Category: Education

Many clients come to Realm of Caring looking for help in improving their quality of sleep. The great news is that research is continuing to show us that cannabinoid therapy may help. Certain cannabinoids have shown through studies the ability to benefit our sleep-wake cycles, decrease nightmares, lessen the conditions that interfere with our sleep, and assist in actually falling asleep. 

 

Before we go on, let’s get into some background information and understanding. 

 

Sleep Challenges in America

 

Circadian rhythm is our biological rhythm in a 24-hour period, coming from the Latin circa meaning around and dies meaning day. The most commonly known is the sleep-wake cycle, which in chronobiology, is tied to day and night or lightness and darkness. An out-of-sync circadian cycle may be associated with poor health outcomes. 

 

Insomnia is recognized by the American Psychiatric Association as the most common sleep disorder, involving problems getting to sleep or staying asleep with symptoms being episodic, persistent, and/or recurrent. This sleep disorder is known to cause distress or impairment. A survey published by the American Academy of Sleep Medicine found that 12% Americans reported a diagnosis of chronic insomnia. 

 

The National Sleep Foundation shared the following statistics in their 2025 report:

 

• 6 in 10 adults do not get enough sleep
• Nearly 4 in 10 adults struggle to fall asleep at least 3 nights per week
• Almost half of adults experience difficulty staying asleep at least 3 nights per week 
• 3 in 4 adults say good quality sleep positively impacts their ability to flourish – with women more often reporting stronger perceived benefits

 

What does our Endocannabinoid System have to do with Sleep? 

 

Our Endocannabinoid System (ECS) is composed of endocannabinoids, as well as two distinct receptors known as CB1 and CB2, and enzymes responsible for the metabolism of endocannabinoids. It has been found that the expression pattern of CB1 and CB2 receptors are influenced by light-dark cycles and therefore appear to align with circadian rhythms. Furthermore, it has been shown in studies with rodents that the ECS may potentially modulate those rhythms to promote sleep. 

 

Phytocannabinoids may provide an indirect benefit to sleep through mitigating conditions that often disrupt sleep. Major cannabinoids found in the cannabis plant, such as cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) may reduce anxiety, inflammation, and/or pain – all factors that may disrupt sleep. 

 

CBD and Sleep

 

Although CBD is not a naturally sedative molecule on its own, research has shown that high quantities may have “sedative-like qualities”, potentially due to the effect on cortisol levels. 

 

CBD also has therapeutic properties that have the potential to mitigate symptoms that interfere with sleep. It also has the potential to improve sleep-wake cycles leading to an increase in the percentage of total sleep over time.

 

Among the several researched properties, CBD may benefit as an anxiolytic, anti-inflammatory, and analgesic. The anxiolytic properties of CBD may help to improve sleep by mitigating anxiety or stress-induced insomnia. Stress induces a sleep-related feature known as rapid eye movement (or REM) sleep rebound, this is an increase in REM sleep during the nightly sleep cycles. People experiencing REM sleep rebound may spend more time in REM then they would during a night of normal, healthy sleep.

 

Inflammation is a root cause of autoimmune disorders including arthritis, diabetes, irritable bowel syndrome (IBS), crohn’s disease, and others – all which have an effect on body clock function that can lead to sleep disorders. A study by Northwestern found in mice this link between inflammation and what controls the body clock. By limiting this inflammation, we may lessen the effects on our body clock functions and have more restful sleep. 

 

A study in 2005 showed that people reporting insomnia symptoms are at least three times more likely to have a chronic painful physical condition. These events may then become cyclical in that pain may disrupt sleep and sleep deprivation can increase pain perception. In the majority of animal studies, CBD has been known to exert analgesic effects; co-administering with THC may provide more benefit to this therapeutic action. 

 

Our circadian rhythm aligns our sleep and wakefulness with day and night to provide stability in restorative rest that enables increased daytime activity. Low doses of CBD may be associated with wakefulness to help our focus and cognition during the day. Studies show that therapeutic levels of CBD administration may increase total sleep time and decrease frequency of arousals at night – leading to an increase in total percentage of sleep over time. 

 

THC and Sleep

 

In comparison to CBD, THC has shown in studies as having an affect on mental and physical sedation, even in low amounts. THC also has positive therapeutic benefits that may lead to better sleep.

 

Nightmares are associated with posttraumatic stress disorder (PTSD) often resulting in this being considered a “treatment-resistant” condition. Initial research has shown the benefit cannabinoids can have in managing nightmares linked with PTSD. A study with military veterans and prison inmates receiving Nabilone, a synthetic form of THC, found a reduction in nightmare presence and intensity. This increased participants’ hours of sleep per night. 

 

Just as mentioned with CBD, THC is also beneficial for mitigating pain-induced insomnia or wakefulness. When it comes to pain studies and medical cannabis with significant THC content, benefits consistently show moderate to high symptom management of chronic pain. 

 

A normal amount of apneic events in a healthy individual is about 4 per hour while asleep. Sleep apnea is the most prevalent form of sleep-disordered breathing in the United States and a number of animal and human studies have been conducted to examine cannabinoids as potential therapeutic alternatives to continued positive airway pressure (CPAP) machines, which are currently being utilized.

 

THC shares properties of the endocannabinoid Oleamide, which benefits apneic events. Results in one animal study showed that both the endocannabinoid Oleamide and the exogenous cannabinoid THC reduced apneic events, suggesting therapeutic promise for those who suffer with sleep apnea. 

 

Limitations in Cannabinoid Research

 

A recent systematic review on cannabis and sleep architecture highlighted the mixed results that are available in literature. While surveys suggest that sleep is the most commonly reported targeted symptom to address with cannabis use and 85% of medicinal users reporting sleep improvement, studying the effect of cannabis on sleep is complicated. Chronic users may need higher quantities of THC and find it necessary for sleep, while first-time users may have an unsavory experience due to limited available guidance. 

 

Next Steps and Getting Started

 

Here are some best practices if you are looking to incorporate cannabinoid therapy as a tool:

 

• Start low and go slow – find your therapeutic dose at the lowest amount.
• Quality of product matters, use this guide to vet product companies before you buy.
• Pairing cannabinoids with adaptogens (like functional mushrooms) may provide additional benefit, but this remains an emerging frontier. If you want to bring this up to your doctor but don’t know where to start, we can help. 
• Document your journey through journaling.
• Join an available research study to further our understanding of cannabinoids and sleep.

