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Research Library

A-Z Conditions  Participate in ORR

Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa.

  • Journal : CNS Neurological Disorders Drug Targers
  • Publication Year : 2014
  • Authors : Alexandre R. de Mello Schier; Natalia P. de Oliveira Ribeiro; Danielle S. Coutinho; Sergio Machado; Oscar Arias-Carrión; José A. Crippa; Anotonio W. Zuardi; Antonio E. Nardi; Adriana C. Silva

Anxiety and depression are pathologies that affect human beings in many aspects of life, including social life, productivity and health. Cannabidiol (CBD) is a constituent non-psychotomimetic of Cannabis sativa with great psychiatric potential, including uses as an antidepressant-like and anxiolytic-like compound. The aim of this study is to review studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Studies involving animal models, performing a variety of experiments on the above-mentioned disorders, such as the forced swimming test (FST), elevated plus maze (EPM) and Vogel conflict test (VCT), suggest that CBD exhibited an anti-anxiety and antidepressant effects in animal models discussed. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2. Most of the studies demonstrated a good interaction between CBD and the 5-HT1A neuro-receptor.

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Conditions:

  • Anxiety, Depression

Research Information:

Research Keywords:

  • anxiety, Anxiolotyic-like, cannabidiol, cannabis sativa, CBD, major depression

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