Category: Featured

Fibromyalgia can feel relentless. For those living with it, the daily reality often includes widespread pain, exhaustion, migraines, brain fog, sleep struggles, and mood changes. Standard treatments from antidepressants and muscle relaxants to physical therapy and lifestyle changes can help, but many people still find their symptoms stubbornly persistent.

 

A recently published case report explored an option for symptom relief: cannabidiol (CBD), specifically surveying the use of Epidiolex, the FDA-approved pharmaceutical form of CBD. While Epidiolex is currently only approved for rare forms of epilepsy, this research highlights an emerging conversation about CBD’s potential role in managing fibromyalgia.

 

The Research Spotlight: Two Cases of Relief

 

The published article followed two individuals with treatment-resistant fibromyalgia. Despite trying multiple conventional therapies, their symptoms remained overwhelming. When each was introduced to Epidiolex (a purified CBD isolate) their pain, sleep quality, and overall wellbeing significantly improved.

 

This is a small case series, not a large clinical trial, so it can’t prove that CBD is universally effective. But it adds momentum to a growing body of research suggesting cannabinoids may help ease the complex symptom picture of fibromyalgia.

 

Explore more in our Research Library

 

Isolate vs. Full-Spectrum CBD: What’s the Difference?

 

It’s important to note that Epidiolex is a CBD isolate. That means it contains only pure CBD, without any other compounds from the cannabis plant.

 

In contrast, most consumer-available CBD products are sold as full-spectrum or broad-spectrum:

 

• Full-spectrum: Includes CBD along with other cannabinoids (like CBG, CBC, and small amounts of THC), terpenes, and flavonoids.

 

• Broad-spectrum: Similar to full-spectrum but typically without THC.

 

Why does this matter? Many researchers believe these compounds may work together synergistically in what’s known as the entourage effect, which potentially amplifies CBD’s benefits for pain, mood, and sleep.

 

What We Know About Cannabis and Fibromyalgia

 

So far, the evidence for cannabis and fibromyalgia is still emerging:

 

• Results published in Pain Practice suggest a potentially significant role that cannabis can play for women with treatment-resistant Fibromyalgia. Further studies are warranted for long-term use, but short-term use is associated with enhanced quality of life via improved markers such as pain and sleep.

 

• A published systematic review found cannabis to be safe and well tolerated for those suffering with Fibromyalgia with no serious adverse events reported. 

 

• Findings from a published article in Journal of Clinical Rheumatology showed that after commencing the use of medicinal cannabis, all patients identified with Fibromyalgia reported a significant improvement in every parameter on the questionnaire provided and 50% stopped taking any other medications for their diagnosis.

 

At the very least, these studies are expanding the conversation: for some individuals, cannabinoid therapy may offer hope when conventional options fall short.

 

 

Why This Matters for People with Fibromyalgia

 

Because fibromyalgia touches so many aspects of health, approaches that target multiple systems may hold more promise. Whole-plant hemp extracts, with their mix of cannabinoids and aromatic terpenes, could offer benefits beyond CBD isolate alone.

 

That said, consumer CBD products vary widely in quality, potency, and labeling accuracy. What’s on the bottle isn’t always what’s inside, which makes education and support so important.

 

Tips for Exploring CBD with Fibromyalgia

 

If you’re curious about whether CBD could be part of your fibromyalgia management, here are some steps to take:

 

• Choose wisely: Look for products with third-party lab testing and transparent ingredient sourcing.

 

• Start low, go slow: Begin with a low dose and gradually increase until you find your “sweet spot.”

 

• Track your journey: Note changes in pain, sleep, energy, and mood so you can better understand what works.

 

• Talk with your provider: CBD can interact with other medications. Having a doctor in the loop is essential.

 

• See it as a tool, not a cure: CBD may help manage symptoms, but it works best as part of a holistic plan including movement, stress management, nutrition, and support.

 

For additional reading, check out our Client Resources for guides and education on cannabis therapies.

 

You Don’t Have to Navigate This Alone

 

If you are living with fibromyalgia and want to explore CBD but feel overwhelmed by the options just know you are not alone. At Realm of Caring, our care team offers free 1:1 support to help you:

 

• Understand the latest research.

 

• Find high-quality products you can trust.

 

• Learn how to have open, safe conversations with your doctor.

 

• Develop a personalized approach that fits your needs.

 

Connect with our care team today. Relief may not look the same for everyone, but you deserve to explore every option that could improve your quality of life.

 

Alcohol is one of the most widely consumed substances in the world. For many, drinking is part of social life, yet the consequences of overuse include liver damage, increased risk of chronic disease, and a staggering toll on mental health and relationships. As researchers look for safer strategies to support recovery and reduce harm, cannabidiol (CBD) has emerged as a promising ally.

 

CBD, a non-intoxicating compound from the cannabis plant, has gained attention for its potential therapeutic benefits, which include reducing anxiety and supporting better sleep. Now, new research suggests CBD may also support individuals struggling with alcohol use disorder (AUD) and play a role in harm reduction.

 

CBD and the Liver: A Potential Protective Role

 

Chronic alcohol use is toxic to the liver, often leading to fatty liver disease, inflammation, and cirrhosis. Interestingly, preclinical studies suggest that CBD may offer protective effects against alcohol-induced liver injury.

 

CBD has shown in studies to reduce oxidative stress and inflammation, two of the primary drivers of liver damage from alcohol consumption. While more human research is needed, these findings raise an important possibility: CBD may help buffer the liver against some of the toxic effects of alcohol and may even prevent neuronal loss, potentially supporting overall health in people at risk.

 

CBD and Alcohol Cravings

 

Beyond physical damage, one of the most challenging aspects of AUD is the cycle of craving and relapse. Preliminary evidence indicates that CBD may help here, too.

 

Research has shown that CBD interacts with the brain’s endocannabinoid system (ECS), which plays a role in regulating stress, reward, and addictive behaviors. In rodent models, CBD reduced alcohol-seeking behavior and relapse triggered by stress or environmental cues.

 

Though human trials are still limited, early clinical studies suggest that CBD’s ability to reduce anxiety and improve sleep may indirectly help individuals manage alcohol cravings and maintain recovery.

