Abstract Cannabis sativa L. is a dioecious species known to produce over 1600 chemical constituents, including more than 180 cannabinoids classified into 11 structural groups. These bioactive compounds are predominantly synthesised in the glandular trichomes of female inflorescences. However, sex determination in C. sativa is influenced by both genetic and environmental factors, often leading to the development of male flowers on female plants. This unintended fertilisation reduces cannabinoid yield and increases genetic heterogeneity and challenges in medical cannabis production. Haploid and doubled haploid (DH) technologies offer a promising solution by rapidly generating homozygous lines from gametophytic (e.g., unpollinated ovaries and ovules) or sporophytic tissues (e.g., anthers and...

Please use this link to access this publication. Abstract Introduction Renal infarction is a rare cause for an acute renal failure. At the time being, there is no sufficient correlation to the consumption of cannabis described. Case history A 40-year-old male patient presented to our emergency room because of pain in the right renal bed. Examination and findings The duplex ultrasound showed no ectasia, but the computed tomography confirmed a renal infraction on the right side. The further diagnostics gave no indication of a classical pathogenesis, but there was a constant consumption of cannabis documented. Therapy and course We decided for a conservative treatment with analgesia, diagnostic laboratory...

Abstract Importance  Despite evidence that individuals with a cannabis use disorder (CUD) are at elevated risk of psychosis and that the neurotransmitter dopamine has a role in psychosis, the mechanism linking cannabis use and psychosis remains unclear. Objective  To use neuromelanin-sensitive magnetic resonance imaging (MRI), referred to as the neuromelanin-MRI signal, a practical, proxy measure of dopamine function, to assess whether a common alteration in the dopamine system may be implicated in CUD and psychosis and whether this alteration can be observed in those with a CUD whether or not they have a diagnosis of first-episode schizophrenia (FES). Design, Setting, and Participants  This longitudinal observational cohort study recruited...

Please use this link to access this publication. Abstract Background: Rapid changes in the legalized cannabis market have led to the predominance of high-concentration delta-9-tetrahydrocannabinol (THC) cannabis products. Purpose: To systematically review associations of high-concentration THC cannabis products with mental health outcomes. Data Sources: Ovid MEDLINE through May 2025; EMBASE, Allied and Complementary Medicine Database, Cochrane Library, Database of Abstracts of Reviews of Effects, CINAHL, and Toxicology Literature Online through August 2024. Study Selection: Two reviewers independently selected studies with high-concentration THC defined as greater than 5 mg or greater than 10% THC per serving or labeled as “high-potency concentrate,” “shatter,” or “dab.” Data...

Please use this link to access this publication. Abstract Catatonia is a diagnosis characterized by a combination of abnormal movements, behaviors, and withdrawal. It has been linked to mental health diagnoses such as schizophrenia and mood disorders. Catatonia is both traumatic for the patient and linked to multiple negative downstream medical diagnoses. Marijuana is a frequently utilized recreational drug that has been shown to have various neuropsychiatric effects in recent years. This report describes the case of a young adult male presenting with catatonia in the setting of cannabis use without other predisposing factors. It adds to the growing evidence of cannabis-associated catatonia, and...

Abstract Beneficial cannabis use has sparked growing interest among researchers, leading to an increase in empirical studies exploring its phytochemistry and applications. However, understanding the overall research orientation remains limited. This study aims to bridge this gap by conducting a bibliometric analysis of 7841 documents published from 2012 to 2022. The analysis reveals an annual growth rate of 16.83 %, with a focus on medicine, pharmacology, toxicology, pharmaceutics, biochemistry, genetics, molecular biology, and neuroscience. Performance analysis highlights metrics of sources, countries, affiliations, and authors, while science mapping identifies keywords, thematic evolution, and citation/co-authorship patterns. Notably, Morocco, despite its limited initial contributions, has shown recent steady growth in cannabis research, with an annual growth...

Abstract Cannabis use has increased significantly in the last decade. This article presents a case where a patient needed more local anesthetic (LA) than usual to induce effective anesthesia during hair transplant surgery. The reason cannabis users often need more LA is poorly understood. One possibility is that cannabis withdrawal effect makes patients more sensitive to pain and stress. Additionally, vasodilatory property of cannabis may speed up LA clearance from the application site. The interactions of two major cannabinoids, cannabidiol (CBD) and tetrahydrocannabinol (THC), with cannabinoid receptor type 1 (CB1), cannabinoid receptor type 2 (CB2), and transient receptor potential vanilloid 1 (TRPV1) receptors are...

Abstract Vaping-associated spontaneous pneumothorax (VASP) is a new diagnosis created to describe spontaneous pneumothorax associated with the use of vape devices. We describe a case of bilateral VASP in a previously healthy 15-year-old male who was vaping cannabis concentrate. This is the first case report of VASP involving the sole usage of cannabis concentrate. This patient reported vaping for only 6 months before initial presentation. As rates of vaping cannabis concentrate increase among adolescents, VASP should be considered in the differential diagnosis of chest pain in adolescents who vape nicotine or cannabis.

Please use this link to access this publication. Abstract The past 30 years in the United States have seen a shift towards increasing decriminalization and legalization of cannabis products. Despite the evolving legal landscape, adolescent cannabis use appears to have remained relatively stable, while use among young adults has increased. Cannabis-related emergency department visits, hospitalizations, and unintentional ingestions, particularly among young children, have all increased, with the availability of higher potency products such as concentrates and edibles likely playing a role. Cannabis intoxication should be suspected in youth presenting with altered mental status, somnolence, anxiety or euphoria, tachycardia, and conjunctival injection. In adolescents presenting with cyclic vomiting, cannabinoid hyperemesis syndrome should be considered. Long-term effects of...

Abstract As a wide group of medicines, the effectiveness and safety of ‘medical cannabis’ products is likely to vary in relation to product-specific dimensions such as potency, dosage, route of administration, and cannabinoid composition. Systematic reviews can perform a crucial role in analysing and synthesising the outcomes of medical cannabis interventions found in empirical research. We analysed 23 contemporary systematic reviews on the effectiveness and safety of medical cannabis to discern the extent to which this body of work aimed to capture, and ultimately captured, the differing outcomes of medical cannabis products by product-specific dimensions of treatment. We further highlighted the methodological reasons given...