Please use this link to access this publication. Abstract Cannabis sativa L. is gaining attention as a multifunctional species for environmental remediation due to its high biomass productivity, pollutant tolerance, and versatility. This review synthesizes its application across three environmental media: soil, water, and air. In soil systems, hemp has been investigated for the remediation of heavy metals, organic pollutants (f.ex., PAHs), and radionuclides, via mechanisms such as phytoextraction, rhizodegradation, and phytostabilization. Aquatic applications include biosorption (using raw and chemically modified hemp-derived materials to remove nutrients, heavy metals, dyes, and pharmaceuticals), hydroponic phytoremediation of landfill leachate, and field cultivation with treated wastewater irrigation. The review analysis reveals that hemp-based soil remediation, particularly for heavy metals, is the most developed...

Please use this link to access this publication. Abstract Cannabis sativa is one of the oldest medicinal plants in human history. Even ancient physicians from hundreds of years ago used Cannabis sativa to treat several conditions like pain. In the modern era, the research community, including health-care providers, have witnessed wide-scale changes in cannabis policy, legislation, and marketing, with a parallel increase in patient interest. A simple search in PubMed using “cannabis and pain” as keywords provides more than 2,400 articles, about 80% of which were published in the last 8–10 years. Several advancements have been achieved in understanding the complex chemistry of cannabis along with its multiple...

Please use this link to access this publication. Abstract Introduction: Cannabis vaporization is useful for individuals requiring fast-acting method of cannabis administration and for individuals using smoked cannabis as a harm reduction tool. There is a need for guidance on how to assess if a patient is a vaporization candidate and how to safely initiate and monitor cannabis vaporization. Methods: An overview of safe cannabis vaporization, including practical guidance and tactics to promote the lowest-risk use, is provided. This review was developed through a combination of expert clinical opinion and reviewing the available literature. Results: Dried cannabis vaporizers and metered-dose inhalers are recommended to be used over...

Abstract Chronic non-cancer pain, defined by the Center for Disease Control and Prevention (CDC) as lasting beyond three months, significantly affects individuals’ quality of life and is often linked to various medical conditions or injuries. Its management is complex. Cannabis, containing the key compounds Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), has garnered interest for its potential in pain management, though it remains controversial due to its psychoactive effects and illegal status in many countries. THC provides pain relief by blocking nociceptive stimuli but has psychoactive effects and may potentially induce dependency. CBD has calming and antipsychotic properties. The inhalation of cannabis offers quick relief but...

Abstract Background The use of cannabis has been associated with both therapeutic and harmful effects. As with cigarette smoking, cannabis smoking may affect the epigenetic regulation (e.g., DNA methylation) of gene expression which could result in long term health effects. The study of DNA methylation in cannabis smoking has to date been restricted to young adults and there remains yet no evaluation of whether cannabis smoking cessation can reverse epigenetic disturbances. Here, we aimed to investigate the relationship between genome-wide DNA methylation and cannabis smoking. Methods We used peripheral blood from a subset of older adults within the Canadian Cohort of Obstructive Lung Disease...

Abstract Background and aim Video gaming (VG) and cannabis use are two behaviors that are particularly prevalent among adolescents and young adults, as they can both be sedentary activities that are used to help decompress. As such, this raises questions about the possible relationship between VG and cannabis use. The aim of the present review is to document the relationship between VG and cannabis use. Methods A scoping review identified 25 articles published between 2000 and February 2025, and presenting original findings on the relationship between VG and cannabis use. Results Results demonstrate that existing literature is heterogeneous in its methods and measures. Nonetheless,...

Please use this link to access this publication. Abstract Epidemiological data have provided evidence that psychotic-like experiences (PLEs) occur in the general population without clinical impairment. According to the psychosis continuum hypothesis, PLEs are subject to multiple risk factors. This review synthesizes current research on biological, substance use-related, and environmental risk factors for PLEs in non-clinical populations. PubMed/Medline and Scopus databases were searched for peer-reviewed studies published until January 2024 investigating risk factors for PLEs in non-clinical samples. Following PRISMA guidelines, 38 full-text articles were analyzed after title/abstract and full-text screening (PROSPERO registration ID: N 1001,807). Four main risk factor categories emerged. Biological vulnerabilities...

Abstract Cannabis is the most widely consumed illicit substance worldwide, with rising use particularly among adolescents and young adults. Accumulating evidence indicates that chronic cannabis use may negatively impact several domains of cognition, yet findings across studies remain varied and fragmented. This comprehensive review synthesizes current knowledge on the long-term cognitive consequences of cannabis use, focusing on attention, executive functioning, learning, memory, language, motor coordination, and social cognition. Consistent impairments have been observed in domains such as attention, executive function, memory, and learning; however, most evidence derives from studies of acute or residual effects. Evidence of long-lasting deficits after extended abstinence remains more limited...

Please use this link to access this publication. Abstract Objective: Amid continuously rising concentrations of delta-9-tetrahydrocannabinol (THC) in cannabis (i.e., potency), high-potency cannabis is a major topic in contemporary cannabis policy discussions, yet its impact on health is not well understood. The authors conducted a systematic review of observational and experimental studies examining the relationship between high-potency cannabis use and a range of health outcomes. Methods: Records were obtained from a systematic search of five biomedical research databases. The authors developed ecologically relevant potency (percent THC) exposure-comparison categories (1%–9%, 10%–19%, 20%–30%, kief/resin [∼30%–50%], concentrates [≥60%]) and used a landmark scientific report on cannabis and...

Please use this link to access this publication. Abstract Purpose of review This review examines the literature associating cannabis with schizophrenia, glutamate dysregulation in schizophrenia, and cannabis involvement in glutamate pathways. Cannabis use is widespread among adolescents world-wide and is sold legally in many countries for recreational use in a variety of forms. Most people use it without lasting effects, but a portion of individuals have negative reactions that manifest in acute psychotic symptoms, and in some, symptoms continue even after the use of cannabis has ceased. To date, there is a huge gap in our understanding of why this occurs. Recent findings Recent...