 

Harm Reduction: Alcohol, Cannabis, and the Middle Ground

 

Harm reduction is the idea of minimizing risks rather than insisting on complete abstinence. For some, cannabis is used as a substitute for alcohol, with research showing people may reduce alcohol intake when using cannabis.

 

However, this raises a cautionary note for a subset of individuals as substituting alcohol with cannabis could increase the risk of developing cannabis use disorder (CUD). Here, CBD may again serve as a unique tool. Unlike THC, CBD is non-intoxicating and has been investigated as a possible treatment for substance use disorders because of its calming and anti-craving properties.

 

This suggests CBD could be a “middle ground” in harm reduction strategies as a way to help reduce alcohol consumption without swapping one intoxicating substance for another.

 

What This Means for You

 

The research on CBD, alcohol, and addiction is still in its early stages but the results so far are compelling. CBD may:

 

• Support liver health by reducing oxidative stress and inflammation.

 

• Help reduce alcohol cravings and relapse risk.

 

• Serve as part of a harm reduction strategy without increasing intoxication risks.

 

If you or someone you love is curious about exploring CBD as part of an alcohol harm reduction or recovery strategy, you don’t have to navigate it alone.

 

Connect with Us

 

At Realm of Caring, our mission is to empower you with unbiased, research-backed information. Our care team offers free 1:1 support to help you:

 

• Find safe, high-quality CBD products.

 

• Learn how to discuss CBD use with your doctor.

 

• Get answers to your research questions.

 

Reach out today to take the next step toward a healthier relationship with wellness.

August 15th is National Relaxation Day that serves as a gentle reminder to pause, breathe, and let some of life’s stress roll off your shoulders. While there are many ways to unwind, some people are exploring how cannabis compounds like CBD and THC, in very small amounts, may support a calmer state of mind.

 

What is Microdosing? 

 

Microdosing refers to consuming very small amounts of a substance to experience potential benefits without strong or unwanted effects. In the context of cannabis, microdosing THC may offer certain therapeutic effects such as supporting relaxation, focus, or mood without the more intoxicating or overwhelming experience that higher doses can bring.

 

A Quick Look at the Cannabis Plant

 

The cannabis plant contains more than 100 cannabinoids, which are naturally occurring compounds that interact with the body’s Endocannabinoid System (ECS). Two of the most well-known and abundantly available in the cannabis plant are:

 

Delta-9-Tetrahydrocannabinol (THC): The primary cannabinoid responsible for the “high” associated with cannabis use and researched for its therapeutic potential.

 

Cannabidiol (CBD): A non-intoxicating cannabinoid studied for potential roles in reducing anxiety and improving sleep, among others. 

 

The ECS is a key regulator of stress response, critical to assist our bodies in returning to a relaxed state. The interaction of plant-based cannabinoids, such as THC and CBD, and our ECS makes cannabis a likely candidate for alleviating the symptoms of many health conditions, to include stress. In fact, cannabis has been used medicinally for thousands of years in various societies around the world to reduce the physiological and psychological consequences of stress and fear.

 

Why Relaxation Matters for Health

 

Chronic stress can take a toll on mental, physical, and emotional health. Research shows that regular relaxation practices may help lower blood pressure, improve sleep quality, reduce muscle tension, and support emotional balance. National Relaxation Day, observed annually on August 15th, serves as a reminder to step back from daily pressures and prioritize stress management for long-term wellness.

 

CBD and Relaxation: What the Evidence Shows

 

CBD has been studied for its potential to help the body adapt to stress by interacting with neurotransmitters such as serotonin, dopamine, and GABA, which are involved in mood regulation and relaxation.

 

Survey data from thousands of CBD consumers suggest that many report:

 

• Calmer mood during stressful situations 
• Reduced feelings of mild or temporary anxiety 
• Improved sleep quality 

 

Research indicates that CBD’s effects can vary depending on product type, dose, and individual body chemistry. Common ways people incorporate CBD into relaxation routines include:

 

• Tinctures for faster absorption 
• Edibles for convenience and taste 
• Topicals for localized tension relief 
• Bath products for a spa-like experience 

 

Microdosing THC: A Low-Impact Approach

 

Microdosing THC involves consuming a very small amount (often 2 mg or less per serving) to potentially experience benefits such as reduced stress, improved focus, or relief from discomfort without intoxicating effects.

 

Low amounts of THC may have different effects compared to higher doses. For example:

 

• Some research suggests small amounts may support mood and relaxation, while larger amounts could have the opposite effect. 
• Low-dose THC has been explored for its potential to help with pain management without significant intoxication. 

Importantly, microdosing is highly individual. What is “low” for one person may be too much for another. This is why the “start low, go slow” approach is often recommended when beginning with any cannabinoid product.

 

CBD and THC Together

 

There is growing interest in the “entourage effect,” the theory that cannabinoids and terpenes may work better together than alone. CBD may help moderate some of THC’s unwanted effects, such as anxiety or rapid heart rate, while enhancing potential benefits for relaxation, mood, and discomfort.

 

Other things to keep in mind before you consume:

 

• Intention matters
• Quality of product matters
• Free 1:1 support is just a phone call away

 

Conclusion

 

While research is ongoing, both CBD and microdosed THC are being explored as tools that may support relaxation and balance by working with the body’s endocannabinoid system. For those interested in cannabinoids, understanding dosing, individual variability, and product selection is key to making informed choices about how they fit into a broader wellness routine.

 

Founded by Heather Jackson and Paige Figi in 2013, Realm of Caring (RoC) began as a small, community-driven nonprofit – a lifeline for families seeking hope for their ailing children. Early on, RoC’s founding moms helped pioneer changes in medical cannabis laws across the United States. In fact, in the first 18 months, they helped change laws in 19 states, enabling families to legally access hemp-derived CBD therapies for conditions like intractable epilepsy. What started at the grassroots level in Colorado quickly evolved into a broader movement for education, advocacy, and change. Over the past 12 years, RoC has revolutionized how patients, caregivers, and even lawmakers approach cannabis, chipping away at stigma and influencing policy nationwide. Medical cannabis is now legal in the majority of states – a shift due in part to relentless advocacy by RoC and the families it empowered. This transformation from a local support network to a nationally respected leader exemplifies the theme “From Grassroots to Global,” as RoC’s impact now reaches far beyond its humble beginnings.

