Abstract Background Cannabis use during pregnancy has been increasing and is associated with adverse neonatal outcomes, such as low birth weight (LBW) and preterm birth (PTB). It remains largely unknown whether the association between cannabis use in pregnancy and increased risk of adverse neonatal outcomes is impacted by the frequency of cannabis use and whether thresholds exist below which risk is not significantly increased. The objective of this systematic review is to assess whether the association between cannabis use during pregnancy and the risk of adverse neonatal outcomes is dependent on the frequency of use and whether risk thresholds exist. Methods For this systematic review...

Please use this link to access this publication. Abstract In recent times, several longitudinal studies aimed at clarifying whether cannabis use during adolescence might play a causal role in the subsequent risk of developing bipolar disorder have been published. Although their methodological heterogeneity precludes any meta-analytic approaches, evidence from these studies can be systematically evaluated using the Bradford Hill criteria. A biological gradient is supported by evidence on the dose-response relationship between exposure severity and outcome. As such, the effect of cannabis use on bipolar disorder onset is likely to be strong, coherent, plausible, and based on a clear temporality. In addition, some analogies...

Please use this link to access this publication. Abstract Cannabis polysaccharides (CPs) have attracted growing interest due to their diverse structures and potential bioactivities. This review consolidated current knowledge on the CPs extraction, their characterization, molecular properties and biofunctional potentials. Composition of the CPs varied by plant part, cultivar and origin with most studies focused on seed derived polysaccharides. Extraction methods, particularly the hot water and enzyme assisted extractions differ in temperature, duration and solid–liquid ratio influencing the final yield and molecular integrity. Advanced analyses such as HPAEC-PAD, HPSEC, GC–MS and FT–IR revealed monosaccharides such as mannose, glucose, galactose, glucuronic acid and galacturonic acid, along...

Abstract Adolescence is an immature but adventurous time period of exploration. Due to rapid developments of the brain with unbalanced release of neurotransmitters, adolescents are prone to impulsivity that may carry out potentially dangerous behaviors. According to the Centers for Disease Control and Prevention, more than one-third of high school students have reported the use of cannabis or marijuana in 2019, and the trend has not declined since. Previous studies have shown that cannabis not only affects cognitive and social behaviors, but also produces psychological responses to stress. In this review, we have summarized recent studies on cannabis-produced effects during the unique period of...

ABSTRACT The therapeutic potential of medical cannabis has garnered significant attention in recent years, prompting an urgent need for a comprehensive understanding of its effectiveness across various health outcomes. This article presents an Evidence Map that systematically summarizes clinical evidence on the use of medical cannabis, including the health conditions it addresses, the interventions employed, and the resulting clinical outcomes. The objective is to map the effectiveness of medical cannabis in relation to a wide range of health outcomes. The systematic review process involved two independent, blinded literature researchers who screened the search output using Rayyan software. For studies deemed relevant, full texts were...

Please use this link to access this publication. Abstract The cannabis gray market poses significant public health concerns and remains a major threat to consumer and/or potential consumer uptake of regulated cannabis markets in jurisdictions with legal state-sponsored cannabis programs. In this perspective, we provide an overview of the cannabis gray market, and describe an integrated epidemiological and regulatory science framework to study the gray market. Using tobacco regulatory science as a guide, we introduce example cannabis regulatory science research activities as a means to improve the field’s understanding of the cannabis gray market. Cannabis regulatory science is a developing field that can improve...

Please use this link to access this publication. Abstract Up to 10% of women may use cannabis during pregnancy; this is of concern because constituents of cannabis cross the placental barrier and potentially influence neurodevelopment by acting on cannabinoid receptors in the developing fetal brain. In this context, a recent meta analysis of 13 observational studies found that gestational exposure to cannabis was associated with a small increase in the risk of autism spectrum disorder (ASD; relative risk [RR], 1.30) and with an even smaller increase in the risk of attention deficit/hyperactivity disorder (ADHD; RR, 1.13); the latter finding was probably supported by publication...

ABSTRACT With the partial legalization of high-THC Cannabis sativa across 23 states for recreational use and 38 states for medical purposes in the United States, the Cannabis industry is poised for significant growth. Projected to reach a sales volume of $50.7 billion by 2028, this growth is driven by the trend of lifting Cannabis prohibition. High-THC C. sativa cultivars, containing more than 0.3% delta-9 tetrahydrocannabinol (Δ9-THC) as defined by the 2018 US Farm Bill, are used for both medicinal and recreational purposes. Cannabis sativa is a short day, dioecious, annual plant, where female plants are favored for THC production, which requires seed feminization techniques to ensure an accurate female plant population. This involves using...

Abstract: Cannabis is the most used drug worldwide with an estimated 219 million users. This narrative review aims to explore the adverse effects and therapeutic applications of cannabis and cannabinoids on the eye, given its growing clinical and non-clinical uses. The current literature reports several adverse ocular effects of cannabis and cannabinoids, including eyelid tremor, ptosis, reduced corneal endothelial cell density, dry eyes, red eyes, and neuro-retinal dysfunction. Cannabinoids may transiently impair night vision, depth perception, binocular and monocular contrast sensitivity, and dynamic visual acuity. Cannabinoids are not currently considered a first-line treatment option for any ocular conditions. Δ-9-tetrahydrocannabinol been shown to result in...

Abstract Objectives As a growing body of research has linked cannabis consumption and problematic Internet use (PIU), more insight is needed to interpret this association. This scoping review aims to summarize the available literature on PIU and cannabis consumption and to underlie future avenues of research. Methods We conducted an electronic search including all papers published from database inception until May 2023, using keywords related to PIU and cannabis use in the following databases: Academic Search Complete, APA PsychInfo, PubMed, SocINDEX, MEDLINE, CINAHL, and Psychology and Behavioral Sciences Collection. Studies eligible for this review had to meet the following criteria: (1) the primary theme...