Abstract Background: Awareness has recently risen about the potential associated risks to the cardiovascular health of cannabis users. The objective was to evaluate the possible association between major adverse cardiovascular events (MACE) and the use of cannabis or cannabinoids. Methods: Original pharmacoepidemiological studies providing risk estimates on cannabis-related MACE (ie, cardiovascular death, non-fatal acute coronary syndrome (ACS) including myocardial infarction (MI) or non-fatal stroke) published from 1 January 2016 to 31 January 2023 were included in the systematic review exploring PubMed, Web of Science and Scopus (last search: 20 September 2023). Design, duration, baseline characteristics, exposure, inclusion criteria, sample size, effect size and confusing factors, including...

Please use this link to access this publication. Abstract Importance: Cannabis use during adolescence and young adulthood may affect academic achievement; however, the magnitude of association remains unclear. Objective: To conduct a systematic review evaluating the association between cannabis use and academic performance. Data sources: CINAHL, EMBASE, MEDLINE, PsycInfo, PubMed, Scopus, and Web of Science from inception to November 10, 2023. Study selection: Observational studies examining the association of cannabis use with academic outcomes were selected. The literature search identified 17 622 unique citations. Data extraction and synthesis: Pairs of reviewers independently assessed risk of bias and extracted data. Both random-effects models and fixed-effects models were used for meta-analyses,...

Please use this link to access this publication. Abstract Cannabis and Veterinary Medicine explores the growing role of cannabis in veterinary medicine, highlighting its therapeutic potential and challenges. It discusses the complexities of the endocannabinoid system and its regulation of physiologic processes. Emphasis is placed on cannabinoids like delta-9-tetrahydrocannabinol, cannabidiol, and minor cannabinoids, alongside terpenes and flavonoids. In addition, the article addresses legal issues, clinical applications, safety, dosing strategies, and the significance of product quality.

Abstract The endocannabinoid signalling system (ECS) plays a critical role from the very beginning of embryogenesis. Accordingly, the ECS is engaged early on in nervous system development, starting from neurulation, supported by the identification of ECS components—both receptors and enzymes controlling endocannabinoid metabolism—at these early stages. In particular, regarding the brain, the ECS is involved in the tightly regulated sequence of events that comprise brain development, from neurogenesis to neuronal migration, morphological guidance for neuronal connectivity, and synaptic circuitry refinement. The importance of this broad role of the ECS across various brain development processes is further underscored by the growing understanding of the consequences...

Abstract Background: This review article addresses the vaping chemistry of manufactured cannabis concentrates-a topic that remains under-researched despite the widespread availability and growing popularity of these products. Given their current prevalence and the fact that many of the findings discussed herein are from early-stage investigations, further research is essential to fully assess the public health risks associated with concentrate use. The purpose of this article is to help begin to bridge this knowledge gap by outlining the technical challenges of studying cannabis concentrates and to present evidence-based data concerning toxicant exposures as a foundation for future investigations. Methods: A search of cannabis concentrate vaping within the...

Abstract Cannabis is a psychoactive substance the availability and use of which, in various forms, has been liberalized in many countries across the world. Cannabis use, including by women of reproductive age, has become increasingly common, with (in some studies) >5% of women using the substance even during pregnancy to self treat nausea, vomiting, stress, anxiety, depression, insomnia, chronic pain, and other conditions. Women who use cannabis during pregnancy are more likely to have a medical or mental health condition; they are commonly unaware that cannabis is associated with pregnancy related risks. These risks arise from effects of cannabis on cannabinoid receptors in the...

Abstract Purpose of Review Review recent research regarding the relationship between cannabis use, weight, eating behaviors, eating disorders, and physical activity. Recent Findings Cannabis, particularly the cannabinoid Δ9-tegrahydrocannabinol (THC), is associated with increased appetite, food cravings, overconsumption, and decreased physical activity. Cannabidiol (CBD) appears to be associated with decreased appetite. While cannabis use is not correlated with binge eating, cannabis use disorder is associated with loss of control eating. Despite cannabis’ association with unhealthy eating and sedentary behavior, most studies suggest that cannabis use is not associated with weight gain, or may even facilitate weight loss. Summary The state of the literature regarding the...

Please use this link to access this publication. Abstract Cannabis (also called marijuana) is naturally derived from the cannabis plant and can be consumed in many different product formulations that have varying concentrations of tetrahydrocannabinol (THC), the most prevalent psychoactive substance. Almost half of states in the United States have legalized recreational use for adults. Fortunately, longitudinal epidemiological studies indicate that less than 20% of youth report current cannabis use and that their lifetime use has actually decreased over the last few decades. Nevertheless, with the increasing availability of different formulations with higher concentrations of THC and notable increase in use among adults, pediatricians...

Please use this link to access this publication. Abstract Purpose of review Cannabis sativa and constituent cannabinoids are in widespread use for the treatment of sleep disorders where many patients desire pharmacotherapy. Previous reviews highlight a lack of high-quality evidence to support the efficacy and long-term safety of cannabinoids in various conditions. We aim to provide an update of recent original research evaluating cannabinoid-based therapeutics in sleep disorders. Recent findings We identified twenty-one recent studies of cannabinoids for insomnia, subjective sleep impairment, obstructive sleep apnoea, rapid eye movement sleep behaviour disorder, and restless legs syndrome. We note trends towards the use of minor cannabinoids, studies...

Abstract The legalization of cannabis for medical and recreational purposes has progressed internationally. Cannabis and cannabinoids are advocated for a plethora of medical indications. An increasing number of medical and nonmedical users regularly consume large doses of delta-9-Tetrahydrocannabinol (THC), the main active component of cannabis. Aim: to summarize the evidence on (1) risks of recreational cannabis use and (2) effectiveness and safety of medicinal cannabis. Findings on recreational use: Cannabis is mostly used to experience its acute rewarding effects. Regular use of high THC products can produce addiction (cannabis use disorder or CUD). Acute consumption of high THC doses (including unintentionally) can cause time-limited...