 

Realm of Caring’s no cost hotline is available to you! Reach out for support today. 

 

Sexual Health Awareness Month and Libido

 

Sexual Health Awareness Month is a time to highlight how intimacy and desire contribute to overall wellbeing. Libido, the natural drive for sex, can shift at different life stages and is influenced by everything from stress to hormones. For many people, especially women navigating perimenopause and menopause, these changes can feel disruptive. Cannabis has become a promising aid for sexual health, with growing research and personal accounts suggesting it may help rekindle desire and improve satisfaction.

 

 

How Cannabis May Enhance Libido

 

Research suggests cannabis affects libido through multiple pathways, both physical and psychological.

 

Reducing Stress and Anxiety

Anxiety is one of the most common barriers to sexual arousal. Cannabis has been shown to promote relaxation and reduce inhibitions, helping people feel more present during intimacy. A 2023 study published in Journal of Cannabis Research found that cannabis users often experienced greater sexual desire, stronger orgasms, and higher overall satisfaction compared to non-users.

 

Heightening Sensory Experience

Cannabis can enhance sensory perception, making touch and physical intimacy feel more intense. This may explain why many users report increased arousal and more pleasurable sexual encounters.

 

Supporting Women in Perimenopause and Menopause

Declining estrogen levels during menopause can cause vaginal dryness, pain during sex, and reduced libido. Cannabis’s anti-inflammatory and analgesic properties may help alleviate discomfort. In one study of women with sexual dysfunction, those who used cannabis before sex reported better lubrication and greater satisfaction. Surveys of menopausal women also show many use cannabis to manage symptoms like mood changes, sleep disruption, and low libido.

 

Effects for Men

Men also report benefits from cannabis use, including increased sexual frequency and satisfaction. However, moderation is key. Research suggests that while low to moderate use may enhance libido and performance, heavy or chronic use could have drawbacks, such as impacts on testosterone or erectile function.

 

 

The Role of the Endocannabinoid System

 

The endocannabinoid system regulates mood, stress, and reproduction, and may interact with reproductive hormones like estrogen. Researchers are still exploring how cannabis affects these pathways, but early findings suggest cannabis may help restore balance during times of hormonal fluctuation, such as perimenopause.

 

 

What the Research Tells Us

 

Self-reported data: Much of the evidence comes from surveys, where participants consistently report improved sexual experiences with cannabis use.

 

Clinical trials: Controlled studies are still limited, but the data so far supports the idea that cannabis can positively influence arousal, lubrication, orgasm, and overall sexual satisfaction.

 

Caution with dosage: Cannabis often follows a biphasic effect—low doses may enhance libido, while high doses could dampen it.

 

 

Practical Tips for Using Cannabis for Sexual Health

 

• Start low and go slow, especially with THC.
• Reach out for support to understand the different forms and what might be best for you (inhaled, edible, topical).
• Use cannabis intentionally before sexual activity to maximize benefits.
• Pair cannabis use with lifestyle strategies like open communication, stress management, and healthy sleep.
• Consult with a healthcare provider before beginning or adjusting cannabis use, especially if taking other medications.

 

 

Why This Matters During Sexual Health Awareness Month

 

Sexual health is an important but often overlooked dimension of wellness. For people navigating changes in libido—whether due to stress, age, or hormonal transitions—cannabis offers a promising option for support. While more research is needed, the evidence so far highlights cannabis as a potential tool to enhance intimacy, reduce barriers like pain and anxiety, and support healthier, more fulfilling sexual experiences.

 

Cannabis is not a cure-all, but it can be an empowering aid in sexual health for both men and women. During Sexual Health Awareness Month, conversations like these are vital for breaking stigma and offering hope. If you’re curious about how cannabis might support your sexual wellbeing, consider exploring the research further and connecting with resources like the Cannabis Health Research Initiative.

As researchers and educators at Realm of Caring, we believe in a holistic, evidence-informed approach to supporting healthy aging and addressing Alzheimer’s disease. While aging is inevitable, there are natural strategies that show promising potential both for maintaining cognitive health and for helping manage symptoms in Alzheimer’s. In this post, we’ll explore what current research says about cannabinoids and complementary botanicals (including functional mushrooms) for brain health, quality of life, and aging well.

 

Understanding the Challenge: Aging, Alzheimer’s, and Brain Health

 

As we age, our bodies undergo changes. Skin becomes less elastic, muscle mass decreases, sleep patterns shift, and chronic conditions like cardiovascular disease and Alzheimer’s become more likely. Alzheimer’s disease is a progressive neurodegenerative disorder impacting memory, thinking, and behavior. There is no cure yet, but interventions that slow progression, reduce symptoms, or support quality of life are critically important. Statistics estimate millions of Americans are affected, and that number is expected to grow.

 

CBD & Cannabinoids: What the Research Suggests

 

Neuroprotection and Antioxidant Effects

 

One of the mechanisms by which cannabidiol (CBD) may help is by mitigating oxidative stress and excitotoxicity – both key contributors in Alzheimer’s pathology. Research shows that CBD can block or modulate harmful glutamate levels, acting comparably in some experiments to industrial antioxidants. This helps reduce damage to neurons. 

 

Interactions with Immune Cells & Inflammatory Pathways

 

The CB2 receptors, part of the endocannabinoid system, are expressed in microglial cells (the brain’s immune cells). Activation of these receptors by cannabinoids may help reduce neuroinflammation, which is a driving force in Alzheimer’s disease. By modulating inflammatory responses, CBD may help slow the progression of neurodegenerative events. 

 

Managing Behavioral & Lifestyle Symptoms

 

Neuropsychiatric symptoms such as sleep disturbances, agitation, depression, and anxiety often accompany Alzheimer’s. CBD and THC:CBD combinations have been studied for their effects on improved sleep quality through reducing sleep latency, lengthening sleep duration, and limiting awakenings. Some observational studies show reduced agitation and better mood in Alzheimer’s patients using cannabinoid extracts under supervision. 

