Category: Education

As the Halloween candy aisle looms and sugar consumption spikes, many Americans are becoming increasingly aware of just how detrimental excess sugar can be for our health. What if there were more to maintaining healthy blood-sugar control than simply cutting sweets? Emerging research into cannabinoids, especially Cannabidiol (CBD),  suggests they may play a role in how our bodies process sugar and regulate metabolism. For people at risk of type 2 diabetes, or those simply hoping to support balanced sugar metabolism while still navigating seasonal indulgences, it is worth exploring what the science shows, what remains speculative, and how cannabinoids might potentially assist alongside (not instead of) established lifestyle and wellness regimens. 

 

Why Sugar Metabolism Matters Right Now

 

Sugar, or glucose, metabolism is the process by which energy in the foods we eat is made available as fuel for the body. After we eat, our pancreas releases insulin, a hormone that helps move glucose from the bloodstream into our cells for energy or storage. However, when this system is overloaded, either from excessive sugar intake or too little activity, insulin sensitivity can decrease. This means the body needs more insulin to get the same effect, setting the stage for higher blood sugar levels and metabolic challenges. 

 

Maintaining balanced glucose levels is essential for people living with diabetes or are prediabetic as well as those seeing sustained energy and overall wellness. 

 

Introducing the Endocannabinoid System (ECS) and Cannabinoids

 

The ECS helps to regulate several bodily processes. This includes appetite, mood, pain, inflammation, and energy balance. It is composed of receptors found throughout the body and brain, including those areas involved in metabolism: fat cells, liver, and muscles. 

 

Cannabidiol (CBD) is one of major, non-intoxicating, phytocannabinoids found in Cannabis sativa with researched antioxidant, anti-inflammatory, antipsychotic, and anxiolytic properties. It has been reported to have therapeutic effect on diabetes, cardiovascular diseases, cancers, and neurodegenerative diseases; attributed to its potent antioxidant properties. 

 

What Research Shows So Far: Considering Obesity and Type 2 Diabetes

 

Data is limited for cannabinoids and metabolic processes; however when it comes to glucose homeostasis, CBD appears to maintain it while sensitizing adipose tissue to insulin, and reducing fasting glucose levels. 

 

A 2013 published study further investigated findings from previous epidemiological studies that found lower prevalence rates of obesity and diabetes mellitus in cannabis users compared to those who have never used cannabis. Their results found that cannabis use (not specifically CBD) was associated with 16% lower fasting insulin levels and a significant association between cannabis use and smaller waist circumferences. 

 

A more recently published study, in March of 2025, provides strong evidence of CBD’s antidiabetic potential, particularly through its ability to modulate glucose metabolism and tendency to regulate insulin levels. 

 

What Research Shows So Far: Additional Health Risks Attributed to Excessive Sugar

 

Studies show that high sugar intake may be attributed to increased inflammation, heart disease, elevated blood pressure, and cognitive decline. 

 

CBD has been researched for the many ways it may benefit our heart health, some of the most notable therapeutic actions of the molecule are the anti-inflammatory and antioxidant properties. The therapeutic potentials of CBD are why it is being considered in research for the prevention and treatment of these conditions and diseases. In addition, CBD has particularly gained momentum because it does not appear to have effects on resting blood pressure or heart rate, rather it has shown in vivo to reduce the cardiovascular response to various stress types. 

 

Prolonged CBD therapy has shown positive improvements in psychological symptoms and cognition. Currently, using cannabinoids to benefit neurological issues and serve as a neuroprotectant is being studied. The antioxidant properties of cannabinoids, such as CBD, may have the ability to provide neuroprotection. As well, research is showing that elevation of cannabinoid receptor activity could potentially slow down the progression of brain ageing and alleviate symptoms associated with neurodegenerative disorders, therefore cannabinoids with the ability to activate receptors may provide these additional benefits.

 

Practical Integration: CBD as a Supportive Tool

 

If you’re curious about using CBD to support a balanced metabolism (or for other health concerns), here are a few practical tips to keep in mind as you incorporate it into your holistic wellness routine: 

 

CBD is not a cure or replacement for healthy habits. Balanced nutrition, regular physical activity, hydration, and sleep remain the cornerstones of blood sugar health.

 

Quality matters. Choose products that are third-party tested, clearly labeled, and sourced from reputable brands. Realm of Caring’s Care Team can help guide you toward safe, evidence-based options.

 

Start low and go slow. The right dose can vary widely depending on the individual, product type, and health goals.

 

Talk with your healthcare provider. CBD may interact with certain medications, including those that affect blood sugar or liver enzymes.

 

Timing and mindfulness. Around high-sugar events (like Halloween), pairing CBD with mindful eating, fiber-rich snacks, and post-meal activity can all contribute to steadier glucose levels.

 

Looking Ahead

 

Scientists are continuing to study how cannabinoids may influence metabolism, inflammation, and energy balance. For now, the evidence points to CBD playing a supportive role, particularly through its effects on inflammation and oxidative stress. 

Further research is needed and Realm of Caring has several opportunities for you to join (and win gift cards)! Visit our research participation page to find out more.

Menopause is a natural transition that most women experience between the ages of 45 and 55. It occurs 12 months after cessation of a woman’s final menstrual cycle; following this time period, a woman enters postmenopause. The stage leading up to menopause, known as perimenopause, often begins in the early 40s (however may start in their 30s) and brings its own set of challenges. During this time, fluctuating hormones can disrupt sleep, mood, energy, and cognitive clarity, leaving many women feeling out of sync with their bodies and minds. 

