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Cannabinoid Delivery Systems for Pain and Inflammation Treatment
There is a growing body of evidence to suggest that cannabinoids are beneficial for a range of clinical conditions, including pain, inflammation, epilepsy, sleep disorders, the symptoms of multiple sclerosis, anorexia, schizophrenia and other conditions. The transformation of cannabinoids from herbal preparations into highly regulated prescription drugs is therefore progressing rapidly. The development of such […]
A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
BACKGROUND. Cannabidiol (CBD) is a nonpsychoactive phytocannabinoid used in multiple sclerosis and intractable epilepsies. Preclinical studies show CBD has numerous cardiovascular benefits, including a reduced blood pressure (BP) response to stress. The aim of this study was to investigate if CBD reduces BP in humans. METHODS. Nine healthy male volunteers were given 600 mg of […]
Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death
The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. In this study, we have investigated the effects of a nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant […]
A Cross-Sectional and Prospective Comparison of Medicinal Cannabis Users and Controls on Self-Reported Health
Introduction. Despite widespread legalization, the impact of medicinal cannabis use on patient level health and quality of life has not been carefully evaluated. The objective of this study was to characterize self-reported demographics, health characteristics, quality of life, and health care utilization of Cannabis Users compared with Controls. Methods. A longitudinal, cross-sectional web-based survey study […]
The Endocannabinoid System of Animals
Our understanding of the Endocannabinoid System of animals, and its ubiquitous presence in nearly all members of Animalia, has opened the door to novel approaches targeting pain management, cancer therapeutics, modulation of neurologic disorders, stress reduction, anxiety management, and inflammatory diseases. Both endogenous and exogenous endocannabinoid-related molecules are able to function as direct ligands or, […]
Use of CBD-Rich Hemp Nutraceutical in Healthy Dogs and Cats
The use of cannabidiol (CBD)-rich hemp-based nutraceuticals is increasing in dogs and cats for disorders related to anxiety, seizures, cancer and pain. To date, there is little information related to appropriate dosing or long-term effects on serum chemistry or complete blood counts (CBC), and little data on the pharmacokinetics of single- or long-term dosing in […]
Pharmacokinetics, Safety, and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs
Osteoarthritis (OA) is the most common chronic condition that dogs face. If diagnosed, it is important to focus on managing the symptoms versus find a cure. This study shows that cannabidiol (CBD) can help increase comfort and activity levels in dogs with OA. Objectives: The objectives of this study were to determine basic oral pharmacokinetics, […]
US Veterinarians’ Knowledge, Experience, and Perception Regarding the Use of Cannabidiol for Canine Medical Conditions
Due to the myriad of laws concerning cannabis, there is little empirical research regarding the veterinary use of cannabidiol (CBD). This study used the Veterinary Information Network (VIN) to gauge US veterinarians’ knowledge level, views and experiences related to the use of cannabinoids in the medical treatment of dogs. Participants (n = 2130) completed an […]
A selective review of medical cannabis in cancer pain management
Cancer is one of the most common reported conditions for using medical cannabis. This review can be useful to practitioners and policy makers when making decisions on use for cancer patients and cannabis in the future. Insufficient management of cancer-associated chronic and neuropathic pain adversely affects patient quality of life. Patients who do not respond […]
Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control
The United States is currently undergoing a tragic opioid epidemic. We have a duty to try to curb this disaster. This study shows that by taking cannabis as an adjunct treatment, patients may be able to lower the amount of opioids needed to find pain relief. Abstract Background: There is currently little evidence regarding the […]