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Research Library

A-Z Conditions  Participate in ORR

Clinical Outcome Data of Children Treated with Cannabis-Based Medicinal Products for Treatment Resistant Epilepsy

  • Journal : Neuropediatrics
  • Publication Year : 2023
  • Authors : Simon Erridge, Carl Holvey, Ross Coomber, Jonathan Hoare, Shaheen Khan, Michael W. Platt, James J. Rucker, Mark W. Weatherall, Sushil Beri, Mikael H. Sodergren

Abstract

 

Background There is a paucity of high-quality evidence of the efficacy and safety of cannabis-based medicinal products in treatment of treatment-resistant epilepsy (TRE) in children.

Methods A case series of children (<18 years old) with TRE from the UK Medical Cannabis Registry was analyzed. Primary outcomes were 50% reduction in seizure frequency, changes in the Impact of Pediatric Epilepsy Score (IPES), and incidence of adverse events.

Results Thirty-five patients were included in the analysis. Patients were prescribed during their treatment with the following: CBD isolate oils (n ¼ 19), CBD broad-spectrum oils (n ¼ 17), and CBD/9 -THC combination therapy (n ¼ 17). Twenty-three (65.7%) patients achieved a50% reduction in seizure frequency. 94.1% (n¼ 16) of patients treated with CBD and 9 -THC observed a 50% reduction in seizure frequency compared to 31.6% (n ¼ 6) and 17.6% (n¼ 3) of patients treated with CBD isolates and broad-spectrum CBD products, respectively (p< 0.001). Twenty-six (74.3%) adverse events were reported by 16 patients (45.7%). The majority of these were mild (n ¼ 12; 34.2%) and moderate (n¼ 10; 28.6%).

Conclusion The results of this study demonstrate a positive signal of improved seizure frequency in children treated with Cannabis-based medicinal products (CBMPs) for TRE. Moreover, the results suggest that CBMPs are well-tolerated in the short term. The limitations mean causation cannot be determined in this open-label, case series.

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