• 719-347-5400
  • info@realmofcaring.org
  • 719-347-5400
  • info@realmofcaring.org
  • Home
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Blog
      • Blog: Client Stories
      • Blog: Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
    • Aspen Green Giveaway
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
Menu
  • Home
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Blog
      • Blog: Client Stories
      • Blog: Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
    • Aspen Green Giveaway
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
  • Donate
  • Register
  • Login
  • Home
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Blog
      • Blog: Client Stories
      • Blog: Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
    • Aspen Green Giveaway
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
Menu
  • Home
  • Research
    • Observational Research Registry
    • Company Interest
    • Research Library
  • Resources
    • Client Portal
      • Dosing & Administration
      • Client Education Series
      • Client F.A.Q.
        • Client Additional Questions
      • For Pets
      • Glossary
      • Observational Research Registry
      • Printable Resources
      • Supported Brands
    • Healthcare Portal
      • Dosing & Administration
      • Join Our List of Healthcare Professionals
      • Practitioner Education
    • Blog
      • Blog: Client Stories
      • Blog: Education
    • Find a Provider
      • Locate a Healthcare Professional
      • MMJ Recommendations
    • Aspen Green Giveaway
  • About
    • Who We Are
    • In the News
    • Supported Brands
    • Our Supporters
    • Financials
  • Contact Us
  • Donate
  • Login
  • Alzheimer Disease/pathology, Animals, Base Sequence, Cannabidiol/pharmacology, Cannabinoids/pharmacology, Cells, Cultured, DNA Primers, Humans, immunohistochemistry, In Vitro Techniques, Messenger/metabolism, Mice, Microglia/drug effects, Nitric Oxide/biosynthesis, Polymerase Chain Reaction, rats, RNA
Loading...

Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease

Microglial activation is an invariant feature of Alzheimer's disease (AD). It is noteworthy that cannabinoids are neuroprotective by preventing β-amyloid (Aβ)-induced microglial activation both in vitro and in vivo. On the other hand, the phytocannabinoid cannabidiol (CBD) has shown anti-inflammatory properties in different paradigms. In the present study, we compared the effects of CBD with those of other cannabinoids on microglial cell functions in vitro and on learning behavior and cytokine expression after Aβ intraventricular administration to mice. CBD, (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl) pyrrolo-[1,2,3-d,e]-1,4-benzoxazin-6-yl]-1-naphthalenyl-methanone [WIN 55,212-2 (WIN)], a mixed CB(1)/CB(2) agonist, and 1,1-dimethylbutyl-1-deoxy-Δ(9)-tetrahydrocannabinol [JWH-133 (JWH)], a CB(2)-selective agonist, concentration-dependently decreased ATP-induced (400 μM) increase in intracellular calcium...
Read More

Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impacts upon the central processing of pain is crucial for the identification of novel analgesic targets/new therapeutic strategies. Inhibitory cannabinoid 2 (CB2) receptors attenuate peripheral immune cell function and modulate central neuro-immune responses in models of neurodegeneration. Systemic administration of the CB2 receptor agonist JWH133 attenuated OAinduced pain behaviour, and the changes in circulating pro- and anti-inflammatory cytokines exhibited in this model. Electrophysiological studies revealed that spinal administration of JWH133...
Read More

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition

Background: ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific ErbB2-targeted therapies have been designed, only a small percentage of patients respond to these treatments and most of them eventually relapse. The existence of this population of particularly aggressive and non-responding or relapsing patients urges the search for novel therapies. The purpose of this study was to determine whether cannabinoids might constitute a new therapeutic tool for the treatment of ErbB2-positive breast tumors. We analyzed their antitumor potential in a well established and clinically relevant model of ErbB2-driven metastatic breast cancer: the MMTV-neu mouse. We also...
Read More

Hypothalamic POMC neurons promote cannabinoid-induced feeding

Hypothalamic pro-opiomelanocortin (POMC) neurons promote satiety. Cannabinoid receptor 1 (CB1R) is critical for the central regulation of food intake. Here we test whether CB1R-controlled feeding in sated mice is paralleled by decreased activity of POMC neurons. We show that chemical promotion of CB1R activity increases feeding, and notably, CB1R activation also promotes neuronal activity of POMC cells. This paradoxical increase in POMC activity was crucial for CB1R-induced feeding, because designer-receptors-exclusively-activated-by-designer-drugs (DREADD)-mediated inhibition of POMC neurons diminishes, whereas DREADD-mediated activation of POMC neurons enhances CB1R-driven feeding. The Pomc gene encodes both the anorexigenic peptide α-melanocyte-stimulating hormone, and the opioid peptide β-endorphin. CB1R activation selectively increases...
Read More

Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver.

Effects of four cannabinoids [cannabidiol (CBD), delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol, and cannabinol] on hepatic microsomal oxidation of testosterone (17 beta-hydroxy-androst-4-ene-3-one) were examined in adult male rats. Only CBD (30 microM) competitively inhibited 2 alpha-hydroxy-testosterone (2 alpha-OH-T) and 16 alpha-OH-T formation by hepatic microsomes but did not affect androstenedione (androst-4-ene-3,17-dione) and 7 alpha-OH-T formation. Kinetic analyses demonstrated that the inhibitory profile of CBD for testosterone oxidation was different from those of SKF 525-A, which caused competitive inhibition for 2 alpha- and 16 alpha-hydroxylations and noncompetitive inhibition for 6 alpha-hydroxylation, and of metyrapone, which inhibited only 6 beta-hydroxylation competitively. CBD also suppressed formation of 2 alpha-OH-T,...
Read More

REGISTER WITH THE RoC TODAY!

Realm of Caring focuses on research, education, building community, and improving quality of life. We are an educational resource for consumers, physicians, scientists, governments and the media.
Register now
  • 5040 Corporate Plaza Drive, Suite 7R, Colorado Springs, CO 80919
  • 719-347-5400
  • info@realmofcaring.org

Copyright © 2021 / Realm of Caring Foundation, Inc

  • Privacy
  • Disclaimer