many physicians believe has substantial therapeutic uses. The medical literature contains a growing […]

November 4, 2024


White matter integrity after cannabidiol administration for treatment resistant epilepsy


Please use this link to access this publication. Abstract Objective The effects of individual cannabinoids on white matter integrity are unclear. Human studies have shown white matter maturation alterations in […]

April 29, 2024


Where, When and With Whom: Cannabis Use, Settings and Self-Regulation Rules


Abstract This article examines to what extent and how cannabis users in different countries, with different cannabis legislation and policies practice normalization and self-regulation of cannabis use in everyday life. […]

July 5, 2025


Where Do Adults in the United States Obtain Cannabis? A Nationally Representative Study Examining the Relationships Between Sociodemographic Factors, Cannabis Use Characteristics and Sources of Cannabis


Please use this link to access this publication. Abstract Objective: Characterization of population subgroups based on where they acquire cannabis is unexplored. We examine relationships between sociodemographic characteristics, cannabis use […]

March 10, 2025


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