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A National Survey of Marijuana Use Among US Adults With Medical Conditions, 2016-2017

IMPORTANCE The number of states legalizing marijuana for medical and recreational use is increasing. Little is known regarding how or why adults with medical conditions use it. OBJECTIVES To report the prevalence and patterns of marijuana use among adults with and without medical conditions, overall and by socio-demographic group,and to further examine the associations between […]


Acute Effects of Smoked and Vaporized Cannabis in Healthy Adults Who Infrequently Use Cannabis

IMPORTANCE Vaporization is an increasingly popular method for cannabis administration,and policy changes have increased adult access to cannabis drastically.Controlled examinations of cannabis vaporization among adults with infrequent current cannabis use patterns(>30 day ssince lastuse)are needed. OBJECTIVE: To evaluate the acute dose effects of smoked and vaporized cannabis using controlled administration methods. DESIGN,SETTING,AND PARTICIPANTS This within-participant,double-blind,crossover […]


A new ESI-LC_MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis

A new ESI-LC_MS approach for comprehensive metabolic profiling of phytocannabinoids in Cannabis


δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats

PnTx4(6-1), henceforth renamed δ-Ctenitoxin-Pn1a (δ-CNTX-Pn1a), a peptide from Phoneutria nigriventer spider venom, initially described as an insect toxin, binds to site 3 of sodium channels in nerve cord synaptosomes and slows down sodium current inactivation in isolated axons in cockroaches (Periplaneta americana). δ-CNTX-Pn1a does not cause any apparent toxicity to mice, when intracerebroventricularly injected (30 […]


β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice

Recent evidence suggests that the cannabinoid receptor subtype 2 (CB2) is implicated in anxiety and depression disorders, although few systematic studies in laboratory animals have been reported. The aim of the current experiments was to test the effects of the CB2 receptor potent-selective agonist β-caryophyllene (BCP) in animals subjected to models of anxiolytic- and antidepressant-like […]


Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

Background: Cannabis therapy has been considered an effective treatment for spasticity, although clinical reports of symptom reduction in multiple sclerosis (MS) describe mixed outcomes. Recently introduced therapies of combined Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) extracts have potential for symptom relief with the possibility of reducing intoxication and other side effects. Although several past reviews have […]


Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

Background: From an early age, humans look longer at preferred stimuli and also typically look longer at facial expressions of emotion, particularly happy faces. Atypical gaze patterns towards social stimuli are common in autism spectrum conditions (ASC). However, it is unknown whether gaze fixation patterns have any genetic basis. In this study, we tested whether […]


D9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells

v9-Tetrahydrocannabinol (THC), the major active component of marijuana, induced apoptosis in C6.9 glioma cells, as determined by DNA fragmentation and loss of plasma membrane asymmetry. THC stimulated sphingomyelin hydrolysis in C6.9 glioma cells. THC and N-acetylsphingosine, a cellpermeable ceramide analog, induced apoptosis in several transformed neural cells but not in primary astrocytes or neurons. Although […]


Use of Prescription Pain Medications Among Medical Cannabis Patients: Comparisons of Pain Levels, Functioning, and Patterns of Alcohol and Other Drug Use

Objective: Management of chronic pain is one of the most common reasons given by individuals seeking medical cannabis. However, very little information exists about the concurrent use of cannabis and prescription pain medication (PPM). This study fills this gap in knowledge by systematically comparing medical cannabis users who use or do not use PPM, with […]


Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child

Objective: To evaluate the effectiveness of dronabinol (delta-9-THC) as supplementary therapy in a child with autistic disorder. Methods: A child who met the DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) criteria for a diagnosis of autistic disorder and who took no other medication during the observation time was included in an open and uncontrolled […]


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