 

In fact, studies suggest that nearly 85% of women experience symptoms during menopause, varying in severity and type to include: hot flashes, night sweats, sleep disturbances, mood swings, and decreased libido. As awareness grows, many women are seeking natural, evidence-informed strategies to support their well-being. Two emerging areas of interest are cannabinoids and functional mushrooms, which may complement traditional approaches and promote balance during this transitional period.

 

Understanding Hormonal Changes and the Endocannabinoid System

 

The hormonal fluctuations of perimenopause and menopause impact nearly every system in the body. Declining estrogen levels can lead to sleep disruptions, mood changes, brain fog, and decreased bone density. Interestingly, estrogen also interacts with the endocannabinoid system (ECS), a biological system that regulates balance across multiple physiological processes.

 

Research indicates that during menopause, cannabinoid receptor expression and endocannabinoids levels are altered. Therefore, the ECS may serve as a potential therapeutic target in preventing the effects of menopause-related diseases such as obesity, osteoporosis, cardiovascular disease, and cancer-types. This is where phytocannabinoids from plants such as cannabidiol (CBD), delta-9-tetrahydrocannabinol (THC), cannabidiolic acid (CBDA), cannabigerol (CBG), and cannabichromene (CBC) (among others) may help to regulate the ECS. 

 

How Cannabinoids May Help

 

Cannabinoids interact with ECS receptors throughout the body, influencing everything from mood and sleep to immune response and pain management. Here is a closer look at how they may support common symptoms of perimenopause and menopause:

 

Mood and Anxiety

CBD has been shown to modulate serotonin and GABA activity, neurotransmitters responsible for regulating mood and reducing anxiety. Many women report improvements in stress, irritability, and emotional instability during perimenopause after using CBD or balanced cannabinoid formulas.

 

Sleep and Night Sweats

THC can promote sleep and reduce nighttime disturbances, while CBD may help regulate sleep-wake cycles without sedation. While limited in research and mostly anecdotal to date, CBD has shown to have “significant and unexpected improvements” in excessive sweating. CBD’s interaction with serotonin receptors may play a role in temperature regulation, which may also benefit hot flashes. 

 

Muscle, Joint, and Bone Health

Several cannabinoids exhibit anti-inflammatory properties that may ease joint and muscle pain. Some studies suggest that cannabinoids can even support bone health by preventing bone degenerative conditions such as osteoporosis. CBD specifically may aid in the repair of bone fractures and increase bone mass.

 

Cognitive Support

As estrogen declines, some women experience “brain fog” or mild cognitive changes. Cannabinoids’ antioxidant and neuroprotective effects may help preserve mental clarity and support overall brain function.

 

Gastrointestinal Health and Metabolism

CBD may reduce gut inflammation, improve immune response, and support metabolic balance. This may help manage weight fluctuations through the browning of white adipose tissue and prohibiting oxidative stress to lower the risk of Type 2 Diabetes, often associated with menopause.

 

Sexual Health

Cannabinoids may help with vaginal discomfort, low libido, and painful intercourse by reducing spasms and enhancing relaxation. Products like topical creams and suppositories interact directly with female ECS receptors, bypassing metabolism and supporting local tissue health.

 

Functional Mushrooms for Hormonal and Emotional Balance

 

Functional mushrooms, long celebrated in traditional medicine, are gaining attention for their adaptogenic properties, which may help women navigate hormonal changes with more ease. Key mushrooms include:

 

• Reishi (Ganoderma lucidum): Known as the “mushroom of immortality,” reishi may support stress response, immune function, and sleep quality.
• Lion’s Mane (Hericium erinaceus): Celebrated for neurotrophic effects, it may enhance cognition, memory, and mood.
• Turkey Tail (Coriolus versicolor): Rich in antioxidants and immune-supportive compounds, it may help reduce inflammation and promote gut health.
• Cordyceps (Cordyceps sinensis): Traditionally used to improve energy, stamina, and respiratory function, cordyceps may also support sexual and metabolic health.
• Chaga (Inonotus obliquus): High in antioxidants, chaga may protect against oxidative stress and support cardiovascular health.

 

Combining mushrooms with other wellness practices may promote resilience, emotional stability, and cognitive support during perimenopause and menopause.

 

A Natural Synergy: Cannabinoids Meet Functional Mushrooms

 

Many women are now exploring the combined benefits of cannabinoids, functional mushrooms, and other herbal supplements for holistic support. According to a leading brand in women’s wellness, Opal & Joy, their functional mushroom and cannabinoid blends are specifically formulated to support the female endocannabinoid and endocrine systems, offering potential benefits for mood, sleep, and hormonal balance.

 

The brand was born out of co-founder Tiffany Tompkins’ acute and difficult personal experience with early perimenopause symptoms—including severe sleep disruptions, anxiety, hot flashes, joint pain, and more—starting in her late thirties. 

 

Having spent the last decade working in hemp and cannabis media, co-founder Melissa Zissou suggested Tiffany try CBD, which helped to alleviate the intensity of some of her symptoms. This led them to create a range of premium, clean and targeted sleep supplements that are clinically formulated using scientifically studied ingredients, including Ashwagandha, reishi, passionflower, full-spectrum CBD, the terpene linalool and more. 