 

Healthy Aging Beyond Alzheimer’s

 

For people aging without Alzheimer’s (or before onset), cannabinoids have been studied for benefits with skin health (hydration, antioxidant effect, anti-inflammatory), appetite regulation, cardiovascular health (anti‐inflammatory, antioxidant), metabolic health, pain and arthritis, muscle maintenance, and sleep quality. These benefits may help delay or mitigate risk factors associated with Alzheimer’s.

 

Practical Considerations & Safety for Cannabinoid Therapy

 

• Start low, go slow: Individual response to cannabinoids can vary. It is important to seek individualized support.

• Source and quality matter: Products should be high‐quality, tested for purity, consistent cannabinoid content, and free of contaminants. Check out the Quality of Product Matters Guide.

• Interactions: CBD may interact with medications; immune status, liver health, overall health status must be considered. Consult with you physician or a pharmacist if you are taking several medications.

• Legality and regulation: Laws vary by state and country; ensure compliance and proper documentation. Realm of Caring’s Observational Research Registry (ORR) is helping to gather real‐world data on safety and outcomes.

 

Complementary Botanicals & Functional Mushrooms

 

While cannabinoids show promise, combining them with other plant botanicals and functional mushrooms may offer synergistic effects for brain health and aging:

 

• Botanicals like turmeric, ginkgo biloba, bacopa have antioxidant, anti‐inflammatory, and neuroprotective properties in preliminary studies. When used appropriately, they may support cognition, memory, and vascular health.

• Functional mushrooms such as lion’s mane, reishi, cordyceps, and chaga are gaining attention. Lion’s mane, for example, has compounds that may stimulate nerve growth factor (NGF), which supports neuron health; anti‐inflammatory and antioxidant effects have been observed in animal and small human trials. Reishi and chaga add immune modulation and reduce oxidative stress, which are valuable in the context of Alzheimer’s and aging.

 

Toward a Holistic Plan

 

Pulling all this together, here’s what a holistic plan might look like:

 

• Adopt a nutrient‐rich, anti‐inflammatory diet (fruits, vegetables, healthy fats, mushrooms, botanicals).

• Include cannabinoids (CBD, or balanced THC:CBD in legal regions) under guidance, targeting symptoms like sleep disturbances, mood, inflammation.

• Incorporate botanicals and functional mushrooms as adjuncts for neuroprotection and immune support.

• Prioritize lifestyle factors: physical activity, restful sleep, stress management, social connection.

• Monitor, adjust, and always consult qualified professionals to tailor choices, monitor efficacy, and avoid adverse effects.

 

At Realm of Caring, our mission is to support you with rigorous research, client education, and community care. As new evidence emerges, we hope to offer increasing clarity on how CBD, other cannabinoids, botanicals, and functional mushrooms may be integrated into a safe, holistic regimen for Alzheimer’s and healthy aging. If you have questions about specific products, dosing, or strategies, our care specialists are available to help.

 

Inflammation is at the root of many health challenges, from arthritis and gut issues to brain fog and chronic pain. While inflammation is a natural defense mechanism, when it becomes chronic, it can fuel disease progression and significantly impact quality of life. Increasingly, research is showing that cannabis compounds may help regulate inflammation and support the body in finding balance.

 

The Endocannabinoid System and Inflammation

 

The endocannabinoid system (ECS) is a network of receptors, endocannabinoids, and enzymes that work to maintain homeostasis in the body. Among several other physiological actions, the ECS is a modulator of immune system activity. 

 

Cannabinoids from the cannabis plant interact with the ECS, potentially dialing down excessive inflammation. Research has found that cannabinoids can modulate immune cell activity, reduce oxidative stress, and calm overactive inflammatory pathways.

 

How CBD Might Help with Inflammation

 

CBD (cannabidiol) doesn’t produce intoxication, but it does have powerful anti-inflammatory effects. Studies show that CBD may:

 

• Reduce neurogenic inflammation, which is linked to chronic inflammatory diseases such as multiple sclerosis (MS), migraine, diabetes, and Parkinson’s disease.
• Calm intestinal inflammation by interacting with serotonin receptors and the gut’s immune system. This may assist in providing relief in conditions such as Crohn’s disease, inflammatory bowel disease (IBD), and ulcerative colitis.
• Benefits the healing process of joints and muscles by interacting with inflammatory mediator receptors and pathways. CBD may help control localized inflammation that causes pain and tissue damage in arthritic joints as well as alleviate muscle soreness after exercise or injury.

 

Consistent administration seems to be key, Researchers note that regular CBD use may build up its effects over time, rather than acting as a quick fix. Explore more on CBD and inflammation in our research library.

 

THC, Microdosing, and Pain Relief

 

THC is often associated with its euphoric effects, but in smaller amounts (microdosing) it may relieve pain and inflammation without noticeable intoxication. THC activates CB2 receptors in the immune system, which can reduce swelling and inflammatory signaling.

 

For some people, combining CBD with very low doses of THC (as in full-spectrum CBD products) may provide a more comprehensive anti-inflammatory effect. Research suggests that this synergy could support pain relief in arthritis, inflammatory bowel diseases, and neuro-inflammatory conditions.

 

CBDA for Inflammation

 

Cannabidiolic acid (CBDA) is one of three cannabinoid precursor compounds converted from Cannabigerolic acid (CBGA). CBGA also converts to the precursor compounds Tetrahydrocannabinolic acid (THCA) and Cannabichromenic acid (CBCA) or may convert to its non-acidic form, Cannabigerol (CBG).

 

CBDA inhibits the COX-2 Enzyme. These enzymes are associated with inflammation after injury or infection. Therefore, by blocking COX-2 Enzymes, CBDA may relieve inflammation and associated pain. In a rodent study, equivalent amounts of CBD and CBDA were administered to test efficiency in reducing hyperalgesia. The low amount of CBD was not efficient in reducing this increased sensitivity to pain when exposed to normal stimuli. The CBDA, on the other hand, did reduce hyperalgesia at that same low amount. In the same study, amounts of THC and CBDA so low that they were deemed “ineffective” were administered. When these ineffective, low amounts were combined it was shown in the animal models to have anti-inflammatory and anti-hyperalgesia effects on acute inflammation.

