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Research Library

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Cannabis use amongst patients with inflammatory bowel disease

  • Journal : European Journal of Gastroenterology & Hepatology
  • Publication Year : 2011
  • Authors : Simon Lala, Neeraj Prasad, Manijeh Ryana, Sabrena Tangria, Mark S. Silverberga, Allan Gordona, & Hillary Steinharta

Background: Experimental evidence suggests the endogenous cannabinoid system may protect against colonic inflammation, leading to the possibility that activation of this system may have a therapeutic role in inflammatory bowel disease (IBD). Medicinal use of cannabis for chronic pain and other symptoms has been reported in a number of medical conditions. We aimed to evaluate cannabis use in patients with IBD.

Methods: One hundred patients with ulcerative colitis (UC) and 191 patients with Crohn’s disease (CD) attending a tertiary-care outpatient clinic completed a questionnaire regarding current and previous cannabis use, socioeconomic factors, disease history and medication use, including complimentary alternative medicines. Quality of life was assessed using the short-inflammatory bowel disease questionnaire.

Results: A comparable proportion of UC and CD patients reported lifetime [48/95 (51%) UC vs. 91/189 (48%) CD] or current [11/95 (12%) UC vs. 30/189 (16%) CD] cannabis use. Of lifetime users, 14/43 (33%) UC and 40/80 (50%) CD patients have used it to relieve IBD-related symptoms, including abdominal pain, diarrhoea and reduced appetite. Patients were more likely to use cannabis for symptom relief if they had a history of abdominal surgery [29/48 (60%) vs. 24/74 (32%); P = 0.002], chronic analgesic use [29/41 (71%) vs. 25/81 (31%); P < 0.001], complimentary alternative medicine use [36/66 (55%) vs. 18/56 (32%); P = 0.01] and a lower short inflammatory bowel disease questionnaire score (45.1 ± 2.1 vs. 50.3 ± 1.5; P = 0.03). Patients who had used cannabis [60/139 (43%)] were more likely than nonusers [13/133 (10%); P < 0.001 vs. users] to express an interest in participating in a hypothetical therapeutic trial of cannabis for IBD.

Conclusion: Cannabis use is common amongst patients with IBD for symptom relief, particularly amongst those with a history of abdominal surgery, chronic abdominal pain and/or a low quality of life index. The therapeutic benefits of cannabinoid derivatives in IBD may warrant further exploration.

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Conditions:

  • Gastrointestinal Disease

Research Information:

Research Keywords:

  • Cannabis, complimentary alternative medicine, Crohn’s Disease, Inflammatory bowel disease (IBD), ulcerative colitis

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