 

“Sleep is everything,” explains Tiffany, “when you don’t get enough sleep, all your symptoms are compounded. Studies show that up to 60% of women suffer from sleep disturbances during perimenopause. Our products are designed to help you get the deep, restorative sleep you need to show up for yourself.”

 

The synergy of cannabinoids, mushrooms, and herbal supplements may help regulate stress responses, inflammation, and nervous system function to promote better sleep and create a foundation for greater overall well-being during the menopausal transition. “Everything we do is about supporting your body’s natural rhythms through clean, plant-based solutions — no gimmicks, no hormone spikes, no synthetic junk,” says Tiffany.

 

“Our mission is to encourage women to be ‘Perimenoproud™’, which aligns with the idea that the transition is not a breakdown, but a time of empowerment and mid-life magic,” says Melissa. “Being Perimenoproud means embracing change, supporting each other, and demanding products, conversations and science that actually serves women.”

 

Tips for Getting Started

 

1. Start low and go slow: Everyone responds differently; begin with small doses of cannabinoids or mushroom supplements.
2. Track your symptoms: Note improvements in mood, sleep, and energy to find the right combination.
3. Consult a professional: Speak with a qualified healthcare provider or our Care Team to individualize your therapy.
4. Choose high-quality products: Look for third-party tested supplements and cannabinoid products from trusted sources.

 

Concluding Thoughts

 

Perimenopause and menopause are life stages that can bring significant challenges, but also opportunities for self-care and holistic wellness. Evidence suggests that cannabinoids and functional mushrooms may support hormone balance, mood, sleep, cognition, and overall vitality. By exploring these natural tools thoughtfully, women can find individualized strategies to thrive during this transition and embrace it as a new chapter of empowered living.

Many clients come to Realm of Caring looking for help in improving their quality of sleep. The great news is that research is continuing to show us that cannabinoid therapy may help. Certain cannabinoids have shown through studies the ability to benefit our sleep-wake cycles, decrease nightmares, lessen the conditions that interfere with our sleep, and assist in actually falling asleep. 

 

Before we go on, let’s get into some background information and understanding. 

 

Sleep Challenges in America

 

Circadian rhythm is our biological rhythm in a 24-hour period, coming from the Latin circa meaning around and dies meaning day. The most commonly known is the sleep-wake cycle, which in chronobiology, is tied to day and night or lightness and darkness. An out-of-sync circadian cycle may be associated with poor health outcomes. 

 

Insomnia is recognized by the American Psychiatric Association as the most common sleep disorder, involving problems getting to sleep or staying asleep with symptoms being episodic, persistent, and/or recurrent. This sleep disorder is known to cause distress or impairment. A survey published by the American Academy of Sleep Medicine found that 12% Americans reported a diagnosis of chronic insomnia. 

 

The National Sleep Foundation shared the following statistics in their 2025 report:

 

• 6 in 10 adults do not get enough sleep
• Nearly 4 in 10 adults struggle to fall asleep at least 3 nights per week
• Almost half of adults experience difficulty staying asleep at least 3 nights per week 
• 3 in 4 adults say good quality sleep positively impacts their ability to flourish – with women more often reporting stronger perceived benefits

 

What does our Endocannabinoid System have to do with Sleep? 

 

Our Endocannabinoid System (ECS) is composed of endocannabinoids, as well as two distinct receptors known as CB1 and CB2, and enzymes responsible for the metabolism of endocannabinoids. It has been found that the expression pattern of CB1 and CB2 receptors are influenced by light-dark cycles and therefore appear to align with circadian rhythms. Furthermore, it has been shown in studies with rodents that the ECS may potentially modulate those rhythms to promote sleep. 

 

Phytocannabinoids may provide an indirect benefit to sleep through mitigating conditions that often disrupt sleep. Major cannabinoids found in the cannabis plant, such as cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) may reduce anxiety, inflammation, and/or pain – all factors that may disrupt sleep. 

 

CBD and Sleep

 

Although CBD is not a naturally sedative molecule on its own, research has shown that high quantities may have “sedative-like qualities”, potentially due to the effect on cortisol levels. 

 

CBD also has therapeutic properties that have the potential to mitigate symptoms that interfere with sleep. It also has the potential to improve sleep-wake cycles leading to an increase in the percentage of total sleep over time.

 

Among the several researched properties, CBD may benefit as an anxiolytic, anti-inflammatory, and analgesic. The anxiolytic properties of CBD may help to improve sleep by mitigating anxiety or stress-induced insomnia. Stress induces a sleep-related feature known as rapid eye movement (or REM) sleep rebound, this is an increase in REM sleep during the nightly sleep cycles. People experiencing REM sleep rebound may spend more time in REM then they would during a night of normal, healthy sleep.

 

Inflammation is a root cause of autoimmune disorders including arthritis, diabetes, irritable bowel syndrome (IBS), crohn’s disease, and others – all which have an effect on body clock function that can lead to sleep disorders. A study by Northwestern found in mice this link between inflammation and what controls the body clock. By limiting this inflammation, we may lessen the effects on our body clock functions and have more restful sleep. 

 

A study in 2005 showed that people reporting insomnia symptoms are at least three times more likely to have a chronic painful physical condition. These events may then become cyclical in that pain may disrupt sleep and sleep deprivation can increase pain perception. In the majority of animal studies, CBD has been known to exert analgesic effects; co-administering with THC may provide more benefit to this therapeutic action. 

