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Novel cannabidiol aspartame combination treatment (JW-100) significantly reduces ISGA score in atopic dermatitis: Results from a randomized double-blinded placebo-controlled interventional study

  • Journal : Journal of Cosmetic Dermatology Volume 21, Issue 4
  • Publication Year : 2022
  • Authors : Yanrui Gao MD, Yingfang Li MD, Yimei Tan MS, Wei Liu MD, PhD, Sara Ouaddi ScB, John McCoy PhD, Maja Kovacevic MD, Mirna Situm MD, PhD, Andrija Stanimirovic MD, Marissa Li MD, Carlos Wambier MD, PhD, Andy Goren MD, Ying Zou MD

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Abstract

Background

Atopic dermatitis (AD) is a common and chronic inflammatory skin disease that erupts periodically. Although the negative impact of the disorder on overall quality of life has been well established, new treatments for AD are still needed. Various studies have reported on cannabidiol’s effectiveness in relieving pain and easing inflammation while not presenting major health risks.

Aims

In this communication, we aim to demonstrate the effectiveness of a novel cannabidiol (CBD) and aspartame formulation, JW-100, in relieving signs and symptoms of AD.

Patients/Methods

We conducted a double-blinded placebo-controlled interventional study randomizing patients to one of three treatment groups: JW-100 (CBD plus aspartame), CBD only, or placebo topical formulations. The Investigator’s Static Global Assessment (ISGA) score was used to document any changes in AD resulting from the applied interventions at 14 days.

Results

Fifty-seven patients completed the trial and were included in the final analysis. The ISGA score of the patients at baseline was 2.56, 2.24, and 2.24, for the JW-100, CBD, and placebo groups, respectively. After two weeks of treatment, the ISGA score reduced by 1.28, 0.81, and 0.71, for the JW-100, CBD, and placebo groups, respectively. The JW-100 cohorts demonstrated statistically significant ISGA score reduction (p = 0.042). 50% of patients in the JW-100 group achieved ISGA score of clear or almost clear (0 or 1) with at least a 2-grade improvement from baseline after treatment (p = 0.028). Only 20% and 15% of patients in the CBD only and placebo groups reported ISGA score of clear or almost clear (0 or 1).

Conclusions

JW-100, a novel topical formulation containing CBD and aspartame, was demonstrated to produce statistically significant improvements in AD following 14 days of topical application.

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  • Cannabidiol (CBD)

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