 

CBG for Inflammation

 

Cannabigerol (CBG) was first discovered and synthesized by Raphael Mechoulam and Yehiel Gaoni in 1964. As previously mentioned, it is derived from cannabigerolic acid (CBGA) once heated, becoming a very stable molecule.

 

Animal studies have shown CBG to reduce the effects of inflammatory bowel disease. Several studies, in vitro and in animal models, have also shown CBG to have neuroprotective potential for reducing the severity of neurological illnesses, such as Huntington disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and MS. The anti-inflammatory and antioxidant benefits contribute to reducing glutamate-induced oxidative stress and cell death, as shown in mouse models.

 

Consistency Matters

 

One of the most important takeaways from the research is that consistent administration may be necessary to witness anti-inflammatory benefit. Like many wellness strategies, cannabinoids may take time to build their effects. Sticking to a routine and keeping track of responses can help individuals find what works best for them.

 

Concluding Thoughts

 

While promising evidence is mounting for the use of several cannabinoids for inflammation-related conditions, more large-scale clinical trials are needed. Cannabinoids such as CBD, THC, CBDA, and CBG show real potential in calming inflammation, relieving pain, and improving quality of life for people living with acute and chronic inflammatory conditions. The key is understanding how these compounds interact with your unique body and doing so safely with guidance.

 

Introduction

 

When facing cancer, many people look beyond traditional treatments for options that might help manage symptoms or even fight the disease itself. Cannabis is often part of that conversation. At Realm of Caring, we hear from families every day who are exploring cannabinoid therapy with curiosity and hope. One scientific concept that comes up often is angiogenesis; but what does that mean, and how does cannabis connect to it?

 

 

What is Angiogenesis?

 

 

Angiogenesis is the process by which new blood vessels form in the body. Normally, this is an essential function as it helps heal wounds and allows tissues to grow. But in cancer, angiogenesis can work against us. Tumors can “hijack” this process to create their own blood supply, feeding their growth and enabling them to spread. This is why many cancer therapies aim to stop or slow angiogenesis.

 

 

Where Cannabis Fits In

 

 

Some preclinical research suggests that cannabinoids, especially delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may have antiangiogenic properties. In other words, they may help reduce the formation of these new blood vessels that tumors need to thrive. Research also shows cannabinoids may play a role in apoptosis (programmed cell death), another process that can slow the spread of cancer cells.

 

However, it is important to note that most of this research is early stage, conducted in labs or animal models. We do not yet have large, controlled human trials that confirm exactly how cannabis works against cancer.

 

 

Setting Expectations: Cannabis in Cancer Care

 

 

Because of these research gaps, cannabis should be approached realistically:

 

• For symptom management:  Lower doses of cannabinoids are often enough to help with nausea, pain, sleep, appetite, and overall quality of life during treatment.
• For anticancer effects: Some individuals pursue higher-dose regimens that include THC. While there are powerful stories of success, these are anecdotal, and what works for one person may not work for another.
• Safety matters: Cannabis is generally considered safe to use alongside chemotherapy and radiation, but there are exceptions (such as some immunotherapies and hormone-sensitive cancers). Always involve your oncology team in the conversation.

 

 

Holistic Healing

 

 

At Realm of Caring, we also encourage looking at the bigger picture. Cancer care isn’t just about one therapy, rather about giving the body the best chance to heal. That includes nutrition, minimizing toxic exposures, managing stress, and nurturing emotional and spiritual well-being. Cannabis may be one part of that holistic approach.

 

 

Key Takeaways

 

• Angiogenesis is how tumors grow new blood vessels; stopping it is a major focus of cancer therapies.
• Early research suggests cannabinoids may influence angiogenesis and apoptosis, but more human studies are needed.
• Cannabis is not a replacement for conventional care but may complement it, especially for symptom relief.
• Every person responds differently; dosing and outcomes vary widely.

 

 

Closing

 

Exploring cannabis during cancer care requires both hope and realism. At Realm of Caring, we’ve supported families through more than 300,000 interactions and 2.5 million minutes of guidance since 2013. Our Care Specialists are here to provide education, tools, and compassion as you navigate your journey.

 

Reach out to us anytime to talk with a Care Specialist and learn more about safe, informed approaches to cannabinoid therapy.

 

View our Cancer Administration Guidelines. 

 

Fibromyalgia can feel relentless. For those living with it, the daily reality often includes widespread pain, exhaustion, migraines, brain fog, sleep struggles, and mood changes. Standard treatments from antidepressants and muscle relaxants to physical therapy and lifestyle changes can help, but many people still find their symptoms stubbornly persistent.

 

A recently published case report explored an option for symptom relief: cannabidiol (CBD), specifically surveying the use of Epidiolex, the FDA-approved pharmaceutical form of CBD. While Epidiolex is currently only approved for rare forms of epilepsy, this research highlights an emerging conversation about CBD’s potential role in managing fibromyalgia.

 

The Research Spotlight: Two Cases of Relief

 

The published article followed two individuals with treatment-resistant fibromyalgia. Despite trying multiple conventional therapies, their symptoms remained overwhelming. When each was introduced to Epidiolex (a purified CBD isolate) their pain, sleep quality, and overall wellbeing significantly improved.

 

This is a small case series, not a large clinical trial, so it can’t prove that CBD is universally effective. But it adds momentum to a growing body of research suggesting cannabinoids may help ease the complex symptom picture of fibromyalgia.

 

Explore more in our Research Library

 

Isolate vs. Full-Spectrum CBD: What’s the Difference?

 

It’s important to note that Epidiolex is a CBD isolate. That means it contains only pure CBD, without any other compounds from the cannabis plant.

 

In contrast, most consumer-available CBD products are sold as full-spectrum or broad-spectrum:

 

• Full-spectrum: Includes CBD along with other cannabinoids (like CBG, CBC, and small amounts of THC), terpenes, and flavonoids.

 

• Broad-spectrum: Similar to full-spectrum but typically without THC.

 

Why does this matter? Many researchers believe these compounds may work together synergistically in what’s known as the entourage effect, which potentially amplifies CBD’s benefits for pain, mood, and sleep.

