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Research Library

Realm of Caring's Latest Published Research

Likelihood of Positive Urine Screens of THC-COOH After Daily Use of Full-Spectrum Hemp Extracts

January 23, 2023

Recent studies have shown that even low amounts of D9-tetrahydrocannbinol (THC) within a cannabidiol (CBD) product can result in positive 11-nor-9-carboxy-D9- tetrahydrocannabinol (THC-COOH; a metabolite of THC) urine drug screens.

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Online survey of medicinal cannabis users: Qualitative analysis of patient-level data

September 6, 2022

Aim: To characterize perceived benefits and challenges experienced by medicinal cannabis users.   Methods: An anonymous online survey collected demographics, health information, and open-ended responses from medicinal cannabis users regarding perceptions, motivations,

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Antidepressant and Anxiolytic Effects of Medicinal Cannabis Use in an Observational Trial

September 9, 2021

Background: Anxiety and depressive disorders are highly prevalent. Patients are increasingly using medicinal cannabis products to treat these disorders, but little is known about the effects of medicinal cannabis use on

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Cross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsy

July 27, 2021

Abstract:    Recent approval of Epidiolex (pharmaceutical cannabidiol/CBD) for the treatment of Lennox Gastaut syndrome (LGS) and Dravet syndrome highlights a therapeutic efficacy of CBD in the treatment of epilepsy.

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A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health

May 19, 2020

Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to

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Cannabis use among individuals with depression symptoms: differences among military-connected and civilian clients


Please use this link to access this publication. ABSTRACT Background Despite the association between depression symptoms and cannabis use, it is unknown how military affiliation may modify this relationship. Methods […]

May 2, 2025


Brain Function Outcomes of Recent and Lifetime Cannabis Use


Abstract Importance  Cannabis use has increased globally, but its effects on brain function are not fully known, highlighting the need to better determine recent and long-term brain activation outcomes of cannabis […]


Historical change in associations between perceived risk, disapproval, and use of cannabis among young adults ages 19–30, 2011–2022


Please use this link to access this publication. Abstract Background The current study used U.S. young adult data to examine overall and age group-specific historical trends in (a) mean perceived […]

May 1, 2025


Associations between adult cannabis use and chronic health conditions in a nationally representative sample of the United States


Please use this link to access this publication. ABSTRACT Background This study examined associations between cannabis use among U.S. adults with chronic health conditions in a nationally representative sample. Methods […]


Multi-Modal Cannabis Use Among U.S. Young Adults: Findings from the 2022 and 2023 BRFSS in 23 States


Abstract Cannabis use among young adults in the U.S. has nearly doubled in recent years, driven by diverse methods of consumption and evolving cannabis legalization. Multi-modal cannabis use among young […]


Low doses of cannabis extract ameliorate non-motor symptoms of Parkinson’s disease patients: a case series


Abstract Introduction: Parkinson’s disease (PD) is mainly characterized by motor symptoms including muscle rigidity, resting tremor and bradykinesia. However, the management of the non-motor symptoms represent a relevant clinical challenger in […]


Drug interactions in a sample of inpatients diagnosed with cannabis use disorder


Abstract The majority of patients with cannabis use disorder (CUD) regularly take medication. Cannabinoids influence metabolism of some commonly prescribed drugs. However, little is known about the characteristics and frequency […]


The Intersection of Rurality, Unmet Treatment Need, and Cannabis Use for Adults with Chronic Pain


Abstract Objective: Rates of chronic pain are higher among rural versus urban individuals and rural individuals experience higher levels of socioeconomic disadvantage, poor or no health insurance coverage, and unmet […]

April 26, 2025


Inpatient outcomes of rheumatoid arthritis in hospitalized patients using cannabis: data from the National Inpatient Sample


Please use this link to access this publication. Abstract Background Despite advancements in rheumatoid arthritis (RA) treatment, effective pain management remains challenging, with many patients also experiencing insomnia, anxiety, and […]


Cannabis Consumption Among Adults Aged 55–65 in Canada, 2018–2021


Abstract Cannabis consumption among aging adults in Canada is increasing. The aims of the study were to examine cannabis consumption patterns before and after non-medical cannabis legalization and assess whether […]


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