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Effects of Chronic, Low-Dose Cannabinoids, Cannabidiol, Delta-9-Tetrahydrocannabinol and a Combination of Both, on Amyloid Pathology in the 5xFAD Mouse Model of Alzheimer’s Disease

  • Journal : Cannabis and Cannabinoid Research
  • Publication Year : 2023
  • Authors : María Andrea Arnanz, Samuel Ruiz de Martín Esteban, Ana María Martínez Relimpio, Neta Rimmerman, Nurit Tweezer Zaks, María Teresa Grande, & Julián Romero

Abstract

Background: There is an urgent need for novel therapies to treat Alzheimer’s disease. Among others, the use of cannabinoids such as delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) has been proposed as a putative approach based on their anti-inflammatory effects.

Methods: The present work was designed to explore the effects of chronic (28 days) treatment with low doses of cannabinoids: CBD (0.273 mg/kg), THC (0.205 mg/kg) or a combination of both (CBD:THC; 0.273 mg/kg:0.205 mg/kg) in the 5xFAD mouse model of AD.

Results: Our data revealed that THC-treated 5xFAD mice (but not other treatment groups) exhibited anxiogenic and depressant-like behavior. A significant improvement in spatial memory was observed only in the CBD:THC-treated group. Interestingly, all cannabinoid-treated groups showed significantly increased cortical levels of the insoluble form of beta amyloid 1-42. These effects were not accompanied by changes in molecular parameters of inflammation at the mRNA or protein level.

Conclusions: These data reveal differential effects of chronic, low-dose cannabinoids and point to a role of these cannabinoids in the processing of amyloid peptides in the brains of 5xFAD mice.

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Conditions:

  • Alzheimer's Dementia

Research Information:

Research Keywords:

  • ∆9-tetrahydrocannabinol (THC), Cannabidiol (CBD), Cannabinoid/s

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