 

Milestones in Research: ORR and Scientific Breakthroughs

 

A cornerstone of RoC’s success has been its commitment to research. Recognizing the lack of data on cannabinoid therapy, RoC partnered with Johns Hopkins University to launch the Observational Research Registry (ORR) – an online, IRB-approved study tracking health outcomes in cannabis users and non-users over time. Since its launch in 2016, the ORR has grown into the largest cannabinoid therapy research program in the United States. This long-term registry has allowed researchers to gather invaluable real-world evidence on how people use cannabis and hemp-derived CBD, the benefits they experience, and any risks involved. In collaboration with Johns Hopkins, RoC published its first peer-reviewed study from ORR data in the journal Cannabis and Cannabinoid Research, marking a major milestone in legitimizing CBD therapy with scientific evidence. The study found that participants using artisanal (non-pharmaceutical) CBD reported greater health satisfaction, improved sleep, and lower anxiety and depression compared to non-users. Notably, adults using CBD even saw fewer hospital visits and sick days, highlighting tangible improvements in quality of life. These findings provided hard data to back up what families had been reporting anecdotally for years – that cannabis therapies can profoundly improve well-being.

 

RoC’s research momentum hasn’t stopped there. Nearly half a dozen papers have been generated or are in progress from the ORR, covering conditions from epilepsy to anxiety and chronic pain. In 2022, for instance, RoC and Johns Hopkins researchers surveyed 808 patients with neurological or pain-related disorders; 77% reported positive effects from medicinal cannabis, including reduced pain (28% of respondents), improved sleep (18%), and less anxiety (22%). Such real-world data are helping to fill gaps in clinical knowledge. It’s no surprise that RoC’s Executive Director Sasha Kalcheff-Korn emphasizes leading with science. As Matthew Lowe, PhD (RoC’s Senior Director of Research) noted, “large-scale research is a necessary, ethical, and essential safeguard to minimize negative side effects and adverse reactions.” – a testament to RoC’s leadership in generating evidence. The registry’s success even led to a federal research collaboration: in 2023, RoC joined as a collaborator to an NIH-funded project awarded to Johns Hopkins to develop a national medicinal cannabis use registry. This project, known as the Cannabis and Health Research Initiative enrolls first-time users in the National Cannabis Study while lending the data to a greater repository, open for academic collaboration. From a grassroots data-gathering effort to a nationally recognized research initiative, RoC has firmly established itself as a scientific authority in the cannabis field.

 

Advocacy Wins: Championing Access and Policy Change

 

While building the science, RoC has never lost sight of its advocacy roots. The organization was born from advocacy as parents fought for their children’s right to try a natural therapy. That spirit continues to drive RoC’s work today. Breaking the cannabis stigma has been a central focus: RoC “stands out for its unwavering commitment to empowering individuals seeking cannabinoid therapy” and has a remarkable story of dismantling cannabis stigmas through education and outreach. Each personal story of healing shared, each public presentation or media appearance, has chipped away at misconceptions and fear. The results are evident in shifting public opinion – as Heather Jackson puts it, “…we are seeing this therapy move to the forefront as an option instead of a last one”. Back in 2012, discussing CBD openly was controversial; today, doctors themselves refer patients to RoC for guidance, a clear sign of progress.

 

RoC has also been on the front lines of policy advocacy. Beyond the early wave of state-level CBD legislation (e.g. “Charlotte’s Web” laws), RoC continues to engage policymakers to ensure safe and sensible cannabis regulations. In Colorado, for example, when an overly restrictive hemp bill (SB 205) threatened patient access, RoC sprang into action “in overdrive to protect access to these life-saving medicines.” Heather Jackson and the RoC team rallied stakeholders and helped get the bill amended to strike a balance – protecting consumers from unsafe products without cutting off access to full-spectrum hemp options. This is just one instance of RoC’s advocacy wins. Nationally, RoC has lent its voice to federal efforts like the push for an FDA regulatory framework for CBD and the call to deschedule cannabis from Schedule I, which would remove barriers to research and access. As a nonprofit, RoC isn’t motivated by profit, but by compassion and justice, speaking up so that no family has to uproot their lives or break the law to get a chance at wellness. Each advocacy victory (big or small) means more people can access cannabinoid therapies without stigma or legal peril.

 

Community Support and Education: Empowering Thousands

 

Even as it grew globally, RoC has remained deeply committed to community support. At its heart, RoC is about people helping people. Over 12 years, RoC’s Care Team has provided free, personalized guidance to tens of thousands of clients around the world. Whether it’s a parent desperate for administration support for their child’s seizures, a veteran seeking alternatives for pain management, or an elderly patient curious about CBD for arthritis – RoC’s specialists are there to listen and help. The organization offers one-on-one phone consultations, email support, and an array of educational resources, all at no cost. In fact, RoC has fielded over 260,000 inquiries through its call center, totaling more than 2.5 million minutes on the phone providing support and information, a staggering indicator of both the need and RoC’s dedication. These interactions often turn into relationships; many who once were callers in crisis have become members of the RoC family, celebrating improvements and sharing their journeys.

 

Education is another pillar of RoC’s mission. The team curates a Research Library and weekly informational blogs, hosts monthly webinars on topics ranging from cannabinoid basics to the latest scientific findings, and even runs virtual support groups and a community book club. All these efforts align with RoC’s belief that knowledge is power. By equipping patients, caregivers, and healthcare professionals with evidence-based information, RoC helps individuals make informed decisions about cannabis therapy. The website itself is a rich resource – a hub where you can find dosing guides, FAQs, a glossary of terms, and even a portal for medical professionals seeking education on cannabinoid treatments. This commitment to education and support has built a global community. RoC has become an educational resource for consumers, physicians, scientists, governments and the media, bridging the gap between the scientific world and the public. In doing so, it empowers families to advocate for their health and fosters a compassionate community united by the goal of improving quality of life through plant-based therapy.

