We examined whether acetylcholine release in the hippocampus and striatum and noradrenaline release in the hippocampus is altered in CB1 receptor-de®cient mice. The electrically evoked tritium over¯ow from hippocampal slices preincubated with [3 H]-choline was increased by about 100% in CB1 7/7 compared to CB1 +/+ mice whereas the electrically evoked tritium over¯ow from striatal slices preincubated with [3 H]-choline and from hippocampal slices preincubated with [3 H]- noradrenaline did not dier. The cannabinoid receptor agonist, WIN 55,212-2, inhibited, and the CB1 receptor antagonist, SR 141716, facilitated, the evoked tritium over¯ow from hippocampal slices (preincubated with [3 H]-choline) from CB1 +/+ as opposed to...
