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Practical use of pharmaceutically purified oral cannabidiol in Dravet syndrome and Lennox-Gastaut syndrome

  • Journal : Expert Review of Neurotherapeutics Volume 21, 2021 - Issue 1
  • Publication Year : 2021
  • Authors : Simona Lattanzi, Gaetano Zaccara, Emilio Russo, Angela La Neve, Monica Anna Maria Lodi & Pasquale Striano

Please use this link to access this publication.

ABSTRACT
Introduction
Pharmaceutically purified oral cannabidiol (CBD) has been recently approved by the US Food and Drug Administration and European Medicines Agency as treatment of seizures associated with Dravet syndrome (DS) and Lennox-Gastaut syndrome (LGS), which are severe and difficult-to-treat developmental and epileptic encephalopathies with onset in early childhood.

Areas covered
This review will critically review the pharmacokinetic properties of CBD, the interactions with antiseizure and non-antiseizure medications, and the main tolerability and safety issues to provide guidance for its use in everyday practice.

Expert opinion
CBD is metabolized in the liver and can influence the activity of enzymes involved in drug metabolism. The best characterized drug-drug interaction is between CBD and clobazam. The most common adverse events include somnolence, gastrointestinal discomfort, and increase in serum transaminases. High-grade purified CBD oral solution represents an effective therapeutic option in patients with DS and LGS. The findings cannot be extrapolated to other cannabis-based products, synthetic cannabinoids for medicinal use and non-medicinal cannabis and CBD derivatives.

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Conditions:

  • Drug Interactions, Epilepsy

Research Information:

Research Keywords:

  • Cannabidiol (CBD)

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