 

Challenges and Hope: The Road Ahead

 

As we celebrate how far RoC has come, we also candidly acknowledge the ongoing challenges that remain. Despite much progress, legal and financial hurdles still hinder the full potential of cannabinoid therapy. Access and policy are at the forefront. Because cannabis remains a Schedule I substance at the federal level, research is harder to conduct and patients in some states still struggle with limited access or confusing regulations. The stigma hasn’t vanished overnight either; misconceptions linger in some corners, and RoC’s work in educating the public and healthcare community must continue with vigor. Another challenge is research funding. As Heather Jackson has openly noted, RoC is a traditional nonprofit and “needs aligned industry partners, philanthropic donors and the community to invest in our impact if we are truly going to make a big difference.” Unlike commercial enterprises, RoC relies on grants and donations to fund its research and outreach programs – and securing those resources is a constant struggle in an industry that is still finding its footing.

 

Yet, the tone is overwhelmingly hopeful. Each year on National CBD Day, we’re reminded of how dramatically the landscape has changed in a short time and how RoC’s persistence has contributed to that change. Cannabis therapies that were once considered fringe are rapidly moving toward mainstream acceptance. People from all walks of life are now exploring hemp-derived CBD and medicinal cannabis as wellness options, often at the recommendation of their doctors, which was unheard of a decade ago. The data collected and published by RoC are validating the benefits (better sleep, less anxiety, improved well-being) that early adopters experienced. Policymakers are slowly coming around, evidenced by bipartisan efforts to create sensible regulations and even interest from federal agencies in studying cannabis. The road hasn’t been easy – and there is much work ahead to ensure equitable access, continued research, and the dismantling of outdated stigma – but RoC’s journey so far proves that change is possible when passionate people unite around a common cause.

 

Joining the Mission: How You Can Help

 

Celebrating 12 years is not just about looking back – it’s about forging ahead with even greater determination. Realm of Caring’s story is still being written, and you can be a part of its next chapter. How? By lending your support and voice. If RoC has touched your life or you believe in the power of this work, consider making a donation – big or small, every bit fuels critical research and keeps vital education and support services free for those who need them. As a 501(c)(3) nonprofit, RoC relies on community generosity to continue its programs and to fund groundbreaking studies that could inform the medical community and change policy. You can also directly participate in research: the Observational Research Registry is always seeking more contributors. Enrolling in the ORR (which is open to anyone, whether you use cannabis or not) is a simple but impactful way to advance knowledge. Your anonymous survey data becomes part of the evidence that researchers and policymakers look at when shaping the future of cannabis therapy. And of course, you can spread the word – share RoC’s resources with friends, join its webinars, or become an advocate in your own community.

 

On this 12th birthday and in celebration of National CBD Day, we at Realm of Caring are filled with gratitude and optimism. Together, we’ve come so far – from a few families searching for hope, to a global community tens of thousands strong. Yet our work is far from finished. By continuing to stand together – scientists, supporters, clients, and advocates – we will push the boundaries of knowledge, overcome the remaining challenges in access and stigma, and ensure that everyone who can benefit from cannabinoid therapy has the chance to do so. Here’s to 12 years of progress and to a future where plant-powered wellness is available to all. Thank you for being part of our journey, and happy National CBD Day!

 

— The Realm of Caring Team

If you’ve browsed a CBD store or hemp dispensary lately, you may have come across terms like “Delta-8 THC,” “Delta-9 THC,” and “hemp-derived THC.” They may sound similar, but the differences between them can have a big impact on how they affect your body – and your legal standing depending on where you live.

 

At Realm of Caring, we are here to help you make informed, empowered decisions. Whether you are exploring plant-based therapies for the first time or are a seasoned cannabis consumer, understanding how different forms of THC behave in the body is essential.

 

What is THC, Anyway?

 

THC, short for tetrahydrocannabinol, is the primary intoxicating compound found in cannabis. It binds to CB1 receptors in the brain and nervous system, which can influence mood, memory, pain perception, appetite, and more.

 

When most people refer to THC, they’re talking about Delta-9 THC, the compound responsible for the classic “high” associated with cannabis. But due to evolving laws and consumer demand, other forms of THC have emerged in the market,  including Delta-8 THC and hemp-derived Delta-9 THC.

 

Delta-9 THC: The Classic Compound

 

Delta-9 THC is the most researched and abundant form of THC found naturally in the cannabis plant. It’s well known for its intoxicating effects at moderate to high doses, and it has also been studied for potential medicinal and therapeutic uses including:

 

• Reducing nausea and vomiting (especially during chemotherapy)
• Stimulating appetite
• Supporting pain relief
• Easing muscle spasticity (especially in conditions like MS)

 

Because Delta-9 THC is federally classified as a Schedule I controlled substance, it is still highly regulated. However, hemp-derived Delta-9 THC (less than 0.3% by dry weight, per the 2018 Farm Bill) is allowed under federal law, a nuance that some companies use to sell THC-containing edibles, vapes, and tinctures nationwide.

 

Consumer Tip: While hemp-derived Delta-9 is legal in many states, it still produces the same psychoactive effects. Always start with a low dose and understand how your body reacts.

 

Delta-8 THC: A Close Cousin, But Not the Same

 

Delta-8 THC is a cannabinoid that occurs in very small amounts naturally in hemp and cannabis. To produce Delta-8 products at scale, manufacturers typically convert CBD into Delta-8 through a chemical process called isomerization, which alters the molecular structure.

 

Delta-8 and Delta-9 THC are nearly identical, sharing the same molecular formula (C₂₁H₃₀O₂), (which also happens to be the same molecular formula as cannabinoids cannabichromene (CBC) and cannabidiol (CBD), and the hormone progesterone) and both bind to CB1 receptors in the brain. But Delta-8 is generally considered potentially less potent and less intoxicating, which has made it popular among people seeking relief without a strong high.

 

Some promising studies, including research in pediatric cancer patients, show Delta-8 may help reduce nausea with fewer side effects than Delta-9 THC. In mouse models, it has also shown the potential to increase appetite and cognitive performance without as much psychoactivity.

