Please use this link to access this publication. Abstract Aims Cannabis use is highly prevalent in patients seeking treatment for opioid use disorder. Studies have shown mixed results on the association between cannabis use and opioid use as well as the impact of MOUD on cannabis use. The current study aims to investigate the effects of buprenorphine versus naltrexone on cannabis use outcomes in treatment seeking individuals with Opioid Use Disorder (OUD). Methods The current study was based on data from the CTN-0051 X:BOT trial, which compared the time to return to significant opioid use survival outcomes of two treatment seeking groups, one receiving Extended-Release Naltrexone (XR-naltrexone) (N = 283) versus...

Abstract Background: Chronic noncancer pain (CNCP) affects one in five adults and is commonly managed with long-term opioid therapy. Concerns regarding rare but catastrophic harms associated with opioids, including overdose and death, have generated interest in alternatives including cannabis; however, the comparative cost-effectiveness of these management options is uncertain. Methods: We used findings from a network meta-analysis of 90 randomized trials to develop a 1-year microsimulation model to compare costs and quality-adjusted life years (QALY) between oral medical cannabis and opioids for CNCP. We used a publicly funded health care payer perspective for our analyses and obtained cost and utility data from publicly available...

Abstract Background: Existing scales that measure cannabis use motives have failed to incorporate the full range of motives that underpin cannabis consumption, especially with the increased use of medical cannabis. The current research aimed to develop a novel, psychometrically robust scale that comprehensively measures cannabis use motives. Here, we report the development and validation of the Comprehensive Cannabis Motives Questionnaire (CCMQ). Method: Cannabis users completed a 45-item questionnaire measuring a range of cannabis use motives. A UK English-speaking sample (n = 450) provided data for exploratory factor analysis. A second UK English-speaking sample (n = 200) was used for confirmatory factor analysis. Test–retest reliability was based on a...

Abstract In patients with schizophrenia, cannabis use exacerbates symptoms and can lead to a relapse of psychosis. Some experimental studies in healthy volunteers suggest that pre-treatment with cannabidiol (CBD) may reduce these effects, but others do not. Here, we investigated whether pre-treatment with CBD ameliorates the acute adverse effects of cannabis in patients with schizophrenia. Participants (n = 30) had schizophrenia or schizoaffective disorder plus a comorbid cannabis use disorder. In a double-blind, randomised, placebo-controlled, crossover trial, participants received oral CBD 1000 mg or placebo three hours before inhaling vaporised cannabis (containing Δ9-tetrahydrocannabinol (THC) 20–60 mg). The primary outcome was delayed verbal recall measured with the Hopkins Verbal...

Please use this link to access this publication. Abstract Cannabis hyperemesis syndrome (CHS) is a condition characterized by recurrent episodes of severe nausea and vomiting associated with chronic cannabis use. This case report describes a 16.5-year-old male patient who presented with a 2-year history of recurrent vomiting episodes lasting up to 10 days, accompanied by abdominal pain and weight loss. After extensive diagnostic workup and exclusion of other causes, CHS was diagnosed based on the temporal relationship between cannabis use and symptom onset. The patient's symptoms resolved with supportive care and cessation of cannabis use. This case highlights the importance of considering CHS in...

ABSTRACT Objective: The use of electronic vaporisers to deliver cannabis (‘cannabis vaping’) has increased rapidly among young people. This systematic review and meta-analysis aimed to summarise current evidence on the psychosocial characteristics of adolescents and young adults who vape cannabis. Method: PubMed, PsycINFO, Scopus, and Web of Science were searched for original publications since 2003. We summarised and meta-analysed studies on adolescents (12-18 years) and young adults (19-34 years) that reported sociodemographic, mental health, and other substance use correlates of cannabis vaping. Results: Thirty-one studies from the U.S., Canada, England, New Zealand, and Switzerland met eligibility criteria (n=568,304): twenty-six on adolescents (12-18 years; n=554,934), five...

Abstract Background Cannabis use during pregnancy is increasingly common and is associated with adverse health outcomes for pregnant individuals and their offspring. Identifying preconception factors that are associated with prenatal cannabis use is critical to inform early prevention and intervention. This study tested whether frequency of preconception cannabis use was associated with cannabis use during early pregnancy using data from a large healthcare system with universal screening for cannabis use. Methods This observational study included pregnant individuals in Kaiser Permanente Northern California (KPNC) who self-reported any cannabis use (daily, weekly, or monthly or less) during the year before pregnancy from 2011 to 2022 (excluding...

Abstract Aims: We measured the effects of public health-oriented cannabis access compared with the illegal market on cannabis use and related mental health outcomes in adult cannabis users. Design: This was a two-arm, parallel group, open-label, randomized controlled trial. Follow-up outcome measurement took place after 6 months. Setting: The study was conducted in Basel-Stadt, Switzerland. Participants: A total of 378 adult (aged ≥18 years) cannabis users were enrolled and randomized between August 2022 and March 2023, although only 374 users who completed baseline measures could be included. Intervention and comparator: Participants were randomly assigned to the intervention group with public health-oriented recreational cannabis access in pharmacies (regulated cannabis products,...

Please use this link to access this publication. Abstract Introduction Cannabis use and misuse have mental health implications, particularly affecting mood and anxiety symptoms. Vortioxetine, a potent serotonin partial agonist/antagonist reuptake inhibitor antidepressant, has well-established effects in treating depressive and anxiety disorders and may serve as a potential treatment for individuals with cannabis use disorder and comorbid mood symptoms. In the current study, we aimed to investigate the efficacy of vortioxetine for cannabis users with anxiety and depressive symptoms alongside their cannabis dependence. Methods This 6-month prospective, randomized controlled interventional pilot study investigated if vortioxetine could improve cannabis dependence, comorbid anxiety and/or depressive symptoms,...