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Bronchodilator Effect of Delta-Tetrahydrocannabinol

  • Journal : British Journal of Clinical Pharmacology
  • Publication Year : 1978
  • Authors : J.P. R. Hartley; S.G. Nogrady; A. Seaton; J.D.P. Graham

The principal psycho-active constituent of cannabis, ∆-trans-tetrahydrocannabinol (∆-THC) has bronchodilator activity in man, both in normal subjects (Vachon, Fitzgerald, Solliday, Gould & Gaensler, 1973; Tashkin, Shapiro & Frank, 1973) and in asthmatic patients (Tashkin, Shapiro & Frank, 1974). It may be given orally, but in order to achieve significant effects, doses in excess of 10 mg must be used and patients then experience psychic disturbance. A dose of 200 ug, is an effective bronchodilator when delivered by inhalation from a pressurized aerosol, and no measurable systemic absorption takes place (Williams, Hartley & Graham, 1976). Higher doses frequently cause transient coughing and chest discomfort in asthmatic patients. The present study was undertaken to examine the effect of smaller doses of ∆-THC on ventilatory function, in terms of maximal response, duration and dose-response relation.

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Conditions:

  • D9-Tetrahydrocannabinol (THC), Pulmonary Function

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Research Keywords:

  • asthma, bronchodilator, pressurized aerosol

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