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Found 770 Results

Motor effects of delta 9 THC in cerebellar Lurcher mutant mice

The present study evaluated the effects of the principal active component of marijuana (delta 9 THC) on motor abilities and motor learning in mice with cerebellar dysfunction. For this purpose, spontaneous locomotor activity, equilibrium abilities, muscular tone, motor coordination and motor learning were investigated in Lurcher mutant and non-mutant B6/CBA mice 20 min after i.p. […]


Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity

Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms involved by studying N-methyl-Daspartate (NMDA) toxicity in cultured murine cerebrocortical neurons in vitro and mouse cerebral cortex in vivo. The cannabinoid agonist R()-[2,3-dihydro-5-methyl-3-[(morpholinyl)- methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)- methanone mesylate [R()-Win 55212] reduced neuronal death in murine cortical cultures treated with 20 M NMDA, and its protective effect was […]



Molecular Mechanisms of Cannabinoid Protection from Neuronal Excitotoxicity

Cannabinoids protect neurons from excitotoxic injury. We investigated the mechanisms involved by studying N-methyl-Daspartate (NMDA) toxicity in cultured murine cerebrocortical neurons in vitro and mouse cerebral cortex in vivo. The cannabinoid agonist R()-[2,3-dihydro-5-methyl-3-[(morpholinyl)- methyl]pyrrolo[1,2,3-de]-1,4-benzoxazin-yl]-(1-naphthalenyl)- methanone mesylate [R()-Win 55212] reduced neuronal death in murine cortical cultures treated with 20 M NMDA, and its protective effect was […]



Modulation of Inflammatory Responses by a Cannabinoid-2–Selective Agonistafter Spinal Cord Injury

The goal of the current investigation was to evaluate the mechanisms through which administration of a selective cannabinoid-2 (CB2) agonist (O-1966) modifies inflammatory responses and helps to improve function following spinal cord injury. A comparison of motor function, autonomic function, and inflammatory responses was made between animals treated with O-1966 (5 mg/kg IP) and animals […]


Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent

Introduction: Cannabinoid compounds, both nonspecific as well as agonists selective for either cannabinoid receptor 1 (CB1 ) or cannabinoid receptor 2 (CB2 ), have been shown to modulate the tumor microenvironment by inducing apoptosis in tumor cells in several model systems. The mechanism of this modulation remains only partially delineated, and activity induced via the […]


Modulating the endocannabinoid system in human health and disease: successes and failures

The discovery of the endocannabinoid system (ECS; comprising of G-protein coupled cannabinoid 1 and 2 receptors, their endogenous lipid ligands or endocannabinoids, and synthetic and metabolizing enzymes, triggered an avalanche of experimental studies that have implicated the ECS in a growing number of physiological/pathological functions. They also suggested that modulating ECS activity holds therapeutic promise […]


Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?

Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system?. Am J Physiol Endocrinol Metab 307: E1–E13, 2014. First published May 6, 2014; doi:10.1152/ajpendo.00100.2014.—The endocannabinoid system (ECS) regulates numerous cellular and physiological processes through the activation of receptors targeted by endogenously produced ligands called endocannabinoids. Importantly, this signaling system is known […]


Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated Modulation of LPS-Induced Activation of BV-2 Microglial Cells

Cannabinoids are known to exert immunosuppressive activities. However, the mechanisms which contribute to these effects are unknown. Using lipopolysaccharide (LPS) to activate BV-2 microglial cells, we examined how D9 – tetrahydrocannabinol (THC), the major psychoactive component of marijuana, and cannabidiol (CBD) the non-psychoactive component, modulate the inflammatory response. Microarray analysis of genome-wide mRNA levels was […]


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