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Post-Mortem Toxicology: A Systematic Review of Death Cases Involving Synthetic Cannabinoid Receptor Agonists
Abstract Background: Synthetic cannabinoid receptor agonists (SCRAs) have become the largest group of new psychoactive substances monitored by the European Union Early Warning System. Despite the
August 30, 2025
Possible Endocannabinoid Control of Colorectal Cancer Growth
Abstract Background & aims: The endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit cancer cell proliferation by acting at cannabinoid receptors (CBRs). We studied (1). the levels of
September 19, 2019
Possible actions of cannabidiol in obsessive-compulsive disorder by targeting the WNT/β-catenin pathway
Please use this link to access publication Abstract Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder characterized by recurrent and distinctive obsessions and/or compulsions. The etiologies
February 1, 2024
Positive Effect of Cannabis sativa L. Herb Extracts on Skin Cells and Assessment of Cannabinoid-Based Hydrogels Properties
Abstract The skin is an organ that is constantly exposed to many external factors that can affect its structure and function. Due to the presence
December 17, 2024
Positive Allosteric Modulation of CB1 Cannabinoid Receptor Signaling Enhances Morphine Antinociception and Attenuates Morphine Tolerance Without Enhancing Morphine- Induced Dependence or Reward
ABSTRACT Opioid analgesics represent a critical treatment for chronic pain in the analgesic ladder of the World Health Organization. However, their use can result in
September 27, 2025
Positive Allosteric Modulation of CB1 and CB2 Cannabinoid Receptors Enhances the Neuroprotective Activity of a Dual CB1R/CB2R Orthosteric Agonist
Abstract Preclinical studies highlighted that compounds targeting cannabinoid receptors could be useful for developing novel therapies against neurodegenerative disorders. However, the chronic use of orthosteric
October 2, 2025
Polish Physicians’ Perspectives on Medical Cannabis Policy and Educational Needs: Results of An Online Survey
Abstract (1) Background: In November 2017, medical cannabis was legalized in Poland. Until now, there have been no studies conducted to examine the perspectives of
August 2, 2025
PMON252 Δ-9-tetrahydrocannabinol does not affect motility, morphology or viability, but alters the transcriptome of cryopreserved sperm
Abstract Cannabis is one of the most widely consumed recreational drugs among reproductive aged adults around the globe. It is known that Δ-9-tetrahydrocannabinol (THC), the
February 28, 2024
PLGA Nanoparticles for the Intraperitoneal Administration of CBD in the Treatment of Ovarian Cancer: In Vitro and In Ovo Assessment
Abstract The intraperitoneal administration of chemotherapeutics has emerged as a potential route in ovarian cancer treatment. Nanoparticles as carriers for these agents could be interesting
July 1, 2024
Plasma anandamide concentrations are lower in children with autism spectrum disorder
Abstract Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication. Although the underlying biological mechanisms
April 19, 2021
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