 

However, most Delta-8 THC on the market is synthetically derived and unregulated. This means:

 

• There is limited oversight on how it’s produced
• Lab testing is inconsistent or absent
• Products may contain contaminants or significantly more THC than advertised

 

Many states have taken action to ban or restrict Delta-8 sales due to concerns about consumer safety, especially when products skirt regulations intended for marijuana-derived THC.

 

Consumer Tip: Be cautious with Delta-8. Look for third-party lab tests and avoid products that don’t disclose how the cannabinoid was derived or what’s in it.

 

Hemp-Derived THC: Legal Loopholes and Consumer Confusion

 

The term “hemp-derived THC” typically refers to cannabinoids like Delta-8 or Delta-9 that are sourced from hemp (cannabis plants with less than 0.3% Delta-9 THC by dry weight). Because of this federal definition, manufacturers are able to infuse hemp-derived cannabinoids into edibles and oils, sometimes containing enough THC to produce intoxicating effects, even if technically compliant with the letter of the law.

 

While this may seem like a win for accessibility, it creates a confusing consumer landscape. Products may appear to be CBD-only or “non-psychoactive” based on hemp labeling, but in reality they can:

 

• Cause a THC high
• Show up on a drug test
• Contain synthetic or unregulated compounds

 

As a result, consumers seeking non-intoxicating relief may unknowingly purchase products that affect their cognition, coordination, or overall health.

 

Consumer Tip: Read labels and seek transparency with a company prior to purchasing. 

 

Awareness is Everything

 

All forms of THC – whether Delta-9, Delta-8, or hemp-derived – have psychoactive potential at certain doses. The key difference lies in how they’re made, how much we know about their safety, and how they’re regulated.

 

At Realm of Caring, we advocate for transparency, research, and consumer safety. Here’s what we recommend:

 

• Start low and go slow, especially with new or unfamiliar products
• Ask for Certificates of Analysis (COAs) from third-party labs
• Choose products from trusted sources that explain their extraction process
• Stay up-to-date on your state laws

 

And most importantly, don’t be afraid to ask questions. Our care team is here to help you navigate the world of cannabis with confidence.

 

Each July, National Hemp Month offers us a moment to reflect on the incredible potential of the hemp plant—not just as a source of therapeutic cannabinoids, but also as a powerhouse of nutritional wellness. While much attention is rightly given to cannabinoids like CBD and THC, hemp seeds deserve their own spotlight. Rich in essential fatty acids, hemp seeds provide a near-perfect balance of Omega-6 to Omega-3—an attribute that sets them apart from many other plant-based foods.

 

 

Why Omega Fatty Acids Matter

Omega-6 and Omega-3 are polyunsaturated fatty acids (PUFAs), meaning they are crucial for human health but must be obtained through diet. These fats play essential roles in:

• Supporting brain function and development
• Regulating metabolism and hormone production
• Reducing inflammation
• Promoting cardiovascular health

While both are essential, modern diets often over-index on Omega-6 (commonly found in processed seed oils) and under-consume Omega-3s, leading to an imbalanced ratio that may increase the risk of chronic disease [1].

 

 

The Ideal Ratio—and How Hemp Delivers

Health experts recommend an Omega-6 to Omega-3 ratio close to 4:1 or even 2:1, yet the typical Western diet can skew as high as 20:1 [2]. This imbalance has been linked to increased inflammation, which may play a role in conditions such as arthritis, cardiovascular disease, and metabolic syndrome [3].

Enter hemp seeds: uniquely balanced with a 3:1 ratio of Omega-6 to Omega-3 fatty acids—just what our bodies crave [4]. This makes hemp one of the most effective plant-based sources for restoring equilibrium in our fat intake.

 

 

Gamma-Linolenic Acid (GLA): A Unique Benefit

Hemp seeds also contain gamma-linolenic acid (GLA), a less commonly found Omega-6 fatty acid with notable anti-inflammatory properties. GLA has been studied for its potential to support:

• Hormonal health, especially in those with PMS or menopausal symptoms [5]
• Skin conditions like eczema and dermatitis [6]
• Immune system balance

This makes hemp seeds particularly supportive for individuals looking to integrate whole-body wellness through nutrition.

 

 

Whole Food, Whole Body Benefits

Incorporating hemp seeds into your daily routine is easy and beneficial. A couple of tablespoons offer:

• 10 grams of protein
• 12 grams of Omegas
• Vital minerals such as magnesium, iron, and zinc
• A complete amino acid profile

This nutrient density supports overall wellness—nourishing the body, brain, and beyond.

 

 

Hemp and the Bigger Picture

At Realm of Caring, we believe in exploring the full spectrum of hemp’s therapeutic potential. Whether it’s participating in groundbreaking cannabinoid research or educating on the plant’s nutritional gifts, our mission is rooted in holistic health and evidence-based care.

As we celebrate National Hemp Month, let’s honor the often-overlooked power of hemp seeds. Adding them to your smoothie, oatmeal, salad, or favorite baked goods isn’t just a culinary choice—it’s a wellness strategy grounded in science.

 

References

[1] Simopoulos, A. P. (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & Pharmacotherapy, 56(8), 365–379.
[2] Lands, W. E. M. (2012). Historical perspectives on the impact of n-3 and n-6 nutrients on health. Progress in Lipid Research, 50(5), 345–352.
[3] Patterson, E. et al. (2012). Health implications of high dietary omega-6 polyunsaturated fatty acids. Journal of Nutrition and Metabolism, 2012, 539426.
[4] House, J. D. et al. (2010). Nutritional composition of hemp seed and products. Journal of Agricultural and Food Chemistry, 58(22), 11801–11807.
[5] Horrobin, D. F. (1993). Gamma linolenic acid in the treatment of PMS. American Journal of Clinical Nutrition, 57(5 Suppl), 847S–852S.
[6] Morse, N. L. et al. (2010). Benefits of GLA in skin conditions. Journal of Dermatological Treatment, 21(3), 129–134.