 

What We Know About Cannabis and Fibromyalgia

 

So far, the evidence for cannabis and fibromyalgia is still emerging:

 

• Results published in Pain Practice suggest a potentially significant role that cannabis can play for women with treatment-resistant Fibromyalgia. Further studies are warranted for long-term use, but short-term use is associated with enhanced quality of life via improved markers such as pain and sleep.

 

• A published systematic review found cannabis to be safe and well tolerated for those suffering with Fibromyalgia with no serious adverse events reported. 

 

• Findings from a published article in Journal of Clinical Rheumatology showed that after commencing the use of medicinal cannabis, all patients identified with Fibromyalgia reported a significant improvement in every parameter on the questionnaire provided and 50% stopped taking any other medications for their diagnosis.

 

At the very least, these studies are expanding the conversation: for some individuals, cannabinoid therapy may offer hope when conventional options fall short.

 

 

Why This Matters for People with Fibromyalgia

 

Because fibromyalgia touches so many aspects of health, approaches that target multiple systems may hold more promise. Whole-plant hemp extracts, with their mix of cannabinoids and aromatic terpenes, could offer benefits beyond CBD isolate alone.

 

That said, consumer CBD products vary widely in quality, potency, and labeling accuracy. What’s on the bottle isn’t always what’s inside, which makes education and support so important.

 

Tips for Exploring CBD with Fibromyalgia

 

If you’re curious about whether CBD could be part of your fibromyalgia management, here are some steps to take:

 

• Choose wisely: Look for products with third-party lab testing and transparent ingredient sourcing.

 

• Start low, go slow: Begin with a low dose and gradually increase until you find your “sweet spot.”

 

• Track your journey: Note changes in pain, sleep, energy, and mood so you can better understand what works.

 

• Talk with your provider: CBD can interact with other medications. Having a doctor in the loop is essential.

 

• See it as a tool, not a cure: CBD may help manage symptoms, but it works best as part of a holistic plan including movement, stress management, nutrition, and support.

 

For additional reading, check out our Client Resources for guides and education on cannabis therapies.

 

You Don’t Have to Navigate This Alone

 

If you are living with fibromyalgia and want to explore CBD but feel overwhelmed by the options just know you are not alone. At Realm of Caring, our care team offers free 1:1 support to help you:

 

• Understand the latest research.

 

• Find high-quality products you can trust.

 

• Learn how to have open, safe conversations with your doctor.

 

• Develop a personalized approach that fits your needs.

 

Connect with our care team today. Relief may not look the same for everyone, but you deserve to explore every option that could improve your quality of life.

 

Alcohol is one of the most widely consumed substances in the world. For many, drinking is part of social life, yet the consequences of overuse include liver damage, increased risk of chronic disease, and a staggering toll on mental health and relationships. As researchers look for safer strategies to support recovery and reduce harm, cannabidiol (CBD) has emerged as a promising ally.

 

CBD, a non-intoxicating compound from the cannabis plant, has gained attention for its potential therapeutic benefits, which include reducing anxiety and supporting better sleep. Now, new research suggests CBD may also support individuals struggling with alcohol use disorder (AUD) and play a role in harm reduction.

 

CBD and the Liver: A Potential Protective Role

 

Chronic alcohol use is toxic to the liver, often leading to fatty liver disease, inflammation, and cirrhosis. Interestingly, preclinical studies suggest that CBD may offer protective effects against alcohol-induced liver injury.

 

CBD has shown in studies to reduce oxidative stress and inflammation, two of the primary drivers of liver damage from alcohol consumption. While more human research is needed, these findings raise an important possibility: CBD may help buffer the liver against some of the toxic effects of alcohol and may even prevent neuronal loss, potentially supporting overall health in people at risk.

 

CBD and Alcohol Cravings

 

Beyond physical damage, one of the most challenging aspects of AUD is the cycle of craving and relapse. Preliminary evidence indicates that CBD may help here, too.

 

Research has shown that CBD interacts with the brain’s endocannabinoid system (ECS), which plays a role in regulating stress, reward, and addictive behaviors. In rodent models, CBD reduced alcohol-seeking behavior and relapse triggered by stress or environmental cues.

 

Though human trials are still limited, early clinical studies suggest that CBD’s ability to reduce anxiety and improve sleep may indirectly help individuals manage alcohol cravings and maintain recovery.

 

Harm Reduction: Alcohol, Cannabis, and the Middle Ground

 

Harm reduction is the idea of minimizing risks rather than insisting on complete abstinence. For some, cannabis is used as a substitute for alcohol, with research showing people may reduce alcohol intake when using cannabis.

 

However, this raises a cautionary note for a subset of individuals as substituting alcohol with cannabis could increase the risk of developing cannabis use disorder (CUD). Here, CBD may again serve as a unique tool. Unlike THC, CBD is non-intoxicating and has been investigated as a possible treatment for substance use disorders because of its calming and anti-craving properties.

 

This suggests CBD could be a “middle ground” in harm reduction strategies as a way to help reduce alcohol consumption without swapping one intoxicating substance for another.

 

What This Means for You

 

The research on CBD, alcohol, and addiction is still in its early stages but the results so far are compelling. CBD may:

 

• Support liver health by reducing oxidative stress and inflammation.

 

• Help reduce alcohol cravings and relapse risk.

 

• Serve as part of a harm reduction strategy without increasing intoxication risks.

 

If you or someone you love is curious about exploring CBD as part of an alcohol harm reduction or recovery strategy, you don’t have to navigate it alone.

 

Connect with Us

 

At Realm of Caring, our mission is to empower you with unbiased, research-backed information. Our care team offers free 1:1 support to help you:

 

• Find safe, high-quality CBD products.

 

• Learn how to discuss CBD use with your doctor.

 

• Get answers to your research questions.

 

Reach out today to take the next step toward a healthier relationship with wellness.

August 15th is National Relaxation Day that serves as a gentle reminder to pause, breathe, and let some of life’s stress roll off your shoulders. While there are many ways to unwind, some people are exploring how cannabis compounds like CBD and THC, in very small amounts, may support a calmer state of mind.

 

What is Microdosing? 

