Abstract Cannabis has been used for both recreational and medicinal purposes for more than 4 millennia. Cannabis has been studied in various medical disorders including neurological disorders. There are well-known…
…to all these properties, the interest of the scientific community for it has grown. Indeed, CBD is a great candidate for the management of neurological diseases. The purpose of our…
…oxidative stress, perturbed mitochondrial function, and the impaired immune system, indicates medicinal values. These events are involved in most neurological diseases and prompt the gradual progression of the disease. At…
…investigate cannabinoid modulation of ICa. Results: THCA and THC inhibited the peak current amplitude CaV3.1 with pEC50s of 6.0±0.7 and 5.6±0.4, respectively. THC (1 μM) or THC produced a significant…
…presence of THC, rather the interplay of phytocannabinoids. These cannabinoid combinations may mitigate side effects or improve the therapeutic activity of THC. A recent study examined effects of THC-dominant…
…THC, a key component of RSO, may help in reducing the growth and spread of cancer cells. Pain Management The high THC content in RSO can be effective in pain…
…affecting the white matter. Termed “reversible,” the norm is a return to the previous neurological state. However, this recovery is not always guaranteed, with potential neurological sequelae or even progression…
…not affect hyperthermia-induced seizures in Scn1a+/− mice. A Δ9-THCA/Δ9-THC mixture was anticonvulsant in the 6-Hz threshold test, but purified Δ9-THCA and Δ9-THC had no effect. Conversely, both Δ9-THCA and Δ9-THC…
…Delayed verbal recall was impaired by THC and only occurred under placebo condition (Z=-2.201, p=0.028), suggesting a protective effect of THCV. THCV also inhibited THC-induced increased heart rate (Z=-2.193, p=0.028)….
…11-OH-THC, and THC-COOH using a previously validated LC–MS/MS method. Results: CBD and THC were quickly absorbed (mean Tmax of 2.4–2.9 h). Maximum plasma concentrations (Cmax) ranged from 36–511 ng/mL and…
