Skip to the content
  • 719-347-5400
  • info@realmofcaring.org
  • 719-347-5400
  • info@realmofcaring.org
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
Menu
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
  • Donate
  • Register
  • Login
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
Menu
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
  • Donate
  • Register
  • Login

Research Library

A-Z Conditions  Participate in ORR

The Endocannabinoid System, Cannabinoids, and Pain

  • Journal : Rambam Maimonides Medical Journal
  • Publication Year : 2013
  • Authors : Perry G. Fine; Mark J. Rosenfeld

The endocannabinoid system is involved in a host of homeostatic and physiologic functions, including
modulation of pain and inflammation. The specific roles of currently identified endocannabinoids that act
as ligands at endogenous cannabinoid receptors within the central nervous system (primarily but not
exclusively CB1 receptors) and in the periphery (primarily but not exclusively CB2 receptors) are only
partially elucidated, but they do exert an influence on nociception. Exogenous plant-based cannabinoids
(phytocannabinoids) and chemically related compounds, like the terpenes, commonly found in many foods,
have been found to exert significant analgesic effects in various chronic pain conditions. Currently, the use
of Δ9-tetrahydrocannabinol is limited by its psychoactive effects and predominant delivery route (smoking),
as well as regulatory or legal constraints. However, other phytocannabinoids in combination, especially
cannabidiol and β-caryophyllene, delivered by the oral route appear to be promising candidates for the
treatment of chronic pain due to their high safety and low adverse effects profiles. This review will provide
the reader with the foundational basic and clinical science linking the endocannabinoid system and the
phytocannabinoids with their potentially therapeutic role in the management of chronic pain.

Read the Full Article

Share This:

Share on Twitter Share on Facebook Share on LinkedIn Share on Email
NextCannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptorsNext

Conditions:

  • Endocannabinoid System (ECS), Pain

Research Information:

Research Keywords:

  • Cannabinoid receptors, Cannabinoids, chronic pain, endocannabinoid system, Phytocannabinoids

Search the Research Library >

Follow Us:

Facebook Twitter Youtube

REGISTER WITH THE RoC TODAY!

Realm of Caring focuses on research, education, building community, and improving quality of life. We are an educational resource for consumers, physicians, scientists, governments and the media.
Register now
  • 5040 Corporate Plaza Drive, Suite 7R, Colorado Springs, CO 80919
  • 719-347-5400
  • info@realmofcaring.org

Copyright © 2023 / Realm of Caring Foundation, Inc

  • Privacy
  • Disclaimer