Please use this link to access this publication. Abstract The growing use of cannabis for both recreational and medicinal purposes has raised concerns about its cutaneous adverse effects. While systemic implications of cannabis are widely reported, dermatological manifestations remain underrecognized and underreported. This review aims to consolidate existing literature on cannabis-related dermatological complications, including allergic contact dermatitis, urticaria, Stevens-Johnson syndrome (SJS), and cannabis-induced arteritis. Emphasis is placed on mechanisms involving the endocannabinoid system in the skin, case reports of dermatological reactions, and implications for clinical dermatology. A structured methodology was applied to source peer-reviewed articles from databases including PubMed and Scopus, selecting studies published...

Please use this link to access this publication. Abstract Cannabis use represents a significant risk factor for both psychotic disorders and suicidal behaviors, with growing evidence suggesting complex interactions between these variables. This systematic review examines the relationship between cannabis use and suicide risk in first-episode psychosis (FEP) patients, and explores underlying mechanisms, moderating factors, and intervention strategies. Following PRISMA guidelines, we analyzed 50 studies involving 12,764 FEP patients. Results demonstrate that cannabis use, especially high-potency cannabis used regularly, is associated with significantly increased suicide risk with studies consistently reporting elevated odds ratios (ranging from 1.43 to 1.84), and dose-dependent effects—daily use showing higher risk (studies reporting OR: 2.73,...

Abstract The increasing prevalence of cannabis use, with an estimated 219 million users globally, underscores the need to examine its potential health impacts. This review focuses on the arrhythmogenic properties of cannabis, particularly considering its active component, tetrahydrocannabinol, and its interactions with the endocannabinoid system. Epidemiological data and multiple studies indicate a significant association between cannabis use and various arrhythmias, particularly atrial fibrillation. The risk is notably higher among younger users and males. Additionally, case reports have linked cannabis use to other arrhythmias such as ventricular tachycardia and ventricular fibrillation, especially in individuals with underlying cardiac abnormalities. This review also discusses the arrhythmogenic potential...

Please use this link to access this publication. Abstract Cannabis has been consumed for centuries, but global regulatory changes over the past three decades have increased the availability and consumption of cannabis. Cannabinoids are touted to have therapeutic potential for many diseases and could be a replacement for opioids for analgesia and sedation. However, cannabinoids can cause substantial adverse cardiovascular events that would mitigate any potential benefit. The endocannabinoid system regulates mood, satiety and memory, and modulates the cardiovascular system. The link between cannabinoids and cardiovascular disease, which used to be limited to evidence from preclinical studies, case reports and case series, is now...

Abstract This review focuses on Cannabis Hyperemesis Syndrome (CHS) in youth, a condition linked to chronic cannabis use and characterized by cyclic vomiting, abdominal pain, and dehydration. The objectives were to explore CHS progression in youth and its impact on health, and to assess current treatment strategies. There are the three distinct phases of CHS: prodromal, hyperemetic, and recovery. During the prodromal phase, individuals experience early morning nausea and discomfort, often mistakenly alleviated by continued cannabis use. The hyperemetic phase is marked by severe vomiting, dehydration, and complications like electrolyte imbalances, leading to potentially serious health risks. Temporary relief may be experienced through hot...

Abstract Background Increasing legalization of recreational cannabis and availability of cannabinoid products has resulted in expanded use, which is associated with adverse effects including concerns over increased risk of motor vehicle collision (MVC). We aimed to explore the association between cannabis consumption and MVC. Methods We searched MEDLINE, EMBASE, CINAHL, Cochrane library, SCOPUS, PsycInfo, Web of Science, TRID from inception to November 2024. We included studies assessing the association between cannabis consumption on MVC fatalities, any injuries, and culpability/unsafe driving actions. Pairs of reviewers independently screened search results, extracted data, and assessed risk of bias. We used a DerSimonian and Laird random-effects model for...

Abstract Cannabis has a long history as a medicine and was a part of medical practice until the late 19th century. The discovery of cannabidiol (CBD) and ∆9-tetrahydrocannabinol (THC) in the mid-20th century, and then the various components of the endocannabinoid system (ECS) over the following decades has again brought cannabis back into the public eye as a potential therapeutic agent. At present, cannabis is being used in the community across the world for both recreational and medical purposes. In the case of medical usage, it may be prescribed by a medical doctor or purchased either legally or illicitly for medical purposes such as...

ABSTRACT Background: The occurrence of stroke in young people has risen significantly. This can easily lead to physical disabilities, swallowing difficulties, and cognitive impairment, among other issues, having a profound impact on families and society. Risk factors for stroke in young people differ from those for traditional stroke, with cannabis abuse emerging as a significant high-risk factor. However, the extent of the impact of cannabis abuse on the occurrence of stroke and the rate of disability in young people remains unclear. To clarify this issue and provide evidence supporting the primary prevention of stroke in young people, this systematic review and meta-analysis summarizes the latest...

Please use this link to access this publication. Abstract Introduction Current literature addressing fetal cannabis exposure and neonatal outcomes is based on subjective measures with varying levels of significance. This systematic review and meta-analysis determined if neonates with fetal cannabis exposure have an increased odds of being born small for gestational age, low birth weight, admitted to the Neonatal Intensive Care Unit (NICU) immediately after delivery, and/or preterm. Methods To identify relevant articles, we searched five databases using standard search criteria. Two authors used the Newcastle–Ottawa Scale to exclude articles with a high risk of bias. To estimate the combined effect, we calculated pooled...

Please use this link to access this publication. Abstract Background While an association between cannabis use and the risk of atherosclerotic cardiovascular diseases (ASCVD) has been reported numerous times, it remains inconclusive as to whether this link is causal in nature. We sought to consolidate data from observational studies to explore the association between ever use of cannabis and ASCVD outcomes, including myocardial infarction, stroke, and a combined measure of any adverse cardiovascular events in comparison to non-users or controls. Methods We performed a systematic literature search on PubMed, Scopus, ScienceDirect, and Cochrane Library for relevant studies from inception until April 2024. Statistical analyses utilized RevMan 5.4 with a random effects model....