 

Our circadian rhythm aligns our sleep and wakefulness with day and night to provide stability in restorative rest that enables increased daytime activity. Low doses of CBD may be associated with wakefulness to help our focus and cognition during the day. Studies show that therapeutic levels of CBD administration may increase total sleep time and decrease frequency of arousals at night – leading to an increase in total percentage of sleep over time. 

 

THC and Sleep

 

In comparison to CBD, THC has shown in studies as having an affect on mental and physical sedation, even in low amounts. THC also has positive therapeutic benefits that may lead to better sleep.

 

Nightmares are associated with posttraumatic stress disorder (PTSD) often resulting in this being considered a “treatment-resistant” condition. Initial research has shown the benefit cannabinoids can have in managing nightmares linked with PTSD. A study with military veterans and prison inmates receiving Nabilone, a synthetic form of THC, found a reduction in nightmare presence and intensity. This increased participants’ hours of sleep per night. 

 

Just as mentioned with CBD, THC is also beneficial for mitigating pain-induced insomnia or wakefulness. When it comes to pain studies and medical cannabis with significant THC content, benefits consistently show moderate to high symptom management of chronic pain. 

 

A normal amount of apneic events in a healthy individual is about 4 per hour while asleep. Sleep apnea is the most prevalent form of sleep-disordered breathing in the United States and a number of animal and human studies have been conducted to examine cannabinoids as potential therapeutic alternatives to continued positive airway pressure (CPAP) machines, which are currently being utilized.

 

THC shares properties of the endocannabinoid Oleamide, which benefits apneic events. Results in one animal study showed that both the endocannabinoid Oleamide and the exogenous cannabinoid THC reduced apneic events, suggesting therapeutic promise for those who suffer with sleep apnea. 

 

Limitations in Cannabinoid Research

 

A recent systematic review on cannabis and sleep architecture highlighted the mixed results that are available in literature. While surveys suggest that sleep is the most commonly reported targeted symptom to address with cannabis use and 85% of medicinal users reporting sleep improvement, studying the effect of cannabis on sleep is complicated. Chronic users may need higher quantities of THC and find it necessary for sleep, while first-time users may have an unsavory experience due to limited available guidance. 

 

Next Steps and Getting Started

 

Here are some best practices if you are looking to incorporate cannabinoid therapy as a tool:

 

• Start low and go slow – find your therapeutic dose at the lowest amount.
• Quality of product matters, use this guide to vet product companies before you buy.
• Pairing cannabinoids with adaptogens (like functional mushrooms) may provide additional benefit, but this remains an emerging frontier. If you want to bring this up to your doctor but don’t know where to start, we can help. 
• Document your journey through journaling.
• Join an available research study to further our understanding of cannabinoids and sleep.

 

Realm of Caring’s no cost hotline is available to you! Reach out for support today. 

 

Sexual Health Awareness Month and Libido

 

Sexual Health Awareness Month is a time to highlight how intimacy and desire contribute to overall wellbeing. Libido, the natural drive for sex, can shift at different life stages and is influenced by everything from stress to hormones. For many people, especially women navigating perimenopause and menopause, these changes can feel disruptive. Cannabis has become a promising aid for sexual health, with growing research and personal accounts suggesting it may help rekindle desire and improve satisfaction.

 

 

How Cannabis May Enhance Libido

 

Research suggests cannabis affects libido through multiple pathways, both physical and psychological.

 

Reducing Stress and Anxiety

Anxiety is one of the most common barriers to sexual arousal. Cannabis has been shown to promote relaxation and reduce inhibitions, helping people feel more present during intimacy. A 2023 study published in Journal of Cannabis Research found that cannabis users often experienced greater sexual desire, stronger orgasms, and higher overall satisfaction compared to non-users.

 

Heightening Sensory Experience

Cannabis can enhance sensory perception, making touch and physical intimacy feel more intense. This may explain why many users report increased arousal and more pleasurable sexual encounters.

 

Supporting Women in Perimenopause and Menopause

Declining estrogen levels during menopause can cause vaginal dryness, pain during sex, and reduced libido. Cannabis’s anti-inflammatory and analgesic properties may help alleviate discomfort. In one study of women with sexual dysfunction, those who used cannabis before sex reported better lubrication and greater satisfaction. Surveys of menopausal women also show many use cannabis to manage symptoms like mood changes, sleep disruption, and low libido.

 

Effects for Men

Men also report benefits from cannabis use, including increased sexual frequency and satisfaction. However, moderation is key. Research suggests that while low to moderate use may enhance libido and performance, heavy or chronic use could have drawbacks, such as impacts on testosterone or erectile function.

 

 

The Role of the Endocannabinoid System

 

The endocannabinoid system regulates mood, stress, and reproduction, and may interact with reproductive hormones like estrogen. Researchers are still exploring how cannabis affects these pathways, but early findings suggest cannabis may help restore balance during times of hormonal fluctuation, such as perimenopause.

 

 

What the Research Tells Us

 

Self-reported data: Much of the evidence comes from surveys, where participants consistently report improved sexual experiences with cannabis use.

 

Clinical trials: Controlled studies are still limited, but the data so far supports the idea that cannabis can positively influence arousal, lubrication, orgasm, and overall sexual satisfaction.

 

Caution with dosage: Cannabis often follows a biphasic effect—low doses may enhance libido, while high doses could dampen it.