 

At Realm of Caring, we believe in meeting people where they are, whether they’re exploring cannabis for the first time or looking for new options when other methods fall short. Suppositories are one such option, and while they may not be mainstream yet, they’re offering meaningful relief to people of all genders.

 

 

CBD and Cannabis Suppositories: A Groundbreaking Option for Targeted Relief

 

When we talk about cannabis wellness, most people think of tinctures, gummies, capsules, or inhalation. But there’s a lesser-known method that’s gaining attention for its effectiveness, especially when targeted relief is needed: suppositories.

 

 

What Are Suppositories?

 

Cannabis suppositories are small, moldable forms, typically made with cocoa butter, that are inserted vaginally or rectally. They contain cannabinoids like CBD, THC, or a combination, and are designed to melt and absorb into nearby tissues, delivering effects locally and systemically.

 

Unlike oral methods, suppositories bypass the digestive system and liver, allowing for higher absorption and fewer psychoactive effects, even when THC is present. This makes them an appealing option for those who want the benefits of cannabis without the “high.”

 

 

Why This Method Matters

 

Cannabinoids delivered via suppositories may provide faster relief and better bioavailability than oral consumption. The mucosal tissues in the rectum and vagina are rich in blood vessels, which means cannabinoids can enter the bloodstream directly.

 

This method can be especially beneficial for those with:

• GI sensitivities
• Difficulty swallowing or digesting oral products
• A need for local, pelvic-area support

 

 

Benefits for Women

 

Women are finding cannabis suppositories helpful for a wide range of concerns:

• Menstrual cramps and bloating
• Endometriosis, a condition that often goes underdiagnosed and undertreated
• Sexual health, helping with lubrication, tension, and relaxation
• Menopause symptoms, including dryness, anxiety, and insomnia

 

By applying cannabinoids directly where inflammation and tension occur, some women report profound and fast-acting relief, often within 15 to 30 minutes.

 

 

Benefits for Men

 

While less frequently discussed, men are also benefiting from rectal cannabis suppositories. This method may help:

• Prostate and pelvic inflammation
• Rectal discomfort (including from hemorrhoids or IBD)
• Chronic pain and insomnia

 

For men seeking non-oral options or those navigating conditions like prostate cancer or GI disorders, suppositories offer a discreet, non-invasive, and potentially powerful therapeutic route.

 

 

Considerations Before You Try

 

Suppositories may be unfamiliar to many, so education is key:

• Start low and go slow – especially if THC is included
• Use clean hands or gloves for insertion and lie down for optimal absorption
• Store products in a cool, dark place to maintain integrity
• Speak to your healthcare provider if you’re undergoing other treatments or using prescription medications

 

As always, Realm of Caring is here to guide you with science-backed resources and personalized support.

 

Looking Ahead: The Need for Research

 

While anecdotal evidence is promising, there’s still much to learn. Realm of Caring is committed to supporting the research that will better inform use, access, and policy around cannabis therapies, including suppositories. We encourage curious consumers and medical professionals alike to stay engaged as the science evolves.

 

Join a Realm of Caring study today!

 

Final Thoughts

 

Suppositories may not be the first thing you think of when you consider cannabis therapy, but for many, they’ve become a game-changer.

 

If you’re looking for localized relief without systemic side effects, or you simply want to expand your wellness toolkit, suppositories might be worth exploring.

 

We’re here to answer your questions, connect you with the right resources, and make sure that everyone – regardless of gender, condition, or background – has access to safe, informed, and empowering plant-based care.

 

June is Men’s Health Month, a time to spotlight the unique health challenges men face and empower them with tools that support long-term wellbeing. In recent years, cannabis has emerged as a promising ally in men’s health – supporting everything from stress and sleep to inflammation, sexual health, and emotional balance. While stigma still lingers, education and research are helping men reframe cannabis use as a legitimate part of a proactive health and wellness routine.

 

At Realm of Caring, we’ve spoken with countless male clients who’ve turned to cannabinoids, like CBD, THC, CBG, and more, not to escape, but to engage: with their families, their physical health, their mental clarity, and their personal goals.

 

Stress and Mental Health: The Silent Struggle

 

Many men are conditioned to “tough it out,” avoiding mental health support or downplaying stress and anxiety. But this strategy can backfire, leading to chronic stress, high blood pressure, poor sleep, and even depression. That’s where cannabis-based therapies may offer a gentler path forward.

 

Cannabinoids interact with the body’s endocannabinoid system (ECS), which helps regulate mood, sleep, pain, and immune function. For some men, adding CBD or a balanced CBD:THC product to their wellness regimen may help:

 

• Reduce anxious thoughts 
• Improve emotional regulation 
• Support deeper, more restorative sleep 
• Increase presence and resilience in daily life 

 

One study showed that low-dose THC may reduce anxiety, while CBD appears to have anxiolytic (anti-anxiety) properties without intoxication. But the key is intentional use, not excess. Realm of Caring’s free guided support can help individuals and caregivers personalize their cannabinoid use to avoid common pitfalls and maximize benefit.

 

Read more: Managing Stress with Cannabis – Men’s Health Awareness

 

Physical Wellness: From Inflammation to Hormonal Health

 

As men age, inflammation, pain, and hormone fluctuations (especially testosterone) can impact vitality. Cannabis may offer support in these areas too.

 

• Chronic Pain & Inflammation: Cannabinoids like CBD and CBG show anti-inflammatory properties and may support recovery from workouts, injuries, or chronic pain conditions. 
• Sleep Quality: THC, when used responsibly in low doses, may help men fall asleep faster and sleep longer, while CBD may help with staying asleep and waking feeling refreshed. 
• Sexual Health: While research is still growing, some men report increased libido and improved sexual function, likely due to cannabis’s ability to lower anxiety, boost blood flow, and enhance sensation. 
• Metabolic Health: Emerging evidence links cannabis use with a lower prevalence of obesity and improved insulin sensitivity, but this depends on dose, product type, and lifestyle factors. 

Read more: Cannabis Use and Men’s Health

 

Breaking Stigma, Building Confidence

 

Cannabis is not a cure-all, but for many men, it’s a powerful part of a holistic health plan that includes regular check-ups, movement, healthy food, and open conversations about stress, emotions, and goals.

