Please use this link to access this publication. Abstract Background Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural mechanisms underlying risk for problem-level use is critical to facilitate the development of more effective prevention and treatment approaches. Methods In the current study, we applied a whole-brain, data-driven, machine learning approach to identify neural features predictive of problem-level cannabis use in a nonclinical sample of college students (n = 191, 58% female) based on reward task functional connectivity data. We further examined...

Abstract The therapeutic potential of cannabinoids and other ligands of cannabinoid receptors attracts considerable attention due to their diverse pharmacological effects and utility in various medical applications. However, challenges such as low solubility, limited bioavailability, and potential side effects hinder their broad clinical use. Nanoformulation techniques offer a promising approach to address these issues and optimize the therapeutic effectiveness of cannabinoids and other cannabinoid receptor ligands. This comprehensive review explores the advancements in nanoformulation strategies to enhance the therapeutic efficacy and safety of synthetic cannabinoids and related compounds, such as CB13, rimonabant, and HU-211, which have been studied in a range of preclinical models...

Abstract Histoplasma capsulatum is a pathogenic dimorphic fungus with evolving epidemiology. Initially described as endemic to the Ohio and Mississippi river valleys, the infection now regularly occurs in central and eastern United States, with cases reported across the entire country. Transmission happens via inhalation of conidia during activities that disturb fungal hyphae. Sporadic cases related to individual exposures now outnumber work-related outbreak cases in the United States. We describe 2 fatal cases of histoplasmosis in Rochester, New York, associated with exposure to bat guano as a fertilizer for cannabis cultivation, including 1 case in which it was commercially obtained.

Abstract Aim To evaluate the effectiveness, safety and cost-effectiveness of psychosocial interventions for cannabis use disorder (CUD). Methods A systematic review of randomized controlled trials (RCTs; PROSPERO protocol CRD42024553382) of psychosocial interventions for CUD lasting >4 sessions, delivered synchronously, to individuals with CUD aged ≥16 years, in inpatient, outpatient or community-based settings. We searched databases (MEDLINE/PsycInfo/Cochrane CENTRAL) to 12 June 2024. We assessed results using Risk of Bias 2 and conducted pairwise meta-analyses. Primary outcomes were continuous- and point-abstinence and withdrawal intensity at the end of treatment, treatment completion and adverse events. Results We included 22 RCTs (3304 participants). Relative to an inactive/non-specific comparator,...

Please use this link to access this publication. Introduction Concurrent use (co-use) of tobacco and cannabis is common among both adults and youth1. Co-use is linked to greater dependence and difficulty quitting both substances2, and increased toxicant exposure3. Overwhelmingly, co-use research has not established the most prevalent tobacco and cannabis product combinations involved. Improving understanding of this issue is important to guide emerging research involving smoking and vaping, since both substances are often consumed through these modalities. We examined prevalence of tobacco-cannabis co-use and the most common product combinations among US adults and youth. Methods Cross-sectional data were from Wave 7 (2022–2023) of the...

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ABSTRACT Objective: Given the interest in the potential effects of cannabis on medical students, this study aims to establish the prevalence of recreational use within this population. Methods:We searched MEDLINE, LILACS, PubMed, Embase, PsycINFO/PsycArticles/APA Books), and SciELO for observational studies published before June 9, 2025, that reported cannabis use prevalence among medical students. We conducted subgroup analyses based on gender, study cycle, school type, decade of publication, and world region. Data were pooled using a random-effects model. Results: Our search identified 109 studies meeting the inclusion criteria, published between 1971 and 2025, encompassing data from 62,444 participants from 32 countries. Lifetime prevalence was 29.2%,...