ABSTRACT Background A third of epilepsy patients fail to enter seizure remission despite optimal therapeutic management. Cannabis-based medicinal products (CBMPs) have shown promise as a potential therapy. However, a paucity of high-quality literature regarding CBMPs’ efficacy and safety profile means further investigation is needed. The study aimed to examine changes in epilepsy-specific and general health-related quality of life (HRQoL) patient-reported outcome measures (PROMs) in individuals with treatment-resistant epilepsy. Methods A case series of patients with epilepsy from the UK Medical Cannabis Registry analyzed changes in Quality of Life in Epilpesy-31 (QOILE-31), Single-Item Sleep Quality Score (SQS), EQ-5D-5L, Generalized Anxiety Disorder-7 (GAD-7) and Patient Global...

Please use this link to access this publication. Abstract Acute cannabis exposure can transiently impair cognitive performance, increasing the risk of accidental injury and potentially disrupting activities of daily living. Although sex differences in responses to cannabis have been reported, no systematic review has examined whether these extend to acute cognitive effects. Our primary aim was to examine sex differences in the acute effects of cannabis (including isolated delta-9-tetrahydrocannabinol [THC]) on cognition in humans. Our secondary aim was to determine if sex differences in the acute effects of cannabis vary by cognitive domain, route of administration, or dosing paradigm. Following PRISMA guidelines, we conducted...

Please use this link to access this publication. Abstract Purpose: This study aimed to review the literature on the impact of medical cannabis (MC) on the quality of life (QoL) of cancer patients. Materials and Methods: A critical review was conducted using PubMed, Latin American and Caribbean Health Sciences Literature, Scopus, Virtual Health Library, and Embase. The inclusion criteria were access to the full content; in English, Spanish, or Portuguese; published until January 2025, relating “Cancer,” “Quality of Life,” and “Medical Cannabis.” Of the 267 articles identified, 16 were selected for the final analysis. Results: The studies suggest that MC can improve mental health, sleep, appetite, and...

Abstract Background: Considering the effects of environmental factors and genetic predispositions on mental health outcomes, the current work concentrated on the cannabinoid receptor 1 (CNR1) gene single-nucleotide polymorphism (SNP) rs1049353 as one of the primary genetic markers for cannabis-induced psychosis (CIP). By analyzing this SNP, the study contributes to the corpus of information to identify genetic traits that ultimately predict the response of an evolving disease following exposure to a particular substance after gene and environmental interaction and risk of a particular disease. Methods: Grouped by CIP, cannabis use without psychosis, schizophrenia unlinked to cannabis use, and a healthy control group, a thorough investigation...

Please use this link to access this publication. Abstract The relationship between cannabis use and mental health is complex, as studies often report seemingly contradictory findings regarding whether cannabis use results in more positive or negative treatment outcomes. With an increasing number of individuals using cannabis for both recreational (i.e., non-medical) and medical purposes, it is critical to gain a deeper understanding of the ways in which cannabis may be helpful or harmful for those diagnosed with psychiatric disorders. Although cannabis is composed of hundreds of compounds, studies assessing the effects of “cannabis” most often report the impact of delta-9-tetrahydrocannabinol (d9-THC), the primary intoxicating...

Please use this link to access this publication. ABSTRACT This letter responds to Cernat et al.'s study on counseling about cannabis use during pregnancy and lactation, drawing parallels with addiction treatment practices in Taiwan. We highlight the importance of open, non-judgmental approaches and harm reduction strategies in counseling pregnant women with substance use disorders. Our experience at a psychiatric center in Taiwan emphasizes the need for continuous counseling throughout pregnancy and postpartum, particularly given the observed increase in cannabis use among new mothers. We support the study's emphasis on exploring patients' perceived benefits from cannabis use and addressing underlying reasons for use. By integrating insights...

Background: Rising cannabis use poses significant challenges in the administration of general anesthetics, particularly propofol, due to potential alterations in pharmacodynamics caused by tetrahydrocannabinol and its interactions with central nervous system receptors. This systematic review and meta-analysis aims to consolidate the existing literature to quantify propofol requirements in cannabis users, highlighting the complex relationship between cannabis use and anesthetic management. Methods: A systematic search of English-language literature was conducted to identify studies with data on propofol dosing in adult cannabis users. Propofol requirements were defined as the total intraoperative dose needed to achieve and maintain adequate sedation or anesthesia, assessed using parameters like monitoring and...

Abstract Wellens syndrome is a rare variant of acute coronary syndrome (ACS) that often heralds an impending large anterior wall myocardial infarction. We present the case of a young male with no traditional coronary artery disease (CAD) risk factors. Despite only minimally elevated troponin levels, the patient's smoking history, serial electrocardiogram (ECG) changes, and the emerging evidence linking cannabis use to cardiovascular risk contributed to the timely diagnosis of Wellens syndrome. Although cannabis is increasingly accepted for medical and recreational use, growing concerns have been raised about its potential adverse cardiovascular effects. This case highlights the importance of early identification and prompt intervention. In Wellens syndrome,...

Abstract Background Cannabis use during pregnancy is becoming more prevalent. While numerous studies have explored the relationship of cannabis use during pregnancy and outcomes for mothers and infants, uncertainty remains regarding the impact of cannabis use on pregnancy complications and later-life outcomes for offspring. Aims To produce a summary of the short and long-term effects of prenatal cannabis exposure on fetal growth and development, neonatal conditions, later-life, and maternal outcomes. Materials and Methods An overview of systematic reviews, an evidence and gap map, targeted updates of previous reviews, and de novo evidence synthesis was conducted. The databases searched include PubMed (National Center for Biotechnology Information); MEDLINE...

Please use this link to access this publication. Abstract The development of the brain is a highly coordinated process that begins early in gestation and relies on intricate interactions between maternal and fetal immune systems. Disruptions to this delicate prenatal immune environment can significantly impact fetal brain development, increasing the risk of a spectrum of neurological and behavioral disorders, including autism spectrum disorder (ASD), schizophrenia, depression, and anxiety. While maternal exposure to viral and bacterial infections has been extensively studied as a driver of these disruptions, emerging research highlights the potential role of non-infectious exposures—such as drugs of abuse and environmental contaminants—in shaping neurodevelopmental...