 

Through our research collaborations and observational studies with institutions like Johns Hopkins University, Realm of Caring continues to document how cannabis supports real people across a variety of health conditions. Our community-based model empowers men to track outcomes, improve their quality of life, and make informed decisions, not guesses.

 

How Realm of Caring Can Help

 

• Free one-on-one support: Talk to a care specialist who can help you or a loved one start a cannabinoid routine based on science, not hype. 
• Cannabis Research Library: Explore peer-reviewed findings on cannabis and men’s health. 
• Education & Advocacy: Learn how to advocate for your health and access safe, reliable products. 

 

We’re here to help you make confident decisions in your wellness journey. Because self-care is not weakness; it’s strength.

This past week, Realm of Caring’s Executive Director, Sasha Kalcheff-Korn, moderated one of the most future-focused conversations at the Benzinga Cannabis Capital Conference. The panel, “Pharma-Grade Cannabis: A Long-Term Play for Investors & Operators Alike?”, brought together a powerhouse lineup of experts pioneering the next era of cannabis as medicine:

 

• Steve Bastasini, Co-Founder & CEO of Kanavos, Inc.
• Jim Sanfilippo, Co-Founder & CEO of VIST Labs
• Duncan Mackie, PhD, Director of Pharmacology & Experimental Therapeutics at Bud & Mary’s
• Dana Lambert, PhD, President & CEO of Andira Pharmaceuticals
• Shaun Land, President & CEO of Irvine Labs

 

Together, they explored what it truly takes to develop cannabis into pharmaceutical-grade products; from rigorous R&D and regulatory navigation to breakthrough innovations in safety, delivery, and formulation.

 

For anyone invested in the therapeutic future of cannabis – patients, researchers, regulators, or purpose-driven brands – this conversation delivered a clear message: the future of cannabis as medicine is already in motion.

Key Takeaways

 

1. The Path to Pharma Is Real and Growing

• Several panelists are already deep into the pharmaceutical pathway with cannabinoid-based drugs aimed at unmet medical needs; like superbug infections, breast cancer, Parkinson’s, sleep disorders, and atopic dermatitis.

• Companies like Andira Pharmaceuticals under Dana’s leadership are taking isolated cannabinoids through FDA drug approval processes, leveraging programs like Breakthrough Therapy Designation and Qualified Infectious Disease Product status to fast-track development. But as Duncan with Bud & Mary’s emphasized, there are several pathways to take and opportunities to take more than one in this moving, shifting regulatory landscape.

• Panelists echoed that pharma-level R&D is more achievable than many believe, especially with growing regulatory familiarity and a rising number of FDA cannabinoid precedents (like dronabinol/Marinol).

 

2. Innovation in Safety and Delivery Is Catching Up

• Safety was a recurring theme, especially for immunocompromised patients. Jim with VIST Labs emphasized the need for sterilized, pathogen-free inhalable cannabis, calling out widespread contamination risks in current markets.

• Sterile post-harvest packaging, modified atmosphere technology, and cryogenic vapor sterilization are tools being adopted to ensure that cannabis meets the standards of inhaled therapeutics.

• On the delivery side, panelists discussed new formulations (gels, powders, and emulsions) that improve bioavailability and can be targeted to specific organs.

 

3. Intellectual Property (IP) Is Fueling the Future

• Companies are investing heavily in IP; particularly in formulations, delivery systems, and novel combinations of cannabinoids and other plant compounds.

• Panelists emphasized that IP isn’t just a defensive strategy; it’s the core of valuation and acquisition potential. Some companies are already filing globally and protecting multi-layered innovation stacks.
• Shaun with Irvine Labs emphasized that even if a product is not patentable, it is often still worth bringing it to market; so don’t let fear stop you from bringing a worthy product to patients who would benefit. 

 

4. Cannabis as Medicine Requires Clean Labels, Accurate Dosing

• There’s a growing awareness that inconsistent labeling and oxidation of cannabinoids can mislead patients and degrade therapeutic potential.

• Modified atmosphere packaging, common in the food industry, was suggested as a necessary next step for cannabis producers to ensure stability and truth-in-labeling, especially for products sitting on dispensary shelves for months.

 

5. Wellness, Pharma, and the “Blue Ocean” in Between

• While pharma is the ultimate gold standard, several speakers highlighted the vast potential between wellness and prescription-grade therapeutics.

• From functional edibles with therapeutic benefits to collaborations with nutrition giants, the wellness sector could be a key stepping stone to mainstream adoption.

• Tech platforms like Kanavos Inc. under Steve’s leadership are building semantic AI tools to make scientific data on cannabinoids more accessible to prescribers, patients, and regulators alike.

What We’re Excited About at Realm of Caring

 

• Elevated Safety Standards: It’s clear the industry is moving toward cleaner, more consistent products that put patient health first, something Realm of Caring has long advocated for.

• New Drug Candidates: Realm of Caring has conducted rigorous, observational research for nearly a decade; studies that pave the way for clinical trials. With more clinical trials underway for cannabinoid-based treatments in infection control and cancer, we are hopeful about expanded therapeutic options backed by rigorous data.

• Patient-First Innovation: Beyond the science, what resonated most was the shared commitment to solving real problems for real people; especially those failed by current options.

Looking Ahead

 

Realm of Caring remains dedicated to supporting research, elevating patient voices, and advocating for regulatory and product standards that reflect the true potential of cannabis as medicine. As Sasha shared in the panel, “This is the conversation for anyone serious about the future of cannabis as medicine.”

 

We’re thrilled to be part of it and we invite all patients, caregivers, researchers, and innovators to join us as we push toward a future where quality, access, and efficacy are non-negotiable.

 

To watch the full panel discussion, see the video here. 

Creatine is having a moment, and for a good reason. Backed by decades of research, it has become a staple for athletes as well as anyone seeking improved cognitive and physical performance. But there are other natural compounds making waves in the wellness world, which make up the cannabis plant. 

 

While they work differently in the body, creatine and cannabis share surprising common ground. And, more importantly, both remind us that health is not about a singular “miracle cure”, but about layering multiple tools that can support our entire, internal systems. 