 

Microdosing refers to consuming very small amounts of a substance to experience potential benefits without strong or unwanted effects. In the context of cannabis, microdosing THC may offer certain therapeutic effects such as supporting relaxation, focus, or mood without the more intoxicating or overwhelming experience that higher doses can bring.

 

A Quick Look at the Cannabis Plant

 

The cannabis plant contains more than 100 cannabinoids, which are naturally occurring compounds that interact with the body’s Endocannabinoid System (ECS). Two of the most well-known and abundantly available in the cannabis plant are:

 

Delta-9-Tetrahydrocannabinol (THC): The primary cannabinoid responsible for the “high” associated with cannabis use and researched for its therapeutic potential.

 

Cannabidiol (CBD): A non-intoxicating cannabinoid studied for potential roles in reducing anxiety and improving sleep, among others. 

 

The ECS is a key regulator of stress response, critical to assist our bodies in returning to a relaxed state. The interaction of plant-based cannabinoids, such as THC and CBD, and our ECS makes cannabis a likely candidate for alleviating the symptoms of many health conditions, to include stress. In fact, cannabis has been used medicinally for thousands of years in various societies around the world to reduce the physiological and psychological consequences of stress and fear.

 

Why Relaxation Matters for Health

 

Chronic stress can take a toll on mental, physical, and emotional health. Research shows that regular relaxation practices may help lower blood pressure, improve sleep quality, reduce muscle tension, and support emotional balance. National Relaxation Day, observed annually on August 15th, serves as a reminder to step back from daily pressures and prioritize stress management for long-term wellness.

 

CBD and Relaxation: What the Evidence Shows

 

CBD has been studied for its potential to help the body adapt to stress by interacting with neurotransmitters such as serotonin, dopamine, and GABA, which are involved in mood regulation and relaxation.

 

Survey data from thousands of CBD consumers suggest that many report:

 

• Calmer mood during stressful situations 
• Reduced feelings of mild or temporary anxiety 
• Improved sleep quality 

 

Research indicates that CBD’s effects can vary depending on product type, dose, and individual body chemistry. Common ways people incorporate CBD into relaxation routines include:

 

• Tinctures for faster absorption 
• Edibles for convenience and taste 
• Topicals for localized tension relief 
• Bath products for a spa-like experience 

 

Microdosing THC: A Low-Impact Approach

 

Microdosing THC involves consuming a very small amount (often 2 mg or less per serving) to potentially experience benefits such as reduced stress, improved focus, or relief from discomfort without intoxicating effects.

 

Low amounts of THC may have different effects compared to higher doses. For example:

 

• Some research suggests small amounts may support mood and relaxation, while larger amounts could have the opposite effect. 
• Low-dose THC has been explored for its potential to help with pain management without significant intoxication. 

Importantly, microdosing is highly individual. What is “low” for one person may be too much for another. This is why the “start low, go slow” approach is often recommended when beginning with any cannabinoid product.

 

CBD and THC Together

 

There is growing interest in the “entourage effect,” the theory that cannabinoids and terpenes may work better together than alone. CBD may help moderate some of THC’s unwanted effects, such as anxiety or rapid heart rate, while enhancing potential benefits for relaxation, mood, and discomfort.

 

Other things to keep in mind before you consume:

 

• Intention matters
• Quality of product matters
• Free 1:1 support is just a phone call away

 

Conclusion

 

While research is ongoing, both CBD and microdosed THC are being explored as tools that may support relaxation and balance by working with the body’s endocannabinoid system. For those interested in cannabinoids, understanding dosing, individual variability, and product selection is key to making informed choices about how they fit into a broader wellness routine.

 

Founded by Heather Jackson and Paige Figi in 2013, Realm of Caring (RoC) began as a small, community-driven nonprofit – a lifeline for families seeking hope for their ailing children. Early on, RoC’s founding moms helped pioneer changes in medical cannabis laws across the United States. In fact, in the first 18 months, they helped change laws in 19 states, enabling families to legally access hemp-derived CBD therapies for conditions like intractable epilepsy. What started at the grassroots level in Colorado quickly evolved into a broader movement for education, advocacy, and change. Over the past 12 years, RoC has revolutionized how patients, caregivers, and even lawmakers approach cannabis, chipping away at stigma and influencing policy nationwide. Medical cannabis is now legal in the majority of states – a shift due in part to relentless advocacy by RoC and the families it empowered. This transformation from a local support network to a nationally respected leader exemplifies the theme “From Grassroots to Global,” as RoC’s impact now reaches far beyond its humble beginnings.

 

Milestones in Research: ORR and Scientific Breakthroughs

 

A cornerstone of RoC’s success has been its commitment to research. Recognizing the lack of data on cannabinoid therapy, RoC partnered with Johns Hopkins University to launch the Observational Research Registry (ORR) – an online, IRB-approved study tracking health outcomes in cannabis users and non-users over time. Since its launch in 2016, the ORR has grown into the largest cannabinoid therapy research program in the United States. This long-term registry has allowed researchers to gather invaluable real-world evidence on how people use cannabis and hemp-derived CBD, the benefits they experience, and any risks involved. In collaboration with Johns Hopkins, RoC published its first peer-reviewed study from ORR data in the journal Cannabis and Cannabinoid Research, marking a major milestone in legitimizing CBD therapy with scientific evidence. The study found that participants using artisanal (non-pharmaceutical) CBD reported greater health satisfaction, improved sleep, and lower anxiety and depression compared to non-users. Notably, adults using CBD even saw fewer hospital visits and sick days, highlighting tangible improvements in quality of life. These findings provided hard data to back up what families had been reporting anecdotally for years – that cannabis therapies can profoundly improve well-being.

