Skip to the content
  • 719-347-5400
  • info@realmofcaring.org
  • 719-347-5400
  • info@realmofcaring.org
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • Medical Cannabis Cards
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
Menu
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • Medical Cannabis Cards
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
  • Donate
  • Register
  • Login
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • Medical Cannabis Cards
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
Menu
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
    • Women’s Veteran Study
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Find a Provider
      • Locate a Healthcare Professional
      • Medical Cannabis Cards
  • Blog
    • Blog: Client Stories
    • Blog: Education
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
    • Call or Email
    • Request an Appointment
  • Donate
  • Register
  • Login

Research Library

A-Z Conditions  Participate in ORR

Evidence that the plant cannabinoid cannabigerol is a highly potent α2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist

  • Journal : British Journal of Pharmacology
  • Publication Year : 2010
  • Authors : MG Cascio, LA Gauson, LA Stevenson, RA Ross and RG Pertwee

Background and purpose:

Cannabis is the source of at least seventy phytocannabinoids. The pharmacology of most of these has been little investigated, three notable exceptions being D9 -tetrahydrocannabinol, cannabidiol and D9 -tetrahydrocannabivarin. This investigation addressed the question of whether the little-studied phytocannabinoid, cannabigerol, can activate or block any G protein-coupled receptor.

 

Experimental approach: The [35S]GTPgS binding assay, performed with mouse brain membranes, was used to test the ability of cannabigerol to produce G protein-coupled receptor activation or blockade. Its ability to displace [3 H]CP55940 from mouse CB1 and human CB2 cannabinoid receptors and to inhibit electrically evoked contractions of the mouse isolated vas deferens was also investigated.

 

Key results: In the brain membrane experiments, cannabigerol behaved as a potent a2-adrenoceptor agonist (EC50 = 0.2 nM) and antagonized the 5-HT1A receptor agonist, R-(+)-8-hydroxy-2-(di-n-propylamino)tetralin (apparent KB = 51.9 nM). At 10 mM, it also behaved as a CB1 receptor competitive antagonist. Additionally, cannabigerol inhibited evoked contractions of the vas deferens in a manner that appeared to be a2-adrenoceptor-mediated (EC50 = 72.8 nM) and displayed significant affinity for mouse CB1 and human CB2 receptors.

 

Conclusions and implications: This investigation has provided the first evidence that cannabigerol can activate a2-adrenoceptors, bind to cannabinoid CB1 and CB2 receptors and block CB1 and 5-HT1A receptors. It will now be important to investigate why cannabigerol produced signs of agonism more potently in the [35S]GTPgS binding

Read the Full Article

Share This:

Share on Twitter Share on Facebook Share on LinkedIn Share on Email
PrevPreviousPhytocannabinoids promote viability and functional adipogenesis of bonemarrow-derived mesenchymal stem cells through different molecular targets
NextCross-sectional and longitudinal evaluation of cannabidiol (CBD) product use and health among people with epilepsyNext

Conditions:

Research Information:

Research Keywords:

Search the Research Library >

Follow Us:

Facebook Twitter Youtube

REGISTER WITH RoC TODAY!

Realm of Caring focuses on research, education, building community, and improving quality of life. We are an educational resource for consumers, physicians, scientists, governments and the media.
Register now
  • PO Box 15224, Colorado Springs, CO 80935
  • 719-347-5400
  • info@realmofcaring.org

Copyright © 2023 / Realm of Caring Foundation, Inc

  • Privacy
  • Disclaimer