 

 

The “Brain Boosters”: Cognitive and Mental Health Benefits

 

 

Creatine plays a role in providing energy through the creatine kinase (CK) and phosphocreatine (PCr) system. Several studies pointed to supplementation of creatine to assist with mental fatigue through improving cognition, executive function, and/or memory. Initial trials and few observational studies point to the alteration of depression-like behaviors with creatine supplementation. 

 

One of the major cannabinoids found in the cannabis plant, cannabidiol (CBD), has gained the attention of the research community when it comes to influence on brain function. Recent research suggests that CBD use for those with pathological conditions may see improved cognitive processes. This includes improved attention, executive function, working memory, and episodic memory.

 

For neurodegenerative diseases, CBD has shown to be a promising therapeutic agent. Several studies point to the ability of CBD to inhibit progression of Alzheimer’s disease. Although the mechanisms of the neuroprotective effects have not fully been discovered, research points to CBD’s role in reducing neuroinflammation, reducing oxidative stress, and improving cognitive performance by preventing the development of social recognition deficit.

 

Higher resting hippocampal blood flow is associated with better memory performance. Results were published in 2020 from a randomized, crossover, double-blind study where 15 healthy participants were administered oral CBD to assess how CBD influences cerebral brain flow in regions involved with memory processing. Their findings suggest that CBD does increase cerebral brain flow to the key regions involved in memory processing, particularly in the hippocampus.

 

Data indicate that repeated administration of CBD may produce an effect that is consistent with results from studies testing traditional anti-anxiety and antidepressant medications. These are known to be clinically relevant findings as CBD is known to benefit while exhibiting few side effects, supporting the initiation of clinical trials testing the efficacy of CBD-based compounds for the treatment of mood disorders. 

 

The serotonergic mechanism of CBD is distinct from commonly used antidepressant medications in that it does not appear to produce symptoms of withdrawal. CBD has also been shown to synergize with other serotonergic medications. Data suggests that CBD could facilitate the antidepressant effect induced by these antidepressant drugs, therefore allowing the SSRIs to be administered at lower doses, resulting in fewer side effects. 

 

In a recently published observational study, it was found that medicinal cannabis use was associated with lower self-reported depression. Initiation of medicinal cannabis during the follow-up period was associated with significantly decreased anxiety and depressive symptoms, an effect that was not observed in Controls who had not initiated cannabis use.

 

“Brain Booster” Takeaway: Both creatine and cannabinoids from the cannabis plant continue to be studied for their benefit to neurodegenerative conditions and improving quality of life for high-stress environments that can impact cognitive function and mental health. 

 

 

Performance and Recovery: From Gym Gains to Restorative Sleep

 

 

As we age, we are susceptible to losing strength, muscle mass, and bone mass while increasing body fat. Several studies performed in older adults, older men, and postmenopausal women suggest that creatine supplementation may promote gains in muscle mass and strength as well as bone density. A recent meta-analysis on the effects of creatine supplementation on body composition found that it may help maintain muscle mass while promoting fat mass loss.

 

When understanding the effects of creatine on sleep, a study published in 2006 reported that sleep-deprived participants better maintained random movement generation, time to react to choices, mood state, and balance when using creatine supplements. 

 

For recovery, CBD is looked to for anti-inflammatory, reducing oxidative stress, and decreasing muscle soreness. Cannabigerol (CBG) and Cannabidiolic acid (CBDA) may also offer potent anti-inflammatory and analgesic effects to promote healing post-workout. These benefits may also lead to improved sleep, by limiting stress-induced inflammation and pain. 

 

Cannabinoids cannabinol (CBN), delta-9-tetrahydrocannabinol (THC) are cannabinoids more often regarded for their sleep-promoting benefits, which may be realized at even micro-dosed amounts. 

 

Performance and Recovery Takeaway: While creatine is more widely known for muscle building and fat loss (“gains”) several cannabinoids have been studied for their recovery benefits. Both may work together to enhance overall performance. 

 

 

Metabolic Health: Focusing on the Body’s Ability to Regulate

 

 

Evidence has rapidly accumulated over time that creatine supplementation reports to help lower cholesterol, triglycerides, reduce accumulating fat on the liver, serve as an antioxidant, enhance glycemic control, and reduce the risk of heart disease. 

 

Given studies related to creatine and glucose management, there is sufficient evidence to suggest that supplementation of creatine may enhance glucose uptake and insulin sensitivity, particularly when simultaneously initiating in an exercise program. 

 

Currently, there are very few natural pharmaceutical solutions available for the treatment of metabolic syndrome. In 2023 researchers published findings analyzing a full-spectrum cannabis oil (CBD:THC, 2:1) to understand the usefulness of cannabis in metabolic syndrome, notably for blood pressure, serum metabolic parameters, and liver damage. Their study showed data that resulted in significant improvements across several metabolic syndrome parameters in animal models fed a sucrose-rich diet. They observed lower systolic and diastolic blood pressure, decreased serum levels, improved liver abnormalities, and pain relief. 

 

Researchers in 2017 reported CBD’s impact on blood pressure in healthy humans following an oral dose of 600mg showing that increased blood pressure levels as a result of stressful situations were weakened. Over time we have seen repeated actions of acute or chronic CBD treatment in reducing the cardiovascular response to models of stress, making it known to be an anxiolytic. 

 

For diabetes prevention, tetrahydrocannabivarin (THCV) has recently been looked to for aiding weight loss. There is also research to show the promise of CBD and THCV in reducing insulin resistance and moderating blood sugars.

 

Metabolic Health Takeaway: Both creatine and cannabis compounds are showing to support metabolic regulation, a key to long-term health. 

 

 

Conclusion: Layer, Don’t Lean

 

 

Creatine isn’t the answer. Neither is cannabis. But together they reflect a modern, integrative approach to health that supports systems rather than symptoms. If you are looking to enhance performance, energy, and mood, the most sustainable approach is layering lifestyle, diet, movement, and the right supplementation for you. 

 

Curious about how to start incorporating cannabinoids into your wellness routine safely and effectively? Learn more with us at Realm of Caring.