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Research Library

A-Z Conditions  Participate in ORR

Involvement of the endocannabinoid system in drug addiction

  • Journal : TRENDS in Neuroscience
  • Publication Year : 2006
  • Authors : Rafael Maldonado; Olga Valverde; Fernando Berrendero

Recent studies have shown that the endocannabinoid system is involved in the common neurobiological mechanism underlying drug addiction. This system participates in the primary rewarding effects of cannabinoids, nicotine, alcohol and opioids, through the release of endocannabinoids in the ventral tegmental area. Endocannabinoids are also involved in the motivation to seek drugs by a dopamine-independent mechanism, demonstrated for psychostimulants and opioids. The endocannabinoid system also participates in the common mechanisms underlying relapse to drugseeking behaviour by mediating the motivational effects of drug-related environmental stimuli and drug reexposure. In agreement, clinical trials have suggested that the CB1 cannabinoid antagonist rimonabant can cause smoking cessation. Thus, CB1 cannabinoid antagonists could represent a new generation of compounds to treat drug addiction.

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Conditions:

  • Addiction

Research Information:

Research Keywords:

  • Animal/physiology, Animals, Appetitive Behavior/physiology, Behavior, Cannabinoid, Cannabinoid Receptor Modulators/metabolism, CB1/antagonists & inhibitors, CB1/therapeutic use, Endocannabinoids, Humans, Knockout, Mice, Neuronal Plasticity/physiology, rats, Receptor, Recurrence, Reward, Substance-Related Disorders/drug therapy, Substance-Related Disorders/metabolism, Ventral Tegmental Area/metabolism

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