 

 

Practical Tips for Using Cannabis for Sexual Health

 

• Start low and go slow, especially with THC.
• Reach out for support to understand the different forms and what might be best for you (inhaled, edible, topical).
• Use cannabis intentionally before sexual activity to maximize benefits.
• Pair cannabis use with lifestyle strategies like open communication, stress management, and healthy sleep.
• Consult with a healthcare provider before beginning or adjusting cannabis use, especially if taking other medications.

 

 

Why This Matters During Sexual Health Awareness Month

 

Sexual health is an important but often overlooked dimension of wellness. For people navigating changes in libido—whether due to stress, age, or hormonal transitions—cannabis offers a promising option for support. While more research is needed, the evidence so far highlights cannabis as a potential tool to enhance intimacy, reduce barriers like pain and anxiety, and support healthier, more fulfilling sexual experiences.

 

Cannabis is not a cure-all, but it can be an empowering aid in sexual health for both men and women. During Sexual Health Awareness Month, conversations like these are vital for breaking stigma and offering hope. If you’re curious about how cannabis might support your sexual wellbeing, consider exploring the research further and connecting with resources like the Cannabis Health Research Initiative.

As researchers and educators at Realm of Caring, we believe in a holistic, evidence-informed approach to supporting healthy aging and addressing Alzheimer’s disease. While aging is inevitable, there are natural strategies that show promising potential both for maintaining cognitive health and for helping manage symptoms in Alzheimer’s. In this post, we’ll explore what current research says about cannabinoids and complementary botanicals (including functional mushrooms) for brain health, quality of life, and aging well.

 

Understanding the Challenge: Aging, Alzheimer’s, and Brain Health

 

As we age, our bodies undergo changes. Skin becomes less elastic, muscle mass decreases, sleep patterns shift, and chronic conditions like cardiovascular disease and Alzheimer’s become more likely. Alzheimer’s disease is a progressive neurodegenerative disorder impacting memory, thinking, and behavior. There is no cure yet, but interventions that slow progression, reduce symptoms, or support quality of life are critically important. Statistics estimate millions of Americans are affected, and that number is expected to grow.

 

CBD & Cannabinoids: What the Research Suggests

 

Neuroprotection and Antioxidant Effects

 

One of the mechanisms by which cannabidiol (CBD) may help is by mitigating oxidative stress and excitotoxicity – both key contributors in Alzheimer’s pathology. Research shows that CBD can block or modulate harmful glutamate levels, acting comparably in some experiments to industrial antioxidants. This helps reduce damage to neurons. 

 

Interactions with Immune Cells & Inflammatory Pathways

 

The CB2 receptors, part of the endocannabinoid system, are expressed in microglial cells (the brain’s immune cells). Activation of these receptors by cannabinoids may help reduce neuroinflammation, which is a driving force in Alzheimer’s disease. By modulating inflammatory responses, CBD may help slow the progression of neurodegenerative events. 

 

Managing Behavioral & Lifestyle Symptoms

 

Neuropsychiatric symptoms such as sleep disturbances, agitation, depression, and anxiety often accompany Alzheimer’s. CBD and THC:CBD combinations have been studied for their effects on improved sleep quality through reducing sleep latency, lengthening sleep duration, and limiting awakenings. Some observational studies show reduced agitation and better mood in Alzheimer’s patients using cannabinoid extracts under supervision. 

 

Healthy Aging Beyond Alzheimer’s

 

For people aging without Alzheimer’s (or before onset), cannabinoids have been studied for benefits with skin health (hydration, antioxidant effect, anti-inflammatory), appetite regulation, cardiovascular health (anti‐inflammatory, antioxidant), metabolic health, pain and arthritis, muscle maintenance, and sleep quality. These benefits may help delay or mitigate risk factors associated with Alzheimer’s.

 

Practical Considerations & Safety for Cannabinoid Therapy

 

• Start low, go slow: Individual response to cannabinoids can vary. It is important to seek individualized support.

• Source and quality matter: Products should be high‐quality, tested for purity, consistent cannabinoid content, and free of contaminants. Check out the Quality of Product Matters Guide.

• Interactions: CBD may interact with medications; immune status, liver health, overall health status must be considered. Consult with you physician or a pharmacist if you are taking several medications.

• Legality and regulation: Laws vary by state and country; ensure compliance and proper documentation. Realm of Caring’s Observational Research Registry (ORR) is helping to gather real‐world data on safety and outcomes.

 

Complementary Botanicals & Functional Mushrooms

 

While cannabinoids show promise, combining them with other plant botanicals and functional mushrooms may offer synergistic effects for brain health and aging:

 

• Botanicals like turmeric, ginkgo biloba, bacopa have antioxidant, anti‐inflammatory, and neuroprotective properties in preliminary studies. When used appropriately, they may support cognition, memory, and vascular health.

• Functional mushrooms such as lion’s mane, reishi, cordyceps, and chaga are gaining attention. Lion’s mane, for example, has compounds that may stimulate nerve growth factor (NGF), which supports neuron health; anti‐inflammatory and antioxidant effects have been observed in animal and small human trials. Reishi and chaga add immune modulation and reduce oxidative stress, which are valuable in the context of Alzheimer’s and aging.

 

Toward a Holistic Plan

 

Pulling all this together, here’s what a holistic plan might look like:

 

• Adopt a nutrient‐rich, anti‐inflammatory diet (fruits, vegetables, healthy fats, mushrooms, botanicals).

