Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancerrelated death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in antiandrogenic effects. To review currently relevant findings related to effects of cannabinoid receptors in prostate cancer. PubMed search utilizing the terms “cannabis,” “cannabinoids,” “prostate cancer,” and “cancer pain management,” giving preference to most recent publications was done. Articles identified were screened for their relevance to the field of prostate cancer and interest to both urologist and pain specialists. Prostate cancer cells possess increased expression of...