 

RoC’s research momentum hasn’t stopped there. Nearly half a dozen papers have been generated or are in progress from the ORR, covering conditions from epilepsy to anxiety and chronic pain. In 2022, for instance, RoC and Johns Hopkins researchers surveyed 808 patients with neurological or pain-related disorders; 77% reported positive effects from medicinal cannabis, including reduced pain (28% of respondents), improved sleep (18%), and less anxiety (22%). Such real-world data are helping to fill gaps in clinical knowledge. It’s no surprise that RoC’s Executive Director Sasha Kalcheff-Korn emphasizes leading with science. As Matthew Lowe, PhD (RoC’s Senior Director of Research) noted, “large-scale research is a necessary, ethical, and essential safeguard to minimize negative side effects and adverse reactions.” – a testament to RoC’s leadership in generating evidence. The registry’s success even led to a federal research collaboration: in 2023, RoC joined as a collaborator to an NIH-funded project awarded to Johns Hopkins to develop a national medicinal cannabis use registry. This project, known as the Cannabis and Health Research Initiative enrolls first-time users in the National Cannabis Study while lending the data to a greater repository, open for academic collaboration. From a grassroots data-gathering effort to a nationally recognized research initiative, RoC has firmly established itself as a scientific authority in the cannabis field.

 

Advocacy Wins: Championing Access and Policy Change

 

While building the science, RoC has never lost sight of its advocacy roots. The organization was born from advocacy as parents fought for their children’s right to try a natural therapy. That spirit continues to drive RoC’s work today. Breaking the cannabis stigma has been a central focus: RoC “stands out for its unwavering commitment to empowering individuals seeking cannabinoid therapy” and has a remarkable story of dismantling cannabis stigmas through education and outreach. Each personal story of healing shared, each public presentation or media appearance, has chipped away at misconceptions and fear. The results are evident in shifting public opinion – as Heather Jackson puts it, “…we are seeing this therapy move to the forefront as an option instead of a last one”. Back in 2012, discussing CBD openly was controversial; today, doctors themselves refer patients to RoC for guidance, a clear sign of progress.

 

RoC has also been on the front lines of policy advocacy. Beyond the early wave of state-level CBD legislation (e.g. “Charlotte’s Web” laws), RoC continues to engage policymakers to ensure safe and sensible cannabis regulations. In Colorado, for example, when an overly restrictive hemp bill (SB 205) threatened patient access, RoC sprang into action “in overdrive to protect access to these life-saving medicines.” Heather Jackson and the RoC team rallied stakeholders and helped get the bill amended to strike a balance – protecting consumers from unsafe products without cutting off access to full-spectrum hemp options. This is just one instance of RoC’s advocacy wins. Nationally, RoC has lent its voice to federal efforts like the push for an FDA regulatory framework for CBD and the call to deschedule cannabis from Schedule I, which would remove barriers to research and access. As a nonprofit, RoC isn’t motivated by profit, but by compassion and justice, speaking up so that no family has to uproot their lives or break the law to get a chance at wellness. Each advocacy victory (big or small) means more people can access cannabinoid therapies without stigma or legal peril.

 

Community Support and Education: Empowering Thousands

 

Even as it grew globally, RoC has remained deeply committed to community support. At its heart, RoC is about people helping people. Over 12 years, RoC’s Care Team has provided free, personalized guidance to tens of thousands of clients around the world. Whether it’s a parent desperate for administration support for their child’s seizures, a veteran seeking alternatives for pain management, or an elderly patient curious about CBD for arthritis – RoC’s specialists are there to listen and help. The organization offers one-on-one phone consultations, email support, and an array of educational resources, all at no cost. In fact, RoC has fielded over 260,000 inquiries through its call center, totaling more than 2.5 million minutes on the phone providing support and information, a staggering indicator of both the need and RoC’s dedication. These interactions often turn into relationships; many who once were callers in crisis have become members of the RoC family, celebrating improvements and sharing their journeys.

 

Education is another pillar of RoC’s mission. The team curates a Research Library and weekly informational blogs, hosts monthly webinars on topics ranging from cannabinoid basics to the latest scientific findings, and even runs virtual support groups and a community book club. All these efforts align with RoC’s belief that knowledge is power. By equipping patients, caregivers, and healthcare professionals with evidence-based information, RoC helps individuals make informed decisions about cannabis therapy. The website itself is a rich resource – a hub where you can find dosing guides, FAQs, a glossary of terms, and even a portal for medical professionals seeking education on cannabinoid treatments. This commitment to education and support has built a global community. RoC has become an educational resource for consumers, physicians, scientists, governments and the media, bridging the gap between the scientific world and the public. In doing so, it empowers families to advocate for their health and fosters a compassionate community united by the goal of improving quality of life through plant-based therapy.

 

Challenges and Hope: The Road Ahead

 

As we celebrate how far RoC has come, we also candidly acknowledge the ongoing challenges that remain. Despite much progress, legal and financial hurdles still hinder the full potential of cannabinoid therapy. Access and policy are at the forefront. Because cannabis remains a Schedule I substance at the federal level, research is harder to conduct and patients in some states still struggle with limited access or confusing regulations. The stigma hasn’t vanished overnight either; misconceptions linger in some corners, and RoC’s work in educating the public and healthcare community must continue with vigor. Another challenge is research funding. As Heather Jackson has openly noted, RoC is a traditional nonprofit and “needs aligned industry partners, philanthropic donors and the community to invest in our impact if we are truly going to make a big difference.” Unlike commercial enterprises, RoC relies on grants and donations to fund its research and outreach programs – and securing those resources is a constant struggle in an industry that is still finding its footing.

 

Yet, the tone is overwhelmingly hopeful. Each year on National CBD Day, we’re reminded of how dramatically the landscape has changed in a short time and how RoC’s persistence has contributed to that change. Cannabis therapies that were once considered fringe are rapidly moving toward mainstream acceptance. People from all walks of life are now exploring hemp-derived CBD and medicinal cannabis as wellness options, often at the recommendation of their doctors, which was unheard of a decade ago. The data collected and published by RoC are validating the benefits (better sleep, less anxiety, improved well-being) that early adopters experienced. Policymakers are slowly coming around, evidenced by bipartisan efforts to create sensible regulations and even interest from federal agencies in studying cannabis. The road hasn’t been easy – and there is much work ahead to ensure equitable access, continued research, and the dismantling of outdated stigma – but RoC’s journey so far proves that change is possible when passionate people unite around a common cause.