• Include cannabinoids (CBD, or balanced THC:CBD in legal regions) under guidance, targeting symptoms like sleep disturbances, mood, inflammation.

• Incorporate botanicals and functional mushrooms as adjuncts for neuroprotection and immune support.

• Prioritize lifestyle factors: physical activity, restful sleep, stress management, social connection.

• Monitor, adjust, and always consult qualified professionals to tailor choices, monitor efficacy, and avoid adverse effects.

 

At Realm of Caring, our mission is to support you with rigorous research, client education, and community care. As new evidence emerges, we hope to offer increasing clarity on how CBD, other cannabinoids, botanicals, and functional mushrooms may be integrated into a safe, holistic regimen for Alzheimer’s and healthy aging. If you have questions about specific products, dosing, or strategies, our care specialists are available to help.

 

Inflammation is at the root of many health challenges, from arthritis and gut issues to brain fog and chronic pain. While inflammation is a natural defense mechanism, when it becomes chronic, it can fuel disease progression and significantly impact quality of life. Increasingly, research is showing that cannabis compounds may help regulate inflammation and support the body in finding balance.

 

The Endocannabinoid System and Inflammation

 

The endocannabinoid system (ECS) is a network of receptors, endocannabinoids, and enzymes that work to maintain homeostasis in the body. Among several other physiological actions, the ECS is a modulator of immune system activity. 

 

Cannabinoids from the cannabis plant interact with the ECS, potentially dialing down excessive inflammation. Research has found that cannabinoids can modulate immune cell activity, reduce oxidative stress, and calm overactive inflammatory pathways.

 

How CBD Might Help with Inflammation

 

CBD (cannabidiol) doesn’t produce intoxication, but it does have powerful anti-inflammatory effects. Studies show that CBD may:

 

• Reduce neurogenic inflammation, which is linked to chronic inflammatory diseases such as multiple sclerosis (MS), migraine, diabetes, and Parkinson’s disease.
• Calm intestinal inflammation by interacting with serotonin receptors and the gut’s immune system. This may assist in providing relief in conditions such as Crohn’s disease, inflammatory bowel disease (IBD), and ulcerative colitis.
• Benefits the healing process of joints and muscles by interacting with inflammatory mediator receptors and pathways. CBD may help control localized inflammation that causes pain and tissue damage in arthritic joints as well as alleviate muscle soreness after exercise or injury.

 

Consistent administration seems to be key, Researchers note that regular CBD use may build up its effects over time, rather than acting as a quick fix. Explore more on CBD and inflammation in our research library.

 

THC, Microdosing, and Pain Relief

 

THC is often associated with its euphoric effects, but in smaller amounts (microdosing) it may relieve pain and inflammation without noticeable intoxication. THC activates CB2 receptors in the immune system, which can reduce swelling and inflammatory signaling.

 

For some people, combining CBD with very low doses of THC (as in full-spectrum CBD products) may provide a more comprehensive anti-inflammatory effect. Research suggests that this synergy could support pain relief in arthritis, inflammatory bowel diseases, and neuro-inflammatory conditions.

 

CBDA for Inflammation

 

Cannabidiolic acid (CBDA) is one of three cannabinoid precursor compounds converted from Cannabigerolic acid (CBGA). CBGA also converts to the precursor compounds Tetrahydrocannabinolic acid (THCA) and Cannabichromenic acid (CBCA) or may convert to its non-acidic form, Cannabigerol (CBG).

 

CBDA inhibits the COX-2 Enzyme. These enzymes are associated with inflammation after injury or infection. Therefore, by blocking COX-2 Enzymes, CBDA may relieve inflammation and associated pain. In a rodent study, equivalent amounts of CBD and CBDA were administered to test efficiency in reducing hyperalgesia. The low amount of CBD was not efficient in reducing this increased sensitivity to pain when exposed to normal stimuli. The CBDA, on the other hand, did reduce hyperalgesia at that same low amount. In the same study, amounts of THC and CBDA so low that they were deemed “ineffective” were administered. When these ineffective, low amounts were combined it was shown in the animal models to have anti-inflammatory and anti-hyperalgesia effects on acute inflammation.

 

CBG for Inflammation

 

Cannabigerol (CBG) was first discovered and synthesized by Raphael Mechoulam and Yehiel Gaoni in 1964. As previously mentioned, it is derived from cannabigerolic acid (CBGA) once heated, becoming a very stable molecule.

 

Animal studies have shown CBG to reduce the effects of inflammatory bowel disease. Several studies, in vitro and in animal models, have also shown CBG to have neuroprotective potential for reducing the severity of neurological illnesses, such as Huntington disease (HD), amyotrophic lateral sclerosis (ALS), Parkinson’s disease, and MS. The anti-inflammatory and antioxidant benefits contribute to reducing glutamate-induced oxidative stress and cell death, as shown in mouse models.

 

Consistency Matters

 

One of the most important takeaways from the research is that consistent administration may be necessary to witness anti-inflammatory benefit. Like many wellness strategies, cannabinoids may take time to build their effects. Sticking to a routine and keeping track of responses can help individuals find what works best for them.

 

Concluding Thoughts

 

While promising evidence is mounting for the use of several cannabinoids for inflammation-related conditions, more large-scale clinical trials are needed. Cannabinoids such as CBD, THC, CBDA, and CBG show real potential in calming inflammation, relieving pain, and improving quality of life for people living with acute and chronic inflammatory conditions. The key is understanding how these compounds interact with your unique body and doing so safely with guidance.

