The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, spontaneous locomotor activity, equilibrium abilities, muscular tone, motor coordination and motor learning were investigated in Lurcher mutant and non-mutant B6/CBA mice 20 min after i.p. administration of 4 or 8 mg kg−1 of delta 9 tetra hydro cannabinol (delta 9 THC). The performances were compared to those obtained by Lurcher and non-mutant mice injected with vehicle (Tween 80). The results showed that at the dose of 4 mg kg−1 but not at the dose...
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