 

Joining the Mission: How You Can Help

 

Celebrating 12 years is not just about looking back – it’s about forging ahead with even greater determination. Realm of Caring’s story is still being written, and you can be a part of its next chapter. How? By lending your support and voice. If RoC has touched your life or you believe in the power of this work, consider making a donation – big or small, every bit fuels critical research and keeps vital education and support services free for those who need them. As a 501(c)(3) nonprofit, RoC relies on community generosity to continue its programs and to fund groundbreaking studies that could inform the medical community and change policy. You can also directly participate in research: the Observational Research Registry is always seeking more contributors. Enrolling in the ORR (which is open to anyone, whether you use cannabis or not) is a simple but impactful way to advance knowledge. Your anonymous survey data becomes part of the evidence that researchers and policymakers look at when shaping the future of cannabis therapy. And of course, you can spread the word – share RoC’s resources with friends, join its webinars, or become an advocate in your own community.

 

On this 12th birthday and in celebration of National CBD Day, we at Realm of Caring are filled with gratitude and optimism. Together, we’ve come so far – from a few families searching for hope, to a global community tens of thousands strong. Yet our work is far from finished. By continuing to stand together – scientists, supporters, clients, and advocates – we will push the boundaries of knowledge, overcome the remaining challenges in access and stigma, and ensure that everyone who can benefit from cannabinoid therapy has the chance to do so. Here’s to 12 years of progress and to a future where plant-powered wellness is available to all. Thank you for being part of our journey, and happy National CBD Day!

 

— The Realm of Caring Team

If you’ve browsed a CBD store or hemp dispensary lately, you may have come across terms like “Delta-8 THC,” “Delta-9 THC,” and “hemp-derived THC.” They may sound similar, but the differences between them can have a big impact on how they affect your body – and your legal standing depending on where you live.

 

At Realm of Caring, we are here to help you make informed, empowered decisions. Whether you are exploring plant-based therapies for the first time or are a seasoned cannabis consumer, understanding how different forms of THC behave in the body is essential.

 

What is THC, Anyway?

 

THC, short for tetrahydrocannabinol, is the primary intoxicating compound found in cannabis. It binds to CB1 receptors in the brain and nervous system, which can influence mood, memory, pain perception, appetite, and more.

 

When most people refer to THC, they’re talking about Delta-9 THC, the compound responsible for the classic “high” associated with cannabis. But due to evolving laws and consumer demand, other forms of THC have emerged in the market,  including Delta-8 THC and hemp-derived Delta-9 THC.

 

Delta-9 THC: The Classic Compound

 

Delta-9 THC is the most researched and abundant form of THC found naturally in the cannabis plant. It’s well known for its intoxicating effects at moderate to high doses, and it has also been studied for potential medicinal and therapeutic uses including:

 

• Reducing nausea and vomiting (especially during chemotherapy)
• Stimulating appetite
• Supporting pain relief
• Easing muscle spasticity (especially in conditions like MS)

 

Because Delta-9 THC is federally classified as a Schedule I controlled substance, it is still highly regulated. However, hemp-derived Delta-9 THC (less than 0.3% by dry weight, per the 2018 Farm Bill) is allowed under federal law, a nuance that some companies use to sell THC-containing edibles, vapes, and tinctures nationwide.

 

Consumer Tip: While hemp-derived Delta-9 is legal in many states, it still produces the same psychoactive effects. Always start with a low dose and understand how your body reacts.

 

Delta-8 THC: A Close Cousin, But Not the Same

 

Delta-8 THC is a cannabinoid that occurs in very small amounts naturally in hemp and cannabis. To produce Delta-8 products at scale, manufacturers typically convert CBD into Delta-8 through a chemical process called isomerization, which alters the molecular structure.

 

Delta-8 and Delta-9 THC are nearly identical, sharing the same molecular formula (C₂₁H₃₀O₂), (which also happens to be the same molecular formula as cannabinoids cannabichromene (CBC) and cannabidiol (CBD), and the hormone progesterone) and both bind to CB1 receptors in the brain. But Delta-8 is generally considered potentially less potent and less intoxicating, which has made it popular among people seeking relief without a strong high.

 

Some promising studies, including research in pediatric cancer patients, show Delta-8 may help reduce nausea with fewer side effects than Delta-9 THC. In mouse models, it has also shown the potential to increase appetite and cognitive performance without as much psychoactivity.

 

However, most Delta-8 THC on the market is synthetically derived and unregulated. This means:

 

• There is limited oversight on how it’s produced
• Lab testing is inconsistent or absent
• Products may contain contaminants or significantly more THC than advertised

 

Many states have taken action to ban or restrict Delta-8 sales due to concerns about consumer safety, especially when products skirt regulations intended for marijuana-derived THC.

 

Consumer Tip: Be cautious with Delta-8. Look for third-party lab tests and avoid products that don’t disclose how the cannabinoid was derived or what’s in it.

 

Hemp-Derived THC: Legal Loopholes and Consumer Confusion

 

The term “hemp-derived THC” typically refers to cannabinoids like Delta-8 or Delta-9 that are sourced from hemp (cannabis plants with less than 0.3% Delta-9 THC by dry weight). Because of this federal definition, manufacturers are able to infuse hemp-derived cannabinoids into edibles and oils, sometimes containing enough THC to produce intoxicating effects, even if technically compliant with the letter of the law.

 

While this may seem like a win for accessibility, it creates a confusing consumer landscape. Products may appear to be CBD-only or “non-psychoactive” based on hemp labeling, but in reality they can:

 

• Cause a THC high
• Show up on a drug test
• Contain synthetic or unregulated compounds

 

As a result, consumers seeking non-intoxicating relief may unknowingly purchase products that affect their cognition, coordination, or overall health.

 

Consumer Tip: Read labels and seek transparency with a company prior to purchasing. 

 

Awareness is Everything

 

All forms of THC – whether Delta-9, Delta-8, or hemp-derived – have psychoactive potential at certain doses. The key difference lies in how they’re made, how much we know about their safety, and how they’re regulated.

 

At Realm of Caring, we advocate for transparency, research, and consumer safety. Here’s what we recommend:

 

• Start low and go slow, especially with new or unfamiliar products
• Ask for Certificates of Analysis (COAs) from third-party labs
• Choose products from trusted sources that explain their extraction process
• Stay up-to-date on your state laws

 

And most importantly, don’t be afraid to ask questions. Our care team is here to help you navigate the world of cannabis with confidence.