 

Introduction

 

When facing cancer, many people look beyond traditional treatments for options that might help manage symptoms or even fight the disease itself. Cannabis is often part of that conversation. At Realm of Caring, we hear from families every day who are exploring cannabinoid therapy with curiosity and hope. One scientific concept that comes up often is angiogenesis; but what does that mean, and how does cannabis connect to it?

 

 

What is Angiogenesis?

 

 

Angiogenesis is the process by which new blood vessels form in the body. Normally, this is an essential function as it helps heal wounds and allows tissues to grow. But in cancer, angiogenesis can work against us. Tumors can “hijack” this process to create their own blood supply, feeding their growth and enabling them to spread. This is why many cancer therapies aim to stop or slow angiogenesis.

 

 

Where Cannabis Fits In

 

 

Some preclinical research suggests that cannabinoids, especially delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) may have antiangiogenic properties. In other words, they may help reduce the formation of these new blood vessels that tumors need to thrive. Research also shows cannabinoids may play a role in apoptosis (programmed cell death), another process that can slow the spread of cancer cells.

 

However, it is important to note that most of this research is early stage, conducted in labs or animal models. We do not yet have large, controlled human trials that confirm exactly how cannabis works against cancer.

 

 

Setting Expectations: Cannabis in Cancer Care

 

 

Because of these research gaps, cannabis should be approached realistically:

 

• For symptom management:  Lower doses of cannabinoids are often enough to help with nausea, pain, sleep, appetite, and overall quality of life during treatment.
• For anticancer effects: Some individuals pursue higher-dose regimens that include THC. While there are powerful stories of success, these are anecdotal, and what works for one person may not work for another.
• Safety matters: Cannabis is generally considered safe to use alongside chemotherapy and radiation, but there are exceptions (such as some immunotherapies and hormone-sensitive cancers). Always involve your oncology team in the conversation.

 

 

Holistic Healing

 

 

At Realm of Caring, we also encourage looking at the bigger picture. Cancer care isn’t just about one therapy, rather about giving the body the best chance to heal. That includes nutrition, minimizing toxic exposures, managing stress, and nurturing emotional and spiritual well-being. Cannabis may be one part of that holistic approach.

 

 

Key Takeaways

 

• Angiogenesis is how tumors grow new blood vessels; stopping it is a major focus of cancer therapies.
• Early research suggests cannabinoids may influence angiogenesis and apoptosis, but more human studies are needed.
• Cannabis is not a replacement for conventional care but may complement it, especially for symptom relief.
• Every person responds differently; dosing and outcomes vary widely.

 

 

Closing

 

Exploring cannabis during cancer care requires both hope and realism. At Realm of Caring, we’ve supported families through more than 300,000 interactions and 2.5 million minutes of guidance since 2013. Our Care Specialists are here to provide education, tools, and compassion as you navigate your journey.

 

Reach out to us anytime to talk with a Care Specialist and learn more about safe, informed approaches to cannabinoid therapy.

 

View our Cancer Administration Guidelines. 

 

Fibromyalgia can feel relentless. For those living with it, the daily reality often includes widespread pain, exhaustion, migraines, brain fog, sleep struggles, and mood changes. Standard treatments from antidepressants and muscle relaxants to physical therapy and lifestyle changes can help, but many people still find their symptoms stubbornly persistent.

 

A recently published case report explored an option for symptom relief: cannabidiol (CBD), specifically surveying the use of Epidiolex, the FDA-approved pharmaceutical form of CBD. While Epidiolex is currently only approved for rare forms of epilepsy, this research highlights an emerging conversation about CBD’s potential role in managing fibromyalgia.

 

The Research Spotlight: Two Cases of Relief

 

The published article followed two individuals with treatment-resistant fibromyalgia. Despite trying multiple conventional therapies, their symptoms remained overwhelming. When each was introduced to Epidiolex (a purified CBD isolate) their pain, sleep quality, and overall wellbeing significantly improved.

 

This is a small case series, not a large clinical trial, so it can’t prove that CBD is universally effective. But it adds momentum to a growing body of research suggesting cannabinoids may help ease the complex symptom picture of fibromyalgia.

 

Explore more in our Research Library

 

Isolate vs. Full-Spectrum CBD: What’s the Difference?

 

It’s important to note that Epidiolex is a CBD isolate. That means it contains only pure CBD, without any other compounds from the cannabis plant.

 

In contrast, most consumer-available CBD products are sold as full-spectrum or broad-spectrum:

 

• Full-spectrum: Includes CBD along with other cannabinoids (like CBG, CBC, and small amounts of THC), terpenes, and flavonoids.

 

• Broad-spectrum: Similar to full-spectrum but typically without THC.

 

Why does this matter? Many researchers believe these compounds may work together synergistically in what’s known as the entourage effect, which potentially amplifies CBD’s benefits for pain, mood, and sleep.

 

What We Know About Cannabis and Fibromyalgia

 

So far, the evidence for cannabis and fibromyalgia is still emerging:

 

• Results published in Pain Practice suggest a potentially significant role that cannabis can play for women with treatment-resistant Fibromyalgia. Further studies are warranted for long-term use, but short-term use is associated with enhanced quality of life via improved markers such as pain and sleep.

 

• A published systematic review found cannabis to be safe and well tolerated for those suffering with Fibromyalgia with no serious adverse events reported. 

