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  • Kidney, Safety
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Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

The platinum compound cisplatin is one of the most potent chemotherapy agents available to treat various malignancies. Nephrotoxicity is a common complication of cisplatin chemotherapy, which involves increased oxidative and nitrosative stress, limiting its clinical use. In this study, we have investigated the effects of a nonpsychoactive cannabinoid cannabidiol, which was reported to exert antioxidant effects and has recently been approved for the treatment of inflammation, pain, and spasticity associated with multiple sclerosis in patients in a mouse model of cisplatin-induced nephropathy. Cisplatin induced increased expression of superoxide-generating enzymes RENOX (NOX4) and NOX1, enhanced reactive oxygen species generation, inducible nitric-oxide synthase expression, nitrotyrosine formation,...
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Interpretation of Workplace Tests for Cannabinoids

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Labeling Accuracy of Cannabidiol Extracts Sold Online

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Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes

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Maternal Marijuana Use and Adverse Neonatal Outcomes

OBJECTIVE: To estimate whether marijuana use in pregnancy increases risks for adverse neonatal outcomes and clarify if any increased risk is attributable to marijuana use itself or to confounding factors such as tobacco use. DATA SOURCES: Two authors performed a search of the data through August 2015 utilizing PubMed, Embase, Scopus, Cochrane reviews, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health. METHODS OF STUDY SELECTION: We looked at observational studies that compared rates of prespecified adverse neonatal outcomes in women who used marijuana during pregnancy with women who did not. TABULATION, INTEGRATION, AND RESULTS: Two authors independently extracted data from the selected studies....
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Cannabis Essential Oil: A Preliminary Study for the Evaluation of the Brain Effects

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Cannabis Use in Pregnancy A Tale of 2 Concerns

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Marijuana Use During Pregnancy and Lactation

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Compromised External Validity: Federally Produced Cannabis Does Not Reflect Legal Markets

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Driving Under the Influence of Cannabis An Increasing Public Health Concern

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