 

• Findings from a published article in Journal of Clinical Rheumatology showed that after commencing the use of medicinal cannabis, all patients identified with Fibromyalgia reported a significant improvement in every parameter on the questionnaire provided and 50% stopped taking any other medications for their diagnosis.

 

At the very least, these studies are expanding the conversation: for some individuals, cannabinoid therapy may offer hope when conventional options fall short.

 

 

Why This Matters for People with Fibromyalgia

 

Because fibromyalgia touches so many aspects of health, approaches that target multiple systems may hold more promise. Whole-plant hemp extracts, with their mix of cannabinoids and aromatic terpenes, could offer benefits beyond CBD isolate alone.

 

That said, consumer CBD products vary widely in quality, potency, and labeling accuracy. What’s on the bottle isn’t always what’s inside, which makes education and support so important.

 

Tips for Exploring CBD with Fibromyalgia

 

If you’re curious about whether CBD could be part of your fibromyalgia management, here are some steps to take:

 

• Choose wisely: Look for products with third-party lab testing and transparent ingredient sourcing.

 

• Start low, go slow: Begin with a low dose and gradually increase until you find your “sweet spot.”

 

• Track your journey: Note changes in pain, sleep, energy, and mood so you can better understand what works.

 

• Talk with your provider: CBD can interact with other medications. Having a doctor in the loop is essential.

 

• See it as a tool, not a cure: CBD may help manage symptoms, but it works best as part of a holistic plan including movement, stress management, nutrition, and support.

 

For additional reading, check out our Client Resources for guides and education on cannabis therapies.

 

You Don’t Have to Navigate This Alone

 

If you are living with fibromyalgia and want to explore CBD but feel overwhelmed by the options just know you are not alone. At Realm of Caring, our care team offers free 1:1 support to help you:

 

• Understand the latest research.

 

• Find high-quality products you can trust.

 

• Learn how to have open, safe conversations with your doctor.

 

• Develop a personalized approach that fits your needs.

 

Connect with our care team today. Relief may not look the same for everyone, but you deserve to explore every option that could improve your quality of life.

 

Alcohol is one of the most widely consumed substances in the world. For many, drinking is part of social life, yet the consequences of overuse include liver damage, increased risk of chronic disease, and a staggering toll on mental health and relationships. As researchers look for safer strategies to support recovery and reduce harm, cannabidiol (CBD) has emerged as a promising ally.

 

CBD, a non-intoxicating compound from the cannabis plant, has gained attention for its potential therapeutic benefits, which include reducing anxiety and supporting better sleep. Now, new research suggests CBD may also support individuals struggling with alcohol use disorder (AUD) and play a role in harm reduction.

 

CBD and the Liver: A Potential Protective Role

 

Chronic alcohol use is toxic to the liver, often leading to fatty liver disease, inflammation, and cirrhosis. Interestingly, preclinical studies suggest that CBD may offer protective effects against alcohol-induced liver injury.

 

CBD has shown in studies to reduce oxidative stress and inflammation, two of the primary drivers of liver damage from alcohol consumption. While more human research is needed, these findings raise an important possibility: CBD may help buffer the liver against some of the toxic effects of alcohol and may even prevent neuronal loss, potentially supporting overall health in people at risk.

 

CBD and Alcohol Cravings

 

Beyond physical damage, one of the most challenging aspects of AUD is the cycle of craving and relapse. Preliminary evidence indicates that CBD may help here, too.

 

Research has shown that CBD interacts with the brain’s endocannabinoid system (ECS), which plays a role in regulating stress, reward, and addictive behaviors. In rodent models, CBD reduced alcohol-seeking behavior and relapse triggered by stress or environmental cues.

 

Though human trials are still limited, early clinical studies suggest that CBD’s ability to reduce anxiety and improve sleep may indirectly help individuals manage alcohol cravings and maintain recovery.

 

Harm Reduction: Alcohol, Cannabis, and the Middle Ground

 

Harm reduction is the idea of minimizing risks rather than insisting on complete abstinence. For some, cannabis is used as a substitute for alcohol, with research showing people may reduce alcohol intake when using cannabis.

 

However, this raises a cautionary note for a subset of individuals as substituting alcohol with cannabis could increase the risk of developing cannabis use disorder (CUD). Here, CBD may again serve as a unique tool. Unlike THC, CBD is non-intoxicating and has been investigated as a possible treatment for substance use disorders because of its calming and anti-craving properties.

 

This suggests CBD could be a “middle ground” in harm reduction strategies as a way to help reduce alcohol consumption without swapping one intoxicating substance for another.

 

What This Means for You

 

The research on CBD, alcohol, and addiction is still in its early stages but the results so far are compelling. CBD may:

 

• Support liver health by reducing oxidative stress and inflammation.

 

• Help reduce alcohol cravings and relapse risk.

 

• Serve as part of a harm reduction strategy without increasing intoxication risks.

 

If you or someone you love is curious about exploring CBD as part of an alcohol harm reduction or recovery strategy, you don’t have to navigate it alone.

 

Connect with Us

 

At Realm of Caring, our mission is to empower you with unbiased, research-backed information. Our care team offers free 1:1 support to help you:

 

• Find safe, high-quality CBD products.

 

• Learn how to discuss CBD use with your doctor.

 

• Get answers to your research questions.

 

Reach out today to take the next step toward a healthier relationship with wellness.